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Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrG

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.PROSITE-ProRule annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes UMP from orotate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Orotidine 5'-phosphate decarboxylase (pyrG)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from orotate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei40SubstrateBy similarity1
Active sitei95Proton donorPROSITE-ProRule annotation1
Binding sitei227SubstrateBy similarity1
Binding sitei245SubstrateBy similarity1

GO - Molecular functioni

  • orotidine-5'-phosphate decarboxylase activity Source: AspGD

GO - Biological processi

  • 'de novo' pyrimidine nucleobase biosynthetic process Source: AspGD
  • 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
  • sporocarp development involved in sexual reproduction Source: AspGD

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processPyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Uridine 5'-monophosphate synthase
Short name:
UMP synthase
Gene namesi
Name:pyrG
ORF Names:AN6157
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome I
  • UP000005890 Componenti: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001346591 – 274Orotidine 5'-phosphate decarboxylaseAdd BLAST274

Interactioni

Protein-protein interaction databases

STRINGi162425.CADANIAP00006853

Structurei

3D structure databases

ProteinModelPortaliP10652
SMRiP10652
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni62 – 64Substrate bindingBy similarity3
Regioni93 – 102Substrate bindingBy similarity10

Sequence similaritiesi

Belongs to the OMP decarboxylase family.Curated

Phylogenomic databases

HOGENOMiHOG000213905
InParanoidiP10652
KOiK01591
OMAiMGQQYRT
OrthoDBiEOG092C3SZ1

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR014732 OMPdecase
IPR018089 OMPdecase_AS
IPR001754 OMPdeCOase_dom
IPR011060 RibuloseP-bd_barrel
PfamiView protein in Pfam
PF00215 OMPdecase, 1 hit
SMARTiView protein in SMART
SM00934 OMPdecase, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit
TIGRFAMsiTIGR01740 pyrF, 1 hit
PROSITEiView protein in PROSITE
PS00156 OMPDECASE, 1 hit

Sequencei

Sequence statusi: Complete.

P10652-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSKSHLPYA IRATNHPNPL TSKLFSIAEE KKTNVTVSAD VTTSAELLDL
60 70 80 90 100
ADRLGPYIAV LKTHIDILTD LTPSTLSSLQ SLATKHNFLI FEDRKFIDIG
110 120 130 140 150
NTVQKQYHGG ALRISEWAHI INCAILPGEG IVEALAQTTK SPDFKDANQR
160 170 180 190 200
GLLILAEMTS KGSLATGEYT ARSVEYARKY KGFVMGFVST RALSEVLPEQ
210 220 230 240 250
KEESEDFVVF TTGVNLSDKG DKLGQQYQTP GSAVGRGADF IIAGRGIYKA
260 270
DDPVEAVQRY REEGWKAYEK RVGL
Length:274
Mass (Da):30,102
Last modified:May 1, 2007 - v2
Checksum:i9724A3EFC603E70A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti169 – 170YT → SQ in AAB66359 (PubMed:3328733).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19132 Genomic DNA Translation: AAB66359.1
AACD01000105 Genomic DNA Translation: EAA57943.1
BN001301 Genomic DNA Translation: CBF70070.1
PIRiA29630 DCASOE
RefSeqiXP_663761.1, XM_658669.1

Genome annotation databases

EnsemblFungiiCADANIAT00006853; CADANIAP00006853; CADANIAG00006853
EAA57943; EAA57943; AN6157.2
GeneIDi2870752
KEGGiani:AN6157.2

Similar proteinsi

Entry informationi

Entry nameiPYRF_EMENI
AccessioniPrimary (citable) accession number: P10652
Secondary accession number(s): C8V298, Q5AZX3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: May 1, 2007
Last modified: May 23, 2018
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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