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P10610

- CP2G1_RAT

UniProt

P10610 - CP2G1_RAT

Protein

Cytochrome P450 2G1

Gene

Cyp2g1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. This isozyme seems to be implicated in olfaction.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi439 – 4391Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro
    4. monooxygenase activity Source: RGD

    GO - Biological processi

    1. response to stimulus Source: UniProtKB-KW
    2. sensory perception of smell Source: UniProtKB-KW

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2G1 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIG1
    Cytochrome P450 olfactive
    Cytochrome P450-OLF1
    Gene namesi
    Name:Cyp2g1
    Synonyms:Cyp2g-1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi2477. Cyp2g1.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 494494Cytochrome P450 2G1PRO_0000051765Add
    BLAST

    Proteomic databases

    PaxDbiP10610.
    PRIDEiP10610.

    Expressioni

    Tissue specificityi

    Olfactory epithelium.

    Gene expression databases

    GenevestigatoriP10610.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000028261.

    Structurei

    3D structure databases

    ProteinModelPortaliP10610.
    SMRiP10610. Positions 31-494.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    GeneTreeiENSGT00670000097868.
    HOGENOMiHOG000036992.
    HOVERGENiHBG015789.
    KOiK07417.
    OMAiNESFVEM.
    OrthoDBiEOG7RBZ85.
    PhylomeDBiP10610.
    TreeFamiTF352043.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008067. Cyt_P450_E_grp-I_CYP2A-like.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01684. EP450ICYP2A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P10610-1 [UniParc]FASTAAdd to Basket

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    MALGGAFSIF MTLCLSCLLI LIAWKRTSRG GKLPPGPTPI PFLGNLLQVR    50
    IDATFQSFLK LQKKYGSVFT VYFGPRPVVI LCGHEAVKEA LVDQADDFSG 100
    RGEMPTLEKN FQGYGLALSN GERWKILRRF SLTVLRNFGM GKRSIEERIQ 150
    EEAGYLLEEL HKVKGAPIDP TFYLSRTVSN VICSVVFGKR FDYEDQRFRS 200
    LMKMINESFV EMSMPWAQLY DMYWGVIQYF PGRHNRLYNL IEELKDFIAS 250
    RVKINEASFD PSNPRDFIDC FLIKMYQDKS DPHSEFNLKN LVLTTLNLFF 300
    AGTETVSSTL RYGFLLLMKY PEVEAKIHEE INQVIGTHRT PRVDDRAKMP 350
    YTDAVIHEIQ RLTDIVPLGV PHNVIRDTHF RGYFLPKGTD VYPLIGSVLK 400
    DPKYFRYPEA FYPQHFLDEQ GRFKKNDAFV AFSSGKRICV GEALARMELF 450
    LYFTSILQRF SLRSLVPPAD IDIAHKISGF GNIPPTYELC FMAR 494
    Length:494
    Mass (Da):56,781
    Last modified:July 1, 1989 - v1
    Checksum:i8A06E256A9A48702
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M31931
    , M31923, M31924, M31925, M31926, M31927, M31928, M31929, M31930 Genomic DNA. Translation: AAA41069.1.
    M33296 mRNA. Translation: AAA41070.2.
    PIRiA35551.
    RefSeqiNP_036919.1. NM_012787.1.
    UniGeneiRn.10909.

    Genome annotation databases

    EnsembliENSRNOT00000028261; ENSRNOP00000028261; ENSRNOG00000020827.
    GeneIDi25251.
    KEGGirno:25251.
    UCSCiRGD:2477. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M31931
    , M31923 , M31924 , M31925 , M31926 , M31927 , M31928 , M31929 , M31930 Genomic DNA. Translation: AAA41069.1 .
    M33296 mRNA. Translation: AAA41070.2 .
    PIRi A35551.
    RefSeqi NP_036919.1. NM_012787.1.
    UniGenei Rn.10909.

    3D structure databases

    ProteinModelPortali P10610.
    SMRi P10610. Positions 31-494.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000028261.

    Proteomic databases

    PaxDbi P10610.
    PRIDEi P10610.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000028261 ; ENSRNOP00000028261 ; ENSRNOG00000020827 .
    GeneIDi 25251.
    KEGGi rno:25251.
    UCSCi RGD:2477. rat.

    Organism-specific databases

    CTDi 13108.
    RGDi 2477. Cyp2g1.

    Phylogenomic databases

    eggNOGi COG2124.
    GeneTreei ENSGT00670000097868.
    HOGENOMi HOG000036992.
    HOVERGENi HBG015789.
    KOi K07417.
    OMAi NESFVEM.
    OrthoDBi EOG7RBZ85.
    PhylomeDBi P10610.
    TreeFami TF352043.

    Miscellaneous databases

    NextBioi 605869.

    Gene expression databases

    Genevestigatori P10610.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008067. Cyt_P450_E_grp-I_CYP2A-like.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01684. EP450ICYP2A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Olfactory-specific cytochrome P-450 (P-450olf1; IIG1). Gene structure and developmental regulation."
      Nef P., Larabee T.M., Kagimoto K., Meyer U.A.
      J. Biol. Chem. 265:2903-2907(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Olfactory-specific cytochrome P-450. cDNA cloning of a novel neuroepithelial enzyme possibly involved in chemoreception."
      Nef P., Heldman J., Lazard D., Margalit T., Jaye M., Hanukoglu I., Lancet D.
      J. Biol. Chem. 264:6780-6785(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 2-494.

    Entry informationi

    Entry nameiCP2G1_RAT
    AccessioniPrimary (citable) accession number: P10610
    Secondary accession number(s): Q64589
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3