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P10628 (HXD4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 136. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-D4
Alternative name(s):
Homeobox protein Hox-4.2
Homeobox protein Hox-5.1
Gene names
Name:Hoxd4
Synonyms:Hox-4.2, Hoxd-4
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length250 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the Antp homeobox family. Deformed subfamily.

Contains 1 homeobox DNA-binding domain.

Sequence caution

The sequence AAA20072.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmulticellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 250250Homeobox protein Hox-D4
PRO_0000200211

Regions

DNA binding152 – 21160Homeobox
Motif131 – 1366Antp-type hexapeptide
Compositional bias220 – 22910Ser-rich

Experimental info

Sequence conflict951R → P Ref.1
Sequence conflict951R → P Ref.3
Sequence conflict1431V → A in AAA20072. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P10628 [UniParc].

Last modified September 5, 2006. Version 3.
Checksum: 2B20A00BAD1B8757

FASTA25027,371
        10         20         30         40         50         60 
MAMSSYMVNS KYVDPKFPPC EEYLQGGYLG EQGADYYGSG AQGADFQPSG LYPRPDFGEQ 

        70         80         90        100        110        120 
PFGGGGPGPG SALPARGHGQ EPSGPGSHYG APGERCPAPP PAPLPGARAC SQPTGPKQPP 

       130        140        150        160        170        180 
PGTALKQPAV VYPWMKKVHV NSVNPNYTGG EPKRSRTAYT RQQVLELEKE FHFNRYLTRR 

       190        200        210        220        230        240 
RRIEIAHTLC LSERQIKIWF QNRRMKWKKD HKLPNTKGRS SSSSSCSSSA APGQHLQPMA 

       250 
KDHHTDLTTL 

« Hide

References

« Hide 'large scale' references
[1]"Hox-5.1 defines a homeobox-containing gene locus on mouse chromosome 2."
Featherstone M.S., Baron A., Gaunt S.J., Mattei M.-G., Duboule D.
Proc. Natl. Acad. Sci. U.S.A. 85:4760-4764(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"A proline-rich transcriptional activation domain in murine HOXD-4 (HOX-4.2)."
Rambaldi I., Kovacs E.N., Featherstone M.S.
Nucleic Acids Res. 22:376-382(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION.
[3]"Characterization and retinoic acid responsiveness of the murine Hoxd4 transcription unit."
Folberg A., Kovacs E.N., Featherstone M.S.
J. Biol. Chem. 272:29151-29157(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/Sv.
[4]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Muellerian duct.
[5]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[6]"Hox-1.11 and Hox-4.9 homeobox genes."
Nazarali A., Kim Y., Nirenberg M.
Proc. Natl. Acad. Sci. U.S.A. 89:2883-2887(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 175-198.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J03770 mRNA. Translation: AAA20072.1. Different initiation.
U77364 Genomic DNA. Translation: AAB41222.1.
AK135479 mRNA. Translation: BAE22547.1.
AL928644 Genomic DNA. Translation: CAM20533.1.
M87804 Genomic DNA. Translation: AAA37851.1.
CCDSCCDS16145.1.
PIRA36170.
E42694.
RefSeqNP_034599.2. NM_010469.2.
UniGeneMm.482194.

3D structure databases

ProteinModelPortalP10628.
SMRP10628. Positions 156-211.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid200397. 3 interactions.
STRING10090.ENSMUSP00000047949.

PTM databases

PhosphoSiteP10628.

Proteomic databases

PRIDEP10628.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000047904; ENSMUSP00000047949; ENSMUSG00000079277.
ENSMUST00000111980; ENSMUSP00000107611; ENSMUSG00000079277.
GeneID15436.
KEGGmmu:15436.
UCSCuc008kef.1. mouse.

Organism-specific databases

CTD3233.
MGIMGI:96208. Hoxd4.

Phylogenomic databases

eggNOGNOG314883.
GeneTreeENSGT00750000117486.
HOGENOMHOG000231179.
HOVERGENHBG016849.
InParanoidA2ASN3.
KOK09304.
OMAGLYPRPD.
OrthoDBEOG780RP4.
PhylomeDBP10628.
TreeFamTF352857.

Gene expression databases

ArrayExpressP10628.
BgeeP10628.
GenevestigatorP10628.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio288210.
PROP10628.
SOURCESearch...

Entry information

Entry nameHXD4_MOUSE
AccessionPrimary (citable) accession number: P10628
Secondary accession number(s): A2ASN3, P97451, Q3UXL6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: September 5, 2006
Last modified: July 9, 2014
This is version 136 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries