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P10634

- CP2DQ_RAT

UniProt

P10634 - CP2DQ_RAT

Protein

Cytochrome P450 2D26

Gene

Cyp2d26

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 2 (01 Mar 1992)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi446 – 4461Iron (heme axial ligand)

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro
    4. monooxygenase activity Source: RGD

    GO - Biological processi

    1. female pregnancy Source: RGD
    2. response to drug Source: RGD

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    SABIO-RKP10634.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2D26 (EC:1.14.14.1)
    Alternative name(s):
    CYPIID26
    Cytochrome P450-CMF2
    Cytochrome P450-DB2
    Debrisoquine 4-hydroxylase
    Gene namesi
    Name:Cyp2d26
    Synonyms:Cyp2d-26, Cyp2d2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 7

    Organism-specific databases

    RGDi2471. Cyp2d2.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. intracellular membrane-bounded organelle Source: RGD

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 500500Cytochrome P450 2D26PRO_0000051747Add
    BLAST

    Proteomic databases

    PaxDbiP10634.
    PRIDEiP10634.

    PTM databases

    PhosphoSiteiP10634.

    Expressioni

    Inductioni

    P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

    Gene expression databases

    GenevestigatoriP10634.

    Interactioni

    Protein-protein interaction databases

    IntActiP10634. 1 interaction.
    MINTiMINT-4563997.
    STRINGi10116.ENSRNOP00000012413.

    Structurei

    3D structure databases

    ProteinModelPortaliP10634.
    SMRiP10634. Positions 37-500.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    GeneTreeiENSGT00750000117392.
    HOGENOMiHOG000036991.
    HOVERGENiHBG015789.
    InParanoidiP10634.
    KOiK07414.
    OMAiWVTEEAG.
    OrthoDBiEOG7RBZ85.
    PhylomeDBiP10634.
    TreeFamiTF352043.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01686. EP450ICYP2D.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P10634-1 [UniParc]FASTAAdd to Basket

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    MGLLIGDDLW AVVIFTAIFL LLVDLVHRHK FWTAHYPPGP VPLPGLGNLL    50
    QVDFENMPYS LYKLRSRYGD VFSLQIAWKP VVVINGLKAV RELLVTYGED 100
    TADRPLLPIY NHLGYGNKSK GVVLAPYGPE WREQRRFSVS TLRDFGVGKK 150
    SLEQWVTEEA GHLCDTFAKE AEHPFNPSIL LSKAVSNVIA SLVYARRFEY 200
    EDPFFNRMLK TLKESFGEDT GFMAEVLNAI PILLQIPGLP GKVFPKLNSF 250
    IALVDKMLIE HKKSWDPAQP PRDMTDAFLA EMQKAKGNPE SSFNDENLRL 300
    VVIDLFMAGM VTTSTTLSWA LLLMILHPDV QRRVHEEIDE VIGQVRRPEM 350
    ADQARMPFTN AVIHEVQRFA DIVPTNIPHM TSRDIKFQGF LIPKGTTLIP 400
    NLSSVLKDET VWEKPLRFHP EHFLDAQGNF VKHEAFMPFS AGRRACLGEP 450
    LARMELFLFF TCLLQRFSFS VLAGRPRPST HGVYALPVTP QPYQLCAVAR 500
    Length:500
    Mass (Da):56,684
    Last modified:March 1, 1992 - v2
    Checksum:i23E99250734C2215
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti117 – 1171N → D in AAA41049. (PubMed:3190674)Curated
    Sequence conflicti346 – 3461R → L in AAA41055. (PubMed:3582092)Curated
    Sequence conflicti346 – 3461R → L no nucleotide entry (PubMed:2819073)Curated
    Sequence conflicti358 – 3581F → L in AAA41055. (PubMed:3582092)Curated
    Sequence conflicti358 – 3581F → L no nucleotide entry (PubMed:2819073)Curated
    Sequence conflicti407 – 4071K → E in AAA41055. (PubMed:3582092)Curated
    Sequence conflicti407 – 4071K → E no nucleotide entry (PubMed:2819073)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M16655 mRNA. Translation: AAA41055.1.
    M22330 mRNA. Translation: AAA41049.1.
    X52027 Genomic DNA. Translation: CAA36269.1.
    AB008423 mRNA. Translation: BAA23123.1.
    BC078897 mRNA. Translation: AAH78897.1.
    PIRiB26822.
    RefSeqiNP_036862.1. NM_012730.1.
    UniGeneiRn.91355.

    Genome annotation databases

    EnsembliENSRNOT00000012413; ENSRNOP00000012413; ENSRNOG00000008988.
    GeneIDi25053.
    KEGGirno:25053.
    UCSCiRGD:2471. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M16655 mRNA. Translation: AAA41055.1 .
    M22330 mRNA. Translation: AAA41049.1 .
    X52027 Genomic DNA. Translation: CAA36269.1 .
    AB008423 mRNA. Translation: BAA23123.1 .
    BC078897 mRNA. Translation: AAH78897.1 .
    PIRi B26822.
    RefSeqi NP_036862.1. NM_012730.1.
    UniGenei Rn.91355.

    3D structure databases

    ProteinModelPortali P10634.
    SMRi P10634. Positions 37-500.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P10634. 1 interaction.
    MINTi MINT-4563997.
    STRINGi 10116.ENSRNOP00000012413.

    Chemistry

    BindingDBi P10634.
    ChEMBLi CHEMBL2483.

    PTM databases

    PhosphoSitei P10634.

    Proteomic databases

    PaxDbi P10634.
    PRIDEi P10634.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000012413 ; ENSRNOP00000012413 ; ENSRNOG00000008988 .
    GeneIDi 25053.
    KEGGi rno:25053.
    UCSCi RGD:2471. rat.

    Organism-specific databases

    CTDi 25053.
    RGDi 2471. Cyp2d2.

    Phylogenomic databases

    eggNOGi COG2124.
    GeneTreei ENSGT00750000117392.
    HOGENOMi HOG000036991.
    HOVERGENi HBG015789.
    InParanoidi P10634.
    KOi K07414.
    OMAi WVTEEAG.
    OrthoDBi EOG7RBZ85.
    PhylomeDBi P10634.
    TreeFami TF352043.

    Enzyme and pathway databases

    SABIO-RK P10634.

    Miscellaneous databases

    NextBioi 605254.

    Gene expression databases

    Genevestigatori P10634.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01686. EP450ICYP2D.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Debrisoquine 4-hydroxylase: characterization of a new P450 gene subfamily, regulation, chromosomal mapping, and molecular analysis of the DA rat polymorphism."
      Gonzalez F.J., Matsunaga T., Nagata K., Meyer U.A., Nebert D.W., Pastewka J., Kozak C.A., Gillette J., Gelboin H.V., Hardwick J.P.
      DNA 6:149-161(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The CYP2D gene subfamily: analysis of the molecular basis of the debrisoquine 4-hydroxylase deficiency in DA rats."
      Matsunaga E., Zanger U.M., Hardwick J.P., Gelboin H.V., Meyer U.A., Gonzalez F.J.
      Biochemistry 28:7349-7355(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Four species of cDNAs for cytochrome P450 isozymes immunorelated to P450C-M/F encode for members of P450IID subfamily, increasing the number of members within the subfamily."
      Ishida N., Tawaragi Y., Inuzuka C., Sugita O., Kubota I., Nakazato H., Noguchi T., Sassa S.
      Biochem. Biophys. Res. Commun. 156:681-688(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "The rat P450 IID subfamily: complete sequences of four closely linked genes and evidence that gene conversions maintained sequence homogeneity at the heme-binding region of the cytochrome P450 active site."
      Matsunaga E., Umeno M., Gonzalez F.J.
      J. Mol. Evol. 30:155-169(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Sprague-Dawley.
      Tissue: Liver.
    5. "Expression of four rat CYP2D isoforms in Saccharomyces cerevisiae and their catalytic specificity."
      Wan J., Imaoka S., Chow T., Hiroi T., Yabusaki Y., Funae Y.
      Arch. Biochem. Biophys. 348:383-390(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Liver.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiCP2DQ_RAT
    AccessioniPrimary (citable) accession number: P10634
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: March 1, 1992
    Last modified: October 1, 2014
    This is version 130 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3