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Protein

Cytochrome P450 2D1

Gene

Cyp2d1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi446Iron (heme axial ligand)1

GO - Molecular functioni

GO - Biological processi

  • arachidonic acid metabolic process Source: GO_Central
  • response to drug Source: RGD
  • response to organic cyclic compound Source: RGD
  • response to organic substance Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

SABIO-RKP10633.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2D1 (EC:1.14.14.1)
Alternative name(s):
CYPIID1
Cytochrome P450-CMF1A
Cytochrome P450-DB1
Cytochrome P450-UT-7
Debrisoquine 4-hydroxylase
Gene namesi
Name:Cyp2d1
Synonyms:Cyp2d-1, Cyp2d9
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi708427. Cyp2d1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: RGD
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • organelle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2475.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000517281 – 504Cytochrome P450 2D1Add BLAST504

Proteomic databases

PaxDbiP10633.
PRIDEiP10633.

PTM databases

iPTMnetiP10633.
PhosphoSitePlusiP10633.

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene expression databases

BgeeiENSRNOG00000030182.

Interactioni

Protein-protein interaction databases

MINTiMINT-4564454.
STRINGi10116.ENSRNOP00000041174.

Chemistry databases

BindingDBiP10633.

Structurei

3D structure databases

ProteinModelPortaliP10633.
SMRiP10633.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
HOGENOMiHOG000036991.
HOVERGENiHBG015789.
InParanoidiP10633.
KOiK07414.
PhylomeDBiP10633.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10633-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELLNGTGLW SMAIFTVIFI LLVDLMHRRH RWTSRYPPGP VPWPVLGNLL
60 70 80 90 100
QVDLSNMPYS LYKLQHRYGD VFSLQKGWKP MVIVNRLKAV QEVLVTHGED
110 120 130 140 150
TADRPPVPIF KCLGVKPRSQ GVILASYGPE WREQRRFSVS TLRTFGMGKK
160 170 180 190 200
SLEEWVTKEA GHLCDAFTAQ AGQSINPKAM LNKALCNVIA SLIFARRFEY
210 220 230 240 250
EDPYLIRMVK LVEESLTEVS GFIPEVLNTF PALLRIPGLA DKVFQGQKTF
260 270 280 290 300
MALLDNLLAE NRTTWDPAQP PRNLTDAFLA EVEKAKGNPE SSFNDENLRM
310 320 330 340 350
VVVDLFTAGM VTTATTLTWA LLLMILYPDV QRRVQQEIDE VIGQVRCPEM
360 370 380 390 400
TDQAHMPYTN AVIHEVQRFG DIAPLNLPRF TSCDIEVQDF VIPKGTTLII
410 420 430 440 450
NLSSVLKDET VWEKPHRFHP EHFLDAQGNF VKHEAFMPFS AGRRACLGEP
460 470 480 490 500
LARMELFLFF TCLLQRFSFS VPVGQPRPST HGFFAFPVAP LPYQLCAVVR

EQGL
Length:504
Mass (Da):57,175
Last modified:July 1, 1989 - v1
Checksum:i2F9AD87B4EF327DC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti123 – 124IL → VF in AAA41043 (PubMed:3190674).Curated2
Sequence conflicti173Q → R in AAA41043 (PubMed:3190674).Curated1
Sequence conflicti380F → I in AAA41043 (PubMed:3190674).Curated1
Sequence conflicti380F → I in BAA23122 (PubMed:9434752).Curated1
Sequence conflicti380F → I in AAH78696 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16654 mRNA. Translation: AAA41054.1.
J02867 mRNA. Translation: AAA41001.1.
M22328 mRNA. Translation: AAA41043.1.
AB008422 mRNA. Translation: BAA23122.1.
BC078696 mRNA. Translation: AAH78696.1.
PIRiA26822.
RefSeqiNP_695225.1. NM_153313.1.
UniGeneiRn.91133.

Genome annotation databases

GeneIDi266684.
KEGGirno:266684.
UCSCiRGD:708427. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16654 mRNA. Translation: AAA41054.1.
J02867 mRNA. Translation: AAA41001.1.
M22328 mRNA. Translation: AAA41043.1.
AB008422 mRNA. Translation: BAA23122.1.
BC078696 mRNA. Translation: AAH78696.1.
PIRiA26822.
RefSeqiNP_695225.1. NM_153313.1.
UniGeneiRn.91133.

3D structure databases

ProteinModelPortaliP10633.
SMRiP10633.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4564454.
STRINGi10116.ENSRNOP00000041174.

Chemistry databases

BindingDBiP10633.
ChEMBLiCHEMBL2475.

PTM databases

iPTMnetiP10633.
PhosphoSitePlusiP10633.

Proteomic databases

PaxDbiP10633.
PRIDEiP10633.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi266684.
KEGGirno:266684.
UCSCiRGD:708427. rat.

Organism-specific databases

CTDi266684.
RGDi708427. Cyp2d1.

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
HOGENOMiHOG000036991.
HOVERGENiHBG015789.
InParanoidiP10633.
KOiK07414.
PhylomeDBiP10633.
TreeFamiTF352043.

Enzyme and pathway databases

SABIO-RKP10633.

Miscellaneous databases

PROiP10633.

Gene expression databases

BgeeiENSRNOG00000030182.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCP2D1_RAT
AccessioniPrimary (citable) accession number: P10633
Secondary accession number(s): O35105, Q6AZ78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 2, 2016
This is version 145 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.