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Protein

Homeobox protein Hox-C6

Gene

Hoxc6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi141 – 200HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • anterior/posterior pattern specification Source: MGI
  • embryonic skeletal system development Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-C6
Alternative name(s):
Homeobox protein Hox-3.3
Homeobox protein Hox-6.1
Gene namesi
Name:Hoxc6
Synonyms:Hox-3.3, Hoxc-6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:96197. Hoxc6.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002001751 – 235Homeobox protein Hox-C6Add BLAST235

Proteomic databases

MaxQBiP10629.
PaxDbiP10629.
PRIDEiP10629.

PTM databases

PhosphoSitePlusiP10629.

Expressioni

Gene expression databases

BgeeiENSMUSG00000001661.
CleanExiMM_HOXC6.
ExpressionAtlasiP10629. baseline and differential.
GenevisibleiP10629. MM.

Interactioni

Protein-protein interaction databases

BioGridi200388. 1 interactor.
STRINGi10090.ENSMUSP00000001711.

Structurei

3D structure databases

ProteinModelPortaliP10629.
SMRiP10629.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi122 – 127Antp-type hexapeptide6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi221 – 235Glu/Lys-richAdd BLAST15

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231181.
HOVERGENiHBG016849.
InParanoidiP10629.
KOiK09306.
OMAiRMNSHSE.
OrthoDBiEOG091G09XD.
PhylomeDBiP10629.
TreeFamiTF316310.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PRINTSiPR00024. HOMEOBOX.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform PRII (identifier: P10629-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNSYFTNPSL SCHLAGGQDV LPNVALNSTA YDPVRHFSTY GAAVAQNRIY
60 70 80 90 100
STPFYSPQEN VVFSSSRGPY DYGSNSFYQE KDMLSNCRQN TLGHNTQTSI
110 120 130 140 150
AQDFSSEQGR TAPQDQKASI QIYPWMQRMN SHSGVGYGAD RRRGRQIYSR
160 170 180 190 200
YQTLELEKEF HFNRYLTRRR RIEIANALCL TERQIKIWFQ NRRMKWKKES
210 220 230
NLTSTLSGGG GGATADSLGG KEEKREETEE EKQKE
Length:235
Mass (Da):26,915
Last modified:July 1, 1993 - v2
Checksum:iBD695C7347CB71C0
GO
Isoform PRI (identifier: P10629-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: Missing.

Show »
Length:153
Mass (Da):17,834
Checksum:i291E2439914263AE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15 – 18AGGQ → QQRP in CAA31022 (PubMed:2901346).Curated4
Sequence conflicti131S → N in AAA37854 (PubMed:2458223).Curated1
Sequence conflicti131S → N in CAA34737 (PubMed:2458223).Curated1
Sequence conflicti192R → A in AAA37854 (PubMed:2458223).Curated1
Sequence conflicti192R → A in CAA34737 (PubMed:2458223).Curated1
Sequence conflicti228 – 229TE → QK (PubMed:7905473).Curated2
Sequence conflicti228 – 229TE → QK (PubMed:1684715).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0023931 – 82Missing in isoform PRI. CuratedAdd BLAST82

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03074 mRNA. Translation: AAA37832.1.
M35986 mRNA. Translation: AAA37854.1.
X16511 mRNA. Translation: CAA34518.1.
X16510 mRNA. Translation: CAA34517.1.
S74185 Unassigned DNA. Translation: AAB20717.1.
X12504 mRNA. Translation: CAA31022.1.
X12504 mRNA. Translation: CAA31023.1.
X16838 mRNA. Translation: CAA34737.1.
CCDSiCCDS27895.1. [P10629-1]
PIRiA32167.
A56568.
S00987. WJMSX6.
RefSeqiNP_034595.2. NM_010465.2. [P10629-1]
XP_006520532.1. XM_006520469.2. [P10629-2]
UniGeneiMm.4444.

Genome annotation databases

EnsembliENSMUST00000001711; ENSMUSP00000001711; ENSMUSG00000001661. [P10629-1]
GeneIDi15425.
KEGGimmu:15425.
UCSCiuc007xxc.1. mouse. [P10629-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiHXC6_MOUSE
AccessioniPrimary (citable) accession number: P10629
Secondary accession number(s): Q61683
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1993
Last modified: September 27, 2017
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families