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P10610 (CP2G1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cytochrome P450 2G1

EC=1.14.14.1
Alternative name(s):
CYPIIG1
Cytochrome P450 olfactive
Cytochrome P450-OLF1
Gene names
Name:Cyp2g1
Synonyms:Cyp2g-1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length494 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. This isozyme seems to be implicated in olfaction.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Tissue specificity

Olfactory epithelium.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 494494Cytochrome P450 2G1
PRO_0000051765

Sites

Metal binding4391Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
P10610 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: 8A06E256A9A48702

FASTA49456,781
        10         20         30         40         50         60 
MALGGAFSIF MTLCLSCLLI LIAWKRTSRG GKLPPGPTPI PFLGNLLQVR IDATFQSFLK 

        70         80         90        100        110        120 
LQKKYGSVFT VYFGPRPVVI LCGHEAVKEA LVDQADDFSG RGEMPTLEKN FQGYGLALSN 

       130        140        150        160        170        180 
GERWKILRRF SLTVLRNFGM GKRSIEERIQ EEAGYLLEEL HKVKGAPIDP TFYLSRTVSN 

       190        200        210        220        230        240 
VICSVVFGKR FDYEDQRFRS LMKMINESFV EMSMPWAQLY DMYWGVIQYF PGRHNRLYNL 

       250        260        270        280        290        300 
IEELKDFIAS RVKINEASFD PSNPRDFIDC FLIKMYQDKS DPHSEFNLKN LVLTTLNLFF 

       310        320        330        340        350        360 
AGTETVSSTL RYGFLLLMKY PEVEAKIHEE INQVIGTHRT PRVDDRAKMP YTDAVIHEIQ 

       370        380        390        400        410        420 
RLTDIVPLGV PHNVIRDTHF RGYFLPKGTD VYPLIGSVLK DPKYFRYPEA FYPQHFLDEQ 

       430        440        450        460        470        480 
GRFKKNDAFV AFSSGKRICV GEALARMELF LYFTSILQRF SLRSLVPPAD IDIAHKISGF 

       490 
GNIPPTYELC FMAR 

« Hide

References

[1]"Olfactory-specific cytochrome P-450 (P-450olf1; IIG1). Gene structure and developmental regulation."
Nef P., Larabee T.M., Kagimoto K., Meyer U.A.
J. Biol. Chem. 265:2903-2907(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Olfactory-specific cytochrome P-450. cDNA cloning of a novel neuroepithelial enzyme possibly involved in chemoreception."
Nef P., Heldman J., Lazard D., Margalit T., Jaye M., Hanukoglu I., Lancet D.
J. Biol. Chem. 264:6780-6785(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 2-494.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M31931 expand/collapse EMBL AC list , M31923, M31924, M31925, M31926, M31927, M31928, M31929, M31930 Genomic DNA. Translation: AAA41069.1.
M33296 mRNA. Translation: AAA41070.2.
PIRA35551.
RefSeqNP_036919.1. NM_012787.1.
UniGeneRn.10909.

3D structure databases

ProteinModelPortalP10610.
SMRP10610. Positions 31-494.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000028261.

Proteomic databases

PaxDbP10610.
PRIDEP10610.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000028261; ENSRNOP00000028261; ENSRNOG00000020827.
GeneID25251.
KEGGrno:25251.
UCSCRGD:2477. rat.

Organism-specific databases

CTD13108.
RGD2477. Cyp2g1.

Phylogenomic databases

eggNOGCOG2124.
GeneTreeENSGT00670000097868.
HOGENOMHOG000036992.
HOVERGENHBG015789.
KOK07417.
OMANESFVEM.
OrthoDBEOG7RBZ85.
PhylomeDBP10610.
TreeFamTF352043.

Gene expression databases

GenevestigatorP10610.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008067. Cyt_P450_E_grp-I_CYP2A-like.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR01684. EP450ICYP2A.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio605869.

Entry information

Entry nameCP2G1_RAT
AccessionPrimary (citable) accession number: P10610
Secondary accession number(s): Q64589
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: April 16, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families