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Protein

Fasciclin-1

Gene

Fas1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Neural cell adhesion molecule.

GO - Molecular functioni

  • cell adhesion molecule binding Source: FlyBase

GO - Biological processi

  • axon guidance Source: FlyBase
  • calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: FlyBase
  • extracellular matrix organization Source: GO_Central
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: FlyBase
  • neuron recognition Source: FlyBase
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Fasciclin-1
Alternative name(s):
Fasciclin I
Short name:
FAS I
Short name:
FCN
Gene namesi
Name:Fas1
ORF Names:CG6588
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0262742. Fas1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000000877222 – 625Fasciclin-1Add BLAST604
PropeptideiPRO_0000008773626 – 652Removed in mature formSequence analysisAdd BLAST27

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi47N-linked (GlcNAc...)Sequence analysis1
Glycosylationi368N-linked (GlcNAc...)Sequence analysis1
Glycosylationi416N-linked (GlcNAc...)Sequence analysis1
Glycosylationi441N-linked (GlcNAc...)1 Publication1
Glycosylationi493N-linked (GlcNAc...); atypical1 Publication1
Glycosylationi497N-linked (GlcNAc...)2 Publications1
Lipidationi625GPI-anchor amidated alanineSequence analysis1

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiP10674.
PRIDEiP10674.

Expressioni

Tissue specificityi

Expressed on different subsets of axon bundles (fascicles) in insect embryos.

Gene expression databases

BgeeiFBgn0262742.
ExpressionAtlasiP10674. baseline.
GenevisibleiP10674. DM.

Interactioni

GO - Molecular functioni

  • cell adhesion molecule binding Source: FlyBase

Protein-protein interaction databases

BioGridi67070. 7 interactors.
IntActiP10674. 1 interactor.
STRINGi7227.FBpp0111715.

Structurei

Secondary structure

1652
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi330 – 342Combined sources13
Helixi346 – 352Combined sources7
Beta strandi355 – 362Combined sources8
Helixi364 – 369Combined sources6
Helixi373 – 376Combined sources4
Helixi379 – 388Combined sources10
Beta strandi390 – 393Combined sources4
Helixi397 – 403Combined sources7
Beta strandi405 – 407Combined sources3
Beta strandi411 – 415Combined sources5
Beta strandi419 – 426Combined sources8
Helixi428 – 430Combined sources3
Beta strandi432 – 437Combined sources6
Beta strandi440 – 450Combined sources11
Beta strandi452 – 461Combined sources10
Helixi470 – 476Combined sources7
Helixi478 – 480Combined sources3
Helixi481 – 486Combined sources6
Turni487 – 491Combined sources5
Helixi494 – 497Combined sources4
Beta strandi499 – 508Combined sources10
Helixi510 – 519Combined sources10
Helixi521 – 527Combined sources7
Helixi530 – 532Combined sources3
Helixi533 – 541Combined sources9
Beta strandi544 – 549Combined sources6
Helixi553 – 562Combined sources10
Beta strandi563 – 569Combined sources7
Beta strandi571 – 582Combined sources12
Beta strandi585 – 590Combined sources6
Beta strandi593 – 604Combined sources12
Beta strandi607 – 614Combined sources8
Turni619 – 622Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1O70X-ray2.60A314-628[»]
ProteinModelPortaliP10674.
SMRiP10674.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10674.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 144FAS1 1PROSITE-ProRule annotationAdd BLAST123
Domaini166 – 310FAS1 2PROSITE-ProRule annotationAdd BLAST145
Domaini317 – 463FAS1 3PROSITE-ProRule annotationAdd BLAST147
Domaini467 – 616FAS1 4PROSITE-ProRule annotationAdd BLAST150

Sequence similaritiesi

Contains 4 FAS1 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1437. Eukaryota.
COG2335. LUCA.
GeneTreeiENSGT00530000063860.
InParanoidiP10674.
KOiK19897.
OrthoDBiEOG091G0BWL.
PhylomeDBiP10674.

Family and domain databases

Gene3Di2.30.180.10. 4 hits.
InterProiIPR000782. FAS1_domain.
[Graphical view]
PfamiPF02469. Fasciclin. 4 hits.
[Graphical view]
SMARTiSM00554. FAS1. 4 hits.
[Graphical view]
SUPFAMiSSF82153. SSF82153. 4 hits.
PROSITEiPS50213. FAS1. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: Many isoforms are produced by alternative splicing.1 Publication
Isoform 1 (identifier: P10674-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLNAAALLLA LLCAANAAAA ADLADKLRDD SELSQFYSLL ESNQIANSTL
60 70 80 90 100
SLRSCTIFVP TNEAFQRYKS KTAHVLYHIT TEAYTQKRLP NTVSSDMAGN
110 120 130 140 150
PPLYITKNSN GDIFVNNARI IPSLSVETNS DGKRQIMHII DEVLEPLTVK
160 170 180 190 200
AGHSDTPNNP NALKFLKNAE EFNVDNIGVR TYRSQVTMAK KESVYDAAGQ
210 220 230 240 250
HTFLVPVDEG FKLSARSSLV DGKVIDGHVI PNTVIFTAAA QHDDPKASAA
260 270 280 290 300
FEDLLKVTVS FFKQKNGKMY VKSNTIVGDA KHRVGVVLAE IVKANIPVSN
310 320 330 340 350
GVVHLIHRPL MIIDTTVTQF LQSFKENAEN GALRKFYEVI MDNGGAVLDD
360 370 380 390 400
INSLTEVTIL APSNEAWNSS NINNVLRDRN KMRQILNMHI IKDRLNVDKI
410 420 430 440 450
RQKNANLIAQ VPTVNNNTFL YFNVRGEGSD TVITVEGGGV NATVIQADVA
460 470 480 490 500
QTNGYVHIID HVLGVPYTTV LGKLESDPMM SDTYKMGKFS HFNDQLNNTQ
510 520 530 540 550
RRFTYFVPRD KGWQKTELDY PSAHKKLFMA DFSYHSKSIL ERHLAISDKE
560 570 580 590 600
YTMKDLVKFS QESGSVILPT FRDSLSIRVE EEAGRYVIIW NYKKINVYRP
610 620 630 640 650
DVECTNGIIH VIDYPLLEEK DVVVAGGSYL PESSICIILA NLIMITVAKF

LN
Length:652
Mass (Da):72,599
Last modified:July 1, 1989 - v1
Checksum:i4D846358A47DBFD6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20545 mRNA. Translation: AAA28531.1.
M32311 Genomic DNA. Translation: AAA28529.1.
AE014297 Genomic DNA. Translation: AAN13715.1.
PIRiB29900.
RefSeqiNP_732165.1. NM_169725.2. [P10674-1]
UniGeneiDm.7092.

Genome annotation databases

EnsemblMetazoaiFBtr0083333; FBpp0082783; FBgn0262742. [P10674-1]
GeneIDi42025.
KEGGidme:Dmel_CG6588.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20545 mRNA. Translation: AAA28531.1.
M32311 Genomic DNA. Translation: AAA28529.1.
AE014297 Genomic DNA. Translation: AAN13715.1.
PIRiB29900.
RefSeqiNP_732165.1. NM_169725.2. [P10674-1]
UniGeneiDm.7092.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1O70X-ray2.60A314-628[»]
ProteinModelPortaliP10674.
SMRiP10674.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi67070. 7 interactors.
IntActiP10674. 1 interactor.
STRINGi7227.FBpp0111715.

Proteomic databases

PaxDbiP10674.
PRIDEiP10674.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0083333; FBpp0082783; FBgn0262742. [P10674-1]
GeneIDi42025.
KEGGidme:Dmel_CG6588.

Organism-specific databases

CTDi42025.
FlyBaseiFBgn0262742. Fas1.

Phylogenomic databases

eggNOGiKOG1437. Eukaryota.
COG2335. LUCA.
GeneTreeiENSGT00530000063860.
InParanoidiP10674.
KOiK19897.
OrthoDBiEOG091G0BWL.
PhylomeDBiP10674.

Miscellaneous databases

ChiTaRSiFas1. fly.
EvolutionaryTraceiP10674.
GenomeRNAii42025.
PROiP10674.

Gene expression databases

BgeeiFBgn0262742.
ExpressionAtlasiP10674. baseline.
GenevisibleiP10674. DM.

Family and domain databases

Gene3Di2.30.180.10. 4 hits.
InterProiIPR000782. FAS1_domain.
[Graphical view]
PfamiPF02469. Fasciclin. 4 hits.
[Graphical view]
SMARTiSM00554. FAS1. 4 hits.
[Graphical view]
SUPFAMiSSF82153. SSF82153. 4 hits.
PROSITEiPS50213. FAS1. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFAS1_DROME
AccessioniPrimary (citable) accession number: P10674
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 30, 2016
This is version 149 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.