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P10652

- PYRF_EMENI

UniProt

P10652 - PYRF_EMENI

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Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrG

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei40 – 401SubstrateBy similarity
Active sitei95 – 951Proton donorPROSITE-ProRule annotation
Binding sitei227 – 2271SubstrateBy similarity
Binding sitei245 – 2451SubstrateBy similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: ASPGD

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: ASPGD
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
  3. sporocarp development involved in sexual reproduction Source: ASPGD
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Uridine 5'-monophosphate synthase
Short name:
UMP synthase
Gene namesi
Name:pyrG
ORF Names:AN6157
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000000560: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 274274Orotidine 5'-phosphate decarboxylasePRO_0000134659Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi162425.CADANIAP00006853.

Structurei

3D structure databases

ProteinModelPortaliP10652.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni62 – 643Substrate bindingBy similarity
Regioni93 – 10210Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the OMP decarboxylase family.Curated

Phylogenomic databases

eggNOGiCOG0284.
HOGENOMiHOG000213905.
InParanoidiP10652.
KOiK01591.
OMAiMGQQYRT.
OrthoDBiEOG7CVQ76.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10652-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSKSHLPYA IRATNHPNPL TSKLFSIAEE KKTNVTVSAD VTTSAELLDL
60 70 80 90 100
ADRLGPYIAV LKTHIDILTD LTPSTLSSLQ SLATKHNFLI FEDRKFIDIG
110 120 130 140 150
NTVQKQYHGG ALRISEWAHI INCAILPGEG IVEALAQTTK SPDFKDANQR
160 170 180 190 200
GLLILAEMTS KGSLATGEYT ARSVEYARKY KGFVMGFVST RALSEVLPEQ
210 220 230 240 250
KEESEDFVVF TTGVNLSDKG DKLGQQYQTP GSAVGRGADF IIAGRGIYKA
260 270
DDPVEAVQRY REEGWKAYEK RVGL
Length:274
Mass (Da):30,102
Last modified:May 1, 2007 - v2
Checksum:i9724A3EFC603E70A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti169 – 1702YT → SQ in AAB66359. (PubMed:3328733)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M19132 Genomic DNA. Translation: AAB66359.1.
AACD01000105 Genomic DNA. Translation: EAA57943.1.
BN001301 Genomic DNA. Translation: CBF70070.1.
PIRiA29630. DCASOE.
RefSeqiXP_663761.1. XM_658669.1.

Genome annotation databases

EnsemblFungiiCADANIAT00006853; CADANIAP00006853; CADANIAG00006853.
GeneIDi2870752.
KEGGiani:AN6157.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M19132 Genomic DNA. Translation: AAB66359.1 .
AACD01000105 Genomic DNA. Translation: EAA57943.1 .
BN001301 Genomic DNA. Translation: CBF70070.1 .
PIRi A29630. DCASOE.
RefSeqi XP_663761.1. XM_658669.1.

3D structure databases

ProteinModelPortali P10652.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 162425.CADANIAP00006853.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADANIAT00006853 ; CADANIAP00006853 ; CADANIAG00006853 .
GeneIDi 2870752.
KEGGi ani:AN6157.2.

Phylogenomic databases

eggNOGi COG0284.
HOGENOMi HOG000213905.
InParanoidi P10652.
KOi K01591.
OMAi MGQQYRT.
OrthoDBi EOG7CVQ76.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01740. pyrF. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, mapping and molecular analysis of the pyrG (orotidine-5'-phosphate decarboxylase) gene of Aspergillus nidulans."
    Oakley B.R., Rinehart J.E., Mitchell B.L., Oakley C.E., Carmona C., Gray G.L., May G.S.
    Gene 61:385-399(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  3. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
    Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
    , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Entry informationi

Entry nameiPYRF_EMENI
AccessioniPrimary (citable) accession number: P10652
Secondary accession number(s): C8V298, Q5AZX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: May 1, 2007
Last modified: October 29, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3