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Protein

37S ribosomal protein MRP2, mitochondrial

Gene

MRP2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.2 Publications

GO - Molecular functioni

  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • mitochondrial translation Source: SGD
  • translation Source: GO_Central

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-34295-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
37S ribosomal protein MRP2, mitochondrial
Alternative name(s):
Mitochondrial small ribosomal subunit protein uS14m1 Publication
Gene namesi
Name:MRP2
Ordered Locus Names:YPR166C
ORF Names:P9325.7
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPR166C.
SGDiS000006370. MRP2.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial small ribosomal subunit Source: SGD

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001310171 – 11537S ribosomal protein MRP2, mitochondrialAdd BLAST115

Proteomic databases

MaxQBiP10663.
PRIDEiP10663.

Interactioni

Subunit structurei

Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.4 Publications

Protein-protein interaction databases

BioGridi36339. 11 interactors.
IntActiP10663. 2 interactors.
MINTiMINT-2782100.
STRINGi4932.YPR166C.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5MRCelectron microscopy3.25NN1-115[»]
5MREelectron microscopy3.75NN1-115[»]
5MRFelectron microscopy4.97NN1-115[»]
ProteinModelPortaliP10663.
SMRiP10663.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000039864.
InParanoidiP10663.
KOiK02954.
OMAiKRRQMAF.
OrthoDBiEOG092C5ISA.

Family and domain databases

InterProiView protein in InterPro
IPR001209. Ribosomal_S14.
IPR018271. Ribosomal_S14_CS.
PANTHERiPTHR19836. PTHR19836. 1 hit.
PfamiView protein in Pfam
PF00253. Ribosomal_S14. 1 hit.
PROSITEiView protein in PROSITE
PS00527. RIBOSOMAL_S14. 1 hit.

Sequencei

Sequence statusi: Complete.

P10663-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNFRFPIKT KLPPGFINAR ILRDNFKRQQ FKENEILVKS LKFIARNMNL
60 70 80 90 100
PTKLRLEAQL KLNALPNYMR STQIKNRCVD SGHARFVLSD FRLCRYQFRE
110
NALKGNLPGV KKGIW
Length:115
Mass (Da):13,538
Last modified:July 1, 1989 - v1
Checksum:i90DCF9ABAA72AF8B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15161 Genomic DNA. Translation: AAA74728.1.
U25840 Genomic DNA. Translation: AAB68153.1.
AY558052 Genomic DNA. Translation: AAS56378.1.
BK006949 Genomic DNA. Translation: DAA11583.1.
PIRiB29138. R3BY14.
RefSeqiNP_015492.1. NM_001184263.1.

Genome annotation databases

EnsemblFungiiYPR166C; YPR166C; YPR166C.
GeneIDi856295.
KEGGisce:YPR166C.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiRT02_YEAST
AccessioniPrimary (citable) accession number: P10663
Secondary accession number(s): D6W4G7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: July 5, 2017
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names