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P10632

- CP2C8_HUMAN

UniProt

P10632 - CP2C8_HUMAN

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Protein

Cytochrome P450 2C8

Gene
CYP2C8
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme responsible for the metabolism the anti-cancer drug paclitaxel (taxol).1 Publication

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.1 Publication

Cofactori

Heme group.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei100 – 1001Substrate
Binding sitei204 – 2041Substrate
Binding sitei241 – 2411Substrate
Metal bindingi435 – 4351Iron (heme axial ligand)

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. caffeine oxidase activity Source: BHF-UCL
  3. heme binding Source: InterPro
  4. iron ion binding Source: InterPro
  5. monooxygenase activity Source: BHF-UCL

GO - Biological processi

  1. arachidonic acid metabolic process Source: Reactome
  2. drug metabolic process Source: BHF-UCL
  3. epoxygenase P450 pathway Source: Reactome
  4. exogenous drug catabolic process Source: BHF-UCL
  5. omega-hydroxylase P450 pathway Source: Reactome
  6. organic acid metabolic process Source: BHF-UCL
  7. oxidation-reduction process Source: BHF-UCL
  8. oxidative demethylation Source: BHF-UCL
  9. small molecule metabolic process Source: Reactome
  10. xenobiotic metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_13543. Xenobiotics.
REACT_13797. CYP2E1 reactions.
REACT_150134. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
REACT_150417. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
SABIO-RKP10632.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C8 (EC:1.14.14.1)
Alternative name(s):
CYPIIC8
Cytochrome P450 IIC2
Cytochrome P450 MP-12
Cytochrome P450 MP-20
Cytochrome P450 form 1
S-mephenytoin 4-hydroxylase
Gene namesi
Name:CYP2C8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:2622. CYP2C8.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

MIMi601129. gene+phenotype.
PharmGKBiPA125.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490Cytochrome P450 2C8PRO_0000051699Add
BLAST

Proteomic databases

PaxDbiP10632.
PRIDEiP10632.

PTM databases

PhosphoSiteiP10632.

Expressioni

Inductioni

By phenobarbital.

Gene expression databases

ArrayExpressiP10632.
BgeeiP10632.
CleanExiHS_CYP2C8.
GenevestigatoriP10632.

Organism-specific databases

HPAiHPA013547.
HPA013970.
HPA015066.

Interactioni

Protein-protein interaction databases

BioGridi107936. 12 interactions.
IntActiP10632. 9 interactions.
STRINGi9606.ENSP00000360317.

Structurei

Secondary structure

1
490
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni37 – 393
Helixi42 – 443
Beta strandi47 – 493
Helixi50 – 6112
Beta strandi63 – 697
Beta strandi72 – 776
Helixi80 – 878
Turni88 – 947
Helixi101 – 1077
Turni111 – 1133
Helixi117 – 13014
Turni133 – 1364
Beta strandi137 – 1393
Helixi141 – 15717
Turni158 – 1614
Helixi167 – 18216
Beta strandi183 – 1853
Helixi192 – 20817
Helixi212 – 2187
Helixi220 – 2256
Helixi227 – 25226
Helixi263 – 27311
Helixi284 – 29815
Helixi300 – 31516
Helixi317 – 33014
Beta strandi333 – 3353
Helixi339 – 3446
Helixi346 – 35914
Beta strandi374 – 3763
Beta strandi379 – 3813
Beta strandi386 – 3894
Helixi391 – 3955
Turni398 – 4003
Beta strandi401 – 4033
Helixi409 – 4124
Helixi431 – 4333
Helixi438 – 45518
Beta strandi456 – 4594
Helixi464 – 4663
Beta strandi472 – 4798
Beta strandi485 – 4895

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1PQ2X-ray2.70A/B19-490[»]
2NNHX-ray2.60A/B28-490[»]
2NNIX-ray2.80A28-490[»]
2NNJX-ray2.28A28-490[»]
2VN0X-ray2.70A28-490[»]
ProteinModelPortaliP10632.
SMRiP10632. Positions 28-490.

Miscellaneous databases

EvolutionaryTraceiP10632.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP10632.
KOiK17718.
OMAiMLQIDIK.
PhylomeDBiP10632.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P10632-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEPFVVLVLC LSFMLLFSLW RQSCRRRKLP PGPTPLPIIG NMLQIDVKDI    50
CKSFTNFSKV YGPVFTVYFG MNPIVVFHGY EAVKEALIDN GEEFSGRGNS 100
PISQRITKGL GIISSNGKRW KEIRRFSLTT LRNFGMGKRS IEDRVQEEAH 150
CLVEELRKTK ASPCDPTFIL GCAPCNVICS VVFQKRFDYK DQNFLTLMKR 200
FNENFRILNS PWIQVCNNFP LLIDCFPGTH NKVLKNVALT RSYIREKVKE 250
HQASLDVNNP RDFIDCFLIK MEQEKDNQKS EFNIENLVGT VADLFVAGTE 300
TTSTTLRYGL LLLLKHPEVT AKVQEEIDHV IGRHRSPCMQ DRSHMPYTDA 350
VVHEIQRYSD LVPTGVPHAV TTDTKFRNYL IPKGTTIMAL LTSVLHDDKE 400
FPNPNIFDPG HFLDKNGNFK KSDYFMPFSA GKRICAGEGL ARMELFLFLT 450
TILQNFNLKS VDDLKNLNTT AVTKGIVSLP PSYQICFIPV 490
Length:490
Mass (Da):55,825
Last modified:November 1, 1990 - v2
Checksum:iE920EB2084F477E1
GO
Isoform 2 (identifier: P10632-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-8: MEPFVVLV → MFLQPIAK
     9-110: Missing.

Note: No experimental confirmation available.

Show »
Length:388
Mass (Da):44,358
Checksum:i0A9312FD6D4B9634
GO

Polymorphismi

CYP2C8 genetic variations may be associated with adverse effects of cerivastatin including acute rhabdomyolysis [MIMi:601129].

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti139 – 1391R → K in allele CYP2C8*3. 6 Publications
Corresponds to variant rs11572080 [ dbSNP | Ensembl ].
VAR_012238
Natural varianti154 – 1541E → D in clone MP-12. 1 Publication
VAR_001250
Natural varianti193 – 1931N → K in MP-20. 1 Publication
VAR_001251
Natural varianti244 – 2441I → V.1 Publication
Corresponds to variant rs11572102 [ dbSNP | Ensembl ].
VAR_018958
Natural varianti249 – 2491K → R in clone MP-12. 1 Publication
VAR_001252
Natural varianti264 – 2641I → M in allele CYP2C8*4. 5 Publications
Corresponds to variant rs1058930 [ dbSNP | Ensembl ].
VAR_011754
Natural varianti269 – 2691I → F in allele CYP2C8*2; only found in African-Americans. 4 Publications
Corresponds to variant rs11572103 [ dbSNP | Ensembl ].
VAR_012239
Natural varianti390 – 3901L → S.1 Publication
VAR_016947
Natural varianti399 – 3991K → R in allele CYP2C8*3. 6 Publications
Corresponds to variant rs10509681 [ dbSNP | Ensembl ].
VAR_012240
Natural varianti411 – 4111H → L in clone MP-20. 2 Publications
VAR_001253

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 88MEPFVVLV → MFLQPIAK in isoform 2. VSP_043306
Alternative sequencei9 – 110102Missing in isoform 2. VSP_043307Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti54 – 541F → L no nucleotide entry 1 Publication
Sequence conflicti67 – 671V → L no nucleotide entry 1 Publication
Sequence conflicti76 – 761V → C no nucleotide entry 1 Publication
Sequence conflicti82 – 821A → S in AAH20596. 1 Publication
Sequence conflicti130 – 1301T → N in AAA35739. 1 Publication
Sequence conflicti130 – 1301T → N in AAA35740. 1 Publication
Sequence conflicti130 – 1301T → N no nucleotide entry 1 Publication
Sequence conflicti209 – 2091N → S no nucleotide entry 1 Publication
Sequence conflicti384 – 39310GTTIMALLTS → SFDNKIMLAA in AAA35740. 1 Publication
Sequence conflicti386 – 3861T → A in BAF85442. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M17397 mRNA. Translation: AAA35739.1.
M17398 mRNA. Translation: AAA35740.1.
Y00498 mRNA. Translation: CAA68550.1.
AK292753 mRNA. Translation: BAF85442.1.
AK293328 mRNA. Translation: BAH11492.1.
AK315823 mRNA. Translation: BAF98714.1.
AY514490 Genomic DNA. Translation: AAR89907.1.
AL359672 Genomic DNA. Translation: CAH71307.1.
CH471066 Genomic DNA. Translation: EAW50018.1.
BC020596 mRNA. Translation: AAH20596.1.
X54807 Genomic DNA. Translation: CAA38578.1.
M21941 mRNA. Translation: AAA52160.1.
M21942 mRNA. Translation: AAA52161.1.
X51535 mRNA. Translation: CAA35915.1.
CCDSiCCDS55721.1. [P10632-2]
CCDS7438.1. [P10632-1]
PIRiA29782.
RefSeqiNP_000761.3. NM_000770.3. [P10632-1]
NP_001185782.1. NM_001198853.1.
NP_001185783.1. NM_001198854.1. [P10632-2]
NP_001185784.1. NM_001198855.1.
UniGeneiHs.709188.

Genome annotation databases

EnsembliENST00000371270; ENSP00000360317; ENSG00000138115. [P10632-1]
ENST00000535898; ENSP00000445062; ENSG00000138115. [P10632-2]
GeneIDi1558.
KEGGihsa:1558.
UCSCiuc001kkb.3. human. [P10632-1]
uc010qoc.2. human. [P10632-2]

Polymorphism databases

DMDMi117225.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Cytochrome P450 Allele Nomenclature Committee

CYP2C8 alleles

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M17397 mRNA. Translation: AAA35739.1 .
M17398 mRNA. Translation: AAA35740.1 .
Y00498 mRNA. Translation: CAA68550.1 .
AK292753 mRNA. Translation: BAF85442.1 .
AK293328 mRNA. Translation: BAH11492.1 .
AK315823 mRNA. Translation: BAF98714.1 .
AY514490 Genomic DNA. Translation: AAR89907.1 .
AL359672 Genomic DNA. Translation: CAH71307.1 .
CH471066 Genomic DNA. Translation: EAW50018.1 .
BC020596 mRNA. Translation: AAH20596.1 .
X54807 Genomic DNA. Translation: CAA38578.1 .
M21941 mRNA. Translation: AAA52160.1 .
M21942 mRNA. Translation: AAA52161.1 .
X51535 mRNA. Translation: CAA35915.1 .
CCDSi CCDS55721.1. [P10632-2 ]
CCDS7438.1. [P10632-1 ]
PIRi A29782.
RefSeqi NP_000761.3. NM_000770.3. [P10632-1 ]
NP_001185782.1. NM_001198853.1.
NP_001185783.1. NM_001198854.1. [P10632-2 ]
NP_001185784.1. NM_001198855.1.
UniGenei Hs.709188.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1PQ2 X-ray 2.70 A/B 19-490 [» ]
2NNH X-ray 2.60 A/B 28-490 [» ]
2NNI X-ray 2.80 A 28-490 [» ]
2NNJ X-ray 2.28 A 28-490 [» ]
2VN0 X-ray 2.70 A 28-490 [» ]
ProteinModelPortali P10632.
SMRi P10632. Positions 28-490.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107936. 12 interactions.
IntActi P10632. 9 interactions.
STRINGi 9606.ENSP00000360317.

Chemistry

BindingDBi P10632.
ChEMBLi CHEMBL3721.
DrugBanki DB01424. Aminophenazone.
DB01118. Amiodarone.
DB00613. Amodiaquine.
DB00865. Benzphetamine.
DB00564. Carbamazepine.
DB00439. Cerivastatin.
DB00586. Diclofenac.
DB01095. Fluvastatin.
DB01320. Fosphenytoin.
DB01241. Gemfibrozil.
DB01026. Ketoconazole.
DB01259. Lapatinib.
DB00227. Lovastatin.
DB00683. Midazolam.
DB00471. Montelukast.
DB00622. Nicardipine.
DB01229. Paclitaxel.
DB00252. Phenytoin.
DB01132. Pioglitazone.
DB00912. Repaglinide.
DB01045. Rifampin.
DB00412. Rosiglitazone.
DB00641. Simvastatin.
DB01261. Sitagliptin.
DB01124. Tolbutamide.
DB00214. Torasemide.
DB00755. Tretinoin.
DB00440. Trimethoprim.
DB00682. Warfarin.
DB00549. Zafirlukast.
DB01198. Zopiclone.

PTM databases

PhosphoSitei P10632.

Polymorphism databases

DMDMi 117225.

Proteomic databases

PaxDbi P10632.
PRIDEi P10632.

Protocols and materials databases

DNASUi 1558.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000371270 ; ENSP00000360317 ; ENSG00000138115 . [P10632-1 ]
ENST00000535898 ; ENSP00000445062 ; ENSG00000138115 . [P10632-2 ]
GeneIDi 1558.
KEGGi hsa:1558.
UCSCi uc001kkb.3. human. [P10632-1 ]
uc010qoc.2. human. [P10632-2 ]

Organism-specific databases

CTDi 1558.
GeneCardsi GC10M096786.
HGNCi HGNC:2622. CYP2C8.
HPAi HPA013547.
HPA013970.
HPA015066.
MIMi 601129. gene+phenotype.
neXtProti NX_P10632.
PharmGKBi PA125.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2124.
HOGENOMi HOG000036992.
HOVERGENi HBG015789.
InParanoidi P10632.
KOi K17718.
OMAi MLQIDIK.
PhylomeDBi P10632.
TreeFami TF352043.

Enzyme and pathway databases

Reactomei REACT_13543. Xenobiotics.
REACT_13797. CYP2E1 reactions.
REACT_150134. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
REACT_150417. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
SABIO-RK P10632.

Miscellaneous databases

ChiTaRSi CYP2C8. human.
EvolutionaryTracei P10632.
GeneWikii CYP2C8.
GenomeRNAii 1558.
NextBioi 6434.
PROi P10632.
SOURCEi Search...

Gene expression databases

ArrayExpressi P10632.
Bgeei P10632.
CleanExi HS_CYP2C8.
Genevestigatori P10632.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of multiple human cytochrome P-450 1 cDNAs. The chromosomal localization of the gene and evidence for alternate RNA splicing."
    Okino S.T., Quattrochi L.C., Pendurthi U.R., McBride O.W., Tukey R.H.
    J. Biol. Chem. 262:16072-16079(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT MET-264.
    Tissue: Liver.
  2. "cDNA and amino acid sequences of two members of the human P450IIC gene subfamily."
    Kimura S., Pastewka J., Gelboin H.V., Gonzalez F.J.
    Nucleic Acids Res. 15:10053-10054(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Liver.
  3. "Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily."
    Romkes M., Faletto M.B., Blaisdell J.A., Raucy J.L., Goldstein J.A.
    Biochemistry 30:3247-3255(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT MET-264.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS LYS-139 AND ARG-399.
    Tissue: Liver and Mammary gland.
  5. NIEHS SNPs program
    Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS LYS-139; VAL-244; MET-264; PHE-269 AND ARG-399.
  6. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Liver.
  9. "Isolation of the human cytochrome P-450 IIC8 gene: multiple glucocorticoid responsive elements in the 5' region."
    Ged C., Beaune P.
    Biochim. Biophys. Acta 1088:433-435(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-56.
    Tissue: Blood.
  10. "Molecular cloning, expression and characterization of an endogenous human cytochrome P450 arachidonic acid epoxygenase isoform."
    Zeldin D.C., DuBois R.N., Falck J.R., Capdevila J.H.
    Arch. Biochem. Biophys. 322:76-86(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-15, NUCLEOTIDE SEQUENCE [MRNA] OF 6-490, FUNCTION, CATALYTIC ACTIVITY, VARIANT LEU-411.
    Tissue: Kidney.
  11. "Characterization of cDNAs, mRNAs, and proteins related to human liver microsomal cytochrome P-450 (S)-mephenytoin 4'-hydroxylase."
    Ged C., Umbenhauer D.R., Bellew T.M., Bork R.W., Srivastava P.K., Shinriki N., Lloyd R.S., Guengerich F.P.
    Biochemistry 27:6929-6940(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-490 (ISOFORM 1), VARIANTS ASP-154; LYS-193; ARG-249 AND LEU-411.
    Tissue: Liver.
  12. "Cloning, expression and chromosomal localization of a member of the human cytochrome P450IIC gene sub-family."
    Shephard E.A., Phillips I.R., Santisteban I., Palmer C.N., Povey S.
    Ann. Hum. Genet. 53:23-31(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 34-382 (ISOFORM 1), VARIANT LYS-139.
  13. "Sequence of a human liver cytochrome P-450 cDNA clone."
    Kolyada A.Y.
    Nucleic Acids Res. 18:5550-5550(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 281-490 (ISOFORM 1), VARIANT ARG-399.
  14. "A frameshift variant of CYP2C8 was identified in a patient who suffered from rhabdomyolysis after administration of cerivastatin."
    Ishikawa C., Ozaki H., Nakajima T., Ishii T., Kanai S., Anjo S., Shirai K., Inoue I.
    J. Hum. Genet. 49:582-585(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: POLYMORPHISM.
  15. "Structure of human microsomal cytochrome P450 2C8. Evidence for a peripheral fatty acid binding site."
    Schoch G.A., Yano J.K., Wester M.R., Griffin K.J., Stout C.D., Johnson E.F.
    J. Biol. Chem. 279:9497-9503(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 28-490.
  16. "Determinants of cytochrome P450 2C8 substrate binding: structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid."
    Schoch G.A., Yano J.K., Sansen S., Dansette P.M., Stout C.D., Johnson E.F.
    J. Biol. Chem. 283:17227-17237(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.28 ANGSTROMS) OF 28-490 IN COMPLEX WITH INHIBITORS, SUBSTRATE-BINDING SITES.
  17. "Polymorphisms in human CYP2C8 decrease metabolism of the anticancer drug paclitaxel and arachidonic acid."
    Dai D., Zeldin D.C., Blaisdell J.A., Chanas B., Coulter S.J., Ghanayem B.I., Goldstein J.A.
    Pharmacogenetics 11:597-607(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS LYS-139; PHE-269 AND ARG-399.
  18. "CYP2C8 polymorphisms in Caucasians and their relationship with paclitaxel 6alpha-hydroxylase activity in human liver microsomes."
    Bahadur N., Leathart J.B., Mutch E., Steimel-Crespi D., Dunn S.A., Gilissen R., Houdt J.V., Hendrickx J., Mannens G., Bohets H., Williams F.M., Armstrong M., Crespi C.L., Daly A.K.
    Biochem. Pharmacol. 64:1579-1589(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS LYS-139; MET-264; PHE-269; SER-390 AND ARG-399.
  19. "Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population."
    Solus J.F., Arietta B.J., Harris J.R., Sexton D.P., Steward J.Q., McMunn C., Ihrie P., Mehall J.M., Edwards T.L., Dawson E.P.
    Pharmacogenomics 5:895-931(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS LYS-139; MET-264; PHE-269 AND ARG-399.

Entry informationi

Entry nameiCP2C8_HUMAN
AccessioniPrimary (citable) accession number: P10632
Secondary accession number(s): A8K9N8
, B0AZN2, B7Z1F6, Q5VX93, Q8WWB1, Q9UCZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1990
Last modified: September 3, 2014
This is version 166 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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