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P10633 (CP2D1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2D1

EC=1.14.14.1
Alternative name(s):
CYPIID1
Cytochrome P450-CMF1A
Cytochrome P450-DB1
Cytochrome P450-UT-7
Debrisoquine 4-hydroxylase
Gene names
Name:Cyp2d1
Synonyms:Cyp2d-1, Cyp2d9
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length504 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 504504Cytochrome P450 2D1
PRO_0000051728

Sites

Metal binding4461Iron (heme axial ligand)

Experimental info

Sequence conflict123 – 1242IL → VF in AAA41043. Ref.3
Sequence conflict1731Q → R in AAA41043. Ref.3
Sequence conflict3801F → I in AAA41043. Ref.3
Sequence conflict3801F → I in BAA23122. Ref.4
Sequence conflict3801F → I in AAH78696. Ref.5

Sequences

Sequence LengthMass (Da)Tools
P10633 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: 2F9AD87B4EF327DC

FASTA50457,175
        10         20         30         40         50         60 
MELLNGTGLW SMAIFTVIFI LLVDLMHRRH RWTSRYPPGP VPWPVLGNLL QVDLSNMPYS 

        70         80         90        100        110        120 
LYKLQHRYGD VFSLQKGWKP MVIVNRLKAV QEVLVTHGED TADRPPVPIF KCLGVKPRSQ 

       130        140        150        160        170        180 
GVILASYGPE WREQRRFSVS TLRTFGMGKK SLEEWVTKEA GHLCDAFTAQ AGQSINPKAM 

       190        200        210        220        230        240 
LNKALCNVIA SLIFARRFEY EDPYLIRMVK LVEESLTEVS GFIPEVLNTF PALLRIPGLA 

       250        260        270        280        290        300 
DKVFQGQKTF MALLDNLLAE NRTTWDPAQP PRNLTDAFLA EVEKAKGNPE SSFNDENLRM 

       310        320        330        340        350        360 
VVVDLFTAGM VTTATTLTWA LLLMILYPDV QRRVQQEIDE VIGQVRCPEM TDQAHMPYTN 

       370        380        390        400        410        420 
AVIHEVQRFG DIAPLNLPRF TSCDIEVQDF VIPKGTTLII NLSSVLKDET VWEKPHRFHP 

       430        440        450        460        470        480 
EHFLDAQGNF VKHEAFMPFS AGRRACLGEP LARMELFLFF TCLLQRFSFS VPVGQPRPST 

       490        500 
HGFFAFPVAP LPYQLCAVVR EQGL 

« Hide

References

« Hide 'large scale' references
[1]"Debrisoquine 4-hydroxylase: characterization of a new P450 gene subfamily, regulation, chromosomal mapping, and molecular analysis of the DA rat polymorphism."
Gonzalez F.J., Matsunaga T., Nagata K., Meyer U.A., Nebert D.W., Pastewka J., Kozak C.A., Gillette J., Gelboin H.V., Hardwick J.P.
DNA 6:149-161(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The CYP2D gene subfamily: analysis of the molecular basis of the debrisoquine 4-hydroxylase deficiency in DA rats."
Matsunaga E., Zanger U.M., Hardwick J.P., Gelboin H.V., Meyer U.A., Gonzalez F.J.
Biochemistry 28:7349-7355(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Four species of cDNAs for cytochrome P450 isozymes immunorelated to P450C-M/F encode for members of P450IID subfamily, increasing the number of members within the subfamily."
Ishida N., Tawaragi Y., Inuzuka C., Sugita O., Kubota I., Nakazato H., Noguchi T., Sassa S.
Biochem. Biophys. Res. Commun. 156:681-688(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"Expression of four rat CYP2D isoforms in Saccharomyces cerevisiae and their catalytic specificity."
Wan J., Imaoka S., Chow T., Hiroi T., Yabusaki Y., Funae Y.
Arch. Biochem. Biophys. 348:383-390(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Liver.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M16654 mRNA. Translation: AAA41054.1.
J02867 mRNA. Translation: AAA41001.1.
M22328 mRNA. Translation: AAA41043.1.
AB008422 mRNA. Translation: BAA23122.1.
BC078696 mRNA. Translation: AAH78696.1.
PIRA26822.
RefSeqNP_695225.1. NM_153313.1.
UniGeneRn.91133.

3D structure databases

ProteinModelPortalP10633.
SMRP10633. Positions 37-500.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-4564454.
STRING10116.ENSRNOP00000041174.

Chemistry

BindingDBP10633.
ChEMBLCHEMBL2475.

PTM databases

PhosphoSiteP10633.

Proteomic databases

PaxDbP10633.
PRIDEP10633.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000050002; ENSRNOP00000041174; ENSRNOG00000030182.
GeneID266684.
KEGGrno:266684.
UCSCRGD:708427. rat.

Organism-specific databases

CTD266684.
RGD708427. Cyp2d1.

Phylogenomic databases

eggNOGCOG2124.
GeneTreeENSGT00750000117392.
HOGENOMHOG000036991.
HOVERGENHBG015789.
InParanoidP10633.
KOK07414.
OrthoDBEOG7RBZ85.
PhylomeDBP10633.
TreeFamTF352043.

Enzyme and pathway databases

SABIO-RKP10633.

Gene expression databases

GenevestigatorP10633.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio624484.

Entry information

Entry nameCP2D1_RAT
AccessionPrimary (citable) accession number: P10633
Secondary accession number(s): O35105, Q6AZ78
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: June 11, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families