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P10610

- CP2G1_RAT

UniProt

P10610 - CP2G1_RAT

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Protein

Cytochrome P450 2G1

Gene

Cyp2g1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. This isozyme seems to be implicated in olfaction.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi439 – 4391Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
  4. monooxygenase activity Source: RGD

GO - Biological processi

  1. response to stimulus Source: UniProtKB-KW
  2. sensory perception of smell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Olfaction, Sensory transduction

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2G1 (EC:1.14.14.1)
Alternative name(s):
CYPIIG1
Cytochrome P450 olfactive
Cytochrome P450-OLF1
Gene namesi
Name:Cyp2g1
Synonyms:Cyp2g-1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi2477. Cyp2g1.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 494494Cytochrome P450 2G1PRO_0000051765Add
BLAST

Proteomic databases

PaxDbiP10610.
PRIDEiP10610.

Expressioni

Tissue specificityi

Olfactory epithelium.

Gene expression databases

GenevestigatoriP10610.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028261.

Structurei

3D structure databases

ProteinModelPortaliP10610.
SMRiP10610. Positions 31-494.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP10610.
KOiK07417.
OMAiNESFVEM.
OrthoDBiEOG7RBZ85.
PhylomeDBiP10610.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008067. Cyt_P450_E_grp-I_CYP2A-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01684. EP450ICYP2A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10610-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALGGAFSIF MTLCLSCLLI LIAWKRTSRG GKLPPGPTPI PFLGNLLQVR
60 70 80 90 100
IDATFQSFLK LQKKYGSVFT VYFGPRPVVI LCGHEAVKEA LVDQADDFSG
110 120 130 140 150
RGEMPTLEKN FQGYGLALSN GERWKILRRF SLTVLRNFGM GKRSIEERIQ
160 170 180 190 200
EEAGYLLEEL HKVKGAPIDP TFYLSRTVSN VICSVVFGKR FDYEDQRFRS
210 220 230 240 250
LMKMINESFV EMSMPWAQLY DMYWGVIQYF PGRHNRLYNL IEELKDFIAS
260 270 280 290 300
RVKINEASFD PSNPRDFIDC FLIKMYQDKS DPHSEFNLKN LVLTTLNLFF
310 320 330 340 350
AGTETVSSTL RYGFLLLMKY PEVEAKIHEE INQVIGTHRT PRVDDRAKMP
360 370 380 390 400
YTDAVIHEIQ RLTDIVPLGV PHNVIRDTHF RGYFLPKGTD VYPLIGSVLK
410 420 430 440 450
DPKYFRYPEA FYPQHFLDEQ GRFKKNDAFV AFSSGKRICV GEALARMELF
460 470 480 490
LYFTSILQRF SLRSLVPPAD IDIAHKISGF GNIPPTYELC FMAR
Length:494
Mass (Da):56,781
Last modified:July 1, 1989 - v1
Checksum:i8A06E256A9A48702
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31931
, M31923, M31924, M31925, M31926, M31927, M31928, M31929, M31930 Genomic DNA. Translation: AAA41069.1.
M33296 mRNA. Translation: AAA41070.2.
PIRiA35551.
RefSeqiNP_036919.1. NM_012787.1.
UniGeneiRn.10909.

Genome annotation databases

EnsembliENSRNOT00000028261; ENSRNOP00000028261; ENSRNOG00000020827.
GeneIDi25251.
KEGGirno:25251.
UCSCiRGD:2477. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31931
, M31923 , M31924 , M31925 , M31926 , M31927 , M31928 , M31929 , M31930 Genomic DNA. Translation: AAA41069.1 .
M33296 mRNA. Translation: AAA41070.2 .
PIRi A35551.
RefSeqi NP_036919.1. NM_012787.1.
UniGenei Rn.10909.

3D structure databases

ProteinModelPortali P10610.
SMRi P10610. Positions 31-494.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000028261.

Proteomic databases

PaxDbi P10610.
PRIDEi P10610.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000028261 ; ENSRNOP00000028261 ; ENSRNOG00000020827 .
GeneIDi 25251.
KEGGi rno:25251.
UCSCi RGD:2477. rat.

Organism-specific databases

CTDi 13108.
RGDi 2477. Cyp2g1.

Phylogenomic databases

eggNOGi COG2124.
GeneTreei ENSGT00760000118775.
HOGENOMi HOG000036992.
HOVERGENi HBG015789.
InParanoidi P10610.
KOi K07417.
OMAi NESFVEM.
OrthoDBi EOG7RBZ85.
PhylomeDBi P10610.
TreeFami TF352043.

Miscellaneous databases

NextBioi 605869.

Gene expression databases

Genevestigatori P10610.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008067. Cyt_P450_E_grp-I_CYP2A-like.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01684. EP450ICYP2A.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Olfactory-specific cytochrome P-450 (P-450olf1; IIG1). Gene structure and developmental regulation."
    Nef P., Larabee T.M., Kagimoto K., Meyer U.A.
    J. Biol. Chem. 265:2903-2907(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Olfactory-specific cytochrome P-450. cDNA cloning of a novel neuroepithelial enzyme possibly involved in chemoreception."
    Nef P., Heldman J., Lazard D., Margalit T., Jaye M., Hanukoglu I., Lancet D.
    J. Biol. Chem. 264:6780-6785(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 2-494.

Entry informationi

Entry nameiCP2G1_RAT
AccessioniPrimary (citable) accession number: P10610
Secondary accession number(s): Q64589
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 26, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3