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P10629 (HXC6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 139. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-C6
Alternative name(s):
Homeobox protein Hox-3.3
Homeobox protein Hox-6.1
Gene names
Name:Hoxc6
Synonyms:Hox-3.3, Hoxc-6
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length235 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the Antp homeobox family.

Contains 1 homeobox DNA-binding domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform PRII (identifier: P10629-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform PRI (identifier: P10629-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 235235Homeobox protein Hox-C6
PRO_0000200175

Regions

DNA binding141 – 20060Homeobox
Motif122 – 1276Antp-type hexapeptide
Compositional bias221 – 23515Glu/Lys-rich

Natural variations

Alternative sequence1 – 8282Missing in isoform PRI.
VSP_002393

Experimental info

Sequence conflict15 – 184AGGQ → QQRP in CAA31022. Ref.3
Sequence conflict1311S → N in AAA37854. Ref.4
Sequence conflict1311S → N in CAA34737. Ref.4
Sequence conflict1921R → A in AAA37854. Ref.4
Sequence conflict1921R → A in CAA34737. Ref.4
Sequence conflict228 – 2292TE → QK Ref.1
Sequence conflict228 – 2292TE → QK Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform PRII [UniParc].

Last modified July 1, 1993. Version 2.
Checksum: BD695C7347CB71C0

FASTA23526,915
        10         20         30         40         50         60 
MNSYFTNPSL SCHLAGGQDV LPNVALNSTA YDPVRHFSTY GAAVAQNRIY STPFYSPQEN 

        70         80         90        100        110        120 
VVFSSSRGPY DYGSNSFYQE KDMLSNCRQN TLGHNTQTSI AQDFSSEQGR TAPQDQKASI 

       130        140        150        160        170        180 
QIYPWMQRMN SHSGVGYGAD RRRGRQIYSR YQTLELEKEF HFNRYLTRRR RIEIANALCL 

       190        200        210        220        230 
TERQIKIWFQ NRRMKWKKES NLTSTLSGGG GGATADSLGG KEEKREETEE EKQKE 

« Hide

Isoform PRI [UniParc].

Checksum: 291E2439914263AE
Show »

FASTA15317,834

References

[1]"Spatial localisation of transcripts of the Hox-C6 gene."
Shimeld S.M., Gaunt S.J., Coletta P.L., Geada A.M., Sharpe P.T.
J. Anat. 183:515-523(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Characterisation of the murine Hox-3.3 gene and its promoter."
Coletta P.L., Shimeld S.M., Chaudhuri C., Mueller U., Clarke J.P., Sharpe P.T.
Mech. Dev. 35:129-142(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[3]"Expression of multiple homeobox genes within diverse mammalian haemopoietic lineages."
Kongsuwan K., Webb E., Housiaux P., Adams J.M.
EMBO J. 7:2131-2138(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 15-235.
Tissue: Bone marrow and Spleen.
[4]"Isolation and expression of a new mouse homeobox gene."
Sharpe P.T., Miller J.R., Evans E.P., Burtenshaw M.D., Gaunt S.J.
Development 102:397-407(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 131-235.
Tissue: Kidney.
[5]"Isolation and regional localization of the murine homeobox-containing gene Hox-3.3 to mouse chromosome region 15E."
Schughart K., Pravtcheva D., Newman M.S., Hunihan L.W., Jiang Z., Ruddle F.H.
Genomics 5:76-83(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 133-235.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J03074 mRNA. Translation: AAA37832.1.
M35986 mRNA. Translation: AAA37854.1.
X16511 mRNA. Translation: CAA34518.1.
X16510 mRNA. Translation: CAA34517.1.
S74185 Unassigned DNA. Translation: AAB20717.1.
X12504 mRNA. Translation: CAA31022.1.
X12504 mRNA. Translation: CAA31023.1.
X16838 mRNA. Translation: CAA34737.1.
CCDSCCDS27895.1. [P10629-1]
PIRA32167.
A56568.
WJMSX6. S00987.
RefSeqNP_034595.2. NM_010465.2. [P10629-1]
XP_006520532.1. XM_006520469.1. [P10629-2]
UniGeneMm.4444.

3D structure databases

ProteinModelPortalP10629.
SMRP10629. Positions 148-200.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid200388. 1 interaction.

PTM databases

PhosphoSiteP10629.

Proteomic databases

PRIDEP10629.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000001711; ENSMUSP00000001711; ENSMUSG00000001661. [P10629-1]
GeneID15425.
KEGGmmu:15425.
UCSCuc007xxc.1. mouse. [P10629-1]

Organism-specific databases

CTD3223.
MGIMGI:96197. Hoxc6.

Phylogenomic databases

eggNOGNOG266030.
GeneTreeENSGT00730000110212.
HOGENOMHOG000231181.
HOVERGENHBG016849.
InParanoidP10629.
KOK09306.
OMAMNSYFAN.
PhylomeDBP10629.
TreeFamTF316310.

Gene expression databases

ArrayExpressP10629.
BgeeP10629.
CleanExMM_HOXC6.
GenevestigatorP10629.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSHOXC6. mouse.
NextBio288174.
PROP10629.
SOURCESearch...

Entry information

Entry nameHXC6_MOUSE
AccessionPrimary (citable) accession number: P10629
Secondary accession number(s): Q61683
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1993
Last modified: July 9, 2014
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries