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Protein

Peptide YY

Gene

Pyy

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.

GO - Molecular functioni

  • G-protein coupled receptor binding Source: GO_Central
  • neuropeptide hormone activity Source: RGD

GO - Biological processi

Keywordsi

Molecular functionHormone

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide YY1 Publication
Short name:
PYY1 Publication
Alternative name(s):
Peptide tyrosine tyrosine
Cleaved into the following chain:
Peptide YY(3-36)By similarity
Alternative name(s):
PYY-IIBy similarity
Gene namesi
Name:Pyy
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1593289 Pyy

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 281 PublicationAdd BLAST28
PeptideiPRO_000002539129 – 64Peptide YYAdd BLAST36
PeptideiPRO_000043066631 – 64Peptide YY(3-36)By similarityAdd BLAST34
PropeptideiPRO_000002539268 – 98Add BLAST31

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei41PhosphoserineBy similarity1
Modified residuei64Tyrosine amideBy similarity1

Post-translational modificationi

The peptide YY form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro) to generate peptide YY(3-36).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei30 – 31Cleavage; by FAPBy similarity2

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Phosphoprotein

Proteomic databases

PaxDbiP10631
PRIDEiP10631

Interactioni

GO - Molecular functioni

  • G-protein coupled receptor binding Source: GO_Central
  • neuropeptide hormone activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028323

Structurei

3D structure databases

ProteinModelPortaliP10631
SMRiP10631
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NPY family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0E4 Eukaryota
ENOG4111U8V LUCA
HOGENOMiHOG000252942
HOVERGENiHBG006485
InParanoidiP10631
KOiK05233
PhylomeDBiP10631

Family and domain databases

CDDicd00126 PAH, 1 hit
InterProiView protein in InterPro
IPR001955 Pancreatic_hormone-like
IPR020392 Pancreatic_hormone-like_CS
PANTHERiPTHR10533 PTHR10533, 1 hit
PfamiView protein in Pfam
PF00159 Hormone_3, 1 hit
PRINTSiPR00278 PANCHORMONE
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001267 Pancreatic_hormone-like, 1 hit
SMARTiView protein in SMART
SM00309 PAH, 1 hit
PROSITEiView protein in PROSITE
PS00265 PANCREATIC_HORMONE_1, 1 hit
PS50276 PANCREATIC_HORMONE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10631-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAVRRPWPV MVAMLLVLLA CLGALVDAYP AKPEAPGEDA SPEELSRYYA
60 70 80 90
SLRHYLNLVT RQRYGKREVP AALFSKLLFT DDSENLPFRS RPEGVDQW
Length:98
Mass (Da):11,121
Last modified:July 1, 1989 - v1
Checksum:i994C0C3AD6A8A7DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17523 mRNA Translation: AAA41222.1
S57220 Genomic DNA Translation: AAB19752.1
AB238226 mRNA Translation: BAE46747.1
PIRiA37955 A29364
RefSeqiNP_001029252.1, NM_001034080.1
UniGeneiRn.13173

Genome annotation databases

GeneIDi287730
KEGGirno:287730
UCSCiRGD:1593289 rat

Similar proteinsi

Entry informationi

Entry nameiPYY_RAT
AccessioniPrimary (citable) accession number: P10631
Secondary accession number(s): Q3C1E8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: May 23, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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