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Protein

Cytochrome P450 2D1

Gene

Cyp2d1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi446Iron (heme axial ligand)1

GO - Molecular functioni

GO - Biological processi

  • arachidonic acid metabolic process Source: GO_Central
  • response to drug Source: RGD
  • response to organic cyclic compound Source: RGD
  • response to organic substance Source: RGD

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

SABIO-RKP10633

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2D1 (EC:1.14.14.1)
Alternative name(s):
CYPIID1
Cytochrome P450-CMF1A
Cytochrome P450-DB1
Cytochrome P450-UT-7
Debrisoquine 4-hydroxylase
Gene namesi
Name:Cyp2d1
Synonyms:Cyp2d-1, Cyp2d9
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi708427 Cyp2d1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2475

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000517281 – 504Cytochrome P450 2D1Add BLAST504

Proteomic databases

PaxDbiP10633
PRIDEiP10633

PTM databases

iPTMnetiP10633
PhosphoSitePlusiP10633

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000041174

Chemistry databases

BindingDBiP10633

Structurei

3D structure databases

ProteinModelPortaliP10633
SMRiP10633
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
HOGENOMiHOG000036991
HOVERGENiHBG015789
InParanoidiP10633
KOiK07414
PhylomeDBiP10633
TreeFamiTF352043

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR008069 Cyt_P450_E_grp-I_CYP2D-like
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR01686 EP450ICYP2D
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

P10633-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELLNGTGLW SMAIFTVIFI LLVDLMHRRH RWTSRYPPGP VPWPVLGNLL
60 70 80 90 100
QVDLSNMPYS LYKLQHRYGD VFSLQKGWKP MVIVNRLKAV QEVLVTHGED
110 120 130 140 150
TADRPPVPIF KCLGVKPRSQ GVILASYGPE WREQRRFSVS TLRTFGMGKK
160 170 180 190 200
SLEEWVTKEA GHLCDAFTAQ AGQSINPKAM LNKALCNVIA SLIFARRFEY
210 220 230 240 250
EDPYLIRMVK LVEESLTEVS GFIPEVLNTF PALLRIPGLA DKVFQGQKTF
260 270 280 290 300
MALLDNLLAE NRTTWDPAQP PRNLTDAFLA EVEKAKGNPE SSFNDENLRM
310 320 330 340 350
VVVDLFTAGM VTTATTLTWA LLLMILYPDV QRRVQQEIDE VIGQVRCPEM
360 370 380 390 400
TDQAHMPYTN AVIHEVQRFG DIAPLNLPRF TSCDIEVQDF VIPKGTTLII
410 420 430 440 450
NLSSVLKDET VWEKPHRFHP EHFLDAQGNF VKHEAFMPFS AGRRACLGEP
460 470 480 490 500
LARMELFLFF TCLLQRFSFS VPVGQPRPST HGFFAFPVAP LPYQLCAVVR

EQGL
Length:504
Mass (Da):57,175
Last modified:July 1, 1989 - v1
Checksum:i2F9AD87B4EF327DC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti123 – 124IL → VF in AAA41043 (PubMed:3190674).Curated2
Sequence conflicti173Q → R in AAA41043 (PubMed:3190674).Curated1
Sequence conflicti380F → I in AAA41043 (PubMed:3190674).Curated1
Sequence conflicti380F → I in BAA23122 (PubMed:9434752).Curated1
Sequence conflicti380F → I in AAH78696 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16654 mRNA Translation: AAA41054.1
J02867 mRNA Translation: AAA41001.1
M22328 mRNA Translation: AAA41043.1
AB008422 mRNA Translation: BAA23122.1
BC078696 mRNA Translation: AAH78696.1
PIRiA26822
RefSeqiNP_695225.1, NM_153313.1
UniGeneiRn.91133

Genome annotation databases

GeneIDi266684
KEGGirno:266684
UCSCiRGD:708427 rat

Similar proteinsi

Entry informationi

Entry nameiCP2D1_RAT
AccessioniPrimary (citable) accession number: P10633
Secondary accession number(s): O35105, Q6AZ78
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: May 23, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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