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P10656

- GLNA_CLOSA

UniProt

P10656 - GLNA_CLOSA

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Protein
Glutamine synthetase
Gene
glnA
Organism
Clostridium saccharobutylicum
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutamate-ammonia ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. glutamine biosynthetic process Source: InterPro
  2. nitrogen fixation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine synthetase (EC:6.3.1.2)
Alternative name(s):
Glutamate--ammonia ligase
Gene namesi
Name:glnA
OrganismiClostridium saccharobutylicum
Taxonomic identifieri169679 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 443443Glutamine synthetase
PRO_0000153234Add
BLAST

Interactioni

Subunit structurei

Oligomer of 12 subunits arranged in the form of two hexagons.

Structurei

3D structure databases

ProteinModelPortaliP10656.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
TIGRFAMsiTIGR00653. GlnA. 1 hit.
PROSITEiPS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10656-1 [UniParc]FASTAAdd to Basket

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MAKYTKEDII NLVKENGVKF IRLQFTDIFG TLKNVAITDK QLEKALDNEC    50
MFDGSSIDGF VRIEESDMNL RPNLDSFVIF PWRPQQGKVA RLICDVYKPD 100
GTPFEGDPRH VLKRANADAK ELGYTMNVGP ECEFFLFETD ENGRATTNTQ 150
DKAGYFDLAP TDLGENARRD MTLALEEMGF EIEASHHEVA EGQNEIDFKY 200
GDALTTADNI MTFKLVVKSI AQRHGLHASF MPKPIFGING SGMHVNMSLF 250
KDGKNAFVDE NDKNGLSKVA YQFIAGLLKN IKGMAAVTNP LVNSYKRLVP 300
GYEAPVYLAW SCKNRTALIR VPAARGAGTR VELRCPDPSS NPYLVLACLL 350
QAGLDGIKNN LQPPAEVEAN IFAMTEQERK ENGIDNLPNN LYEAVNYMKE 400
NELAKKALGD HVYGNYVAGK AAEWDDYRTK VHDWELENYL NKY 443
Length:443
Mass (Da):49,682
Last modified:July 1, 1989 - v1
Checksum:iEDE5BF44495151FC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M18966 Genomic DNA. Translation: AAA23241.1.
PIRiA28676. AJCLQA.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M18966 Genomic DNA. Translation: AAA23241.1 .
PIRi A28676. AJCLQA.

3D structure databases

ProteinModelPortali P10656.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProi IPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view ]
Pfami PF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view ]
SUPFAMi SSF54368. SSF54368. 1 hit.
TIGRFAMsi TIGR00653. GlnA. 1 hit.
PROSITEi PS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular analysis and regulation of the glnA gene of the Gram-positive anaerobe Clostridium acetobutylicum."
    Janssen P.J., Jones W.A., Jones D.T., Woods D.R.
    J. Bacteriol. 170:400-408(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC BAA-117 / DSM 13864 / NCP 262.
  2. "Studies on Clostridium acetobutylicum glnA promoters and antisense RNA."
    Janssen P.J., Jones D.T., Woods D.R.
    Mol. Microbiol. 4:1575-1583(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-38.

Entry informationi

Entry nameiGLNA_CLOSA
AccessioniPrimary (citable) accession number: P10656
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 16, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Was originally thought to originate from C.acetobutylicum.
Lacks the tyrosine conserved in bacteria and other archaea, involved in feedback inhibition.

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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