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Protein

Glutathione S-transferase A2

Gene

Gsta2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei9GlutathioneBy similarity1
Binding sitei45Glutathione1 Publication1

GO - Molecular functioni

GO - Biological processi

  • glutathione metabolic process Source: UniProtKB
  • response to stilbenoid Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

ReactomeiR-MMU-156590. Glutathione conjugation.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase A2 (EC:2.5.1.18)
Alternative name(s):
GST class-alpha member 2
Glutathione S-transferase GT41A
Gene namesi
Name:Gsta2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:95863. Gsta2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001857892 – 222Glutathione S-transferase A2Add BLAST221

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei4N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP10648.
PeptideAtlasiP10648.
PRIDEiP10648.

PTM databases

iPTMnetiP10648.
PhosphoSitePlusiP10648.

Expressioni

Gene expression databases

BgeeiENSMUSG00000057933.
CleanExiMM_GSTA2.
ExpressionAtlasiP10648. baseline and differential.
GenevisibleiP10648. MM.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

IntActiP10648. 2 interactors.
MINTiMINT-4080211.
STRINGi10090.ENSMUSP00000034902.

Structurei

Secondary structure

1222
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 12Combined sources7
Helixi14 – 16Combined sources3
Helixi17 – 26Combined sources10
Beta strandi31 – 35Combined sources5
Helixi38 – 46Combined sources9
Beta strandi57 – 60Combined sources4
Beta strandi63 – 67Combined sources5
Helixi68 – 78Combined sources11
Helixi86 – 108Combined sources23
Helixi109 – 111Combined sources3
Turni114 – 116Combined sources3
Helixi117 – 130Combined sources14
Helixi132 – 143Combined sources12
Beta strandi146 – 149Combined sources4
Helixi155 – 171Combined sources17
Helixi172 – 175Combined sources4
Helixi179 – 190Combined sources12
Helixi192 – 198Combined sources7
Helixi210 – 219Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ML6X-ray1.90A/B2-222[»]
ProteinModelPortaliP10648.
SMRiP10648.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10648.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 83GST N-terminalAdd BLAST81
Domaini85 – 208GST C-terminalAdd BLAST124

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni54 – 55Glutathione binding1 Publication2
Regioni67 – 68Glutathione binding1 Publication2

Sequence similaritiesi

Belongs to the GST superfamily. Alpha family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiKOG1695. Eukaryota.
ENOG4111VAU. LUCA.
GeneTreeiENSGT00670000097856.
HOGENOMiHOG000115734.
HOVERGENiHBG053749.
InParanoidiP10648.
KOiK00799.
OMAiIEMIMYL.
OrthoDBiEOG091G0O3D.
TreeFamiTF105321.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR003080. GST_alpha.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSiPR01266. GSTRNSFRASEA.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10648-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGKPVLHYF NARGRMECIR WLLAAAGVEF EEKFIQSPED LEKLKKDGNL
60 70 80 90 100
MFDQVPMVEI DGMKLVQTRA ILNYIATKYD LYGKDMKERA LIDMYTEGIL
110 120 130 140 150
DLTEMIGQLV LCPPDQREAK TALAKDRTKN RYLPAFEKVL KSHGQDYLVG
160 170 180 190 200
NRLTRVDVHL LELLLYVEEL DASLLTPFPL LKAFKSRISS LPNVKKFLHP
210 220
GSQRKPPLDA KQIEEARKVF KF
Length:222
Mass (Da):25,542
Last modified:October 3, 2012 - v3
Checksum:i837FFFC49C56F70F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti199H → Q in AAA37749 (PubMed:3417659).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03958 mRNA. Translation: AAA37749.1.
AC138587 Genomic DNA. No translation available.
CH466522 Genomic DNA. Translation: EDL26384.1.
CH466522 Genomic DNA. Translation: EDL26385.1.
CH466522 Genomic DNA. Translation: EDL26386.1.
CH466522 Genomic DNA. Translation: EDL26387.1.
BC061133 mRNA. Translation: AAH61133.1.
CCDSiCCDS23359.1.
RefSeqiNP_032208.2. NM_008182.3.
XP_006510877.1. XM_006510814.2.
UniGeneiMm.422778.

Genome annotation databases

EnsembliENSMUST00000034902; ENSMUSP00000034902; ENSMUSG00000057933.
GeneIDi14858.
KEGGimmu:14858.
UCSCiuc009quf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03958 mRNA. Translation: AAA37749.1.
AC138587 Genomic DNA. No translation available.
CH466522 Genomic DNA. Translation: EDL26384.1.
CH466522 Genomic DNA. Translation: EDL26385.1.
CH466522 Genomic DNA. Translation: EDL26386.1.
CH466522 Genomic DNA. Translation: EDL26387.1.
BC061133 mRNA. Translation: AAH61133.1.
CCDSiCCDS23359.1.
RefSeqiNP_032208.2. NM_008182.3.
XP_006510877.1. XM_006510814.2.
UniGeneiMm.422778.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ML6X-ray1.90A/B2-222[»]
ProteinModelPortaliP10648.
SMRiP10648.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP10648. 2 interactors.
MINTiMINT-4080211.
STRINGi10090.ENSMUSP00000034902.

PTM databases

iPTMnetiP10648.
PhosphoSitePlusiP10648.

Proteomic databases

PaxDbiP10648.
PeptideAtlasiP10648.
PRIDEiP10648.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034902; ENSMUSP00000034902; ENSMUSG00000057933.
GeneIDi14858.
KEGGimmu:14858.
UCSCiuc009quf.1. mouse.

Organism-specific databases

CTDi2939.
MGIiMGI:95863. Gsta2.

Phylogenomic databases

eggNOGiKOG1695. Eukaryota.
ENOG4111VAU. LUCA.
GeneTreeiENSGT00670000097856.
HOGENOMiHOG000115734.
HOVERGENiHBG053749.
InParanoidiP10648.
KOiK00799.
OMAiIEMIMYL.
OrthoDBiEOG091G0O3D.
TreeFamiTF105321.

Enzyme and pathway databases

ReactomeiR-MMU-156590. Glutathione conjugation.

Miscellaneous databases

EvolutionaryTraceiP10648.
PROiP10648.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000057933.
CleanExiMM_GSTA2.
ExpressionAtlasiP10648. baseline and differential.
GenevisibleiP10648. MM.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR003080. GST_alpha.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSiPR01266. GSTRNSFRASEA.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGSTA2_MOUSE
AccessioniPrimary (citable) accession number: P10648
Secondary accession number(s): Q6P8Q1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: October 3, 2012
Last modified: November 2, 2016
This is version 137 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.