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Protein

Cytochrome P450 2C8

Gene

CYP2C8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme responsible for the metabolism the anti-cancer drug paclitaxel (taxol).2 Publications

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.1 Publication

Cofactori

Kineticsi

  1. KM=7.18 µM for paclitaxel1 Publication
  2. KM=1.35 µM for amodiaquine1 Publication
  1. Vmax=2.18 pmol/min/pmol enzyme with paclitaxel as substrate1 Publication
  2. Vmax=11.30 pmol/min/pmol enzyme with amodiaquine as substrate1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei100Substrate1
Binding sitei204Substrate1
Binding sitei241Substrate1
Metal bindingi435Iron (heme axial ligand)1

GO - Molecular functioni

  • arachidonic acid epoxygenase activity Source: GO_Central
  • aromatase activity Source: UniProtKB-EC
  • caffeine oxidase activity Source: BHF-UCL
  • estrogen 16-alpha-hydroxylase activity Source: BHF-UCL
  • heme binding Source: InterPro
  • iron ion binding Source: InterPro
  • monooxygenase activity Source: BHF-UCL
  • oxygen binding Source: Reactome
  • steroid hydroxylase activity Source: GO_Central

GO - Biological processi

  • drug metabolic process Source: BHF-UCL
  • epoxygenase P450 pathway Source: GO_Central
  • exogenous drug catabolic process Source: BHF-UCL
  • lipid hydroxylation Source: BHF-UCL
  • omega-hydroxylase P450 pathway Source: Reactome
  • organic acid metabolic process Source: BHF-UCL
  • oxidation-reduction process Source: BHF-UCL
  • oxidative demethylation Source: BHF-UCL
  • steroid metabolic process Source: BHF-UCL
  • xenobiotic metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:HS06459-MONOMER.
BRENDAi1.14.14.1. 2681.
ReactomeiR-HSA-211981. Xenobiotics.
R-HSA-211999. CYP2E1 reactions.
R-HSA-2142670. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
R-HSA-2142816. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
SABIO-RKP10632.

Chemistry databases

SwissLipidsiSLP:000001548.
SLP:000001616. [P10632-1]

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C8 (EC:1.14.14.11 Publication)
Alternative name(s):
CYPIIC8
Cytochrome P450 IIC2
Cytochrome P450 MP-12
Cytochrome P450 MP-20
Cytochrome P450 form 1
S-mephenytoin 4-hydroxylase
Gene namesi
Name:CYP2C8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:2622. CYP2C8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

DisGeNETi1558.
MIMi601129. gene+phenotype.
OpenTargetsiENSG00000138115.
PharmGKBiPA125.

Chemistry databases

ChEMBLiCHEMBL3721.
DrugBankiDB05812. Abiraterone.
DB00316. Acetaminophen.
DB00945. Acetylsalicylic acid.
DB00918. Almotriptan.
DB01424. Aminophenazone.
DB01118. Amiodarone.
DB00321. Amitriptyline.
DB00381. Amlodipine.
DB00613. Amodiaquine.
DB00701. Amprenavir.
DB01435. Antipyrine.
DB06605. Apixaban.
DB01076. Atorvastatin.
DB00972. Azelastine.
DB06770. Benzyl alcohol.
DB01393. Bezafibrate.
DB00188. Bortezomib.
DB00835. Brompheniramine.
DB00921. Buprenorphine.
DB01156. Bupropion.
DB06772. Cabazitaxel.
DB00201. Caffeine.
DB00796. Candesartan.
DB00564. Carbamazepine.
DB00748. Carbinoxamine.
DB00446. Chloramphenicol.
DB00608. Chloroquine.
DB00169. Cholecalciferol.
DB00501. Cimetidine.
DB00604. Cisapride.
DB00758. Clopidogrel.
DB00257. Clotrimazole.
DB00363. Clozapine.
DB00907. Cocaine.
DB01394. Colchicine.
DB00531. Cyclophosphamide.
DB00091. Cyclosporine.
DB08912. Dabrafenib.
DB00250. Dapsone.
DB00705. Delavirdine.
DB01234. Dexamethasone.
DB00514. Dextromethorphan.
DB00647. Dextropropoxyphene.
DB00829. Diazepam.
DB00586. Diclofenac.
DB00255. Diethylstilbestrol.
DB00343. Diltiazem.
DB01184. Domperidone.
DB06210. Eltrombopag.
DB08899. Enzalutamide.
DB00530. Erlotinib.
DB00783. Estradiol.
DB00402. Eszopiclone.
DB00977. Ethinyl Estradiol.
DB00773. Etoposide.
DB01023. Felodipine.
DB01039. Fenofibrate.
DB00544. Fluorouracil.
DB01095. Fluvastatin.
DB01320. Fosphenytoin.
DB01241. Gemfibrozil.
DB01218. Halofantrine.
DB00741. Hydrocortisone.
DB01050. Ibuprofen.
DB09054. Idelalisib.
DB01181. Ifosfamide.
DB01029. Irbesartan.
DB00951. Isoniazid.
DB09570. Ixazomib.
DB01221. Ketamine.
DB06738. Ketobemidone.
DB01026. Ketoconazole.
DB01009. Ketoprofen.
DB00448. Lansoprazole.
DB01259. Lapatinib.
DB08918. Levomilnacipran.
DB00451. Levothyroxine.
DB00281. Lidocaine.
DB01583. Liotrix.
DB00836. Loperamide.
DB00455. Loratadine.
DB00678. Losartan.
DB00227. Lovastatin.
DB00603. Medroxyprogesterone Acetate.
DB00784. Mefenamic acid.
DB00814. Meloxicam.
DB00333. Methadone.
DB00916. Metronidazole.
DB00370. Mirtazapine.
DB00764. Mometasone.
DB00471. Montelukast.
DB00295. Morphine.
DB00688. Mycophenolate mofetil.
DB01183. Naloxone.
DB00788. Naproxen.
DB00622. Nicardipine.
DB00184. Nicotine.
DB01115. Nifedipine.
DB04868. Nilotinib.
DB00665. Nilutamide.
DB06712. Nilvadipine.
DB09080. Olodaterol.
DB00338. Omeprazole.
DB01062. Oxybutynin.
DB01229. Paclitaxel.
DB00617. Paramethadione.
DB00715. Paroxetine.
DB06589. Pazopanib.
DB00738. Pentamidine.
DB00850. Perphenazine.
DB00780. Phenelzine.
DB01174. Phenobarbital.
DB00946. Phenprocoumon.
DB00252. Phenytoin.
DB01132. Pioglitazone.
DB00554. Piroxicam.
DB08860. Pitavastatin.
DB08901. Ponatinib.
DB00175. Pravastatin.
DB00794. Primidone.
DB01032. Probenecid.
DB00396. Progesterone.
DB01182. Propafenone.
DB00818. Propofol.
DB00205. Pyrimethamine.
DB00908. Quinidine.
DB00468. Quinine.
DB00481. Raloxifene.
DB08896. Regorafenib.
DB00912. Repaglinide.
DB01045. Rifampicin.
DB01201. Rifapentine.
DB08931. Riociguat.
DB00503. Ritonavir.
DB00412. Rosiglitazone.
DB00938. Salmeterol.
DB01232. Saquinavir.
DB00418. Secobarbital.
DB01037. Selegiline.
DB11362. Selexipag.
DB00641. Simvastatin.
DB01261. Sitagliptin.
DB00398. Sorafenib.
DB00421. Spironolactone.
DB00359. Sulfadiazine.
DB01015. Sulfamethoxazole.
DB06729. Sulfaphenazole.
DB01138. Sulfinpyrazone.
DB00675. Tamoxifen.
DB00799. Tazarotene.
DB00231. Temazepam.
DB00857. Terbinafine.
DB00624. Testosterone.
DB00277. Theophylline.
DB00679. Thioridazine.
DB00208. Ticlopidine.
DB01007. Tioconazole.
DB01124. Tolbutamide.
DB00214. Torasemide.
DB08911. Trametinib.
DB00755. Tretinoin.
DB00897. Triazolam.
DB00347. Trimethadione.
DB00440. Trimethoprim.
DB01361. Troleandomycin.
DB00313. Valproic Acid.
DB00661. Verapamil.
DB08828. Vismodegib.
DB09068. Vortioxetine.
DB00682. Warfarin.
DB00549. Zafirlukast.
DB00495. Zidovudine.
DB01198. Zopiclone.
GuidetoPHARMACOLOGYi1325.

Polymorphism and mutation databases

BioMutaiCYP2C8.
DMDMi117225.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000516991 – 490Cytochrome P450 2C8Add BLAST490

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei100PhosphoserineCombined sources1
Modified residuei249N6-acetyllysineBy similarity1
Modified residuei375N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP10632.
PeptideAtlasiP10632.
PRIDEiP10632.

PTM databases

iPTMnetiP10632.
PhosphoSitePlusiP10632.

Expressioni

Inductioni

By phenobarbital.

Gene expression databases

BgeeiENSG00000138115.
CleanExiHS_CYP2C8.
ExpressionAtlasiP10632. baseline and differential.
GenevisibleiP10632. HS.

Organism-specific databases

HPAiHPA013547.
HPA013970.
HPA015066.

Interactioni

Protein-protein interaction databases

BioGridi107936. 13 interactors.
IntActiP10632. 10 interactors.
STRINGi9606.ENSP00000360317.

Chemistry databases

BindingDBiP10632.

Structurei

Secondary structure

1490
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni37 – 39Combined sources3
Helixi42 – 44Combined sources3
Beta strandi47 – 49Combined sources3
Helixi50 – 61Combined sources12
Beta strandi63 – 69Combined sources7
Beta strandi72 – 77Combined sources6
Helixi80 – 87Combined sources8
Turni88 – 94Combined sources7
Helixi101 – 107Combined sources7
Turni111 – 113Combined sources3
Helixi117 – 130Combined sources14
Turni133 – 136Combined sources4
Beta strandi137 – 139Combined sources3
Helixi141 – 157Combined sources17
Turni158 – 161Combined sources4
Helixi167 – 182Combined sources16
Beta strandi183 – 185Combined sources3
Helixi192 – 208Combined sources17
Helixi212 – 218Combined sources7
Helixi220 – 225Combined sources6
Helixi227 – 252Combined sources26
Helixi263 – 273Combined sources11
Helixi284 – 298Combined sources15
Helixi300 – 315Combined sources16
Helixi317 – 330Combined sources14
Beta strandi333 – 335Combined sources3
Helixi339 – 344Combined sources6
Helixi346 – 359Combined sources14
Beta strandi374 – 376Combined sources3
Beta strandi379 – 381Combined sources3
Beta strandi386 – 389Combined sources4
Helixi391 – 395Combined sources5
Turni398 – 400Combined sources3
Beta strandi401 – 403Combined sources3
Helixi409 – 412Combined sources4
Helixi431 – 433Combined sources3
Helixi438 – 455Combined sources18
Beta strandi456 – 459Combined sources4
Helixi464 – 466Combined sources3
Beta strandi472 – 479Combined sources8
Beta strandi485 – 489Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PQ2X-ray2.70A/B19-490[»]
2NNHX-ray2.60A/B28-490[»]
2NNIX-ray2.80A28-490[»]
2NNJX-ray2.28A28-490[»]
2VN0X-ray2.70A28-490[»]
ProteinModelPortaliP10632.
SMRiP10632.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10632.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP10632.
KOiK17718.
OMAiMLQIDIK.
OrthoDBiEOG091G0BT8.
PhylomeDBiP10632.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P10632-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPFVVLVLC LSFMLLFSLW RQSCRRRKLP PGPTPLPIIG NMLQIDVKDI
60 70 80 90 100
CKSFTNFSKV YGPVFTVYFG MNPIVVFHGY EAVKEALIDN GEEFSGRGNS
110 120 130 140 150
PISQRITKGL GIISSNGKRW KEIRRFSLTT LRNFGMGKRS IEDRVQEEAH
160 170 180 190 200
CLVEELRKTK ASPCDPTFIL GCAPCNVICS VVFQKRFDYK DQNFLTLMKR
210 220 230 240 250
FNENFRILNS PWIQVCNNFP LLIDCFPGTH NKVLKNVALT RSYIREKVKE
260 270 280 290 300
HQASLDVNNP RDFIDCFLIK MEQEKDNQKS EFNIENLVGT VADLFVAGTE
310 320 330 340 350
TTSTTLRYGL LLLLKHPEVT AKVQEEIDHV IGRHRSPCMQ DRSHMPYTDA
360 370 380 390 400
VVHEIQRYSD LVPTGVPHAV TTDTKFRNYL IPKGTTIMAL LTSVLHDDKE
410 420 430 440 450
FPNPNIFDPG HFLDKNGNFK KSDYFMPFSA GKRICAGEGL ARMELFLFLT
460 470 480 490
TILQNFNLKS VDDLKNLNTT AVTKGIVSLP PSYQICFIPV
Length:490
Mass (Da):55,825
Last modified:November 1, 1990 - v2
Checksum:iE920EB2084F477E1
GO
Isoform 2 (identifier: P10632-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-8: MEPFVVLV → MFLQPIAK
     9-110: Missing.

Note: No experimental confirmation available.
Show »
Length:388
Mass (Da):44,358
Checksum:i0A9312FD6D4B9634
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti54F → L no nucleotide entry (PubMed:2729895).Curated1
Sequence conflicti67V → L no nucleotide entry (PubMed:2729895).Curated1
Sequence conflicti76V → C no nucleotide entry (PubMed:2729895).Curated1
Sequence conflicti82A → S in AAH20596 (PubMed:15489334).Curated1
Sequence conflicti130T → N in AAA35739 (PubMed:3500169).Curated1
Sequence conflicti130T → N in AAA35740 (PubMed:3500169).Curated1
Sequence conflicti130T → N no nucleotide entry (PubMed:2009263).Curated1
Sequence conflicti209N → S no nucleotide entry (PubMed:2729895).Curated1
Sequence conflicti384 – 393GTTIMALLTS → SFDNKIMLAA in AAA35740 (PubMed:3500169).Curated10
Sequence conflicti386T → A in BAF85442 (PubMed:14702039).Curated1

Polymorphismi

Several alleles are found in the human population, contributing to interindividual variations in the therapeutic efficacy and toxicity of a myriad of drugs such as paclitaxel or amodiaquine. The allele shown here is CYP2C8*1 (PubMed:26427316). CYP2C8 genetic variations may be associated with adverse effects of cerivastatin including acute rhabdomyolysis [MIMi:601129].1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_012238139R → K in allele CYP2C8*3; reduces enzymatic activity with paclitaxel as substrate; decreases intrinsic clearance of paclitaxel; reduces enzymatic activity with amodiaquine as substrate. 7 PublicationsCorresponds to variant rs11572080dbSNPEnsembl.1
Natural variantiVAR_001250154E → D.1 Publication1
Natural variantiVAR_075541171G → S in allele CYP2C8*6; no effect on affinity or enzymatic activiy with paclitaxel as substrate; decreases affinity for amodiaquine; reduces enzymatic activity with amodiaquine as substrate; decreases intrinsic clearance of amodiaquine. 1 PublicationCorresponds to variant rs142886225dbSNPEnsembl.1
Natural variantiVAR_075542186R → G in allele CYP2C8*8; increases affinity for paclitaxel; reduces enzymatic activity with paclitaxel as substrate; decreases intrinsic clearance of paclitaxel; reduces enzymatic activity with amodiaquine as substrate; decreases intrinsic clearance of amodiaquine. 1 PublicationCorresponds to variant rs72558195dbSNPEnsembl.1
Natural variantiVAR_001251193N → K.1 Publication1
Natural variantiVAR_075543223I → M in allele CYP2C8*13; reduces enzymatic activity with paclitaxel as substrate; decreases intrinsic clearance of paclitaxel; reduces enzymatic activity with amodiaquine as substrate; decreases intrinsic clearance of amodiaquine. 1 Publication1
Natural variantiVAR_075544238A → P in allele CYP2C8*14; reduces enzymatic activity with paclitaxel as substrate; decreases intrinsic clearance of paclitaxel. 1 PublicationCorresponds to variant rs188934928dbSNPEnsembl.1
Natural variantiVAR_018958244I → V.1 PublicationCorresponds to variant rs11572102dbSNPEnsembl.1
Natural variantiVAR_075545247K → R in allele CYP2C8*9; increases enzymatic activity with paclitaxel as substrate; reduces enzymatic activity with amodiaquine as substrate; decreases intrinsic clearance of amodiaquine. 1 PublicationCorresponds to variant rs769460274dbSNPEnsembl.1
Natural variantiVAR_001252249K → R.1 Publication1
Natural variantiVAR_011754264I → M in allele CYP2C8*4; reduces enzymatic activity with paclitaxel as substrate; decreases affinity for amodiaquine. 6 PublicationsCorresponds to variant rs1058930dbSNPEnsembl.1
Natural variantiVAR_012239269I → F in allele CYP2C8*2; only found in African-Americans; increases intrinsic clearance of paclitaxel; decreases affinity for amodiaquine; increases enzymatic activity with amodiaquine as substrate. 5 PublicationsCorresponds to variant rs11572103dbSNPEnsembl.1
Natural variantiVAR_075546383K → N in allele CYP2C8*10; reduces enzymatic activity with paclitaxel as substrate; reduces enzymatic activity with amodiaquine as substrate; decreases intrinsic clearance of amodiaquine. 1 Publication1
Natural variantiVAR_016947390L → S.1 PublicationCorresponds to variant rs72558194dbSNPEnsembl.1
Natural variantiVAR_012240399K → R in allele CYP2C8*3; reduces enzymatic activity with paclitaxel as substrate; decreases intrinsic clearance of paclitaxel; reduces enzymatic activity with amodiaquine as substrate. 7 PublicationsCorresponds to variant rs10509681dbSNPEnsembl.1
Natural variantiVAR_001253411H → L.2 Publications1
Natural variantiVAR_075547461Missing in allele CYP2C8*12; increases enzymatic activity with paclitaxel as substrate; reduces enzymatic activity with amodiaquine as substrate; decreases intrinsic clearance of amodiaquine. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0433061 – 8MEPFVVLV → MFLQPIAK in isoform 2. 1 Publication8
Alternative sequenceiVSP_0433079 – 110Missing in isoform 2. 1 PublicationAdd BLAST102

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17397 mRNA. Translation: AAA35739.1.
M17398 mRNA. Translation: AAA35740.1.
Y00498 mRNA. Translation: CAA68550.1.
AK292753 mRNA. Translation: BAF85442.1.
AK293328 mRNA. Translation: BAH11492.1.
AK315823 mRNA. Translation: BAF98714.1.
AY514490 Genomic DNA. Translation: AAR89907.1.
AL359672 Genomic DNA. Translation: CAH71307.1.
CH471066 Genomic DNA. Translation: EAW50018.1.
BC020596 mRNA. Translation: AAH20596.1.
X54807 Genomic DNA. Translation: CAA38578.1.
M21941 mRNA. Translation: AAA52160.1.
M21942 mRNA. Translation: AAA52161.1.
X51535 mRNA. Translation: CAA35915.1.
CCDSiCCDS55721.1. [P10632-2]
CCDS7438.1. [P10632-1]
PIRiA29782.
RefSeqiNP_000761.3. NM_000770.3. [P10632-1]
NP_001185782.1. NM_001198853.1.
NP_001185783.1. NM_001198854.1. [P10632-2]
NP_001185784.1. NM_001198855.1.
UniGeneiHs.709188.

Genome annotation databases

EnsembliENST00000371270; ENSP00000360317; ENSG00000138115. [P10632-1]
ENST00000535898; ENSP00000445062; ENSG00000138115. [P10632-2]
GeneIDi1558.
KEGGihsa:1558.
UCSCiuc001kkb.4. human. [P10632-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Cytochrome P450 Allele Nomenclature Committee

CYP2C8 alleles

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17397 mRNA. Translation: AAA35739.1.
M17398 mRNA. Translation: AAA35740.1.
Y00498 mRNA. Translation: CAA68550.1.
AK292753 mRNA. Translation: BAF85442.1.
AK293328 mRNA. Translation: BAH11492.1.
AK315823 mRNA. Translation: BAF98714.1.
AY514490 Genomic DNA. Translation: AAR89907.1.
AL359672 Genomic DNA. Translation: CAH71307.1.
CH471066 Genomic DNA. Translation: EAW50018.1.
BC020596 mRNA. Translation: AAH20596.1.
X54807 Genomic DNA. Translation: CAA38578.1.
M21941 mRNA. Translation: AAA52160.1.
M21942 mRNA. Translation: AAA52161.1.
X51535 mRNA. Translation: CAA35915.1.
CCDSiCCDS55721.1. [P10632-2]
CCDS7438.1. [P10632-1]
PIRiA29782.
RefSeqiNP_000761.3. NM_000770.3. [P10632-1]
NP_001185782.1. NM_001198853.1.
NP_001185783.1. NM_001198854.1. [P10632-2]
NP_001185784.1. NM_001198855.1.
UniGeneiHs.709188.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PQ2X-ray2.70A/B19-490[»]
2NNHX-ray2.60A/B28-490[»]
2NNIX-ray2.80A28-490[»]
2NNJX-ray2.28A28-490[»]
2VN0X-ray2.70A28-490[»]
ProteinModelPortaliP10632.
SMRiP10632.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107936. 13 interactors.
IntActiP10632. 10 interactors.
STRINGi9606.ENSP00000360317.

Chemistry databases

BindingDBiP10632.
ChEMBLiCHEMBL3721.
DrugBankiDB05812. Abiraterone.
DB00316. Acetaminophen.
DB00945. Acetylsalicylic acid.
DB00918. Almotriptan.
DB01424. Aminophenazone.
DB01118. Amiodarone.
DB00321. Amitriptyline.
DB00381. Amlodipine.
DB00613. Amodiaquine.
DB00701. Amprenavir.
DB01435. Antipyrine.
DB06605. Apixaban.
DB01076. Atorvastatin.
DB00972. Azelastine.
DB06770. Benzyl alcohol.
DB01393. Bezafibrate.
DB00188. Bortezomib.
DB00835. Brompheniramine.
DB00921. Buprenorphine.
DB01156. Bupropion.
DB06772. Cabazitaxel.
DB00201. Caffeine.
DB00796. Candesartan.
DB00564. Carbamazepine.
DB00748. Carbinoxamine.
DB00446. Chloramphenicol.
DB00608. Chloroquine.
DB00169. Cholecalciferol.
DB00501. Cimetidine.
DB00604. Cisapride.
DB00758. Clopidogrel.
DB00257. Clotrimazole.
DB00363. Clozapine.
DB00907. Cocaine.
DB01394. Colchicine.
DB00531. Cyclophosphamide.
DB00091. Cyclosporine.
DB08912. Dabrafenib.
DB00250. Dapsone.
DB00705. Delavirdine.
DB01234. Dexamethasone.
DB00514. Dextromethorphan.
DB00647. Dextropropoxyphene.
DB00829. Diazepam.
DB00586. Diclofenac.
DB00255. Diethylstilbestrol.
DB00343. Diltiazem.
DB01184. Domperidone.
DB06210. Eltrombopag.
DB08899. Enzalutamide.
DB00530. Erlotinib.
DB00783. Estradiol.
DB00402. Eszopiclone.
DB00977. Ethinyl Estradiol.
DB00773. Etoposide.
DB01023. Felodipine.
DB01039. Fenofibrate.
DB00544. Fluorouracil.
DB01095. Fluvastatin.
DB01320. Fosphenytoin.
DB01241. Gemfibrozil.
DB01218. Halofantrine.
DB00741. Hydrocortisone.
DB01050. Ibuprofen.
DB09054. Idelalisib.
DB01181. Ifosfamide.
DB01029. Irbesartan.
DB00951. Isoniazid.
DB09570. Ixazomib.
DB01221. Ketamine.
DB06738. Ketobemidone.
DB01026. Ketoconazole.
DB01009. Ketoprofen.
DB00448. Lansoprazole.
DB01259. Lapatinib.
DB08918. Levomilnacipran.
DB00451. Levothyroxine.
DB00281. Lidocaine.
DB01583. Liotrix.
DB00836. Loperamide.
DB00455. Loratadine.
DB00678. Losartan.
DB00227. Lovastatin.
DB00603. Medroxyprogesterone Acetate.
DB00784. Mefenamic acid.
DB00814. Meloxicam.
DB00333. Methadone.
DB00916. Metronidazole.
DB00370. Mirtazapine.
DB00764. Mometasone.
DB00471. Montelukast.
DB00295. Morphine.
DB00688. Mycophenolate mofetil.
DB01183. Naloxone.
DB00788. Naproxen.
DB00622. Nicardipine.
DB00184. Nicotine.
DB01115. Nifedipine.
DB04868. Nilotinib.
DB00665. Nilutamide.
DB06712. Nilvadipine.
DB09080. Olodaterol.
DB00338. Omeprazole.
DB01062. Oxybutynin.
DB01229. Paclitaxel.
DB00617. Paramethadione.
DB00715. Paroxetine.
DB06589. Pazopanib.
DB00738. Pentamidine.
DB00850. Perphenazine.
DB00780. Phenelzine.
DB01174. Phenobarbital.
DB00946. Phenprocoumon.
DB00252. Phenytoin.
DB01132. Pioglitazone.
DB00554. Piroxicam.
DB08860. Pitavastatin.
DB08901. Ponatinib.
DB00175. Pravastatin.
DB00794. Primidone.
DB01032. Probenecid.
DB00396. Progesterone.
DB01182. Propafenone.
DB00818. Propofol.
DB00205. Pyrimethamine.
DB00908. Quinidine.
DB00468. Quinine.
DB00481. Raloxifene.
DB08896. Regorafenib.
DB00912. Repaglinide.
DB01045. Rifampicin.
DB01201. Rifapentine.
DB08931. Riociguat.
DB00503. Ritonavir.
DB00412. Rosiglitazone.
DB00938. Salmeterol.
DB01232. Saquinavir.
DB00418. Secobarbital.
DB01037. Selegiline.
DB11362. Selexipag.
DB00641. Simvastatin.
DB01261. Sitagliptin.
DB00398. Sorafenib.
DB00421. Spironolactone.
DB00359. Sulfadiazine.
DB01015. Sulfamethoxazole.
DB06729. Sulfaphenazole.
DB01138. Sulfinpyrazone.
DB00675. Tamoxifen.
DB00799. Tazarotene.
DB00231. Temazepam.
DB00857. Terbinafine.
DB00624. Testosterone.
DB00277. Theophylline.
DB00679. Thioridazine.
DB00208. Ticlopidine.
DB01007. Tioconazole.
DB01124. Tolbutamide.
DB00214. Torasemide.
DB08911. Trametinib.
DB00755. Tretinoin.
DB00897. Triazolam.
DB00347. Trimethadione.
DB00440. Trimethoprim.
DB01361. Troleandomycin.
DB00313. Valproic Acid.
DB00661. Verapamil.
DB08828. Vismodegib.
DB09068. Vortioxetine.
DB00682. Warfarin.
DB00549. Zafirlukast.
DB00495. Zidovudine.
DB01198. Zopiclone.
GuidetoPHARMACOLOGYi1325.
SwissLipidsiSLP:000001548.
SLP:000001616. [P10632-1]

PTM databases

iPTMnetiP10632.
PhosphoSitePlusiP10632.

Polymorphism and mutation databases

BioMutaiCYP2C8.
DMDMi117225.

Proteomic databases

PaxDbiP10632.
PeptideAtlasiP10632.
PRIDEiP10632.

Protocols and materials databases

DNASUi1558.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371270; ENSP00000360317; ENSG00000138115. [P10632-1]
ENST00000535898; ENSP00000445062; ENSG00000138115. [P10632-2]
GeneIDi1558.
KEGGihsa:1558.
UCSCiuc001kkb.4. human. [P10632-1]

Organism-specific databases

CTDi1558.
DisGeNETi1558.
GeneCardsiCYP2C8.
HGNCiHGNC:2622. CYP2C8.
HPAiHPA013547.
HPA013970.
HPA015066.
MIMi601129. gene+phenotype.
neXtProtiNX_P10632.
OpenTargetsiENSG00000138115.
PharmGKBiPA125.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP10632.
KOiK17718.
OMAiMLQIDIK.
OrthoDBiEOG091G0BT8.
PhylomeDBiP10632.
TreeFamiTF352043.

Enzyme and pathway databases

BioCyciZFISH:HS06459-MONOMER.
BRENDAi1.14.14.1. 2681.
ReactomeiR-HSA-211981. Xenobiotics.
R-HSA-211999. CYP2E1 reactions.
R-HSA-2142670. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
R-HSA-2142816. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
SABIO-RKP10632.

Miscellaneous databases

EvolutionaryTraceiP10632.
GeneWikiiCYP2C8.
GenomeRNAii1558.
PROiP10632.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000138115.
CleanExiHS_CYP2C8.
ExpressionAtlasiP10632. baseline and differential.
GenevisibleiP10632. HS.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCP2C8_HUMAN
AccessioniPrimary (citable) accession number: P10632
Secondary accession number(s): A8K9N8
, B0AZN2, B7Z1F6, Q5VX93, Q8WWB1, Q9UCZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1990
Last modified: November 2, 2016
This is version 190 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Alternative splicing has been shown to occur but the shorter forms are believed to be non-functional.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.