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Protein

Peptide YY

Gene

Pyy

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.

GO - Molecular functioni

  • G-protein coupled receptor binding Source: GO_Central
  • neuropeptide hormone activity Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide YY1 Publication
Short name:
PYY1 Publication
Alternative name(s):
Peptide tyrosine tyrosine
Cleaved into the following chain:
Peptide YY(3-36)By similarity
Alternative name(s):
PYY-IIBy similarity
Gene namesi
Name:Pyy
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1593289. Pyy.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 28281 PublicationAdd
BLAST
Peptidei29 – 6436Peptide YYPRO_0000025391Add
BLAST
Peptidei31 – 6434Peptide YY(3-36)By similarityPRO_0000430666Add
BLAST
Propeptidei68 – 9831PRO_0000025392Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei41 – 411PhosphoserineBy similarity
Modified residuei64 – 641Tyrosine amideBy similarity

Post-translational modificationi

The peptide YY form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro) to generate peptide YY(3-36).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei30 – 312Cleavage; by FAPBy similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Phosphoprotein

Proteomic databases

PaxDbiP10631.

Interactioni

GO - Molecular functioni

  • G-protein coupled receptor binding Source: GO_Central
  • neuropeptide hormone activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028323.

Structurei

3D structure databases

ProteinModelPortaliP10631.
SMRiP10631. Positions 29-64.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NPY family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0E4. Eukaryota.
ENOG4111U8V. LUCA.
HOGENOMiHOG000252942.
HOVERGENiHBG006485.
InParanoidiP10631.
KOiK05233.
PhylomeDBiP10631.

Family and domain databases

InterProiIPR001955. Pancreatic_hormone-like.
IPR020392. Pancreatic_hormone-like_CS.
[Graphical view]
PANTHERiPTHR10533. PTHR10533. 1 hit.
PfamiPF00159. Hormone_3. 1 hit.
[Graphical view]
PRINTSiPR00278. PANCHORMONE.
ProDomiPD001267. Pancreatic_hormone-like. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00309. PAH. 1 hit.
[Graphical view]
PROSITEiPS00265. PANCREATIC_HORMONE_1. 1 hit.
PS50276. PANCREATIC_HORMONE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10631-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAVRRPWPV MVAMLLVLLA CLGALVDAYP AKPEAPGEDA SPEELSRYYA
60 70 80 90
SLRHYLNLVT RQRYGKREVP AALFSKLLFT DDSENLPFRS RPEGVDQW
Length:98
Mass (Da):11,121
Last modified:July 1, 1989 - v1
Checksum:i994C0C3AD6A8A7DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17523 mRNA. Translation: AAA41222.1.
S57220 Genomic DNA. Translation: AAB19752.1.
AB238226 mRNA. Translation: BAE46747.1.
PIRiA37955. A29364.
RefSeqiNP_001029252.1. NM_001034080.1.
UniGeneiRn.13173.

Genome annotation databases

GeneIDi287730.
KEGGirno:287730.
UCSCiRGD:1593289. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17523 mRNA. Translation: AAA41222.1.
S57220 Genomic DNA. Translation: AAB19752.1.
AB238226 mRNA. Translation: BAE46747.1.
PIRiA37955. A29364.
RefSeqiNP_001029252.1. NM_001034080.1.
UniGeneiRn.13173.

3D structure databases

ProteinModelPortaliP10631.
SMRiP10631. Positions 29-64.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028323.

Proteomic databases

PaxDbiP10631.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi287730.
KEGGirno:287730.
UCSCiRGD:1593289. rat.

Organism-specific databases

CTDi5697.
RGDi1593289. Pyy.

Phylogenomic databases

eggNOGiENOG410J0E4. Eukaryota.
ENOG4111U8V. LUCA.
HOGENOMiHOG000252942.
HOVERGENiHBG006485.
InParanoidiP10631.
KOiK05233.
PhylomeDBiP10631.

Miscellaneous databases

PROiP10631.

Family and domain databases

InterProiIPR001955. Pancreatic_hormone-like.
IPR020392. Pancreatic_hormone-like_CS.
[Graphical view]
PANTHERiPTHR10533. PTHR10533. 1 hit.
PfamiPF00159. Hormone_3. 1 hit.
[Graphical view]
PRINTSiPR00278. PANCHORMONE.
ProDomiPD001267. Pancreatic_hormone-like. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00309. PAH. 1 hit.
[Graphical view]
PROSITEiPS00265. PANCREATIC_HORMONE_1. 1 hit.
PS50276. PANCREATIC_HORMONE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Peptide YY. Structure of the precursor and expression in exocrine pancreas."
    Leiter A.B., Toder A., Wolfe H.J., Taylor I.L., Cooperman S., Mandel G., Goodman R.H.
    J. Biol. Chem. 262:12984-12988(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Isolation, characterization, and developmental expression of the rat peptide-YY gene."
    Krasinski S.D., Wheeler M.B., Leiter A.B.
    Mol. Endocrinol. 5:433-440(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Pyy gene for peptide synthesis in Rattus norvegicus."
    Pandey J., Hamid Z., Vishwakarma N., Kumar A.
    Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Isolation and sequence of rat peptide YY and neuropeptide Y."
    Corder R., Gaillard R.C., Boehlen P.
    Regul. Pept. 21:253-261(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 29-64.

Entry informationi

Entry nameiPYY_RAT
AccessioniPrimary (citable) accession number: P10631
Secondary accession number(s): Q3C1E8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: July 6, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.