ID   HXC6_MOUSE              Reviewed;         235 AA.
AC   P10629; Q61683;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 2.
DT   24-JAN-2024, entry version 189.
DE   RecName: Full=Homeobox protein Hox-C6;
DE   AltName: Full=Homeobox protein Hox-3.3;
DE   AltName: Full=Homeobox protein Hox-6.1;
GN   Name=Hoxc6; Synonyms=Hox-3.3, Hoxc-6;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7905473;
RA   Shimeld S.M., Gaunt S.J., Coletta P.L., Geada A.M., Sharpe P.T.;
RT   "Spatial localisation of transcripts of the Hox-C6 gene.";
RL   J. Anat. 183:515-523(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=1684715; DOI=10.1016/0925-4773(91)90063-c;
RA   Coletta P.L., Shimeld S.M., Chaudhuri C., Mueller U., Clarke J.P.,
RA   Sharpe P.T.;
RT   "Characterisation of the murine Hox-3.3 gene and its promoter.";
RL   Mech. Dev. 35:129-142(1991).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 15-235.
RC   TISSUE=Bone marrow, and Spleen;
RX   PubMed=2901346; DOI=10.1002/j.1460-2075.1988.tb03052.x;
RA   Kongsuwan K., Webb E., Housiaux P., Adams J.M.;
RT   "Expression of multiple homeobox genes within diverse mammalian
RT   haemopoietic lineages.";
RL   EMBO J. 7:2131-2138(1988).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 131-235.
RC   TISSUE=Kidney;
RX   PubMed=2458223; DOI=10.1242/dev.102.2.397;
RA   Sharpe P.T., Miller J.R., Evans E.P., Burtenshaw M.D., Gaunt S.J.;
RT   "Isolation and expression of a new mouse homeobox gene.";
RL   Development 102:397-407(1988).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 133-235.
RX   PubMed=2570032; DOI=10.1016/0888-7543(89)90089-x;
RA   Schughart K., Pravtcheva D., Newman M.S., Hunihan L.W., Jiang Z.,
RA   Ruddle F.H.;
RT   "Isolation and regional localization of the murine homeobox-containing gene
RT   Hox-3.3 to mouse chromosome region 15E.";
RL   Genomics 5:76-83(1989).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=PRII;
CC         IsoId=P10629-1; Sequence=Displayed;
CC       Name=PRI;
CC         IsoId=P10629-2; Sequence=VSP_002393;
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; J03074; AAA37832.1; -; mRNA.
DR   EMBL; M35986; AAA37854.1; -; mRNA.
DR   EMBL; X16511; CAA34518.1; -; mRNA.
DR   EMBL; X16510; CAA34517.1; -; mRNA.
DR   EMBL; S74185; AAB20717.1; -; Unassigned_DNA.
DR   EMBL; X12504; CAA31022.1; -; mRNA.
DR   EMBL; X12504; CAA31023.1; -; mRNA.
DR   EMBL; X16838; CAA34737.1; -; mRNA.
DR   CCDS; CCDS27895.1; -. [P10629-1]
DR   PIR; A32167; A32167.
DR   PIR; A56568; A56568.
DR   PIR; S00987; WJMSX6.
DR   RefSeq; NP_034595.2; NM_010465.2. [P10629-1]
DR   RefSeq; XP_006520532.1; XM_006520469.2. [P10629-2]
DR   AlphaFoldDB; P10629; -.
DR   SMR; P10629; -.
DR   BioGRID; 200388; 1.
DR   IntAct; P10629; 1.
DR   STRING; 10090.ENSMUSP00000001711; -.
DR   iPTMnet; P10629; -.
DR   PhosphoSitePlus; P10629; -.
DR   MaxQB; P10629; -.
DR   PaxDb; 10090-ENSMUSP00000001711; -.
DR   ProteomicsDB; 267023; -. [P10629-1]
DR   ProteomicsDB; 267024; -. [P10629-2]
DR   Antibodypedia; 15318; 276 antibodies from 31 providers.
DR   DNASU; 15425; -.
DR   Ensembl; ENSMUST00000001711.6; ENSMUSP00000001711.5; ENSMUSG00000001661.6. [P10629-1]
DR   GeneID; 15425; -.
DR   KEGG; mmu:15425; -.
DR   UCSC; uc007xxc.1; mouse. [P10629-1]
DR   AGR; MGI:96197; -.
DR   CTD; 3223; -.
DR   MGI; MGI:96197; Hoxc6.
DR   VEuPathDB; HostDB:ENSMUSG00000001661; -.
DR   eggNOG; KOG0489; Eukaryota.
DR   GeneTree; ENSGT00940000159254; -.
DR   HOGENOM; CLU_061398_1_1_1; -.
DR   InParanoid; P10629; -.
DR   OMA; CHLTGGQ; -.
DR   OrthoDB; 728401at2759; -.
DR   PhylomeDB; P10629; -.
DR   TreeFam; TF316310; -.
DR   BioGRID-ORCS; 15425; 3 hits in 80 CRISPR screens.
DR   ChiTaRS; Hoxc6; mouse.
DR   PRO; PR:P10629; -.
DR   Proteomes; UP000000589; Chromosome 15.
DR   RNAct; P10629; Protein.
DR   Bgee; ENSMUSG00000001661; Expressed in embryonic post-anal tail and 97 other cell types or tissues.
DR   ExpressionAtlas; P10629; baseline and differential.
DR   GO; GO:0005829; C:cytosol; ISO:MGI.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; IGI:MGI.
DR   GO; GO:0048706; P:embryonic skeletal system development; IGI:MGI.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   PANTHER; PTHR45659; HOMEOBOX PROTEIN HOX; 1.
DR   PANTHER; PTHR45659:SF1; HOMEOBOX PROTEIN HOX-C6; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   Genevisible; P10629; MM.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Developmental protein; DNA-binding; Homeobox;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..235
FT                   /note="Homeobox protein Hox-C6"
FT                   /id="PRO_0000200175"
FT   DNA_BIND        141..200
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          200..235
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           122..127
FT                   /note="Antp-type hexapeptide"
FT   COMPBIAS        218..235
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..82
FT                   /note="Missing (in isoform PRI)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_002393"
FT   CONFLICT        15..18
FT                   /note="AGGQ -> QQRP (in Ref. 3; CAA31022)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        131
FT                   /note="S -> N (in Ref. 4; AAA37854/CAA34737)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        192
FT                   /note="R -> A (in Ref. 4; AAA37854/CAA34737)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        228..229
FT                   /note="TE -> QK (in Ref. 1 and 2)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   235 AA;  26915 MW;  BD695C7347CB71C0 CRC64;
     MNSYFTNPSL SCHLAGGQDV LPNVALNSTA YDPVRHFSTY GAAVAQNRIY STPFYSPQEN
     VVFSSSRGPY DYGSNSFYQE KDMLSNCRQN TLGHNTQTSI AQDFSSEQGR TAPQDQKASI
     QIYPWMQRMN SHSGVGYGAD RRRGRQIYSR YQTLELEKEF HFNRYLTRRR RIEIANALCL
     TERQIKIWFQ NRRMKWKKES NLTSTLSGGG GGATADSLGG KEEKREETEE EKQKE
//