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P10629

- HXC6_MOUSE

UniProt

P10629 - HXC6_MOUSE

Protein

Homeobox protein Hox-C6

Gene

Hoxc6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 140 (01 Oct 2014)
      Sequence version 2 (01 Jul 1993)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi141 – 20060HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. anterior/posterior pattern specification Source: MGI
    2. embryonic skeletal system development Source: MGI
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-C6
    Alternative name(s):
    Homeobox protein Hox-3.3
    Homeobox protein Hox-6.1
    Gene namesi
    Name:Hoxc6
    Synonyms:Hox-3.3, Hoxc-6
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:96197. Hoxc6.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 235235Homeobox protein Hox-C6PRO_0000200175Add
    BLAST

    Proteomic databases

    PRIDEiP10629.

    PTM databases

    PhosphoSiteiP10629.

    Expressioni

    Gene expression databases

    ArrayExpressiP10629.
    BgeeiP10629.
    CleanExiMM_HOXC6.
    GenevestigatoriP10629.

    Interactioni

    Protein-protein interaction databases

    BioGridi200388. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP10629.
    SMRiP10629. Positions 148-200.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi122 – 1276Antp-type hexapeptide

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi221 – 23515Glu/Lys-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Antp homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG266030.
    GeneTreeiENSGT00730000110212.
    HOGENOMiHOG000231181.
    HOVERGENiHBG016849.
    InParanoidiP10629.
    KOiK09306.
    OMAiMNSYFAN.
    PhylomeDBiP10629.
    TreeFamiTF316310.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform PRII (identifier: P10629-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNSYFTNPSL SCHLAGGQDV LPNVALNSTA YDPVRHFSTY GAAVAQNRIY    50
    STPFYSPQEN VVFSSSRGPY DYGSNSFYQE KDMLSNCRQN TLGHNTQTSI 100
    AQDFSSEQGR TAPQDQKASI QIYPWMQRMN SHSGVGYGAD RRRGRQIYSR 150
    YQTLELEKEF HFNRYLTRRR RIEIANALCL TERQIKIWFQ NRRMKWKKES 200
    NLTSTLSGGG GGATADSLGG KEEKREETEE EKQKE 235
    Length:235
    Mass (Da):26,915
    Last modified:July 1, 1993 - v2
    Checksum:iBD695C7347CB71C0
    GO
    Isoform PRI (identifier: P10629-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-82: Missing.

    Show »
    Length:153
    Mass (Da):17,834
    Checksum:i291E2439914263AE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti15 – 184AGGQ → QQRP in CAA31022. (PubMed:2901346)Curated
    Sequence conflicti131 – 1311S → N in AAA37854. (PubMed:2458223)Curated
    Sequence conflicti131 – 1311S → N in CAA34737. (PubMed:2458223)Curated
    Sequence conflicti192 – 1921R → A in AAA37854. (PubMed:2458223)Curated
    Sequence conflicti192 – 1921R → A in CAA34737. (PubMed:2458223)Curated
    Sequence conflicti228 – 2292TE → QK(PubMed:7905473)Curated
    Sequence conflicti228 – 2292TE → QK(PubMed:1684715)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 8282Missing in isoform PRI. CuratedVSP_002393Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J03074 mRNA. Translation: AAA37832.1.
    M35986 mRNA. Translation: AAA37854.1.
    X16511 mRNA. Translation: CAA34518.1.
    X16510 mRNA. Translation: CAA34517.1.
    S74185 Unassigned DNA. Translation: AAB20717.1.
    X12504 mRNA. Translation: CAA31022.1.
    X12504 mRNA. Translation: CAA31023.1.
    X16838 mRNA. Translation: CAA34737.1.
    CCDSiCCDS27895.1. [P10629-1]
    PIRiA32167.
    A56568.
    S00987. WJMSX6.
    RefSeqiNP_034595.2. NM_010465.2. [P10629-1]
    XP_006520532.1. XM_006520469.1. [P10629-2]
    UniGeneiMm.4444.

    Genome annotation databases

    EnsembliENSMUST00000001711; ENSMUSP00000001711; ENSMUSG00000001661. [P10629-1]
    GeneIDi15425.
    KEGGimmu:15425.
    UCSCiuc007xxc.1. mouse. [P10629-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J03074 mRNA. Translation: AAA37832.1 .
    M35986 mRNA. Translation: AAA37854.1 .
    X16511 mRNA. Translation: CAA34518.1 .
    X16510 mRNA. Translation: CAA34517.1 .
    S74185 Unassigned DNA. Translation: AAB20717.1 .
    X12504 mRNA. Translation: CAA31022.1 .
    X12504 mRNA. Translation: CAA31023.1 .
    X16838 mRNA. Translation: CAA34737.1 .
    CCDSi CCDS27895.1. [P10629-1 ]
    PIRi A32167.
    A56568.
    S00987. WJMSX6.
    RefSeqi NP_034595.2. NM_010465.2. [P10629-1 ]
    XP_006520532.1. XM_006520469.1. [P10629-2 ]
    UniGenei Mm.4444.

    3D structure databases

    ProteinModelPortali P10629.
    SMRi P10629. Positions 148-200.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200388. 1 interaction.

    PTM databases

    PhosphoSitei P10629.

    Proteomic databases

    PRIDEi P10629.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000001711 ; ENSMUSP00000001711 ; ENSMUSG00000001661 . [P10629-1 ]
    GeneIDi 15425.
    KEGGi mmu:15425.
    UCSCi uc007xxc.1. mouse. [P10629-1 ]

    Organism-specific databases

    CTDi 3223.
    MGIi MGI:96197. Hoxc6.

    Phylogenomic databases

    eggNOGi NOG266030.
    GeneTreei ENSGT00730000110212.
    HOGENOMi HOG000231181.
    HOVERGENi HBG016849.
    InParanoidi P10629.
    KOi K09306.
    OMAi MNSYFAN.
    PhylomeDBi P10629.
    TreeFami TF316310.

    Miscellaneous databases

    ChiTaRSi HOXC6. mouse.
    NextBioi 288174.
    PROi P10629.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P10629.
    Bgeei P10629.
    CleanExi MM_HOXC6.
    Genevestigatori P10629.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Spatial localisation of transcripts of the Hox-C6 gene."
      Shimeld S.M., Gaunt S.J., Coletta P.L., Geada A.M., Sharpe P.T.
      J. Anat. 183:515-523(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Characterisation of the murine Hox-3.3 gene and its promoter."
      Coletta P.L., Shimeld S.M., Chaudhuri C., Mueller U., Clarke J.P., Sharpe P.T.
      Mech. Dev. 35:129-142(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    3. "Expression of multiple homeobox genes within diverse mammalian haemopoietic lineages."
      Kongsuwan K., Webb E., Housiaux P., Adams J.M.
      EMBO J. 7:2131-2138(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 15-235.
      Tissue: Bone marrow and Spleen.
    4. "Isolation and expression of a new mouse homeobox gene."
      Sharpe P.T., Miller J.R., Evans E.P., Burtenshaw M.D., Gaunt S.J.
      Development 102:397-407(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 131-235.
      Tissue: Kidney.
    5. "Isolation and regional localization of the murine homeobox-containing gene Hox-3.3 to mouse chromosome region 15E."
      Schughart K., Pravtcheva D., Newman M.S., Hunihan L.W., Jiang Z., Ruddle F.H.
      Genomics 5:76-83(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 133-235.

    Entry informationi

    Entry nameiHXC6_MOUSE
    AccessioniPrimary (citable) accession number: P10629
    Secondary accession number(s): Q61683
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 140 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3