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P10649

- GSTM1_MOUSE

UniProt

P10649 - GSTM1_MOUSE

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Protein

Glutathione S-transferase Mu 1

Gene
Gstm1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei116 – 1161Substrate By similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB-EC
  2. protein binding Source: MGI
  3. protein heterodimerization activity Source: MGI
  4. protein homodimerization activity Source: MGI

GO - Biological processi

  1. cellular response to drug Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

ReactomeiREACT_215316. Glutathione conjugation.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase Mu 1 (EC:2.5.1.18)
Alternative name(s):
GST 1-1
GST class-mu 1
Glutathione S-transferase GT8.7
pmGT10
Gene namesi
Name:Gstm1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:95860. Gstm1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed3 Publications
Chaini2 – 218217Glutathione S-transferase Mu 1PRO_0000185826Add
BLAST

Proteomic databases

MaxQBiP10649.
PaxDbiP10649.
PRIDEiP10649.

2D gel databases

REPRODUCTION-2DPAGEP10649.
SWISS-2DPAGEP10649.

PTM databases

PhosphoSiteiP10649.

Expressioni

Gene expression databases

ArrayExpressiP10649.
BgeeiP10649.
CleanExiMM_GSTM1.
GenevestigatoriP10649.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

BioGridi200094. 1 interaction.
IntActiP10649. 5 interactions.
MINTiMINT-1869211.

Structurei

3D structure databases

ProteinModelPortaliP10649.
SMRiP10649. Positions 2-218.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 8887GST N-terminalAdd
BLAST
Domaini90 – 208119GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni7 – 82Glutathione binding By similarity
Regioni46 – 505Glutathione binding By similarity
Regioni59 – 602Glutathione binding By similarity
Regioni72 – 732Glutathione binding By similarity

Sequence similaritiesi

Belongs to the GST superfamily. Mu family.

Phylogenomic databases

eggNOGiNOG300089.
GeneTreeiENSGT00550000074559.
HOGENOMiHOG000115735.
HOVERGENiHBG106842.
KOiK00799.
OMAiFIMLCYN.
OrthoDBiEOG7KH9M3.
PhylomeDBiP10649.
TreeFamiTF353040.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003081. GST_mu.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSiPR01267. GSTRNSFRASEM.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10649-1 [UniParc]FASTAAdd to Basket

« Hide

MPMILGYWNV RGLTHPIRML LEYTDSSYDE KRYTMGDAPD FDRSQWLNEK    50
FKLGLDFPNL PYLIDGSHKI TQSNAILRYL ARKHHLDGET EEERIRADIV 100
ENQVMDTRMQ LIMLCYNPDF EKQKPEFLKT IPEKMKLYSE FLGKRPWFAG 150
DKVTYVDFLA YDILDQYRMF EPKCLDAFPN LRDFLARFEG LKKISAYMKS 200
SRYIATPIFS KMAHWSNK 218
Length:218
Mass (Da):25,970
Last modified:January 23, 2007 - v2
Checksum:i91AE34A1B5B44599
GO

Mass spectrometryi

Molecular mass is 25838.4±2 Da from positions 2 - 218. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J03952 mRNA. Translation: AAA37747.1.
J04632 mRNA. Translation: AAA37705.1.
L13448 Genomic DNA. No translation available.
AL671877, AC079042 Genomic DNA. Translation: CAM17697.1.
BC003822 mRNA. Translation: AAH03822.1.
BC046758 mRNA. Translation: AAH46758.1.
BC091763 mRNA. Translation: AAH91763.1.
CCDSiCCDS17747.1.
PIRiH24735.
S30373.
S33860.
RefSeqiNP_034488.1. NM_010358.5.
UniGeneiMm.37199.

Genome annotation databases

EnsembliENSMUST00000004140; ENSMUSP00000004140; ENSMUSG00000058135.
GeneIDi14862.
KEGGimmu:14862.
UCSCiuc008qxx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J03952 mRNA. Translation: AAA37747.1 .
J04632 mRNA. Translation: AAA37705.1 .
L13448 Genomic DNA. No translation available.
AL671877 , AC079042 Genomic DNA. Translation: CAM17697.1 .
BC003822 mRNA. Translation: AAH03822.1 .
BC046758 mRNA. Translation: AAH46758.1 .
BC091763 mRNA. Translation: AAH91763.1 .
CCDSi CCDS17747.1.
PIRi H24735.
S30373.
S33860.
RefSeqi NP_034488.1. NM_010358.5.
UniGenei Mm.37199.

3D structure databases

ProteinModelPortali P10649.
SMRi P10649. Positions 2-218.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200094. 1 interaction.
IntActi P10649. 5 interactions.
MINTi MINT-1869211.

Chemistry

ChEMBLi CHEMBL3722.

PTM databases

PhosphoSitei P10649.

2D gel databases

REPRODUCTION-2DPAGE P10649.
SWISS-2DPAGE P10649.

Proteomic databases

MaxQBi P10649.
PaxDbi P10649.
PRIDEi P10649.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000004140 ; ENSMUSP00000004140 ; ENSMUSG00000058135 .
GeneIDi 14862.
KEGGi mmu:14862.
UCSCi uc008qxx.2. mouse.

Organism-specific databases

CTDi 2944.
MGIi MGI:95860. Gstm1.

Phylogenomic databases

eggNOGi NOG300089.
GeneTreei ENSGT00550000074559.
HOGENOMi HOG000115735.
HOVERGENi HBG106842.
KOi K00799.
OMAi FIMLCYN.
OrthoDBi EOG7KH9M3.
PhylomeDBi P10649.
TreeFami TF353040.

Enzyme and pathway databases

Reactomei REACT_215316. Glutathione conjugation.

Miscellaneous databases

ChiTaRSi GSTM1. mouse.
NextBioi 287105.
PROi P10649.
SOURCEi Search...

Gene expression databases

ArrayExpressi P10649.
Bgeei P10649.
CleanExi MM_GSTM1.
Genevestigatori P10649.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003081. GST_mu.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
PRINTSi PR01267. GSTRNSFRASEM.
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Tissue-specific induction of murine glutathione transferase mRNAs by butylated hydroxyanisole."
    Pearson W.R., Reinhart J., Sisk S.C., Anderson K.S., Adler P.N.
    J. Biol. Chem. 263:13324-13332(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Isolation, characterization, and expression in Escherichia coli of two murine Mu class glutathione S-transferase cDNAs homologous to the rat subunits 3 (Yb1) and 4 (Yb2)."
    Townsend A.J., Goldsmith M.E., Pickett C.B., Cowan K.H.
    J. Biol. Chem. 264:21582-21590(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The structure of two murine class-mu glutathione transferase genes coordinately induced by butylated hydroxyanisole."
    Reinhart J., Pearson W.R.
    Arch. Biochem. Biophys. 303:383-393(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6 and FVB/N.
    Tissue: Brain and Liver.
  6. "Increased synthesis of glutathione S-transferases in response to anticarcinogenic antioxidants. Cloning and measurement of messenger RNA."
    Pearson W.R., Windle J.J., Morrow J.F., Benson A.M., Talalay P.
    J. Biol. Chem. 258:2052-2062(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: PRELIMINARY PROTEIN SEQUENCE OF 2-41.
  7. "Identification of three classes of cytosolic glutathione transferase common to several mammalian species: correlation between structural data and enzymatic properties."
    Mannervik B., Alin P., Guthenberg C., Jensson H., Tahir M.K., Warholm M., Joernvall H.
    Proc. Natl. Acad. Sci. U.S.A. 82:7202-7206(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: PRELIMINARY PROTEIN SEQUENCE OF 2-25.
  8. Lubec G., Kang S.U., Klug S., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-11; 19-31; 33-43; 53-78; 97-108; 137-144; 153-168; 174-192 AND 203-211, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6 and OF1.
    Tissue: Brain and Hippocampus.
  9. "Purification, mass spectrometric characterization, and covalent modification of murine glutathione S-transferases."
    Mitchell A.E., Morin D., Lame M.W., Jones A.D.
    Chem. Res. Toxicol. 8:1054-1062(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION, MASS SPECTROMETRY.
    Strain: CD-1.
    Tissue: Liver.

Entry informationi

Entry nameiGSTM1_MOUSE
AccessioniPrimary (citable) accession number: P10649
Secondary accession number(s): A2AE90, Q58ET5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 146 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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