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P10629

- HXC6_MOUSE

UniProt

P10629 - HXC6_MOUSE

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Protein

Homeobox protein Hox-C6

Gene

Hoxc6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi141 – 20060HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. anterior/posterior pattern specification Source: MGI
  2. embryonic skeletal system development Source: MGI
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-C6
Alternative name(s):
Homeobox protein Hox-3.3
Homeobox protein Hox-6.1
Gene namesi
Name:Hoxc6
Synonyms:Hox-3.3, Hoxc-6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:96197. Hoxc6.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 235235Homeobox protein Hox-C6PRO_0000200175Add
BLAST

Proteomic databases

PRIDEiP10629.

PTM databases

PhosphoSiteiP10629.

Expressioni

Gene expression databases

BgeeiP10629.
CleanExiMM_HOXC6.
ExpressionAtlasiP10629. baseline and differential.
GenevestigatoriP10629.

Interactioni

Protein-protein interaction databases

BioGridi200388. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP10629.
SMRiP10629. Positions 148-200.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi122 – 1276Antp-type hexapeptide

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi221 – 23515Glu/Lys-richAdd
BLAST

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG266030.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231181.
HOVERGENiHBG016849.
InParanoidiP10629.
KOiK09306.
OMAiMNSYFAN.
PhylomeDBiP10629.
TreeFamiTF316310.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform PRII (identifier: P10629-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNSYFTNPSL SCHLAGGQDV LPNVALNSTA YDPVRHFSTY GAAVAQNRIY
60 70 80 90 100
STPFYSPQEN VVFSSSRGPY DYGSNSFYQE KDMLSNCRQN TLGHNTQTSI
110 120 130 140 150
AQDFSSEQGR TAPQDQKASI QIYPWMQRMN SHSGVGYGAD RRRGRQIYSR
160 170 180 190 200
YQTLELEKEF HFNRYLTRRR RIEIANALCL TERQIKIWFQ NRRMKWKKES
210 220 230
NLTSTLSGGG GGATADSLGG KEEKREETEE EKQKE
Length:235
Mass (Da):26,915
Last modified:July 1, 1993 - v2
Checksum:iBD695C7347CB71C0
GO
Isoform PRI (identifier: P10629-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: Missing.

Show »
Length:153
Mass (Da):17,834
Checksum:i291E2439914263AE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti15 – 184AGGQ → QQRP in CAA31022. (PubMed:2901346)Curated
Sequence conflicti131 – 1311S → N in AAA37854. (PubMed:2458223)Curated
Sequence conflicti131 – 1311S → N in CAA34737. (PubMed:2458223)Curated
Sequence conflicti192 – 1921R → A in AAA37854. (PubMed:2458223)Curated
Sequence conflicti192 – 1921R → A in CAA34737. (PubMed:2458223)Curated
Sequence conflicti228 – 2292TE → QK(PubMed:7905473)Curated
Sequence conflicti228 – 2292TE → QK(PubMed:1684715)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8282Missing in isoform PRI. CuratedVSP_002393Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03074 mRNA. Translation: AAA37832.1.
M35986 mRNA. Translation: AAA37854.1.
X16511 mRNA. Translation: CAA34518.1.
X16510 mRNA. Translation: CAA34517.1.
S74185 Unassigned DNA. Translation: AAB20717.1.
X12504 mRNA. Translation: CAA31022.1.
X12504 mRNA. Translation: CAA31023.1.
X16838 mRNA. Translation: CAA34737.1.
CCDSiCCDS27895.1. [P10629-1]
PIRiA32167.
A56568.
S00987. WJMSX6.
RefSeqiNP_034595.2. NM_010465.2. [P10629-1]
XP_006520532.1. XM_006520469.1. [P10629-2]
UniGeneiMm.4444.

Genome annotation databases

EnsembliENSMUST00000001711; ENSMUSP00000001711; ENSMUSG00000001661. [P10629-1]
GeneIDi15425.
KEGGimmu:15425.
UCSCiuc007xxc.1. mouse. [P10629-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03074 mRNA. Translation: AAA37832.1 .
M35986 mRNA. Translation: AAA37854.1 .
X16511 mRNA. Translation: CAA34518.1 .
X16510 mRNA. Translation: CAA34517.1 .
S74185 Unassigned DNA. Translation: AAB20717.1 .
X12504 mRNA. Translation: CAA31022.1 .
X12504 mRNA. Translation: CAA31023.1 .
X16838 mRNA. Translation: CAA34737.1 .
CCDSi CCDS27895.1. [P10629-1 ]
PIRi A32167.
A56568.
S00987. WJMSX6.
RefSeqi NP_034595.2. NM_010465.2. [P10629-1 ]
XP_006520532.1. XM_006520469.1. [P10629-2 ]
UniGenei Mm.4444.

3D structure databases

ProteinModelPortali P10629.
SMRi P10629. Positions 148-200.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200388. 1 interaction.

PTM databases

PhosphoSitei P10629.

Proteomic databases

PRIDEi P10629.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000001711 ; ENSMUSP00000001711 ; ENSMUSG00000001661 . [P10629-1 ]
GeneIDi 15425.
KEGGi mmu:15425.
UCSCi uc007xxc.1. mouse. [P10629-1 ]

Organism-specific databases

CTDi 3223.
MGIi MGI:96197. Hoxc6.

Phylogenomic databases

eggNOGi NOG266030.
GeneTreei ENSGT00760000118945.
HOGENOMi HOG000231181.
HOVERGENi HBG016849.
InParanoidi P10629.
KOi K09306.
OMAi MNSYFAN.
PhylomeDBi P10629.
TreeFami TF316310.

Miscellaneous databases

ChiTaRSi Hoxc6. mouse.
NextBioi 288174.
PROi P10629.
SOURCEi Search...

Gene expression databases

Bgeei P10629.
CleanExi MM_HOXC6.
ExpressionAtlasi P10629. baseline and differential.
Genevestigatori P10629.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Spatial localisation of transcripts of the Hox-C6 gene."
    Shimeld S.M., Gaunt S.J., Coletta P.L., Geada A.M., Sharpe P.T.
    J. Anat. 183:515-523(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Characterisation of the murine Hox-3.3 gene and its promoter."
    Coletta P.L., Shimeld S.M., Chaudhuri C., Mueller U., Clarke J.P., Sharpe P.T.
    Mech. Dev. 35:129-142(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Expression of multiple homeobox genes within diverse mammalian haemopoietic lineages."
    Kongsuwan K., Webb E., Housiaux P., Adams J.M.
    EMBO J. 7:2131-2138(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 15-235.
    Tissue: Bone marrow and Spleen.
  4. "Isolation and expression of a new mouse homeobox gene."
    Sharpe P.T., Miller J.R., Evans E.P., Burtenshaw M.D., Gaunt S.J.
    Development 102:397-407(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 131-235.
    Tissue: Kidney.
  5. "Isolation and regional localization of the murine homeobox-containing gene Hox-3.3 to mouse chromosome region 15E."
    Schughart K., Pravtcheva D., Newman M.S., Hunihan L.W., Jiang Z., Ruddle F.H.
    Genomics 5:76-83(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 133-235.

Entry informationi

Entry nameiHXC6_MOUSE
AccessioniPrimary (citable) accession number: P10629
Secondary accession number(s): Q61683
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1993
Last modified: November 26, 2014
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3