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Protein

Homeobox protein Hox-D4

Gene

Hoxd4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi152 – 211HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • anterior/posterior pattern specification Source: MGI
  • embryonic skeletal system morphogenesis Source: MGI
  • stem cell differentiation Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-5617472. Activation of anterior HOX genes in hindbrain development during early embryogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-D4
Alternative name(s):
Homeobox protein Hox-4.2
Homeobox protein Hox-5.1
Gene namesi
Name:Hoxd4
Synonyms:Hox-4.2, Hoxd-4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:96208. Hoxd4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002002111 – 250Homeobox protein Hox-D4Add BLAST250

Proteomic databases

MaxQBiP10628.
PaxDbiP10628.
PRIDEiP10628.

PTM databases

PhosphoSitePlusiP10628.

Expressioni

Gene expression databases

BgeeiENSMUSG00000079277.
GenevisibleiP10628. MM.

Interactioni

Protein-protein interaction databases

BioGridi200397. 3 interactors.
STRINGi10090.ENSMUSP00000047949.

Structurei

3D structure databases

ProteinModelPortaliP10628.
SMRiP10628.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi131 – 136Antp-type hexapeptide6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi220 – 229Ser-rich10

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231179.
HOVERGENiHBG016849.
InParanoidiP10628.
KOiK09304.
OMAiGLYPRPD.
OrthoDBiEOG091G09XD.
PhylomeDBiP10628.
TreeFamiTF352857.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10628-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMSSYMVNS KYVDPKFPPC EEYLQGGYLG EQGADYYGSG AQGADFQPSG
60 70 80 90 100
LYPRPDFGEQ PFGGGGPGPG SALPARGHGQ EPSGPGSHYG APGERCPAPP
110 120 130 140 150
PAPLPGARAC SQPTGPKQPP PGTALKQPAV VYPWMKKVHV NSVNPNYTGG
160 170 180 190 200
EPKRSRTAYT RQQVLELEKE FHFNRYLTRR RRIEIAHTLC LSERQIKIWF
210 220 230 240 250
QNRRMKWKKD HKLPNTKGRS SSSSSCSSSA APGQHLQPMA KDHHTDLTTL
Length:250
Mass (Da):27,371
Last modified:September 5, 2006 - v3
Checksum:i2B20A00BAD1B8757
GO

Sequence cautioni

The sequence AAA20072 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti95R → P (PubMed:2898782).Curated1
Sequence conflicti95R → P (PubMed:9360992).Curated1
Sequence conflicti143V → A in AAA20072 (PubMed:2898782).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03770 mRNA. Translation: AAA20072.1. Different initiation.
U77364 Genomic DNA. Translation: AAB41222.1.
AK135479 mRNA. Translation: BAE22547.1.
AL928644 Genomic DNA. Translation: CAM20533.1.
M87804 Genomic DNA. Translation: AAA37851.1.
CCDSiCCDS16145.1.
PIRiA36170.
E42694.
RefSeqiNP_034599.2. NM_010469.2.
UniGeneiMm.482194.

Genome annotation databases

EnsembliENSMUST00000047904; ENSMUSP00000047949; ENSMUSG00000101174.
ENSMUST00000111980; ENSMUSP00000107611; ENSMUSG00000101174.
GeneIDi15436.
KEGGimmu:15436.
UCSCiuc008kef.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03770 mRNA. Translation: AAA20072.1. Different initiation.
U77364 Genomic DNA. Translation: AAB41222.1.
AK135479 mRNA. Translation: BAE22547.1.
AL928644 Genomic DNA. Translation: CAM20533.1.
M87804 Genomic DNA. Translation: AAA37851.1.
CCDSiCCDS16145.1.
PIRiA36170.
E42694.
RefSeqiNP_034599.2. NM_010469.2.
UniGeneiMm.482194.

3D structure databases

ProteinModelPortaliP10628.
SMRiP10628.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200397. 3 interactors.
STRINGi10090.ENSMUSP00000047949.

PTM databases

PhosphoSitePlusiP10628.

Proteomic databases

MaxQBiP10628.
PaxDbiP10628.
PRIDEiP10628.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047904; ENSMUSP00000047949; ENSMUSG00000101174.
ENSMUST00000111980; ENSMUSP00000107611; ENSMUSG00000101174.
GeneIDi15436.
KEGGimmu:15436.
UCSCiuc008kef.1. mouse.

Organism-specific databases

CTDi3233.
MGIiMGI:96208. Hoxd4.

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231179.
HOVERGENiHBG016849.
InParanoidiP10628.
KOiK09304.
OMAiGLYPRPD.
OrthoDBiEOG091G09XD.
PhylomeDBiP10628.
TreeFamiTF352857.

Enzyme and pathway databases

ReactomeiR-MMU-5617472. Activation of anterior HOX genes in hindbrain development during early embryogenesis.

Miscellaneous databases

PROiP10628.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000079277.
GenevisibleiP10628. MM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHXD4_MOUSE
AccessioniPrimary (citable) accession number: P10628
Secondary accession number(s): A2ASN3, P97451, Q3UXL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: September 5, 2006
Last modified: November 2, 2016
This is version 151 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.