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Protein

Glutathione S-transferase Mu 1

Gene

Gstm1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei50GlutathioneBy similarity1
Binding sitei116SubstrateBy similarity1

GO - Molecular functioni

  • glutathione transferase activity Source: MGI
  • identical protein binding Source: MGI
  • protein heterodimerization activity Source: MGI
  • protein homodimerization activity Source: MGI

GO - Biological processi

  • cellular response to drug Source: MGI
  • glutathione metabolic process Source: MGI

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

ReactomeiR-MMU-156590 Glutathione conjugation

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase Mu 1 (EC:2.5.1.18)
Alternative name(s):
GST 1-1
GST class-mu 1
Glutathione S-transferase GT8.7
pmGT10
Gene namesi
Name:Gstm1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:95860 Gstm1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3722

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001858262 – 218Glutathione S-transferase Mu 1Add BLAST217

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34PhosphothreonineCombined sources1
Modified residuei67PhosphoserineBy similarity1
Modified residuei210PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP10649
MaxQBiP10649
PaxDbiP10649
PeptideAtlasiP10649
PRIDEiP10649

2D gel databases

REPRODUCTION-2DPAGEiP10649
SWISS-2DPAGEiP10649

PTM databases

iPTMnetiP10649
PhosphoSitePlusiP10649
SwissPalmiP10649

Expressioni

Gene expression databases

BgeeiENSMUSG00000058135
CleanExiMM_GSTM1
ExpressionAtlasiP10649 baseline and differential
GenevisibleiP10649 MM

Interactioni

Subunit structurei

Homodimer.

GO - Molecular functioni

  • identical protein binding Source: MGI
  • protein heterodimerization activity Source: MGI
  • protein homodimerization activity Source: MGI

Protein-protein interaction databases

BioGridi200094, 3 interactors
IntActiP10649, 6 interactors
MINTiP10649
STRINGi10090.ENSMUSP00000004140

Chemistry databases

BindingDBiP10649

Structurei

3D structure databases

ProteinModelPortaliP10649
SMRiP10649
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 88GST N-terminalAdd BLAST87
Domaini90 – 208GST C-terminalAdd BLAST119

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni7 – 8Glutathione bindingBy similarity2
Regioni43 – 46Glutathione bindingBy similarity4
Regioni59 – 60Glutathione bindingBy similarity2
Regioni72 – 73Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Mu family.Curated

Phylogenomic databases

eggNOGiENOG410IN5J Eukaryota
ENOG4110YU0 LUCA
GeneTreeiENSGT00550000074559
HOGENOMiHOG000115735
HOVERGENiHBG106842
InParanoidiP10649
KOiK00799
PhylomeDBiP10649
TreeFamiTF353040

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR003081 GST_mu
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF14497 GST_C_3, 1 hit
PF02798 GST_N, 1 hit
PRINTSiPR01267 GSTRNSFRASEM
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10649-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPMILGYWNV RGLTHPIRML LEYTDSSYDE KRYTMGDAPD FDRSQWLNEK
60 70 80 90 100
FKLGLDFPNL PYLIDGSHKI TQSNAILRYL ARKHHLDGET EEERIRADIV
110 120 130 140 150
ENQVMDTRMQ LIMLCYNPDF EKQKPEFLKT IPEKMKLYSE FLGKRPWFAG
160 170 180 190 200
DKVTYVDFLA YDILDQYRMF EPKCLDAFPN LRDFLARFEG LKKISAYMKS
210
SRYIATPIFS KMAHWSNK
Length:218
Mass (Da):25,970
Last modified:January 23, 2007 - v2
Checksum:i91AE34A1B5B44599
GO

Mass spectrometryi

Molecular mass is 25838.4±2 Da from positions 2 - 218. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03952 mRNA Translation: AAA37747.1
J04632 mRNA Translation: AAA37705.1
L13448 Genomic DNA No translation available.
AL671877, AC079042 Genomic DNA Translation: CAM17697.1
BC003822 mRNA Translation: AAH03822.1
BC046758 mRNA Translation: AAH46758.1
BC091763 mRNA Translation: AAH91763.1
CCDSiCCDS17747.1
PIRiH24735
S30373
S33860
RefSeqiNP_034488.1, NM_010358.5
UniGeneiMm.37199

Genome annotation databases

EnsembliENSMUST00000004140; ENSMUSP00000004140; ENSMUSG00000058135
GeneIDi14862
KEGGimmu:14862
UCSCiuc008qxx.2 mouse

Similar proteinsi

Entry informationi

Entry nameiGSTM1_MOUSE
AccessioniPrimary (citable) accession number: P10649
Secondary accession number(s): A2AE90, Q58ET5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 174 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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