Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
1 to 25 of 920  Show
  1. 1
    "Human debrisoquine 4-hydroxylase (P450IID1): cDNA and deduced amino acid sequence and assignment of the CYP2D locus to chromosome 22."
    Gonzalez F.J., Vilbois F., Hardwick J.P., McBride O.W., Nebert D.W., Gelboin H.V., Meyer U.A.
    Genomics 2:174-179(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Category: Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).
  2. 2
    "Characterization of the common genetic defect in humans deficient in debrisoquine metabolism."
    Gonzalez F.J., Skoda R.C., Kimura S., Umeno M., Zanger U.M., Nebert D.W., Gelboin H.V., Hardwick J.P., Meyer U.A.
    Nature 331:442-446(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Category: Sequences.
    Tissue: Liver.
    Source: UniProtKB/Swiss-Prot (reviewed).
  3. 3
    "The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene."
    Kimura S., Umeno M., Skoda R.C., Meyer U.A., Gonzalez F.J.
    Am. J. Hum. Genet. 45:889-904(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Category: Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).
  4. 4
    "Identification and characterization of novel sequence variations in the cytochrome P4502D6 (CYP2D6) gene in African Americans."
    Gaedigk A., Bhathena A., Ndjountche L., Pearce R.E., Abdel-Rahman S.M., Alander S.W., Bradford L.D., Rogan P.K., Leeder J.S.
    Pharmacogenomics J. 5:173-182(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE CYP2D6*1), IDENTIFICATION OF ALLELES CYP2D6*41B; CYP2D6*45A; CYP2D6*45B AND CYP2D6*46, VARIANTS HIS-26; LYS-155; CYS-296 AND THR-486, CHARACTERIZATION OF ISOZYMES CYP2D6.45 AND CYP2D6.46.
    Category: Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is mapped to 32 other entries.

  5. 5
    "CYP2D6 evolution and allele diversity among human races."
    Koch W.H., Nikoloff D.M., Lu W., Pan R.M., deLeon J., Wedlund P.J.
    Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT HIS-26.
    Category: Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).
  6. 6
    "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS CYS-296 AND THR-486.
    Category: Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 1545 and mapped to 3 other entries.

  7. 7
    "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS CYS-296 AND THR-486.
    Category: Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 50486 other entries.

  8. 8
    Cited for: CATALYTIC ACTIVITY, SUBCELLULAR LOCATION.
    Category: Function, Subcellular Location.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 3 other entries.

  9. 9
    "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Category: Sequences.
    Tissue: Liver.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 11202 other entries.

  10. 10
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 34-497 IN COMPLEX WITH HEME, FUNCTION.
    Category: Function, Interaction, Structure.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is mapped to 32 other entries.

  11. 11
    "Identification of a new variant CYP2D6 allele lacking the codon encoding Lys-281: possible association with the poor metabolizer phenotype."
    Tyndale R., Aoyama T., Broly F., Matsunaga T., Inaba T., Kalow W., Gelboin H.V., Meyer U.A., Gonzalez F.J.
    Pharmacogenetics 1:26-32(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT CYP2D6*9 LYS-281 DEL.
    Category: Pathology & Biotech, Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).
  12. 12
    "Evidence for a new variant CYP2D6 allele CYP2D6J in a Japanese population associated with lower in vivo rates of sparteine metabolism."
    Yokota H., Tamura S., Furuya H., Kimura S., Watanabe M., Kanazawa I., Kondo I., Gonzalez F.J.
    Pharmacogenetics 3:256-263(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS CYP2D6*10 SER-34 AND THR-486.
    Category: Pathology & Biotech, Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).
  13. 13
    "A missense mutation in exon 6 of the CYP2D6 gene leading to a histidine 324 to proline exchange is associated with the poor metabolizer phenotype of sparteine."
    Evert B., Griese E.U., Eichelbaum M.
    Naunyn Schmiedebergs Arch. Pharmacol. 350:434-439(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT CYP2D6*7 PRO-324.
    Category: Pathology & Biotech, Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is mapped to 32 other entries.

  14. 14
    "An inactive cytochrome P450 CYP2D6 allele containing a deletion and a base substitution."
    Daly A.K., Leathart J.B., London S.J., Idle J.R.
    Hum. Genet. 95:337-341(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT CYP2D6*6B/6C GLU-212.
    Category: Pathology & Biotech, Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).
  15. 15
    "A novel mutant variant of the CYP2D6 gene (CYP2D6*17) common in a black African population: association with diminished debrisoquine hydroxylase activity."
    Masimirembwa C., Persson I., Bertilsson L., Hasler J., Ingelman-Sundberg M.
    Br. J. Clin. Pharmacol. 42:713-719(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT CYP2D6*17 ILE-107.
    Category: Pathology & Biotech, Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).
  16. 16
    "An additional allelic variant of the CYP2D6 gene causing impaired metabolism of sparteine."
    Marez D., Legrand M., Sabbagh N., Lo-Guidice J.-M., Boone P., Broly F.
    Hum. Genet. 97:668-670(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT CYP2D6*12 ARG-42.
    Category: Pathology & Biotech, Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).
  17. 17
    "Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution."
    Marez D., Legrand M., Sabbagh N., Guidice J.M., Spire C., Lafitte J.J., Meyer U.A., Broly F.
    Pharmacogenetics 7:193-202(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS.
    Category: Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).
  18. 18
    "G169R mutation diminishes the metabolic activity of CYP2D6 in Chinese."
    Wang S.L., Lai M.D., Huang J.D.
    Drug Metab. Dispos. 27:385-388(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT CYP2D6*14 ARG-169.
    Category: Pathology & Biotech, Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).
  19. 19
    "Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population."
    Solus J.F., Arietta B.J., Harris J.R., Sexton D.P., Steward J.Q., McMunn C., Ihrie P., Mehall J.M., Edwards T.L., Dawson E.P.
    Pharmacogenomics 5:895-931(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS MET-11; HIS-26; SER-34; MET-91; ARG-94; ILE-107; ILE-120; LYS-155; SER-237; CYS-296; LYS-418; ALA-469; TYR-478 AND THR-486.
    Category: Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 10 other entries.

  20. 20
    "In vitro functional assessment of 22 newly identified CYP2D6 allelic variants in the Chinese population."
    Dai D.P., Geng P.W., Wang S.H., Cai J., Hu L.M., Nie J.J., Hu J.H., Hu G.X., Cai J.P.
    Basic Clin. Pharmacol. Toxicol. 117:39-43(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS CYP2D6*87 VAL-5; GLN-25; CYP2D6*10 SER-34; CYP2D6*88 ALA-104; CYP2D6*89 SER-142; CYP2D6*90 ARG-147; CYP2D6*91 SER-161; LEU-164; LYS-215; SER-219; CYP2D6*93 PRO-249; CYP2D6*2 CYS-296; MET-327; ASN-336; CYP2D6*94 GLY-337; MET-342; GLN-344; CYS-440; CYP2D6*97 LEU-457; CYP2D6*98 ASP-463; CYP2D6*10/2 THR-486 AND CYS-497.
    Category: Pathology & Biotech, Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is mapped to 32 other entries.

  21. 21
    "Genetic polymorphism of CYP2D6, GSTM1 and NAT2 and susceptibility to haematological neoplasias."
    Lemos M.C., Cabrita F.J., Silva H.A., Vivan M., Placido F., Regateiro F.J.
    Carcinogenesis 20:1225-1229(1999) [PubMed] [Europe PMC] [Abstract]
    Category: Pathology & Biotech.
    Annotation: Associated with CANCER: Haematological Neoplasias.Imported.
    Source: GAD:139023.

    This publication is mapped to 80 other entries.

  22. 22
    "A new variant CYP2D6 allele (CYP2D6*21) with a single base insertion in exon 5 in a Japanese population associated with a poor metabolizer phenotype."
    Chida M., Yokoi T., Nemoto N., Inaba M., Kinoshita M., Kamataki T.
    Pharmacogenetics 9:287-293(1999) [PubMed] [Europe PMC] [Abstract]
    Category: Pathology & Biotech.
    Annotation: Associated with METABOLIC: CYP2D6 poor metabolizer phenotype.Imported.
    Source: GAD:139033.

    This publication is mapped to 33 other entries.

  23. 23
    "Failure to respond to treatment with typical antipsychotics is not associated with CYP2D6 ultrarapid hydroxylation."
    Aitchison K.J., Munro J., Wright P., Smith S., Makoff A.J., Sachse C., Sham P.C., Murray R.M., Collier D.A., Kerwin R.W.
    Br J Clin Pharmacol 48:388-394(1999) [PubMed] [Europe PMC] [Abstract]
    Category: Pathology & Biotech.
    Annotation: Not Associated with OTHER: typical antipsychotics.Imported.
    Source: GAD:139039.

    This publication is mapped to 33 other entries.

  24. 24
    "Cytochrome P450 2E1 is the primary enzyme responsible for low-dose carbon tetrachloride metabolism in human liver microsomes."
    Zangar R.C., Benson J.M., Burnett V.L., Springer D.L.
    Chem. Biol. Interact. 125:233-243(2000) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: PathwayImported.
    Source: Reactome:R-HSA-52679.

    This publication is mapped to 10 other entries.

  25. 25
    "Contribution of CYP2E1 and CYP3A to acetaminophen reactive metabolite formation."
    Manyike P.T., Kharasch E.D., Kalhorn T.F., Slattery J.T.
    Clin. Pharmacol. Ther. 67:275-282(2000) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: PathwayImported.
    Source: Reactome:R-HSA-52679.

    This publication is mapped to 10 other entries.

1 to 25 of 920  Show

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health