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P10715

- CYC2_RAT

UniProt

P10715 - CYC2_RAT

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Protein

Cytochrome c, testis-specific

Gene

Cyct

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei15 – 151Heme (covalent)
Binding sitei18 – 181Heme (covalent)
Metal bindingi19 – 191Iron (heme axial ligand)
Metal bindingi81 – 811Iron (heme axial ligand)

GO - Molecular functioni

  1. electron carrier activity Source: InterPro
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. oxidation-reduction process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c, testis-specific
Gene namesi
Name:Cyct
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 3

Organism-specific databases

RGDi2452. Cyct.

Subcellular locationi

Mitochondrion intermembrane space
Note: Loosely associated with the inner membrane.

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
  2. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 105104Cytochrome c, testis-specificPRO_0000108232Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylglycineBy similarity

Post-translational modificationi

Binds 1 heme group per subunit.
Phosphorylation at Tyr-49 and Tyr-98 both reduce by half the turnover in the reaction with cytochrome c oxidase, down-regulating mitochondrial respiration.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiP10715.

PTM databases

PhosphoSiteiP10715.

Expressioni

Tissue specificityi

This is one of two isocytochromes C found in the testis. The other is identical with the form found in other rat tissues. These cytochromes are assumed to be located in the sperm.

Gene expression databases

ExpressionAtlasiP10715. baseline and differential.
GenevestigatoriP10715.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008300.

Structurei

3D structure databases

ProteinModelPortaliP10715.
SMRiP10715. Positions 2-105.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c family.Curated

Phylogenomic databases

eggNOGiNOG270709.
GeneTreeiENSGT00760000119066.
HOGENOMiHOG000009762.
HOVERGENiHBG003023.
KOiK08738.
OMAiEAFENPA.
OrthoDBiEOG7RRF69.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiIPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
IPR003088. Cyt_c_dom.
[Graphical view]
PANTHERiPTHR11961. PTHR11961. 1 hit.
PfamiPF00034. Cytochrom_C. 1 hit.
[Graphical view]
PRINTSiPR00604. CYTCHRMECIAB.
SUPFAMiSSF46626. SSF46626. 1 hit.
PROSITEiPS51007. CYTC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10715-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGDAEAGKKI FIQKCAQCHT VEKGGKHKTG PNLWGLFGRK TGQAPGFSYT
60 70 80 90 100
DANKNKGVIW TEETLMEYLE NPKKYIPGTK MIFAGIKKKS EREDLIQYLK

EATSS
Length:105
Mass (Da):11,743
Last modified:January 23, 2007 - v2
Checksum:i840BF657FBDD9E8C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M20623 mRNA. Translation: AAA41016.1.
M20628, M20627 Genomic DNA. Translation: AAA41015.1.
PIRiA28160. CCRTT.
RefSeqiNP_036972.1. NM_012840.3.
UniGeneiRn.88630.

Genome annotation databases

EnsembliENSRNOT00000008371; ENSRNOP00000008371; ENSRNOG00000024457.
GeneIDi25310.
KEGGirno:25310.
UCSCiRGD:2452. rat.

Cross-referencesi

Web resourcesi

Protein Spotlight

Life shuttle - Issue 76 of November 2006

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M20623 mRNA. Translation: AAA41016.1 .
M20628 , M20627 Genomic DNA. Translation: AAA41015.1 .
PIRi A28160. CCRTT.
RefSeqi NP_036972.1. NM_012840.3.
UniGenei Rn.88630.

3D structure databases

ProteinModelPortali P10715.
SMRi P10715. Positions 2-105.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000008300.

PTM databases

PhosphoSitei P10715.

Proteomic databases

PRIDEi P10715.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000008371 ; ENSRNOP00000008371 ; ENSRNOG00000024457 .
GeneIDi 25310.
KEGGi rno:25310.
UCSCi RGD:2452. rat.

Organism-specific databases

CTDi 13067.
RGDi 2452. Cyct.

Phylogenomic databases

eggNOGi NOG270709.
GeneTreei ENSGT00760000119066.
HOGENOMi HOG000009762.
HOVERGENi HBG003023.
KOi K08738.
OMAi EAFENPA.
OrthoDBi EOG7RRF69.

Miscellaneous databases

NextBioi 606119.
PROi P10715.

Gene expression databases

ExpressionAtlasi P10715. baseline and differential.
Genevestigatori P10715.

Family and domain databases

Gene3Di 1.10.760.10. 1 hit.
InterProi IPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
IPR003088. Cyt_c_dom.
[Graphical view ]
PANTHERi PTHR11961. PTHR11961. 1 hit.
Pfami PF00034. Cytochrom_C. 1 hit.
[Graphical view ]
PRINTSi PR00604. CYTCHRMECIAB.
SUPFAMi SSF46626. SSF46626. 1 hit.
PROSITEi PS51007. CYTC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structure and expression of rodent genes encoding the testis-specific cytochrome c. Differences in gene structure and evolution between somatic and testicular variants."
    Virbasius J.V., Scarpulla R.C.
    J. Biol. Chem. 263:6791-6796(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].

Entry informationi

Entry nameiCYC2_RAT
AccessioniPrimary (citable) accession number: P10715
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3