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Protein

Cytochrome P450 2G1

Gene

Cyp2g1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. This isozyme seems to be implicated in olfaction.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi439Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
Biological processOlfaction, Sensory transduction
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2G1 (EC:1.14.14.1)
Alternative name(s):
CYPIIG1
Cytochrome P450 olfactive
Cytochrome P450-OLF1
Gene namesi
Name:Cyp2g1
Synonyms:Cyp2g-1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi2477 Cyp2g1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000517651 – 494Cytochrome P450 2G1Add BLAST494

Proteomic databases

PaxDbiP10610
PRIDEiP10610

PTM databases

PhosphoSitePlusiP10610

Expressioni

Tissue specificityi

Olfactory epithelium.

Gene expression databases

BgeeiENSRNOG00000020827
GenevisibleiP10610 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028261

Structurei

3D structure databases

ProteinModelPortaliP10610
SMRiP10610
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00880000137861
HOGENOMiHOG000036992
HOVERGENiHBG015789
InParanoidiP10610
KOiK07417
OMAiIKMHQDK
OrthoDBiEOG091G0BT8
PhylomeDBiP10610
TreeFamiTF352043

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR008067 Cyt_P450_E_grp-I_CYP2A-like
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR01684 EP450ICYP2A
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

P10610-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALGGAFSIF MTLCLSCLLI LIAWKRTSRG GKLPPGPTPI PFLGNLLQVR
60 70 80 90 100
IDATFQSFLK LQKKYGSVFT VYFGPRPVVI LCGHEAVKEA LVDQADDFSG
110 120 130 140 150
RGEMPTLEKN FQGYGLALSN GERWKILRRF SLTVLRNFGM GKRSIEERIQ
160 170 180 190 200
EEAGYLLEEL HKVKGAPIDP TFYLSRTVSN VICSVVFGKR FDYEDQRFRS
210 220 230 240 250
LMKMINESFV EMSMPWAQLY DMYWGVIQYF PGRHNRLYNL IEELKDFIAS
260 270 280 290 300
RVKINEASFD PSNPRDFIDC FLIKMYQDKS DPHSEFNLKN LVLTTLNLFF
310 320 330 340 350
AGTETVSSTL RYGFLLLMKY PEVEAKIHEE INQVIGTHRT PRVDDRAKMP
360 370 380 390 400
YTDAVIHEIQ RLTDIVPLGV PHNVIRDTHF RGYFLPKGTD VYPLIGSVLK
410 420 430 440 450
DPKYFRYPEA FYPQHFLDEQ GRFKKNDAFV AFSSGKRICV GEALARMELF
460 470 480 490
LYFTSILQRF SLRSLVPPAD IDIAHKISGF GNIPPTYELC FMAR
Length:494
Mass (Da):56,781
Last modified:July 1, 1989 - v1
Checksum:i8A06E256A9A48702
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31931
, M31923, M31924, M31925, M31926, M31927, M31928, M31929, M31930 Genomic DNA Translation: AAA41069.1
M33296 mRNA Translation: AAA41070.2
PIRiA35551
RefSeqiNP_036919.1, NM_012787.2
UniGeneiRn.10909

Genome annotation databases

EnsembliENSRNOT00000028261; ENSRNOP00000028261; ENSRNOG00000020827
GeneIDi25251
KEGGirno:25251
UCSCiRGD:2477 rat

Similar proteinsi

Entry informationi

Entry nameiCP2G1_RAT
AccessioniPrimary (citable) accession number: P10610
Secondary accession number(s): Q64589
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: February 28, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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