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P10633

- CP2D1_RAT

UniProt

P10633 - CP2D1_RAT

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Protein
Cytochrome P450 2D1
Gene
Cyp2d1, Cyp2d-1, Cyp2d9
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi446 – 4461Iron (heme axial ligand)

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
  4. monooxygenase activity Source: RGD
Complete GO annotation...

GO - Biological processi

  1. response to drug Source: RGD
  2. response to organic cyclic compound Source: RGD
  3. response to organic substance Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

SABIO-RKP10633.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2D1 (EC:1.14.14.1)
Alternative name(s):
CYPIID1
Cytochrome P450-CMF1A
Cytochrome P450-DB1
Cytochrome P450-UT-7
Debrisoquine 4-hydroxylase
Gene namesi
Name:Cyp2d1
Synonyms:Cyp2d-1, Cyp2d9
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 7

Organism-specific databases

RGDi708427. Cyp2d1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: RGD
  2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 504504Cytochrome P450 2D1
PRO_0000051728Add
BLAST

Proteomic databases

PaxDbiP10633.
PRIDEiP10633.

PTM databases

PhosphoSiteiP10633.

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene expression databases

GenevestigatoriP10633.

Interactioni

Protein-protein interaction databases

MINTiMINT-4564454.
STRINGi10116.ENSRNOP00000041174.

Structurei

3D structure databases

ProteinModelPortaliP10633.
SMRiP10633. Positions 37-500.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00750000117392.
HOGENOMiHOG000036991.
HOVERGENiHBG015789.
InParanoidiP10633.
KOiK07414.
OrthoDBiEOG7RBZ85.
PhylomeDBiP10633.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10633-1 [UniParc]FASTAAdd to Basket

« Hide

MELLNGTGLW SMAIFTVIFI LLVDLMHRRH RWTSRYPPGP VPWPVLGNLL    50
QVDLSNMPYS LYKLQHRYGD VFSLQKGWKP MVIVNRLKAV QEVLVTHGED 100
TADRPPVPIF KCLGVKPRSQ GVILASYGPE WREQRRFSVS TLRTFGMGKK 150
SLEEWVTKEA GHLCDAFTAQ AGQSINPKAM LNKALCNVIA SLIFARRFEY 200
EDPYLIRMVK LVEESLTEVS GFIPEVLNTF PALLRIPGLA DKVFQGQKTF 250
MALLDNLLAE NRTTWDPAQP PRNLTDAFLA EVEKAKGNPE SSFNDENLRM 300
VVVDLFTAGM VTTATTLTWA LLLMILYPDV QRRVQQEIDE VIGQVRCPEM 350
TDQAHMPYTN AVIHEVQRFG DIAPLNLPRF TSCDIEVQDF VIPKGTTLII 400
NLSSVLKDET VWEKPHRFHP EHFLDAQGNF VKHEAFMPFS AGRRACLGEP 450
LARMELFLFF TCLLQRFSFS VPVGQPRPST HGFFAFPVAP LPYQLCAVVR 500
EQGL 504
Length:504
Mass (Da):57,175
Last modified:July 1, 1989 - v1
Checksum:i2F9AD87B4EF327DC
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti123 – 1242IL → VF in AAA41043. 1 Publication
Sequence conflicti173 – 1731Q → R in AAA41043. 1 Publication
Sequence conflicti380 – 3801F → I in AAA41043. 1 Publication
Sequence conflicti380 – 3801F → I in BAA23122. 1 Publication
Sequence conflicti380 – 3801F → I in AAH78696. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M16654 mRNA. Translation: AAA41054.1.
J02867 mRNA. Translation: AAA41001.1.
M22328 mRNA. Translation: AAA41043.1.
AB008422 mRNA. Translation: BAA23122.1.
BC078696 mRNA. Translation: AAH78696.1.
PIRiA26822.
RefSeqiNP_695225.1. NM_153313.1.
UniGeneiRn.91133.

Genome annotation databases

EnsembliENSRNOT00000050002; ENSRNOP00000041174; ENSRNOG00000030182.
GeneIDi266684.
KEGGirno:266684.
UCSCiRGD:708427. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M16654 mRNA. Translation: AAA41054.1 .
J02867 mRNA. Translation: AAA41001.1 .
M22328 mRNA. Translation: AAA41043.1 .
AB008422 mRNA. Translation: BAA23122.1 .
BC078696 mRNA. Translation: AAH78696.1 .
PIRi A26822.
RefSeqi NP_695225.1. NM_153313.1.
UniGenei Rn.91133.

3D structure databases

ProteinModelPortali P10633.
SMRi P10633. Positions 37-500.
ModBasei Search...

Protein-protein interaction databases

MINTi MINT-4564454.
STRINGi 10116.ENSRNOP00000041174.

Chemistry

BindingDBi P10633.
ChEMBLi CHEMBL2475.

PTM databases

PhosphoSitei P10633.

Proteomic databases

PaxDbi P10633.
PRIDEi P10633.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000050002 ; ENSRNOP00000041174 ; ENSRNOG00000030182 .
GeneIDi 266684.
KEGGi rno:266684.
UCSCi RGD:708427. rat.

Organism-specific databases

CTDi 266684.
RGDi 708427. Cyp2d1.

Phylogenomic databases

eggNOGi COG2124.
GeneTreei ENSGT00750000117392.
HOGENOMi HOG000036991.
HOVERGENi HBG015789.
InParanoidi P10633.
KOi K07414.
OrthoDBi EOG7RBZ85.
PhylomeDBi P10633.
TreeFami TF352043.

Enzyme and pathway databases

SABIO-RK P10633.

Miscellaneous databases

NextBioi 624484.

Gene expression databases

Genevestigatori P10633.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Debrisoquine 4-hydroxylase: characterization of a new P450 gene subfamily, regulation, chromosomal mapping, and molecular analysis of the DA rat polymorphism."
    Gonzalez F.J., Matsunaga T., Nagata K., Meyer U.A., Nebert D.W., Pastewka J., Kozak C.A., Gillette J., Gelboin H.V., Hardwick J.P.
    DNA 6:149-161(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The CYP2D gene subfamily: analysis of the molecular basis of the debrisoquine 4-hydroxylase deficiency in DA rats."
    Matsunaga E., Zanger U.M., Hardwick J.P., Gelboin H.V., Meyer U.A., Gonzalez F.J.
    Biochemistry 28:7349-7355(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Four species of cDNAs for cytochrome P450 isozymes immunorelated to P450C-M/F encode for members of P450IID subfamily, increasing the number of members within the subfamily."
    Ishida N., Tawaragi Y., Inuzuka C., Sugita O., Kubota I., Nakazato H., Noguchi T., Sassa S.
    Biochem. Biophys. Res. Commun. 156:681-688(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Expression of four rat CYP2D isoforms in Saccharomyces cerevisiae and their catalytic specificity."
    Wan J., Imaoka S., Chow T., Hiroi T., Yabusaki Y., Funae Y.
    Arch. Biochem. Biophys. 348:383-390(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Liver.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiCP2D1_RAT
AccessioniPrimary (citable) accession number: P10633
Secondary accession number(s): O35105, Q6AZ78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: June 11, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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