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Protein

Lysosomal protective protein

Gene

CTSA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins.1 Publication

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1781
Active sitei400By similarity1
Active sitei4571

GO - Molecular functioni

  • carboxypeptidase activity Source: ProtInc
  • enzyme activator activity Source: ProtInc
  • exo-alpha-sialidase activity Source: Reactome
  • serine-type carboxypeptidase activity Source: ParkinsonsUK-UCL

GO - Biological processi

  • glycosphingolipid metabolic process Source: Reactome
  • intracellular protein transport Source: ProtInc
  • negative regulation of chaperone-mediated autophagy Source: ParkinsonsUK-UCL
  • proteolysis Source: ParkinsonsUK-UCL
  • proteolysis involved in cellular protein catabolic process Source: GO_Central
  • regulation of chaperone-mediated autophagy Source: ParkinsonsUK-UCL
  • regulation of protein stability Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Enzyme and pathway databases

BioCyciZFISH:ENSG00000101445-MONOMER.
ZFISH:HS00808-MONOMER.
BRENDAi3.4.16.5. 2681.
ReactomeiR-HSA-1660662. Glycosphingolipid metabolism.
R-HSA-2132295. MHC class II antigen presentation.
R-HSA-4085001. Sialic acid metabolism.
R-HSA-6798695. Neutrophil degranulation.
SABIO-RKP10619.
SignaLinkiP10619.

Protein family/group databases

ESTHERihuman-CTSA. Carboxypeptidase_S10.
MEROPSiS10.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosomal protective protein (EC:3.4.16.5)
Alternative name(s):
Carboxypeptidase C
Carboxypeptidase L
Cathepsin A
Protective protein cathepsin A
Short name:
PPCA
Protective protein for beta-galactosidase
Cleaved into the following 2 chains:
Gene namesi
Name:CTSA
Synonyms:PPGB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:9251. CTSA.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum Source: ProtInc
  • extracellular exosome Source: UniProtKB
  • intracellular membrane-bounded organelle Source: HPA
  • lysosomal lumen Source: Reactome
  • lysosome Source: UniProtKB
  • membrane Source: UniProtKB
  • nucleoplasm Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Lysosome

Pathology & Biotechi

Involvement in diseasei

Galactosialidosis (GSL)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA lysosomal storage disease associated with a combined deficiency of beta-galactosidase and neuraminidase, secondary to a defect in cathepsin A. All patients have clinical manifestations typical of a lysosomal disorder, such as coarse facies, cherry red spots, vertebral changes, foam cells in the bone marrow, and vacuolated lymphocytes. Three phenotypic subtypes are recognized. The early infantile form is associated with fetal hydrops, edema, ascites, visceromegaly, skeletal dysplasia, and early death. The late infantile type is characterized by hepatosplenomegaly, growth retardation, cardiac involvement, and a normal or mildly affected mental state. The juvenile/adult form is characterized by myoclonus, ataxia, angiokeratoma, mental retardation, neurologic deterioration, absence of visceromegaly, and long survival.
See also OMIM:256540
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00138549Q → R in GSL. 1 PublicationCorresponds to variant rs137854541dbSNPEnsembl.1
Natural variantiVAR_06301851S → Y in GSL. 1 Publication1
Natural variantiVAR_00138665W → R in GSL. 1 PublicationCorresponds to variant rs28934603dbSNPEnsembl.1
Natural variantiVAR_00138790S → L in GSL. 1 PublicationCorresponds to variant rs137854542dbSNPEnsembl.1
Natural variantiVAR_063019132V → M in GSL. 1 PublicationCorresponds to variant rs137854545dbSNPEnsembl.1
Natural variantiVAR_063020236L → P in GSL. 1 PublicationCorresponds to variant rs137854546dbSNPEnsembl.1
Natural variantiVAR_001388249Y → N in GSL; small amount of activity. 2 PublicationsCorresponds to variant rs137854544dbSNPEnsembl.1
Natural variantiVAR_001389395Y → C in GSL; loss of activity. 1 PublicationCorresponds to variant rs137854543dbSNPEnsembl.1
Natural variantiVAR_063021406M → T in GSL. 1 PublicationCorresponds to variant rs137854548dbSNPEnsembl.1
Natural variantiVAR_063022439G → S in GSL. 1 PublicationCorresponds to variant rs137854547dbSNPEnsembl.1
Natural variantiVAR_001390440F → V in GSL. 2 PublicationsCorresponds to variant rs137854540dbSNPEnsembl.1
Natural variantiVAR_063023453K → E in GSL. 1 PublicationCorresponds to variant rs137854549dbSNPEnsembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi178S → A: Inactivates the enzyme. 1 Publication1
Mutagenesisi457H → Q: Inactivates the enzyme. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi5476.
MalaCardsiCTSA.
MIMi256540. phenotype.
OpenTargetsiENSG00000064601.
Orphaneti351. Galactosialidosis.
PharmGKBiPA33572.

Chemistry databases

ChEMBLiCHEMBL6115.
GuidetoPHARMACOLOGYi1581.

Polymorphism and mutation databases

BioMutaiCTSA.
DMDMi20178316.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Combined sources2 PublicationsAdd BLAST28
ChainiPRO_000000427429 – 480Lysosomal protective proteinAdd BLAST452
ChainiPRO_000000427529 – 326Lysosomal protective protein 32 kDa chainAdd BLAST298
ChainiPRO_0000004276327 – 480Lysosomal protective protein 20 kDa chainAdd BLAST154

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi88 ↔ 362
Glycosylationi145N-linked (GlcNAc...)2 Publications1
Disulfide bondi240 ↔ 256
Disulfide bondi241 ↔ 246
Disulfide bondi281 ↔ 331
Glycosylationi333N-linked (GlcNAc...)1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

EPDiP10619.
MaxQBiP10619.
PaxDbiP10619.
PeptideAtlasiP10619.
PRIDEiP10619.
TopDownProteomicsiP10619-1. [P10619-1]
P10619-2. [P10619-2]

2D gel databases

OGPiP10619.

PTM databases

iPTMnetiP10619.
PhosphoSitePlusiP10619.
SwissPalmiP10619.

Expressioni

Gene expression databases

BgeeiENSG00000064601.
CleanExiHS_CTSA.
ExpressionAtlasiP10619. baseline and differential.
GenevisibleiP10619. HS.

Organism-specific databases

HPAiCAB024930.
HPA031068.

Interactioni

Subunit structurei

Heterodimer of a 32 kDa chain and a 20 kDa chain; disulfide-linked.

Protein-protein interaction databases

BioGridi111472. 33 interactors.
IntActiP10619. 12 interactors.
MINTiMINT-3007366.
STRINGi9606.ENSP00000361562.

Chemistry databases

BindingDBiP10619.

Structurei

Secondary structure

1480
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi31 – 33Combined sources3
Beta strandi41 – 43Combined sources3
Beta strandi49 – 55Combined sources7
Beta strandi60 – 67Combined sources8
Turni73 – 75Combined sources3
Beta strandi78 – 82Combined sources5
Turni85 – 87Combined sources3
Helixi91 – 96Combined sources6
Beta strandi99 – 103Combined sources5
Beta strandi110 – 112Combined sources3
Helixi117 – 119Combined sources3
Beta strandi120 – 126Combined sources7
Beta strandi136 – 139Combined sources4
Helixi146 – 163Combined sources18
Helixi165 – 167Combined sources3
Beta strandi168 – 170Combined sources3
Beta strandi172 – 177Combined sources6
Helixi180 – 192Combined sources13
Beta strandi199 – 206Combined sources8
Helixi211 – 224Combined sources14
Helixi230 – 240Combined sources11
Helixi254 – 268Combined sources15
Beta strandi269 – 271Combined sources3
Beta strandi286 – 292Combined sources7
Beta strandi295 – 298Combined sources4
Helixi315 – 317Combined sources3
Helixi318 – 321Combined sources4
Beta strandi324 – 327Combined sources4
Helixi335 – 341Combined sources7
Helixi344 – 349Combined sources6
Helixi364 – 369Combined sources6
Beta strandi375 – 377Combined sources3
Helixi378 – 386Combined sources9
Beta strandi391 – 397Combined sources7
Beta strandi401 – 403Combined sources3
Helixi405 – 414Combined sources10
Beta strandi424 – 429Combined sources6
Helixi431 – 433Combined sources3
Beta strandi435 – 444Combined sources10
Beta strandi447 – 452Combined sources6
Helixi459 – 462Combined sources4
Helixi464 – 475Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IVYX-ray2.20A/B29-480[»]
3BP4X-ray1.85C2-10[»]
3BP7X-ray1.80C2-10[»]
3BXNX-ray1.86C2-10[»]
4AZ0X-ray2.17A29-326[»]
B327-480[»]
4AZ3X-ray2.04A29-326[»]
B327-480[»]
4CI9X-ray1.58A29-480[»]
4CIAX-ray1.98A29-480[»]
4CIBX-ray1.89A29-480[»]
4MWSX-ray2.80A/B29-480[»]
4MWTX-ray3.85A/B29-480[»]
ProteinModelPortaliP10619.
SMRiP10619.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10619.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.
GeneTreeiENSGT00860000133774.
HOVERGENiHBG053652.
InParanoidiP10619.
KOiK13289.
PhylomeDBiP10619.
TreeFamiTF323769.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR033124. Ser_caboxypep_his_AS.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 2 hits.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P10619-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIRAAPPPLF LLLLLLLLLV SWASRGEAAP DQDEIQRLPG LAKQPSFRQY
60 70 80 90 100
SGYLKGSGSK HLHYWFVESQ KDPENSPVVL WLNGGPGCSS LDGLLTEHGP
110 120 130 140 150
FLVQPDGVTL EYNPYSWNLI ANVLYLESPA GVGFSYSDDK FYATNDTEVA
160 170 180 190 200
QSNFEALQDF FRLFPEYKNN KLFLTGESYA GIYIPTLAVL VMQDPSMNLQ
210 220 230 240 250
GLAVGNGLSS YEQNDNSLVY FAYYHGLLGN RLWSSLQTHC CSQNKCNFYD
260 270 280 290 300
NKDLECVTNL QEVARIVGNS GLNIYNLYAP CAGGVPSHFR YEKDTVVVQD
310 320 330 340 350
LGNIFTRLPL KRMWHQALLR SGDKVRMDPP CTNTTAASTY LNNPYVRKAL
360 370 380 390 400
NIPEQLPQWD MCNFLVNLQY RRLYRSMNSQ YLKLLSSQKY QILLYNGDVD
410 420 430 440 450
MACNFMGDEW FVDSLNQKME VQRRPWLVKY GDSGEQIAGF VKEFSHIAFL
460 470 480
TIKGAGHMVP TDKPLAAFTM FSRFLNKQPY
Length:480
Mass (Da):54,466
Last modified:April 16, 2002 - v2
Checksum:i46B737DEE775C508
GO
Isoform 2 (identifier: P10619-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     102-118: Missing.

Note: Gene prediction based on EST data.
Show »
Length:463
Mass (Da):52,489
Checksum:i7342A76945E40684
GO

Sequence cautioni

The sequence CAI20248 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19Missing in AAH00597 (PubMed:15489334).Curated1
Sequence conflicti56G → S in AAA36476 (PubMed:3136930).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00138549Q → R in GSL. 1 PublicationCorresponds to variant rs137854541dbSNPEnsembl.1
Natural variantiVAR_06301851S → Y in GSL. 1 Publication1
Natural variantiVAR_00138665W → R in GSL. 1 PublicationCorresponds to variant rs28934603dbSNPEnsembl.1
Natural variantiVAR_00138790S → L in GSL. 1 PublicationCorresponds to variant rs137854542dbSNPEnsembl.1
Natural variantiVAR_063019132V → M in GSL. 1 PublicationCorresponds to variant rs137854545dbSNPEnsembl.1
Natural variantiVAR_063020236L → P in GSL. 1 PublicationCorresponds to variant rs137854546dbSNPEnsembl.1
Natural variantiVAR_001388249Y → N in GSL; small amount of activity. 2 PublicationsCorresponds to variant rs137854544dbSNPEnsembl.1
Natural variantiVAR_001389395Y → C in GSL; loss of activity. 1 PublicationCorresponds to variant rs137854543dbSNPEnsembl.1
Natural variantiVAR_063021406M → T in GSL. 1 PublicationCorresponds to variant rs137854548dbSNPEnsembl.1
Natural variantiVAR_063022439G → S in GSL. 1 PublicationCorresponds to variant rs137854547dbSNPEnsembl.1
Natural variantiVAR_001390440F → V in GSL. 2 PublicationsCorresponds to variant rs137854540dbSNPEnsembl.1
Natural variantiVAR_063023453K → E in GSL. 1 PublicationCorresponds to variant rs137854549dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_054832102 – 118Missing in isoform 2. CuratedAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22960 mRNA. Translation: AAA36476.1.
AK312898 mRNA. Translation: BAG35745.1.
AL008726 Genomic DNA. Translation: CAA15501.1.
AL008726 Genomic DNA. Translation: CAI20248.1. Different initiation.
BC000597 mRNA. Translation: AAH00597.1.
BC093009 mRNA. Translation: AAH93009.1.
CCDSiCCDS46609.1. [P10619-1]
PIRiA31589.
RefSeqiNP_000299.2. NM_000308.3.
NP_001121167.1. NM_001127695.2. [P10619-1]
NP_001161066.1. NM_001167594.2.
UniGeneiHs.609336.

Genome annotation databases

EnsembliENST00000191018; ENSP00000191018; ENSG00000064601. [P10619-1]
ENST00000372459; ENSP00000361537; ENSG00000064601. [P10619-1]
GeneIDi5476.
KEGGihsa:5476.
UCSCiuc002xqj.5. human. [P10619-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22960 mRNA. Translation: AAA36476.1.
AK312898 mRNA. Translation: BAG35745.1.
AL008726 Genomic DNA. Translation: CAA15501.1.
AL008726 Genomic DNA. Translation: CAI20248.1. Different initiation.
BC000597 mRNA. Translation: AAH00597.1.
BC093009 mRNA. Translation: AAH93009.1.
CCDSiCCDS46609.1. [P10619-1]
PIRiA31589.
RefSeqiNP_000299.2. NM_000308.3.
NP_001121167.1. NM_001127695.2. [P10619-1]
NP_001161066.1. NM_001167594.2.
UniGeneiHs.609336.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IVYX-ray2.20A/B29-480[»]
3BP4X-ray1.85C2-10[»]
3BP7X-ray1.80C2-10[»]
3BXNX-ray1.86C2-10[»]
4AZ0X-ray2.17A29-326[»]
B327-480[»]
4AZ3X-ray2.04A29-326[»]
B327-480[»]
4CI9X-ray1.58A29-480[»]
4CIAX-ray1.98A29-480[»]
4CIBX-ray1.89A29-480[»]
4MWSX-ray2.80A/B29-480[»]
4MWTX-ray3.85A/B29-480[»]
ProteinModelPortaliP10619.
SMRiP10619.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111472. 33 interactors.
IntActiP10619. 12 interactors.
MINTiMINT-3007366.
STRINGi9606.ENSP00000361562.

Chemistry databases

BindingDBiP10619.
ChEMBLiCHEMBL6115.
GuidetoPHARMACOLOGYi1581.

Protein family/group databases

ESTHERihuman-CTSA. Carboxypeptidase_S10.
MEROPSiS10.002.

PTM databases

iPTMnetiP10619.
PhosphoSitePlusiP10619.
SwissPalmiP10619.

Polymorphism and mutation databases

BioMutaiCTSA.
DMDMi20178316.

2D gel databases

OGPiP10619.

Proteomic databases

EPDiP10619.
MaxQBiP10619.
PaxDbiP10619.
PeptideAtlasiP10619.
PRIDEiP10619.
TopDownProteomicsiP10619-1. [P10619-1]
P10619-2. [P10619-2]

Protocols and materials databases

DNASUi5476.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000191018; ENSP00000191018; ENSG00000064601. [P10619-1]
ENST00000372459; ENSP00000361537; ENSG00000064601. [P10619-1]
GeneIDi5476.
KEGGihsa:5476.
UCSCiuc002xqj.5. human. [P10619-1]

Organism-specific databases

CTDi5476.
DisGeNETi5476.
GeneCardsiCTSA.
HGNCiHGNC:9251. CTSA.
HPAiCAB024930.
HPA031068.
MalaCardsiCTSA.
MIMi256540. phenotype.
613111. gene.
neXtProtiNX_P10619.
OpenTargetsiENSG00000064601.
Orphaneti351. Galactosialidosis.
PharmGKBiPA33572.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.
GeneTreeiENSGT00860000133774.
HOVERGENiHBG053652.
InParanoidiP10619.
KOiK13289.
PhylomeDBiP10619.
TreeFamiTF323769.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000101445-MONOMER.
ZFISH:HS00808-MONOMER.
BRENDAi3.4.16.5. 2681.
ReactomeiR-HSA-1660662. Glycosphingolipid metabolism.
R-HSA-2132295. MHC class II antigen presentation.
R-HSA-4085001. Sialic acid metabolism.
R-HSA-6798695. Neutrophil degranulation.
SABIO-RKP10619.
SignaLinkiP10619.

Miscellaneous databases

ChiTaRSiCTSA. human.
EvolutionaryTraceiP10619.
GeneWikiiCathepsin_A.
GenomeRNAii5476.
PROiP10619.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000064601.
CleanExiHS_CTSA.
ExpressionAtlasiP10619. baseline and differential.
GenevisibleiP10619. HS.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR033124. Ser_caboxypep_his_AS.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 2 hits.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPPGB_HUMAN
AccessioniPrimary (citable) accession number: P10619
Secondary accession number(s): B2R798
, Q561W6, Q5JZH1, Q96KJ2, Q9BR08, Q9BW68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: April 16, 2002
Last modified: November 30, 2016
This is version 204 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Peptidase families
    Classification of peptidase families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.