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Reviewed, UniProtKB/Swiss-Prot P10648 (GSTA2_MOUSE)

Last modified October 13, 2009. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Glutathione S-transferase A2
    EC=2.5.1.18
Alternative name(s):
    Glutathione S-transferase GT41A
    GST class-alpha member 2
Gene names
Name: Gsta2
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length222 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

Subunit structure

Homodimer.

Sequence similarities

Belongs to the GST superfamily. Alpha family.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

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Ontologies

Keywords
   Molecular functionTransferase
   Technical term3D-structure
Gene Ontology (GO)
   Biological processmetabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionglutathione transferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed
Chain2 – 222221Glutathione S-transferase A2
PRO_0000185789

Regions

Domain3 – 8381GST N-terminal
Domain85 – 208124GST C-terminal

Secondary structure

1 .................................. 222
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
P10648-1 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 72F6FFC49C56F71D

FASTA22225,533
        10         20         30         40         50         60 
MAGKPVLHYF NARGRMECIR WLLAAAGVEF EEKFIQSPED LEKLKKDGNL MFDQVPMVEI 

        70         80         90        100        110        120 
DGMKLVQTRA ILNYIATKYD LYGKDMKERA LIDMYTEGIL DLTEMIGQLV LCPPDQREAK 

       130        140        150        160        170        180 
TALAKDRTKN RYLPAFEKVL KSHGQDYLVG NRLTRVDVHL LELLLYVEEL DASLLTPFPL 

       190        200        210        220 
LKAFKSRISS LPNVKKFLQP GSQRKPPLDA KQIEEARKVF KF

« Hide

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References

[1]"Tissue-specific induction of murine glutathione transferase mRNAs by butylated hydroxyanisole."
Pearson W.R., Reinhart J., Sisk S.C., Anderson K.S., Adler P.N.
J. Biol. Chem. 263:13324-13332(1988) [PubMed: 3417659] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

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Cross-references

Sequence databases

J03958 mRNA. Translation: AAA37749.1.
IPIIPI00116055.
UniGeneMm.422778

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1ML6X-ray1.90A/B2-221[»]
ModBaseSearch...

Protein-protein interaction databases

STRINGP10648.

PTM databases

PhosphoSiteP10648.

Proteomic databases

PRIDEP10648.

Genome annotation databases

EnsemblENSMUST00000034902; ENSMUSP00000034902; ENSMUSG00000057933; Mus musculus. [Genome view]

Organism-specific databases

MGIMGI:95863. Gsta2.

Phylogenomic databases

HOGENOMP10648.
HOVERGENP10648.

Enzyme and pathway databases

BRENDA2.5.1.18. 244.

Gene expression databases

BgeeP10648.
CleanExMM_GSTA2.
GenevestigatorP10648.
GermOnlineENSMUSG00000057933. Mus musculus.

Family and domain databases

InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR017933. Glutathione_S_Trfase/Cl_chnl_C.
IPR003080. GST_alpha.
IPR004046. GST_C.
IPR012335. Thioredoxin_fold.
[Graphical view]
Gene3DG3DSA:1.20.1050.10. GST_C_like. 1 hit.
G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PANTHERPTHR11571:SF4. GST_alpha. 1 hit.
PfamPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSPR01266. GSTRNSFRASEA.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

SOURCESearch...

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Entry information

Entry nameGSTA2_MOUSE
AccessionPrimary (citable) accession number: P10648
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: October 13, 2009
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents