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P10632 (CP2C8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 165. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2C8

EC=1.14.14.1
Alternative name(s):
CYPIIC8
Cytochrome P450 IIC2
Cytochrome P450 MP-12
Cytochrome P450 MP-20
Cytochrome P450 form 1
S-mephenytoin 4-hydroxylase
Gene names
Name:CYP2C8
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length490 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme responsible for the metabolism the anti-cancer drug paclitaxel (taxol). Ref.10

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O. Ref.10

Cofactor

Heme group.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

By phenobarbital.

Polymorphism

CYP2C8 genetic variations may be associated with adverse effects of cerivastatin including acute rhabdomyolysis [MIM:601129].

Sequence similarities

Belongs to the cytochrome P450 family.

Caution

Alternative splicing has been shown to occur but the shorter forms are believed to be non-functional.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
Membrane
Microsome
   Coding sequence diversityAlternative splicing
Polymorphism
   LigandHeme
Iron
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processarachidonic acid metabolic process

Traceable author statement. Source: Reactome

drug metabolic process

Inferred from direct assay PubMed 19651758. Source: BHF-UCL

epoxygenase P450 pathway

Traceable author statement. Source: Reactome

exogenous drug catabolic process

Inferred from direct assay PubMed 18619574. Source: BHF-UCL

omega-hydroxylase P450 pathway

Traceable author statement. Source: Reactome

organic acid metabolic process

Inferred from direct assay PubMed 19651758. Source: BHF-UCL

oxidation-reduction process

Inferred from direct assay PubMed 19651758. Source: BHF-UCL

oxidative demethylation

Inferred from direct assay PubMed 18619574. Source: BHF-UCL

small molecule metabolic process

Traceable author statement. Source: Reactome

xenobiotic metabolic process

Traceable author statement. Source: Reactome

   Cellular_componentendoplasmic reticulum membrane

Traceable author statement. Source: Reactome

   Molecular_functionaromatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

caffeine oxidase activity

Inferred from direct assay PubMed 18619574. Source: BHF-UCL

heme binding

Inferred from electronic annotation. Source: InterPro

iron ion binding

Inferred from electronic annotation. Source: InterPro

monooxygenase activity

Inferred from direct assay PubMed 19651758. Source: BHF-UCL

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P10632-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P10632-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-8: MEPFVVLV → MFLQPIAK
     9-110: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 490490Cytochrome P450 2C8
PRO_0000051699

Sites

Metal binding4351Iron (heme axial ligand)
Binding site1001Substrate
Binding site2041Substrate
Binding site2411Substrate

Natural variations

Alternative sequence1 – 88MEPFVVLV → MFLQPIAK in isoform 2.
VSP_043306
Alternative sequence9 – 110102Missing in isoform 2.
VSP_043307
Natural variant1391R → K in allele CYP2C8*3. Ref.4 Ref.5 Ref.12 Ref.17 Ref.18 Ref.19
Corresponds to variant rs11572080 [ dbSNP | Ensembl ].
VAR_012238
Natural variant1541E → D in clone MP-12. Ref.11
VAR_001250
Natural variant1931N → K in MP-20. Ref.11
VAR_001251
Natural variant2441I → V. Ref.5
Corresponds to variant rs11572102 [ dbSNP | Ensembl ].
VAR_018958
Natural variant2491K → R in clone MP-12. Ref.11
VAR_001252
Natural variant2641I → M in allele CYP2C8*4. Ref.1 Ref.3 Ref.5 Ref.18 Ref.19
Corresponds to variant rs1058930 [ dbSNP | Ensembl ].
VAR_011754
Natural variant2691I → F in allele CYP2C8*2; only found in African-Americans. Ref.5 Ref.17 Ref.18 Ref.19
Corresponds to variant rs11572103 [ dbSNP | Ensembl ].
VAR_012239
Natural variant3901L → S. Ref.18
VAR_016947
Natural variant3991K → R in allele CYP2C8*3. Ref.4 Ref.5 Ref.13 Ref.17 Ref.18 Ref.19
Corresponds to variant rs10509681 [ dbSNP | Ensembl ].
VAR_012240
Natural variant4111H → L in clone MP-20. Ref.10 Ref.11
VAR_001253

Experimental info

Sequence conflict541F → L no nucleotide entry Ref.12
Sequence conflict671V → L no nucleotide entry Ref.12
Sequence conflict761V → C no nucleotide entry Ref.12
Sequence conflict821A → S in AAH20596. Ref.8
Sequence conflict1301T → N in AAA35739. Ref.1
Sequence conflict1301T → N in AAA35740. Ref.1
Sequence conflict1301T → N no nucleotide entry Ref.3
Sequence conflict2091N → S no nucleotide entry Ref.12
Sequence conflict384 – 39310GTTIMALLTS → SFDNKIMLAA in AAA35740. Ref.1
Sequence conflict3861T → A in BAF85442. Ref.4

Secondary structure

............................................................................ 490
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 1, 1990. Version 2.
Checksum: E920EB2084F477E1

FASTA49055,825
        10         20         30         40         50         60 
MEPFVVLVLC LSFMLLFSLW RQSCRRRKLP PGPTPLPIIG NMLQIDVKDI CKSFTNFSKV 

        70         80         90        100        110        120 
YGPVFTVYFG MNPIVVFHGY EAVKEALIDN GEEFSGRGNS PISQRITKGL GIISSNGKRW 

       130        140        150        160        170        180 
KEIRRFSLTT LRNFGMGKRS IEDRVQEEAH CLVEELRKTK ASPCDPTFIL GCAPCNVICS 

       190        200        210        220        230        240 
VVFQKRFDYK DQNFLTLMKR FNENFRILNS PWIQVCNNFP LLIDCFPGTH NKVLKNVALT 

       250        260        270        280        290        300 
RSYIREKVKE HQASLDVNNP RDFIDCFLIK MEQEKDNQKS EFNIENLVGT VADLFVAGTE 

       310        320        330        340        350        360 
TTSTTLRYGL LLLLKHPEVT AKVQEEIDHV IGRHRSPCMQ DRSHMPYTDA VVHEIQRYSD 

       370        380        390        400        410        420 
LVPTGVPHAV TTDTKFRNYL IPKGTTIMAL LTSVLHDDKE FPNPNIFDPG HFLDKNGNFK 

       430        440        450        460        470        480 
KSDYFMPFSA GKRICAGEGL ARMELFLFLT TILQNFNLKS VDDLKNLNTT AVTKGIVSLP 

       490 
PSYQICFIPV 

« Hide

Isoform 2 [UniParc].

Checksum: 0A9312FD6D4B9634
Show »

FASTA38844,358

References

« Hide 'large scale' references
[1]"Characterization of multiple human cytochrome P-450 1 cDNAs. The chromosomal localization of the gene and evidence for alternate RNA splicing."
Okino S.T., Quattrochi L.C., Pendurthi U.R., McBride O.W., Tukey R.H.
J. Biol. Chem. 262:16072-16079(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT MET-264.
Tissue: Liver.
[2]"cDNA and amino acid sequences of two members of the human P450IIC gene subfamily."
Kimura S., Pastewka J., Gelboin H.V., Gonzalez F.J.
Nucleic Acids Res. 15:10053-10054(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Liver.
[3]"Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily."
Romkes M., Faletto M.B., Blaisdell J.A., Raucy J.L., Goldstein J.A.
Biochemistry 30:3247-3255(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT MET-264.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS LYS-139 AND ARG-399.
Tissue: Liver and Mammary gland.
[5]NIEHS SNPs program
Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS LYS-139; VAL-244; MET-264; PHE-269 AND ARG-399.
[6]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Liver.
[9]"Isolation of the human cytochrome P-450 IIC8 gene: multiple glucocorticoid responsive elements in the 5' region."
Ged C., Beaune P.
Biochim. Biophys. Acta 1088:433-435(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-56.
Tissue: Blood.
[10]"Molecular cloning, expression and characterization of an endogenous human cytochrome P450 arachidonic acid epoxygenase isoform."
Zeldin D.C., DuBois R.N., Falck J.R., Capdevila J.H.
Arch. Biochem. Biophys. 322:76-86(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-15, NUCLEOTIDE SEQUENCE [MRNA] OF 6-490, FUNCTION, CATALYTIC ACTIVITY, VARIANT LEU-411.
Tissue: Kidney.
[11]"Characterization of cDNAs, mRNAs, and proteins related to human liver microsomal cytochrome P-450 (S)-mephenytoin 4'-hydroxylase."
Ged C., Umbenhauer D.R., Bellew T.M., Bork R.W., Srivastava P.K., Shinriki N., Lloyd R.S., Guengerich F.P.
Biochemistry 27:6929-6940(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-490 (ISOFORM 1), VARIANTS ASP-154; LYS-193; ARG-249 AND LEU-411.
Tissue: Liver.
[12]"Cloning, expression and chromosomal localization of a member of the human cytochrome P450IIC gene sub-family."
Shephard E.A., Phillips I.R., Santisteban I., Palmer C.N., Povey S.
Ann. Hum. Genet. 53:23-31(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 34-382 (ISOFORM 1), VARIANT LYS-139.
[13]"Sequence of a human liver cytochrome P-450 cDNA clone."
Kolyada A.Y.
Nucleic Acids Res. 18:5550-5550(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 281-490 (ISOFORM 1), VARIANT ARG-399.
[14]"A frameshift variant of CYP2C8 was identified in a patient who suffered from rhabdomyolysis after administration of cerivastatin."
Ishikawa C., Ozaki H., Nakajima T., Ishii T., Kanai S., Anjo S., Shirai K., Inoue I.
J. Hum. Genet. 49:582-585(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: POLYMORPHISM.
[15]"Structure of human microsomal cytochrome P450 2C8. Evidence for a peripheral fatty acid binding site."
Schoch G.A., Yano J.K., Wester M.R., Griffin K.J., Stout C.D., Johnson E.F.
J. Biol. Chem. 279:9497-9503(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 28-490.
[16]"Determinants of cytochrome P450 2C8 substrate binding: structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid."
Schoch G.A., Yano J.K., Sansen S., Dansette P.M., Stout C.D., Johnson E.F.
J. Biol. Chem. 283:17227-17237(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.28 ANGSTROMS) OF 28-490 IN COMPLEX WITH INHIBITORS, SUBSTRATE-BINDING SITES.
[17]"Polymorphisms in human CYP2C8 decrease metabolism of the anticancer drug paclitaxel and arachidonic acid."
Dai D., Zeldin D.C., Blaisdell J.A., Chanas B., Coulter S.J., Ghanayem B.I., Goldstein J.A.
Pharmacogenetics 11:597-607(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS LYS-139; PHE-269 AND ARG-399.
[18]"CYP2C8 polymorphisms in Caucasians and their relationship with paclitaxel 6alpha-hydroxylase activity in human liver microsomes."
Bahadur N., Leathart J.B., Mutch E., Steimel-Crespi D., Dunn S.A., Gilissen R., Houdt J.V., Hendrickx J., Mannens G., Bohets H., Williams F.M., Armstrong M., Crespi C.L., Daly A.K.
Biochem. Pharmacol. 64:1579-1589(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS LYS-139; MET-264; PHE-269; SER-390 AND ARG-399.
[19]"Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population."
Solus J.F., Arietta B.J., Harris J.R., Sexton D.P., Steward J.Q., McMunn C., Ihrie P., Mehall J.M., Edwards T.L., Dawson E.P.
Pharmacogenomics 5:895-931(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS LYS-139; MET-264; PHE-269 AND ARG-399.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M17397 mRNA. Translation: AAA35739.1.
M17398 mRNA. Translation: AAA35740.1.
Y00498 mRNA. Translation: CAA68550.1.
AK292753 mRNA. Translation: BAF85442.1.
AK293328 mRNA. Translation: BAH11492.1.
AK315823 mRNA. Translation: BAF98714.1.
AY514490 Genomic DNA. Translation: AAR89907.1.
AL359672 Genomic DNA. Translation: CAH71307.1.
CH471066 Genomic DNA. Translation: EAW50018.1.
BC020596 mRNA. Translation: AAH20596.1.
X54807 Genomic DNA. Translation: CAA38578.1.
M21941 mRNA. Translation: AAA52160.1.
M21942 mRNA. Translation: AAA52161.1.
X51535 mRNA. Translation: CAA35915.1.
CCDSCCDS55721.1. [P10632-2]
CCDS7438.1. [P10632-1]
PIRA29782.
RefSeqNP_000761.3. NM_000770.3. [P10632-1]
NP_001185782.1. NM_001198853.1.
NP_001185783.1. NM_001198854.1. [P10632-2]
NP_001185784.1. NM_001198855.1.
UniGeneHs.709188.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1PQ2X-ray2.70A/B19-490[»]
2NNHX-ray2.60A/B28-490[»]
2NNIX-ray2.80A28-490[»]
2NNJX-ray2.28A28-490[»]
2VN0X-ray2.70A28-490[»]
ProteinModelPortalP10632.
SMRP10632. Positions 28-490.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107936. 12 interactions.
IntActP10632. 9 interactions.
STRING9606.ENSP00000360317.

Chemistry

BindingDBP10632.
ChEMBLCHEMBL3721.
DrugBankDB01424. Aminophenazone.
DB01118. Amiodarone.
DB00613. Amodiaquine.
DB00865. Benzphetamine.
DB00564. Carbamazepine.
DB00439. Cerivastatin.
DB00586. Diclofenac.
DB01095. Fluvastatin.
DB01320. Fosphenytoin.
DB01241. Gemfibrozil.
DB01026. Ketoconazole.
DB01259. Lapatinib.
DB00227. Lovastatin.
DB00683. Midazolam.
DB00471. Montelukast.
DB00622. Nicardipine.
DB01229. Paclitaxel.
DB00252. Phenytoin.
DB01132. Pioglitazone.
DB00912. Repaglinide.
DB01045. Rifampin.
DB00412. Rosiglitazone.
DB00641. Simvastatin.
DB01261. Sitagliptin.
DB01124. Tolbutamide.
DB00214. Torasemide.
DB00755. Tretinoin.
DB00440. Trimethoprim.
DB00682. Warfarin.
DB00549. Zafirlukast.
DB01198. Zopiclone.

PTM databases

PhosphoSiteP10632.

Polymorphism databases

DMDM117225.

Proteomic databases

PaxDbP10632.
PRIDEP10632.

Protocols and materials databases

DNASU1558.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000371270; ENSP00000360317; ENSG00000138115. [P10632-1]
ENST00000535898; ENSP00000445062; ENSG00000138115. [P10632-2]
GeneID1558.
KEGGhsa:1558.
UCSCuc001kkb.3. human. [P10632-1]
uc010qoc.2. human. [P10632-2]

Organism-specific databases

CTD1558.
GeneCardsGC10M096786.
HGNCHGNC:2622. CYP2C8.
HPAHPA013547.
HPA013970.
HPA015066.
MIM601129. gene+phenotype.
neXtProtNX_P10632.
PharmGKBPA125.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG2124.
HOGENOMHOG000036992.
HOVERGENHBG015789.
InParanoidP10632.
KOK17718.
OMAMLQIDIK.
PhylomeDBP10632.
TreeFamTF352043.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.
SABIO-RKP10632.

Gene expression databases

ArrayExpressP10632.
BgeeP10632.
CleanExHS_CYP2C8.
GenevestigatorP10632.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCYP2C8. human.
EvolutionaryTraceP10632.
GeneWikiCYP2C8.
GenomeRNAi1558.
NextBio6434.
PROP10632.
SOURCESearch...

Entry information

Entry nameCP2C8_HUMAN
AccessionPrimary (citable) accession number: P10632
Secondary accession number(s): A8K9N8 expand/collapse secondary AC list , B0AZN2, B7Z1F6, Q5VX93, Q8WWB1, Q9UCZ9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1990
Last modified: July 9, 2014
This is version 165 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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SIMILARITY comments

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MIM cross-references

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