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Protein

Cytochrome P450 2D26

Gene

Cyp2d26

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi446Iron (heme axial ligand)1

GO - Molecular functioni

GO - Biological processi

  • arachidonic acid metabolic process Source: GO_Central
  • female pregnancy Source: RGD
  • response to drug Source: RGD

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-RNO-211935 Fatty acids
R-RNO-211958 Miscellaneous substrates
R-RNO-211981 Xenobiotics
R-RNO-211999 CYP2E1 reactions
R-RNO-9027307 Biosynthesis of maresin-like SPMs
SABIO-RKP10634

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2D26 (EC:1.14.14.1)
Alternative name(s):
CYPIID26
Cytochrome P450-CMF2
Cytochrome P450-DB2
Debrisoquine 4-hydroxylase
Gene namesi
Name:Cyp2d26
Synonyms:Cyp2d-26, Cyp2d2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi2471 Cyp2d2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2483

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000517471 – 500Cytochrome P450 2D26Add BLAST500

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei249PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP10634
PRIDEiP10634

PTM databases

iPTMnetiP10634
PhosphoSitePlusiP10634

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene expression databases

BgeeiENSRNOG00000008988
GenevisibleiP10634 RN

Interactioni

Protein-protein interaction databases

IntActiP10634, 1 interactor
STRINGi10116.ENSRNOP00000012413

Chemistry databases

BindingDBiP10634

Structurei

3D structure databases

ProteinModelPortaliP10634
SMRiP10634
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00900000140799
HOGENOMiHOG000036991
HOVERGENiHBG015789
InParanoidiP10634
KOiK07414
OMAiHYRYANS
OrthoDBiEOG091G0BT8
PhylomeDBiP10634
TreeFamiTF352043

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR008069 Cyt_P450_E_grp-I_CYP2D-like
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR01686 EP450ICYP2D
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

P10634-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLLIGDDLW AVVIFTAIFL LLVDLVHRHK FWTAHYPPGP VPLPGLGNLL
60 70 80 90 100
QVDFENMPYS LYKLRSRYGD VFSLQIAWKP VVVINGLKAV RELLVTYGED
110 120 130 140 150
TADRPLLPIY NHLGYGNKSK GVVLAPYGPE WREQRRFSVS TLRDFGVGKK
160 170 180 190 200
SLEQWVTEEA GHLCDTFAKE AEHPFNPSIL LSKAVSNVIA SLVYARRFEY
210 220 230 240 250
EDPFFNRMLK TLKESFGEDT GFMAEVLNAI PILLQIPGLP GKVFPKLNSF
260 270 280 290 300
IALVDKMLIE HKKSWDPAQP PRDMTDAFLA EMQKAKGNPE SSFNDENLRL
310 320 330 340 350
VVIDLFMAGM VTTSTTLSWA LLLMILHPDV QRRVHEEIDE VIGQVRRPEM
360 370 380 390 400
ADQARMPFTN AVIHEVQRFA DIVPTNIPHM TSRDIKFQGF LIPKGTTLIP
410 420 430 440 450
NLSSVLKDET VWEKPLRFHP EHFLDAQGNF VKHEAFMPFS AGRRACLGEP
460 470 480 490 500
LARMELFLFF TCLLQRFSFS VLAGRPRPST HGVYALPVTP QPYQLCAVAR
Length:500
Mass (Da):56,684
Last modified:March 1, 1992 - v2
Checksum:i23E99250734C2215
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti117N → D in AAA41049 (PubMed:3190674).Curated1
Sequence conflicti346R → L in AAA41055 (PubMed:3582092).Curated1
Sequence conflicti346R → L no nucleotide entry (PubMed:2819073).Curated1
Sequence conflicti358F → L in AAA41055 (PubMed:3582092).Curated1
Sequence conflicti358F → L no nucleotide entry (PubMed:2819073).Curated1
Sequence conflicti407K → E in AAA41055 (PubMed:3582092).Curated1
Sequence conflicti407K → E no nucleotide entry (PubMed:2819073).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16655 mRNA Translation: AAA41055.1
M22330 mRNA Translation: AAA41049.1
X52027 Genomic DNA Translation: CAA36269.1
AB008423 mRNA Translation: BAA23123.1
BC078897 mRNA Translation: AAH78897.1
PIRiB26822
RefSeqiNP_036862.1, NM_012730.1
UniGeneiRn.91355

Genome annotation databases

EnsembliENSRNOT00000012413; ENSRNOP00000012413; ENSRNOG00000008988
GeneIDi25053
KEGGirno:25053
UCSCiRGD:2471 rat

Similar proteinsi

Entry informationi

Entry nameiCP2DQ_RAT
AccessioniPrimary (citable) accession number: P10634
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: March 1, 1992
Last modified: May 23, 2018
This is version 158 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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