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P10628

- HXD4_MOUSE

UniProt

P10628 - HXD4_MOUSE

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Protein

Homeobox protein Hox-D4

Gene
Hoxd4, Hox-4.2, Hoxd-4
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi152 – 21160HomeoboxAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-D4
Alternative name(s):
Homeobox protein Hox-4.2
Homeobox protein Hox-5.1
Gene namesi
Name:Hoxd4
Synonyms:Hox-4.2, Hoxd-4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:96208. Hoxd4.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 250250Homeobox protein Hox-D4PRO_0000200211Add
BLAST

Proteomic databases

PRIDEiP10628.

PTM databases

PhosphoSiteiP10628.

Expressioni

Gene expression databases

ArrayExpressiP10628.
BgeeiP10628.
GenevestigatoriP10628.

Interactioni

Protein-protein interaction databases

BioGridi200397. 3 interactions.
STRINGi10090.ENSMUSP00000047949.

Structurei

3D structure databases

ProteinModelPortaliP10628.
SMRiP10628. Positions 156-211.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi131 – 1366Antp-type hexapeptide

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi220 – 22910Ser-rich

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG314883.
GeneTreeiENSGT00750000117486.
HOGENOMiHOG000231179.
HOVERGENiHBG016849.
InParanoidiA2ASN3.
KOiK09304.
OMAiGLYPRPD.
OrthoDBiEOG780RP4.
PhylomeDBiP10628.
TreeFamiTF352857.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10628-1 [UniParc]FASTAAdd to Basket

« Hide

MAMSSYMVNS KYVDPKFPPC EEYLQGGYLG EQGADYYGSG AQGADFQPSG    50
LYPRPDFGEQ PFGGGGPGPG SALPARGHGQ EPSGPGSHYG APGERCPAPP 100
PAPLPGARAC SQPTGPKQPP PGTALKQPAV VYPWMKKVHV NSVNPNYTGG 150
EPKRSRTAYT RQQVLELEKE FHFNRYLTRR RRIEIAHTLC LSERQIKIWF 200
QNRRMKWKKD HKLPNTKGRS SSSSSCSSSA APGQHLQPMA KDHHTDLTTL 250
Length:250
Mass (Da):27,371
Last modified:September 5, 2006 - v3
Checksum:i2B20A00BAD1B8757
GO

Sequence cautioni

The sequence AAA20072.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti95 – 951R → P1 Publication
Sequence conflicti95 – 951R → P1 Publication
Sequence conflicti143 – 1431V → A in AAA20072. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J03770 mRNA. Translation: AAA20072.1. Different initiation.
U77364 Genomic DNA. Translation: AAB41222.1.
AK135479 mRNA. Translation: BAE22547.1.
AL928644 Genomic DNA. Translation: CAM20533.1.
M87804 Genomic DNA. Translation: AAA37851.1.
CCDSiCCDS16145.1.
PIRiA36170.
E42694.
RefSeqiNP_034599.2. NM_010469.2.
UniGeneiMm.482194.

Genome annotation databases

EnsembliENSMUST00000047904; ENSMUSP00000047949; ENSMUSG00000079277.
ENSMUST00000111980; ENSMUSP00000107611; ENSMUSG00000079277.
GeneIDi15436.
KEGGimmu:15436.
UCSCiuc008kef.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J03770 mRNA. Translation: AAA20072.1 . Different initiation.
U77364 Genomic DNA. Translation: AAB41222.1 .
AK135479 mRNA. Translation: BAE22547.1 .
AL928644 Genomic DNA. Translation: CAM20533.1 .
M87804 Genomic DNA. Translation: AAA37851.1 .
CCDSi CCDS16145.1.
PIRi A36170.
E42694.
RefSeqi NP_034599.2. NM_010469.2.
UniGenei Mm.482194.

3D structure databases

ProteinModelPortali P10628.
SMRi P10628. Positions 156-211.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200397. 3 interactions.
STRINGi 10090.ENSMUSP00000047949.

PTM databases

PhosphoSitei P10628.

Proteomic databases

PRIDEi P10628.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000047904 ; ENSMUSP00000047949 ; ENSMUSG00000079277 .
ENSMUST00000111980 ; ENSMUSP00000107611 ; ENSMUSG00000079277 .
GeneIDi 15436.
KEGGi mmu:15436.
UCSCi uc008kef.1. mouse.

Organism-specific databases

CTDi 3233.
MGIi MGI:96208. Hoxd4.

Phylogenomic databases

eggNOGi NOG314883.
GeneTreei ENSGT00750000117486.
HOGENOMi HOG000231179.
HOVERGENi HBG016849.
InParanoidi A2ASN3.
KOi K09304.
OMAi GLYPRPD.
OrthoDBi EOG780RP4.
PhylomeDBi P10628.
TreeFami TF352857.

Miscellaneous databases

NextBioi 288210.
PROi P10628.
SOURCEi Search...

Gene expression databases

ArrayExpressi P10628.
Bgeei P10628.
Genevestigatori P10628.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Hox-5.1 defines a homeobox-containing gene locus on mouse chromosome 2."
    Featherstone M.S., Baron A., Gaunt S.J., Mattei M.-G., Duboule D.
    Proc. Natl. Acad. Sci. U.S.A. 85:4760-4764(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "A proline-rich transcriptional activation domain in murine HOXD-4 (HOX-4.2)."
    Rambaldi I., Kovacs E.N., Featherstone M.S.
    Nucleic Acids Res. 22:376-382(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  3. "Characterization and retinoic acid responsiveness of the murine Hoxd4 transcription unit."
    Folberg A., Kovacs E.N., Featherstone M.S.
    J. Biol. Chem. 272:29151-29157(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Muellerian duct.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  6. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 175-198.

Entry informationi

Entry nameiHXD4_MOUSE
AccessioniPrimary (citable) accession number: P10628
Secondary accession number(s): A2ASN3, P97451, Q3UXL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: September 5, 2006
Last modified: July 9, 2014
This is version 136 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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