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Protein

Cytochrome P450 2G1

Gene

Cyp2g1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. This isozyme seems to be implicated in olfaction.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi439 – 4391Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. arachidonic acid epoxygenase activity Source: GO_Central
  2. aromatase activity Source: UniProtKB-EC
  3. heme binding Source: GO_Central
  4. iron ion binding Source: InterPro
  5. monooxygenase activity Source: RGD
  6. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Source: GO_Central
  7. oxygen binding Source: GO_Central
  8. steroid hydroxylase activity Source: GO_Central

GO - Biological processi

  1. epoxygenase P450 pathway Source: GO_Central
  2. exogenous drug catabolic process Source: GO_Central
  3. oxidation-reduction process Source: GO_Central
  4. sensory perception of smell Source: UniProtKB-KW
  5. xenobiotic metabolic process Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Olfaction, Sensory transduction

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2G1 (EC:1.14.14.1)
Alternative name(s):
CYPIIG1
Cytochrome P450 olfactive
Cytochrome P450-OLF1
Gene namesi
Name:Cyp2g1
Synonyms:Cyp2g-1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi2477. Cyp2g1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: GO_Central
  2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. intracellular membrane-bounded organelle Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 494494Cytochrome P450 2G1PRO_0000051765Add
BLAST

Proteomic databases

PaxDbiP10610.
PRIDEiP10610.

Expressioni

Tissue specificityi

Olfactory epithelium.

Gene expression databases

GenevestigatoriP10610.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028261.

Structurei

3D structure databases

ProteinModelPortaliP10610.
SMRiP10610. Positions 31-494.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP10610.
KOiK07417.
OMAiNESFVEM.
OrthoDBiEOG7RBZ85.
PhylomeDBiP10610.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008067. Cyt_P450_E_grp-I_CYP2A-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01684. EP450ICYP2A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10610-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALGGAFSIF MTLCLSCLLI LIAWKRTSRG GKLPPGPTPI PFLGNLLQVR
60 70 80 90 100
IDATFQSFLK LQKKYGSVFT VYFGPRPVVI LCGHEAVKEA LVDQADDFSG
110 120 130 140 150
RGEMPTLEKN FQGYGLALSN GERWKILRRF SLTVLRNFGM GKRSIEERIQ
160 170 180 190 200
EEAGYLLEEL HKVKGAPIDP TFYLSRTVSN VICSVVFGKR FDYEDQRFRS
210 220 230 240 250
LMKMINESFV EMSMPWAQLY DMYWGVIQYF PGRHNRLYNL IEELKDFIAS
260 270 280 290 300
RVKINEASFD PSNPRDFIDC FLIKMYQDKS DPHSEFNLKN LVLTTLNLFF
310 320 330 340 350
AGTETVSSTL RYGFLLLMKY PEVEAKIHEE INQVIGTHRT PRVDDRAKMP
360 370 380 390 400
YTDAVIHEIQ RLTDIVPLGV PHNVIRDTHF RGYFLPKGTD VYPLIGSVLK
410 420 430 440 450
DPKYFRYPEA FYPQHFLDEQ GRFKKNDAFV AFSSGKRICV GEALARMELF
460 470 480 490
LYFTSILQRF SLRSLVPPAD IDIAHKISGF GNIPPTYELC FMAR
Length:494
Mass (Da):56,781
Last modified:July 1, 1989 - v1
Checksum:i8A06E256A9A48702
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31931
, M31923, M31924, M31925, M31926, M31927, M31928, M31929, M31930 Genomic DNA. Translation: AAA41069.1.
M33296 mRNA. Translation: AAA41070.2.
PIRiA35551.
RefSeqiNP_036919.1. NM_012787.1.
UniGeneiRn.10909.

Genome annotation databases

EnsembliENSRNOT00000028261; ENSRNOP00000028261; ENSRNOG00000020827.
GeneIDi25251.
KEGGirno:25251.
UCSCiRGD:2477. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31931
, M31923, M31924, M31925, M31926, M31927, M31928, M31929, M31930 Genomic DNA. Translation: AAA41069.1.
M33296 mRNA. Translation: AAA41070.2.
PIRiA35551.
RefSeqiNP_036919.1. NM_012787.1.
UniGeneiRn.10909.

3D structure databases

ProteinModelPortaliP10610.
SMRiP10610. Positions 31-494.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028261.

Proteomic databases

PaxDbiP10610.
PRIDEiP10610.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028261; ENSRNOP00000028261; ENSRNOG00000020827.
GeneIDi25251.
KEGGirno:25251.
UCSCiRGD:2477. rat.

Organism-specific databases

CTDi13108.
RGDi2477. Cyp2g1.

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP10610.
KOiK07417.
OMAiNESFVEM.
OrthoDBiEOG7RBZ85.
PhylomeDBiP10610.
TreeFamiTF352043.

Miscellaneous databases

NextBioi605869.

Gene expression databases

GenevestigatoriP10610.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008067. Cyt_P450_E_grp-I_CYP2A-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01684. EP450ICYP2A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Olfactory-specific cytochrome P-450 (P-450olf1; IIG1). Gene structure and developmental regulation."
    Nef P., Larabee T.M., Kagimoto K., Meyer U.A.
    J. Biol. Chem. 265:2903-2907(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Olfactory-specific cytochrome P-450. cDNA cloning of a novel neuroepithelial enzyme possibly involved in chemoreception."
    Nef P., Heldman J., Lazard D., Margalit T., Jaye M., Hanukoglu I., Lancet D.
    J. Biol. Chem. 264:6780-6785(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 2-494.

Entry informationi

Entry nameiCP2G1_RAT
AccessioniPrimary (citable) accession number: P10610
Secondary accession number(s): Q64589
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: February 4, 2015
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.