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Protein

Cytochrome P450 2C8

Gene

CYP2C8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme responsible for the metabolism the anti-cancer drug paclitaxel (taxol).2 Publications

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.1 Publication

Cofactori

Kineticsi

  1. KM=7.18 µM for paclitaxel1 Publication
  2. KM=1.35 µM for amodiaquine1 Publication
  1. Vmax=2.18 pmol/min/pmol enzyme with paclitaxel as substrate1 Publication
  2. Vmax=11.30 pmol/min/pmol enzyme with amodiaquine as substrate1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei100 – 1001Substrate
Binding sitei204 – 2041Substrate
Binding sitei241 – 2411Substrate
Metal bindingi435 – 4351Iron (heme axial ligand)

GO - Molecular functioni

GO - Biological processi

  • drug metabolic process Source: BHF-UCL
  • epoxygenase P450 pathway Source: GO_Central
  • exogenous drug catabolic process Source: BHF-UCL
  • omega-hydroxylase P450 pathway Source: Reactome
  • organic acid metabolic process Source: BHF-UCL
  • oxidation-reduction process Source: BHF-UCL
  • oxidative demethylation Source: BHF-UCL
  • xenobiotic metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BRENDAi1.14.14.1. 2681.
ReactomeiR-HSA-211981. Xenobiotics.
R-HSA-211999. CYP2E1 reactions.
R-HSA-2142670. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
R-HSA-2142816. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
SABIO-RKP10632.

Chemistry

SwissLipidsiSLP:000001548.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C8 (EC:1.14.14.11 Publication)
Alternative name(s):
CYPIIC8
Cytochrome P450 IIC2
Cytochrome P450 MP-12
Cytochrome P450 MP-20
Cytochrome P450 form 1
S-mephenytoin 4-hydroxylase
Gene namesi
Name:CYP2C8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:2622. CYP2C8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

MIMi601129. gene+phenotype.
PharmGKBiPA125.

Chemistry

ChEMBLiCHEMBL3721.
DrugBankiDB05812. Abiraterone.
DB00316. Acetaminophen.
DB00945. Acetylsalicylic acid.
DB00918. Almotriptan.
DB01424. Aminophenazone.
DB01118. Amiodarone.
DB00321. Amitriptyline.
DB00381. Amlodipine.
DB00613. Amodiaquine.
DB00701. Amprenavir.
DB01435. Antipyrine.
DB06605. Apixaban.
DB01076. Atorvastatin.
DB00972. Azelastine.
DB06770. Benzyl alcohol.
DB01393. Bezafibrate.
DB00188. Bortezomib.
DB00835. Brompheniramine.
DB00921. Buprenorphine.
DB01156. Bupropion.
DB06772. Cabazitaxel.
DB00201. Caffeine.
DB00796. Candesartan.
DB00564. Carbamazepine.
DB00748. Carbinoxamine.
DB00446. Chloramphenicol.
DB00608. Chloroquine.
DB00169. Cholecalciferol.
DB00501. Cimetidine.
DB00604. Cisapride.
DB00758. Clopidogrel.
DB00257. Clotrimazole.
DB00363. Clozapine.
DB00907. Cocaine.
DB01394. Colchicine.
DB00531. Cyclophosphamide.
DB00091. Cyclosporine.
DB08912. Dabrafenib.
DB00250. Dapsone.
DB00705. Delavirdine.
DB01234. Dexamethasone.
DB00514. Dextromethorphan.
DB00647. Dextropropoxyphene.
DB00829. Diazepam.
DB00586. Diclofenac.
DB00255. Diethylstilbestrol.
DB00343. Diltiazem.
DB01184. Domperidone.
DB06210. Eltrombopag.
DB08899. Enzalutamide.
DB00530. Erlotinib.
DB00783. Estradiol.
DB00402. Eszopiclone.
DB00977. Ethinyl Estradiol.
DB00773. Etoposide.
DB01023. Felodipine.
DB01039. Fenofibrate.
DB00544. Fluorouracil.
DB01095. Fluvastatin.
DB01320. Fosphenytoin.
DB01241. Gemfibrozil.
DB01218. Halofantrine.
DB00741. Hydrocortisone.
DB01050. Ibuprofen.
DB09054. Idelalisib.
DB01181. Ifosfamide.
DB01029. Irbesartan.
DB00951. Isoniazid.
DB09570. Ixazomib.
DB01221. Ketamine.
DB06738. Ketobemidone.
DB01026. Ketoconazole.
DB01009. Ketoprofen.
DB00448. Lansoprazole.
DB01259. Lapatinib.
DB08918. Levomilnacipran.
DB00451. Levothyroxine.
DB00281. Lidocaine.
DB01583. Liotrix.
DB00836. Loperamide.
DB00455. Loratadine.
DB00678. Losartan.
DB00227. Lovastatin.
DB00603. Medroxyprogesterone Acetate.
DB00784. Mefenamic acid.
DB00814. Meloxicam.
DB00333. Methadone.
DB00916. Metronidazole.
DB00370. Mirtazapine.
DB00764. Mometasone.
DB00471. Montelukast.
DB00295. Morphine.
DB00688. Mycophenolate mofetil.
DB01183. Naloxone.
DB00788. Naproxen.
DB00622. Nicardipine.
DB00184. Nicotine.
DB01115. Nifedipine.
DB04868. Nilotinib.
DB00665. Nilutamide.
DB06712. Nilvadipine.
DB09080. Olodaterol.
DB00338. Omeprazole.
DB01062. Oxybutynin.
DB01229. Paclitaxel.
DB00617. Paramethadione.
DB00715. Paroxetine.
DB06589. Pazopanib.
DB00738. Pentamidine.
DB00850. Perphenazine.
DB00780. Phenelzine.
DB01174. Phenobarbital.
DB00946. Phenprocoumon.
DB00252. Phenytoin.
DB01132. Pioglitazone.
DB00554. Piroxicam.
DB08860. Pitavastatin.
DB08901. Ponatinib.
DB00175. Pravastatin.
DB00794. Primidone.
DB01032. Probenecid.
DB00396. Progesterone.
DB01182. Propafenone.
DB00818. Propofol.
DB00205. Pyrimethamine.
DB00908. Quinidine.
DB00468. Quinine.
DB00481. Raloxifene.
DB08896. Regorafenib.
DB00912. Repaglinide.
DB01045. Rifampicin.
DB01201. Rifapentine.
DB08931. Riociguat.
DB00503. Ritonavir.
DB00412. Rosiglitazone.
DB00938. Salmeterol.
DB01232. Saquinavir.
DB00418. Secobarbital.
DB01037. Selegiline.
DB11362. Selexipag.
DB00641. Simvastatin.
DB01261. Sitagliptin.
DB00398. Sorafenib.
DB00421. Spironolactone.
DB00359. Sulfadiazine.
DB01015. Sulfamethoxazole.
DB06729. Sulfaphenazole.
DB01138. Sulfinpyrazone.
DB00675. Tamoxifen.
DB00799. Tazarotene.
DB00231. Temazepam.
DB00857. Terbinafine.
DB00624. Testosterone.
DB00277. Theophylline.
DB00679. Thioridazine.
DB00208. Ticlopidine.
DB01007. Tioconazole.
DB01124. Tolbutamide.
DB00214. Torasemide.
DB08911. Trametinib.
DB00755. Tretinoin.
DB00897. Triazolam.
DB00347. Trimethadione.
DB00440. Trimethoprim.
DB01361. Troleandomycin.
DB00313. Valproic Acid.
DB00661. Verapamil.
DB08828. Vismodegib.
DB09068. Vortioxetine.
DB00682. Warfarin.
DB00549. Zafirlukast.
DB00495. Zidovudine.
DB01198. Zopiclone.
GuidetoPHARMACOLOGYi1325.

Polymorphism and mutation databases

BioMutaiCYP2C8.
DMDMi117225.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490Cytochrome P450 2C8PRO_0000051699Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei100 – 1001PhosphoserineCombined sources
Modified residuei249 – 2491N6-acetyllysineBy similarity
Modified residuei375 – 3751N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP10632.
PeptideAtlasiP10632.
PRIDEiP10632.

PTM databases

iPTMnetiP10632.
PhosphoSiteiP10632.

Expressioni

Inductioni

By phenobarbital.

Gene expression databases

BgeeiENSG00000138115.
CleanExiHS_CYP2C8.
ExpressionAtlasiP10632. baseline and differential.
GenevisibleiP10632. HS.

Organism-specific databases

HPAiHPA013547.
HPA013970.
HPA015066.

Interactioni

Protein-protein interaction databases

BioGridi107936. 13 interactions.
IntActiP10632. 10 interactions.
STRINGi9606.ENSP00000360317.

Chemistry

BindingDBiP10632.

Structurei

Secondary structure

1
490
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni37 – 393Combined sources
Helixi42 – 443Combined sources
Beta strandi47 – 493Combined sources
Helixi50 – 6112Combined sources
Beta strandi63 – 697Combined sources
Beta strandi72 – 776Combined sources
Helixi80 – 878Combined sources
Turni88 – 947Combined sources
Helixi101 – 1077Combined sources
Turni111 – 1133Combined sources
Helixi117 – 13014Combined sources
Turni133 – 1364Combined sources
Beta strandi137 – 1393Combined sources
Helixi141 – 15717Combined sources
Turni158 – 1614Combined sources
Helixi167 – 18216Combined sources
Beta strandi183 – 1853Combined sources
Helixi192 – 20817Combined sources
Helixi212 – 2187Combined sources
Helixi220 – 2256Combined sources
Helixi227 – 25226Combined sources
Helixi263 – 27311Combined sources
Helixi284 – 29815Combined sources
Helixi300 – 31516Combined sources
Helixi317 – 33014Combined sources
Beta strandi333 – 3353Combined sources
Helixi339 – 3446Combined sources
Helixi346 – 35914Combined sources
Beta strandi374 – 3763Combined sources
Beta strandi379 – 3813Combined sources
Beta strandi386 – 3894Combined sources
Helixi391 – 3955Combined sources
Turni398 – 4003Combined sources
Beta strandi401 – 4033Combined sources
Helixi409 – 4124Combined sources
Helixi431 – 4333Combined sources
Helixi438 – 45518Combined sources
Beta strandi456 – 4594Combined sources
Helixi464 – 4663Combined sources
Beta strandi472 – 4798Combined sources
Beta strandi485 – 4895Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1PQ2X-ray2.70A/B19-490[»]
2NNHX-ray2.60A/B28-490[»]
2NNIX-ray2.80A28-490[»]
2NNJX-ray2.28A28-490[»]
2VN0X-ray2.70A28-490[»]
ProteinModelPortaliP10632.
SMRiP10632. Positions 28-490.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10632.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP10632.
KOiK17718.
OMAiMLQIDIK.
OrthoDBiEOG091G0BT8.
PhylomeDBiP10632.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P10632-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPFVVLVLC LSFMLLFSLW RQSCRRRKLP PGPTPLPIIG NMLQIDVKDI
60 70 80 90 100
CKSFTNFSKV YGPVFTVYFG MNPIVVFHGY EAVKEALIDN GEEFSGRGNS
110 120 130 140 150
PISQRITKGL GIISSNGKRW KEIRRFSLTT LRNFGMGKRS IEDRVQEEAH
160 170 180 190 200
CLVEELRKTK ASPCDPTFIL GCAPCNVICS VVFQKRFDYK DQNFLTLMKR
210 220 230 240 250
FNENFRILNS PWIQVCNNFP LLIDCFPGTH NKVLKNVALT RSYIREKVKE
260 270 280 290 300
HQASLDVNNP RDFIDCFLIK MEQEKDNQKS EFNIENLVGT VADLFVAGTE
310 320 330 340 350
TTSTTLRYGL LLLLKHPEVT AKVQEEIDHV IGRHRSPCMQ DRSHMPYTDA
360 370 380 390 400
VVHEIQRYSD LVPTGVPHAV TTDTKFRNYL IPKGTTIMAL LTSVLHDDKE
410 420 430 440 450
FPNPNIFDPG HFLDKNGNFK KSDYFMPFSA GKRICAGEGL ARMELFLFLT
460 470 480 490
TILQNFNLKS VDDLKNLNTT AVTKGIVSLP PSYQICFIPV
Length:490
Mass (Da):55,825
Last modified:November 1, 1990 - v2
Checksum:iE920EB2084F477E1
GO
Isoform 2 (identifier: P10632-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-8: MEPFVVLV → MFLQPIAK
     9-110: Missing.

Note: No experimental confirmation available.
Show »
Length:388
Mass (Da):44,358
Checksum:i0A9312FD6D4B9634
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti54 – 541F → L no nucleotide entry (PubMed:2729895).Curated
Sequence conflicti67 – 671V → L no nucleotide entry (PubMed:2729895).Curated
Sequence conflicti76 – 761V → C no nucleotide entry (PubMed:2729895).Curated
Sequence conflicti82 – 821A → S in AAH20596 (PubMed:15489334).Curated
Sequence conflicti130 – 1301T → N in AAA35739 (PubMed:3500169).Curated
Sequence conflicti130 – 1301T → N in AAA35740 (PubMed:3500169).Curated
Sequence conflicti130 – 1301T → N no nucleotide entry (PubMed:2009263).Curated
Sequence conflicti209 – 2091N → S no nucleotide entry (PubMed:2729895).Curated
Sequence conflicti384 – 39310GTTIMALLTS → SFDNKIMLAA in AAA35740 (PubMed:3500169).Curated
Sequence conflicti386 – 3861T → A in BAF85442 (PubMed:14702039).Curated

Polymorphismi

Several alleles are found in the human population, contributing to interindividual variations in the therapeutic efficacy and toxicity of a myriad of drugs such as paclitaxel or amodiaquine. The allele shown here is CYP2C8*1 (PubMed:26427316). CYP2C8 genetic variations may be associated with adverse effects of cerivastatin including acute rhabdomyolysis [MIMi:601129].1 Publication

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti139 – 1391R → K in allele CYP2C8*3; reduces enzymatic activity with paclitaxel as substrate; decreases intrinsic clearance of paclitaxel; reduces enzymatic activity with amodiaquine as substrate. 7 Publications
Corresponds to variant rs11572080 [ dbSNP | Ensembl ].
VAR_012238
Natural varianti154 – 1541E → D.1 Publication
VAR_001250
Natural varianti171 – 1711G → S in allele CYP2C8*6; no effect on affinity or enzymatic activiy with paclitaxel as substrate; decreases affinity for amodiaquine; reduces enzymatic activity with amodiaquine as substrate; decreases intrinsic clearance of amodiaquine. 1 Publication
Corresponds to variant rs142886225 [ dbSNP | Ensembl ].
VAR_075541
Natural varianti186 – 1861R → G in allele CYP2C8*8; increases affinity for paclitaxel; reduces enzymatic activity with paclitaxel as substrate; decreases intrinsic clearance of paclitaxel; reduces enzymatic activity with amodiaquine as substrate; decreases intrinsic clearance of amodiaquine. 1 Publication
Corresponds to variant rs72558195 [ dbSNP | Ensembl ].
VAR_075542
Natural varianti193 – 1931N → K.1 Publication
VAR_001251
Natural varianti223 – 2231I → M in allele CYP2C8*13; reduces enzymatic activity with paclitaxel as substrate; decreases intrinsic clearance of paclitaxel; reduces enzymatic activity with amodiaquine as substrate; decreases intrinsic clearance of amodiaquine. 1 Publication
VAR_075543
Natural varianti238 – 2381A → P in allele CYP2C8*14; reduces enzymatic activity with paclitaxel as substrate; decreases intrinsic clearance of paclitaxel. 1 Publication
Corresponds to variant rs188934928 [ dbSNP | Ensembl ].
VAR_075544
Natural varianti244 – 2441I → V.1 Publication
Corresponds to variant rs11572102 [ dbSNP | Ensembl ].
VAR_018958
Natural varianti247 – 2471K → R in allele CYP2C8*9; increases enzymatic activity with paclitaxel as substrate; reduces enzymatic activity with amodiaquine as substrate; decreases intrinsic clearance of amodiaquine. 1 Publication
Corresponds to variant rs769460274 [ dbSNP | Ensembl ].
VAR_075545
Natural varianti249 – 2491K → R.1 Publication
VAR_001252
Natural varianti264 – 2641I → M in allele CYP2C8*4; reduces enzymatic activity with paclitaxel as substrate; decreases affinity for amodiaquine. 6 Publications
Corresponds to variant rs1058930 [ dbSNP | Ensembl ].
VAR_011754
Natural varianti269 – 2691I → F in allele CYP2C8*2; only found in African-Americans; increases intrinsic clearance of paclitaxel; decreases affinity for amodiaquine; increases enzymatic activity with amodiaquine as substrate. 5 Publications
Corresponds to variant rs11572103 [ dbSNP | Ensembl ].
VAR_012239
Natural varianti383 – 3831K → N in allele CYP2C8*10; reduces enzymatic activity with paclitaxel as substrate; reduces enzymatic activity with amodiaquine as substrate; decreases intrinsic clearance of amodiaquine. 1 Publication
VAR_075546
Natural varianti390 – 3901L → S.1 Publication
Corresponds to variant rs72558194 [ dbSNP | Ensembl ].
VAR_016947
Natural varianti399 – 3991K → R in allele CYP2C8*3; reduces enzymatic activity with paclitaxel as substrate; decreases intrinsic clearance of paclitaxel; reduces enzymatic activity with amodiaquine as substrate. 7 Publications
Corresponds to variant rs10509681 [ dbSNP | Ensembl ].
VAR_012240
Natural varianti411 – 4111H → L.2 Publications
VAR_001253
Natural varianti461 – 4611Missing in allele CYP2C8*12; increases enzymatic activity with paclitaxel as substrate; reduces enzymatic activity with amodiaquine as substrate; decreases intrinsic clearance of amodiaquine. 1 Publication
VAR_075547

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 88MEPFVVLV → MFLQPIAK in isoform 2. 1 PublicationVSP_043306
Alternative sequencei9 – 110102Missing in isoform 2. 1 PublicationVSP_043307Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17397 mRNA. Translation: AAA35739.1.
M17398 mRNA. Translation: AAA35740.1.
Y00498 mRNA. Translation: CAA68550.1.
AK292753 mRNA. Translation: BAF85442.1.
AK293328 mRNA. Translation: BAH11492.1.
AK315823 mRNA. Translation: BAF98714.1.
AY514490 Genomic DNA. Translation: AAR89907.1.
AL359672 Genomic DNA. Translation: CAH71307.1.
CH471066 Genomic DNA. Translation: EAW50018.1.
BC020596 mRNA. Translation: AAH20596.1.
X54807 Genomic DNA. Translation: CAA38578.1.
M21941 mRNA. Translation: AAA52160.1.
M21942 mRNA. Translation: AAA52161.1.
X51535 mRNA. Translation: CAA35915.1.
CCDSiCCDS55721.1. [P10632-2]
CCDS7438.1. [P10632-1]
PIRiA29782.
RefSeqiNP_000761.3. NM_000770.3. [P10632-1]
NP_001185782.1. NM_001198853.1.
NP_001185783.1. NM_001198854.1. [P10632-2]
NP_001185784.1. NM_001198855.1.
UniGeneiHs.709188.

Genome annotation databases

EnsembliENST00000371270; ENSP00000360317; ENSG00000138115. [P10632-1]
ENST00000535898; ENSP00000445062; ENSG00000138115. [P10632-2]
GeneIDi1558.
KEGGihsa:1558.
UCSCiuc001kkb.4. human. [P10632-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Cytochrome P450 Allele Nomenclature Committee

CYP2C8 alleles

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17397 mRNA. Translation: AAA35739.1.
M17398 mRNA. Translation: AAA35740.1.
Y00498 mRNA. Translation: CAA68550.1.
AK292753 mRNA. Translation: BAF85442.1.
AK293328 mRNA. Translation: BAH11492.1.
AK315823 mRNA. Translation: BAF98714.1.
AY514490 Genomic DNA. Translation: AAR89907.1.
AL359672 Genomic DNA. Translation: CAH71307.1.
CH471066 Genomic DNA. Translation: EAW50018.1.
BC020596 mRNA. Translation: AAH20596.1.
X54807 Genomic DNA. Translation: CAA38578.1.
M21941 mRNA. Translation: AAA52160.1.
M21942 mRNA. Translation: AAA52161.1.
X51535 mRNA. Translation: CAA35915.1.
CCDSiCCDS55721.1. [P10632-2]
CCDS7438.1. [P10632-1]
PIRiA29782.
RefSeqiNP_000761.3. NM_000770.3. [P10632-1]
NP_001185782.1. NM_001198853.1.
NP_001185783.1. NM_001198854.1. [P10632-2]
NP_001185784.1. NM_001198855.1.
UniGeneiHs.709188.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1PQ2X-ray2.70A/B19-490[»]
2NNHX-ray2.60A/B28-490[»]
2NNIX-ray2.80A28-490[»]
2NNJX-ray2.28A28-490[»]
2VN0X-ray2.70A28-490[»]
ProteinModelPortaliP10632.
SMRiP10632. Positions 28-490.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107936. 13 interactions.
IntActiP10632. 10 interactions.
STRINGi9606.ENSP00000360317.

Chemistry

BindingDBiP10632.
ChEMBLiCHEMBL3721.
DrugBankiDB05812. Abiraterone.
DB00316. Acetaminophen.
DB00945. Acetylsalicylic acid.
DB00918. Almotriptan.
DB01424. Aminophenazone.
DB01118. Amiodarone.
DB00321. Amitriptyline.
DB00381. Amlodipine.
DB00613. Amodiaquine.
DB00701. Amprenavir.
DB01435. Antipyrine.
DB06605. Apixaban.
DB01076. Atorvastatin.
DB00972. Azelastine.
DB06770. Benzyl alcohol.
DB01393. Bezafibrate.
DB00188. Bortezomib.
DB00835. Brompheniramine.
DB00921. Buprenorphine.
DB01156. Bupropion.
DB06772. Cabazitaxel.
DB00201. Caffeine.
DB00796. Candesartan.
DB00564. Carbamazepine.
DB00748. Carbinoxamine.
DB00446. Chloramphenicol.
DB00608. Chloroquine.
DB00169. Cholecalciferol.
DB00501. Cimetidine.
DB00604. Cisapride.
DB00758. Clopidogrel.
DB00257. Clotrimazole.
DB00363. Clozapine.
DB00907. Cocaine.
DB01394. Colchicine.
DB00531. Cyclophosphamide.
DB00091. Cyclosporine.
DB08912. Dabrafenib.
DB00250. Dapsone.
DB00705. Delavirdine.
DB01234. Dexamethasone.
DB00514. Dextromethorphan.
DB00647. Dextropropoxyphene.
DB00829. Diazepam.
DB00586. Diclofenac.
DB00255. Diethylstilbestrol.
DB00343. Diltiazem.
DB01184. Domperidone.
DB06210. Eltrombopag.
DB08899. Enzalutamide.
DB00530. Erlotinib.
DB00783. Estradiol.
DB00402. Eszopiclone.
DB00977. Ethinyl Estradiol.
DB00773. Etoposide.
DB01023. Felodipine.
DB01039. Fenofibrate.
DB00544. Fluorouracil.
DB01095. Fluvastatin.
DB01320. Fosphenytoin.
DB01241. Gemfibrozil.
DB01218. Halofantrine.
DB00741. Hydrocortisone.
DB01050. Ibuprofen.
DB09054. Idelalisib.
DB01181. Ifosfamide.
DB01029. Irbesartan.
DB00951. Isoniazid.
DB09570. Ixazomib.
DB01221. Ketamine.
DB06738. Ketobemidone.
DB01026. Ketoconazole.
DB01009. Ketoprofen.
DB00448. Lansoprazole.
DB01259. Lapatinib.
DB08918. Levomilnacipran.
DB00451. Levothyroxine.
DB00281. Lidocaine.
DB01583. Liotrix.
DB00836. Loperamide.
DB00455. Loratadine.
DB00678. Losartan.
DB00227. Lovastatin.
DB00603. Medroxyprogesterone Acetate.
DB00784. Mefenamic acid.
DB00814. Meloxicam.
DB00333. Methadone.
DB00916. Metronidazole.
DB00370. Mirtazapine.
DB00764. Mometasone.
DB00471. Montelukast.
DB00295. Morphine.
DB00688. Mycophenolate mofetil.
DB01183. Naloxone.
DB00788. Naproxen.
DB00622. Nicardipine.
DB00184. Nicotine.
DB01115. Nifedipine.
DB04868. Nilotinib.
DB00665. Nilutamide.
DB06712. Nilvadipine.
DB09080. Olodaterol.
DB00338. Omeprazole.
DB01062. Oxybutynin.
DB01229. Paclitaxel.
DB00617. Paramethadione.
DB00715. Paroxetine.
DB06589. Pazopanib.
DB00738. Pentamidine.
DB00850. Perphenazine.
DB00780. Phenelzine.
DB01174. Phenobarbital.
DB00946. Phenprocoumon.
DB00252. Phenytoin.
DB01132. Pioglitazone.
DB00554. Piroxicam.
DB08860. Pitavastatin.
DB08901. Ponatinib.
DB00175. Pravastatin.
DB00794. Primidone.
DB01032. Probenecid.
DB00396. Progesterone.
DB01182. Propafenone.
DB00818. Propofol.
DB00205. Pyrimethamine.
DB00908. Quinidine.
DB00468. Quinine.
DB00481. Raloxifene.
DB08896. Regorafenib.
DB00912. Repaglinide.
DB01045. Rifampicin.
DB01201. Rifapentine.
DB08931. Riociguat.
DB00503. Ritonavir.
DB00412. Rosiglitazone.
DB00938. Salmeterol.
DB01232. Saquinavir.
DB00418. Secobarbital.
DB01037. Selegiline.
DB11362. Selexipag.
DB00641. Simvastatin.
DB01261. Sitagliptin.
DB00398. Sorafenib.
DB00421. Spironolactone.
DB00359. Sulfadiazine.
DB01015. Sulfamethoxazole.
DB06729. Sulfaphenazole.
DB01138. Sulfinpyrazone.
DB00675. Tamoxifen.
DB00799. Tazarotene.
DB00231. Temazepam.
DB00857. Terbinafine.
DB00624. Testosterone.
DB00277. Theophylline.
DB00679. Thioridazine.
DB00208. Ticlopidine.
DB01007. Tioconazole.
DB01124. Tolbutamide.
DB00214. Torasemide.
DB08911. Trametinib.
DB00755. Tretinoin.
DB00897. Triazolam.
DB00347. Trimethadione.
DB00440. Trimethoprim.
DB01361. Troleandomycin.
DB00313. Valproic Acid.
DB00661. Verapamil.
DB08828. Vismodegib.
DB09068. Vortioxetine.
DB00682. Warfarin.
DB00549. Zafirlukast.
DB00495. Zidovudine.
DB01198. Zopiclone.
GuidetoPHARMACOLOGYi1325.
SwissLipidsiSLP:000001548.

PTM databases

iPTMnetiP10632.
PhosphoSiteiP10632.

Polymorphism and mutation databases

BioMutaiCYP2C8.
DMDMi117225.

Proteomic databases

PaxDbiP10632.
PeptideAtlasiP10632.
PRIDEiP10632.

Protocols and materials databases

DNASUi1558.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371270; ENSP00000360317; ENSG00000138115. [P10632-1]
ENST00000535898; ENSP00000445062; ENSG00000138115. [P10632-2]
GeneIDi1558.
KEGGihsa:1558.
UCSCiuc001kkb.4. human. [P10632-1]

Organism-specific databases

CTDi1558.
GeneCardsiCYP2C8.
HGNCiHGNC:2622. CYP2C8.
HPAiHPA013547.
HPA013970.
HPA015066.
MIMi601129. gene+phenotype.
neXtProtiNX_P10632.
PharmGKBiPA125.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP10632.
KOiK17718.
OMAiMLQIDIK.
OrthoDBiEOG091G0BT8.
PhylomeDBiP10632.
TreeFamiTF352043.

Enzyme and pathway databases

BRENDAi1.14.14.1. 2681.
ReactomeiR-HSA-211981. Xenobiotics.
R-HSA-211999. CYP2E1 reactions.
R-HSA-2142670. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
R-HSA-2142816. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
SABIO-RKP10632.

Miscellaneous databases

EvolutionaryTraceiP10632.
GeneWikiiCYP2C8.
GenomeRNAii1558.
PROiP10632.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000138115.
CleanExiHS_CYP2C8.
ExpressionAtlasiP10632. baseline and differential.
GenevisibleiP10632. HS.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCP2C8_HUMAN
AccessioniPrimary (citable) accession number: P10632
Secondary accession number(s): A8K9N8
, B0AZN2, B7Z1F6, Q5VX93, Q8WWB1, Q9UCZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1990
Last modified: September 7, 2016
This is version 188 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Alternative splicing has been shown to occur but the shorter forms are believed to be non-functional.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.