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Protein

Galanin peptides

Gene

Gal

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3. This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion.By similarity

GO - Molecular functioni

GO - Biological processi

  • cAMP-mediated signaling Source: Ensembl
  • feeding behavior Source: RGD
  • inflammatory response Source: RGD
  • negative regulation of cell proliferation Source: RGD
  • negative regulation of lymphocyte proliferation Source: RGD
  • nervous system development Source: Ensembl
  • neuropeptide signaling pathway Source: RGD
  • positive regulation of apoptotic process Source: RGD
  • positive regulation of catagen Source: Ensembl
  • positive regulation of cortisol secretion Source: Ensembl
  • positive regulation of large conductance calcium-activated potassium channel activity Source: Ensembl
  • positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • protein kinase A signaling Source: Ensembl
  • regulation of glucocorticoid metabolic process Source: RGD
  • regulation of immune response Source: RGD
  • response to drug Source: RGD
  • response to estrogen Source: RGD
  • response to immobilization stress Source: RGD
  • response to insulin Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hormone, Neuropeptide

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Galanin peptides
Cleaved into the following 2 chains:
Gene namesi
Name:Gal
Synonyms:Galn
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi61954. Gal.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: RGD
  • extracellular space Source: GO_Central
  • Golgi apparatus Source: RGD
  • neuronal cell body Source: Ensembl
  • secretory granule Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Propeptidei20 – 3011PRO_0000010457Add
BLAST
Peptidei33 – 6129GalaninPRO_0000010458Add
BLAST
Peptidei65 – 12460Galanin message-associated peptidePRO_0000010459Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei61 – 611Threonine amide
Modified residuei117 – 1171PhosphoserineBy similarity
Modified residuei118 – 1181PhosphoserineBy similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Phosphoprotein

Proteomic databases

PaxDbiP10683.
PRIDEiP10683.

PTM databases

iPTMnetiP10683.

Expressioni

Gene expression databases

GenevisibleiP10683. RN.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020425.

Chemistry

BindingDBiP10683.

Family & Domainsi

Sequence similaritiesi

Belongs to the galanin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZPR. Eukaryota.
ENOG410YNUP. LUCA.
GeneTreeiENSGT00390000009663.
HOGENOMiHOG000112690.
HOVERGENiHBG005799.
InParanoidiP10683.
KOiK05244.
OMAiWSPAKEK.
OrthoDBiEOG79SF01.
PhylomeDBiP10683.
TreeFamiTF335850.

Family and domain databases

InterProiIPR008174. Galanin.
IPR008175. Galanin_pre.
IPR013068. GMAP.
[Graphical view]
PfamiPF01296. Galanin. 1 hit.
PF06540. GMAP. 1 hit.
[Graphical view]
PRINTSiPR00273. GALANIN.
ProDomiPD005962. Galanin. 1 hit.
PD012185. GMAP. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00071. Galanin. 1 hit.
[Graphical view]
PROSITEiPS00861. GALANIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10683-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARGSVILLA WLLLVATLSA TLGLGMPTKE KRGWTLNSAG YLLGPHAIDN
60 70 80 90 100
HRSFSDKHGL TGKRELPLEV EEGRLGSVAV PLPESNIVRT IMEFLSFLHL
110 120
KEAGALDSLP GIPLATSSED LEQS
Length:124
Mass (Da):13,328
Last modified:July 1, 1989 - v1
Checksum:iE45AB91A7E83B989
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03624 mRNA. Translation: AAA41186.1.
M18102 mRNA. Translation: AAA41187.1.
PIRiA28463. RHRTN.
RefSeqiNP_150240.1. NM_033237.1.
UniGeneiRn.8929.

Genome annotation databases

EnsembliENSRNOT00000020425; ENSRNOP00000020425; ENSRNOG00000015156.
GeneIDi29141.
KEGGirno:29141.
UCSCiRGD:61954. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03624 mRNA. Translation: AAA41186.1.
M18102 mRNA. Translation: AAA41187.1.
PIRiA28463. RHRTN.
RefSeqiNP_150240.1. NM_033237.1.
UniGeneiRn.8929.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020425.

Chemistry

BindingDBiP10683.

PTM databases

iPTMnetiP10683.

Proteomic databases

PaxDbiP10683.
PRIDEiP10683.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000020425; ENSRNOP00000020425; ENSRNOG00000015156.
GeneIDi29141.
KEGGirno:29141.
UCSCiRGD:61954. rat.

Organism-specific databases

CTDi51083.
RGDi61954. Gal.

Phylogenomic databases

eggNOGiENOG410IZPR. Eukaryota.
ENOG410YNUP. LUCA.
GeneTreeiENSGT00390000009663.
HOGENOMiHOG000112690.
HOVERGENiHBG005799.
InParanoidiP10683.
KOiK05244.
OMAiWSPAKEK.
OrthoDBiEOG79SF01.
PhylomeDBiP10683.
TreeFamiTF335850.

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiP10683.

Gene expression databases

GenevisibleiP10683. RN.

Family and domain databases

InterProiIPR008174. Galanin.
IPR008175. Galanin_pre.
IPR013068. GMAP.
[Graphical view]
PfamiPF01296. Galanin. 1 hit.
PF06540. GMAP. 1 hit.
[Graphical view]
PRINTSiPR00273. GALANIN.
ProDomiPD005962. Galanin. 1 hit.
PD012185. GMAP. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00071. Galanin. 1 hit.
[Graphical view]
PROSITEiPS00861. GALANIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Isolation and characterization of a complementary DNA (galanin) clone from estrogen-induced pituitary tumor messenger RNA."
    Vrontakis M.E., Peden L.M., Duckworth M.L., Friesen H.G.
    J. Biol. Chem. 262:16755-16758(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiGALA_RAT
AccessioniPrimary (citable) accession number: P10683
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: July 6, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.