Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Homeobox protein Hox-D4

Gene

Hoxd4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi152 – 21160HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. anterior/posterior pattern specification Source: MGI
  2. embryonic skeletal system morphogenesis Source: MGI
  3. stem cell differentiation Source: MGI
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-D4
Alternative name(s):
Homeobox protein Hox-4.2
Homeobox protein Hox-5.1
Gene namesi
Name:Hoxd4
Synonyms:Hox-4.2, Hoxd-4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:96208. Hoxd4.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 250250Homeobox protein Hox-D4PRO_0000200211Add
BLAST

Proteomic databases

PRIDEiP10628.

PTM databases

PhosphoSiteiP10628.

Expressioni

Gene expression databases

BgeeiP10628.
GenevestigatoriP10628.

Interactioni

Protein-protein interaction databases

BioGridi200397. 3 interactions.
STRINGi10090.ENSMUSP00000047949.

Structurei

3D structure databases

ProteinModelPortaliP10628.
SMRiP10628. Positions 156-211.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi131 – 1366Antp-type hexapeptide

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi220 – 22910Ser-rich

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG314883.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231179.
HOVERGENiHBG016849.
InParanoidiP10628.
KOiK09304.
OMAiGLYPRPD.
OrthoDBiEOG780RP4.
PhylomeDBiP10628.
TreeFamiTF352857.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10628-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMSSYMVNS KYVDPKFPPC EEYLQGGYLG EQGADYYGSG AQGADFQPSG
60 70 80 90 100
LYPRPDFGEQ PFGGGGPGPG SALPARGHGQ EPSGPGSHYG APGERCPAPP
110 120 130 140 150
PAPLPGARAC SQPTGPKQPP PGTALKQPAV VYPWMKKVHV NSVNPNYTGG
160 170 180 190 200
EPKRSRTAYT RQQVLELEKE FHFNRYLTRR RRIEIAHTLC LSERQIKIWF
210 220 230 240 250
QNRRMKWKKD HKLPNTKGRS SSSSSCSSSA APGQHLQPMA KDHHTDLTTL
Length:250
Mass (Da):27,371
Last modified:September 5, 2006 - v3
Checksum:i2B20A00BAD1B8757
GO

Sequence cautioni

The sequence AAA20072.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti95 – 951R → P (PubMed:2898782).Curated
Sequence conflicti95 – 951R → P (PubMed:9360992).Curated
Sequence conflicti143 – 1431V → A in AAA20072 (PubMed:2898782).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03770 mRNA. Translation: AAA20072.1. Different initiation.
U77364 Genomic DNA. Translation: AAB41222.1.
AK135479 mRNA. Translation: BAE22547.1.
AL928644 Genomic DNA. Translation: CAM20533.1.
M87804 Genomic DNA. Translation: AAA37851.1.
CCDSiCCDS16145.1.
PIRiA36170.
E42694.
RefSeqiNP_034599.2. NM_010469.2.
UniGeneiMm.482194.

Genome annotation databases

EnsembliENSMUST00000047904; ENSMUSP00000047949; ENSMUSG00000101174.
ENSMUST00000111980; ENSMUSP00000107611; ENSMUSG00000101174.
GeneIDi15436.
KEGGimmu:15436.
UCSCiuc008kef.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03770 mRNA. Translation: AAA20072.1. Different initiation.
U77364 Genomic DNA. Translation: AAB41222.1.
AK135479 mRNA. Translation: BAE22547.1.
AL928644 Genomic DNA. Translation: CAM20533.1.
M87804 Genomic DNA. Translation: AAA37851.1.
CCDSiCCDS16145.1.
PIRiA36170.
E42694.
RefSeqiNP_034599.2. NM_010469.2.
UniGeneiMm.482194.

3D structure databases

ProteinModelPortaliP10628.
SMRiP10628. Positions 156-211.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200397. 3 interactions.
STRINGi10090.ENSMUSP00000047949.

PTM databases

PhosphoSiteiP10628.

Proteomic databases

PRIDEiP10628.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047904; ENSMUSP00000047949; ENSMUSG00000101174.
ENSMUST00000111980; ENSMUSP00000107611; ENSMUSG00000101174.
GeneIDi15436.
KEGGimmu:15436.
UCSCiuc008kef.1. mouse.

Organism-specific databases

CTDi3233.
MGIiMGI:96208. Hoxd4.

Phylogenomic databases

eggNOGiNOG314883.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231179.
HOVERGENiHBG016849.
InParanoidiP10628.
KOiK09304.
OMAiGLYPRPD.
OrthoDBiEOG780RP4.
PhylomeDBiP10628.
TreeFamiTF352857.

Miscellaneous databases

NextBioi288210.
PROiP10628.
SOURCEiSearch...

Gene expression databases

BgeeiP10628.
GenevestigatoriP10628.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Hox-5.1 defines a homeobox-containing gene locus on mouse chromosome 2."
    Featherstone M.S., Baron A., Gaunt S.J., Mattei M.-G., Duboule D.
    Proc. Natl. Acad. Sci. U.S.A. 85:4760-4764(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "A proline-rich transcriptional activation domain in murine HOXD-4 (HOX-4.2)."
    Rambaldi I., Kovacs E.N., Featherstone M.S.
    Nucleic Acids Res. 22:376-382(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  3. "Characterization and retinoic acid responsiveness of the murine Hoxd4 transcription unit."
    Folberg A., Kovacs E.N., Featherstone M.S.
    J. Biol. Chem. 272:29151-29157(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Muellerian duct.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  6. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 175-198.

Entry informationi

Entry nameiHXD4_MOUSE
AccessioniPrimary (citable) accession number: P10628
Secondary accession number(s): A2ASN3, P97451, Q3UXL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: September 5, 2006
Last modified: March 4, 2015
This is version 141 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.