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P10664

- RL4A_YEAST

UniProt

P10664 - RL4A_YEAST

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Protein

60S ribosomal protein L4-A

Gene
RPL4A, RPL2, RPL2A, YBR031W, YBR0315
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Participates in the regulation of the accumulation of its own mRNA.1 Publication

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. RNA binding Source: UniProtKB-KW
  3. structural constituent of ribosome Source: SGD

GO - Biological processi

  1. cytoplasmic translation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29009-MONOMER.
ReactomeiREACT_188965. SRP-dependent cotranslational protein targeting to membrane.
REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_217188. Formation of a pool of free 40S subunits.

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L4-A
Alternative name(s):
L2
RP2
YL2
Gene namesi
Name:RPL4A
Synonyms:RPL2, RPL2A
Ordered Locus Names:YBR031W
ORF Names:YBR0315
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome II

Organism-specific databases

SGDiS000000235. RPL4A.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytosolic large ribosomal subunit Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 36236160S ribosomal protein L4-APRO_0000129367Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication

Post-translational modificationi

N-terminally acetylated by acetyltransferase NatA.1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP10664.
PeptideAtlasiP10664.
PRIDEiP10664.

Expressioni

Gene expression databases

GenevestigatoriP10664.

Interactioni

Subunit structurei

Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
EGD2P388792EBI-15390,EBI-6379

Protein-protein interaction databases

BioGridi32733. 190 interactions.
IntActiP10664. 217 interactions.
MINTiMINT-1325639.
STRINGi4932.YBR031W.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1K5Ymodel-D5-260[»]
1VW8electron microscopy6.10D1-362[»]
1VWUelectron microscopy6.10D1-362[»]
3IZSelectron microscopy-D1-362[»]
3J65electron microscopy8.70D1-362[»]
3O58X-ray4.00D1-362[»]
3O5HX-ray4.00D1-362[»]
3U5EX-ray3.00C1-362[»]
3U5IX-ray3.00C1-362[»]
4B6Aelectron microscopy8.10C1-362[»]
4BYNelectron microscopy4.30C2-362[»]
4BYUelectron microscopy6.60C2-362[»]
4CUWelectron microscopy3.70C1-362[»]
ProteinModelPortaliP10664.
SMRiP10664. Positions 2-362.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000018145.
HOGENOMiHOG000107331.
KOiK02930.
OMAiVASNENK.
OrthoDBiEOG7NSBC8.

Family and domain databases

Gene3Di3.40.1370.10. 1 hit.
InterProiIPR025755. Ribos_L4_C_dom.
IPR002136. Ribosomal_L4/L1e.
IPR013000. Ribosomal_L4/L1e_euk/arc_CS.
IPR023574. Ribosomal_L4_dom.
[Graphical view]
PfamiPF14374. Ribos_L4_asso_C. 1 hit.
PF00573. Ribosomal_L4. 1 hit.
[Graphical view]
SUPFAMiSSF52166. SSF52166. 1 hit.
PROSITEiPS00939. RIBOSOMAL_L1E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10664-1 [UniParc]FASTAAdd to Basket

« Hide

MSRPQVTVHS LTGEATANAL PLPAVFSAPI RPDIVHTVFT SVNKNKRQAY    50
AVSEKAGHQT SAESWGTGRA VARIPRVGGG GTGRSGQGAF GNMCRGGRMF 100
APTKTWRKWN VKVNHNEKRY ATASAIAATA VASLVLARGH RVEKIPEIPL 150
VVSTDLESIQ KTKEAVAALK AVGAHSDLLK VLKSKKLRAG KGKYRNRRWT 200
QRRGPLVVYA EDNGIVKALR NVPGVETANV ASLNLLQLAP GAHLGRFVIW 250
TEAAFTKLDQ VWGSETVASS KVGYTLPSHI ISTSDVTRII NSSEIQSAIR 300
PAGQATQKRT HVLKKNPLKN KQVLLRLNPY AKVFAAEKLG SKKAEKTGTK 350
PAAVFTETLK HD 362
Length:362
Mass (Da):39,092
Last modified:January 23, 2007 - v4
Checksum:i37D0942A10AAE89F
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti38 – 381V → L in AAA34974. 1 Publication
Sequence conflicti144 – 1441K → T in AAA34974. 1 Publication
Sequence conflicti157 – 1571E → D in AAA34974. 1 Publication
Sequence conflicti224 – 2241G → S in AAA34974. 1 Publication
Sequence conflicti241 – 2411G → S in AAA34974. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X76078 Genomic DNA. Translation: CAA53687.1.
J03195 Genomic DNA. Translation: AAA34974.1.
Z35900 Genomic DNA. Translation: CAA84973.1.
BK006936 Genomic DNA. Translation: DAA07152.1.
PIRiS45887.
RefSeqiNP_009587.1. NM_001178379.1.

Genome annotation databases

EnsemblFungiiYBR031W; YBR031W; YBR031W.
GeneIDi852319.
KEGGisce:YBR031W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X76078 Genomic DNA. Translation: CAA53687.1 .
J03195 Genomic DNA. Translation: AAA34974.1 .
Z35900 Genomic DNA. Translation: CAA84973.1 .
BK006936 Genomic DNA. Translation: DAA07152.1 .
PIRi S45887.
RefSeqi NP_009587.1. NM_001178379.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1K5Y model - D 5-260 [» ]
1VW8 electron microscopy 6.10 D 1-362 [» ]
1VWU electron microscopy 6.10 D 1-362 [» ]
3IZS electron microscopy - D 1-362 [» ]
3J65 electron microscopy 8.70 D 1-362 [» ]
3O58 X-ray 4.00 D 1-362 [» ]
3O5H X-ray 4.00 D 1-362 [» ]
3U5E X-ray 3.00 C 1-362 [» ]
3U5I X-ray 3.00 C 1-362 [» ]
4B6A electron microscopy 8.10 C 1-362 [» ]
4BYN electron microscopy 4.30 C 2-362 [» ]
4BYU electron microscopy 6.60 C 2-362 [» ]
4CUW electron microscopy 3.70 C 1-362 [» ]
ProteinModelPortali P10664.
SMRi P10664. Positions 2-362.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 32733. 190 interactions.
IntActi P10664. 217 interactions.
MINTi MINT-1325639.
STRINGi 4932.YBR031W.

Proteomic databases

MaxQBi P10664.
PeptideAtlasi P10664.
PRIDEi P10664.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YBR031W ; YBR031W ; YBR031W .
GeneIDi 852319.
KEGGi sce:YBR031W.

Organism-specific databases

SGDi S000000235. RPL4A.

Phylogenomic databases

GeneTreei ENSGT00390000018145.
HOGENOMi HOG000107331.
KOi K02930.
OMAi VASNENK.
OrthoDBi EOG7NSBC8.

Enzyme and pathway databases

BioCyci YEAST:G3O-29009-MONOMER.
Reactomei REACT_188965. SRP-dependent cotranslational protein targeting to membrane.
REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_217188. Formation of a pool of free 40S subunits.

Miscellaneous databases

NextBioi 971014.

Gene expression databases

Genevestigatori P10664.

Family and domain databases

Gene3Di 3.40.1370.10. 1 hit.
InterProi IPR025755. Ribos_L4_C_dom.
IPR002136. Ribosomal_L4/L1e.
IPR013000. Ribosomal_L4/L1e_euk/arc_CS.
IPR023574. Ribosomal_L4_dom.
[Graphical view ]
Pfami PF14374. Ribos_L4_asso_C. 1 hit.
PF00573. Ribosomal_L4. 1 hit.
[Graphical view ]
SUPFAMi SSF52166. SSF52166. 1 hit.
PROSITEi PS00939. RIBOSOMAL_L1E. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Ribosomal protein L2 in Saccharomyces cerevisiae is homologous to ribosomal protein L1 in Xenopus laevis. Isolation and characterization of the genes."
    Presutti C., Lucioli A., Bozzoni I.
    J. Biol. Chem. 263:6188-6192(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The complete sequence of a 33 kb fragment on the right arm of chromosome II from Saccharomyces cerevisiae reveals 16 open reading frames, including ten new open reading frames, five previously identified genes and a homologue of the SCO1 gene."
    Smits P.H.M., de Haan M., Maat C., Grivell L.A.
    Yeast 10:S75-S80(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. "Complete DNA sequence of yeast chromosome II."
    Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
    , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
    EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. "The ribosomal protein L2 in S. cerevisiae controls the level of accumulation of its own mRNA."
    Presutti C., Ciafre S.-A., Bozzoni I.
    EMBO J. 10:2215-2221(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN L2 MRNA REGULATION.
  6. "NH2-terminal acetylation of ribosomal proteins of Saccharomyces cerevisiae."
    Takakura H., Tsunasawa S., Miyagi M., Warner J.R.
    J. Biol. Chem. 267:5442-5445(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-21, ACETYLATION AT SER-2 BY NATA.
  7. "The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae."
    Planta R.J., Mager W.H.
    Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE, SUBUNIT.
  8. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  9. "Structure of the 80S ribosome from Saccharomyces cerevisiae -- tRNA-ribosome and subunit-subunit interactions."
    Spahn C.M.T., Beckmann R., Eswar N., Penczek P.A., Sali A., Blobel G., Frank J.
    Cell 107:373-386(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING OF 5-260, ELECTRON MICROSCOPY.
  10. "Crystal structure of the eukaryotic ribosome."
    Ben-Shem A., Jenner L., Yusupova G., Yusupov M.
    Science 330:1203-1209(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.0 ANGSTROMS) OF 80S RIBOSOME.
  11. Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 80S RIBOSOME.

Entry informationi

Entry nameiRL4A_YEAST
AccessioniPrimary (citable) accession number: P10664
Secondary accession number(s): D6VQ32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 129 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

There are 2 genes for L4 in yeast.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

External Data

Dasty 3

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