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P10606 (COX5B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 145. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 5B, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide Vb
Gene names
Name:COX5B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length129 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Subcellular location

Mitochondrion inner membrane.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 5B family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3131Mitochondrion Ref.7
Chain32 – 12998Cytochrome c oxidase subunit 5B, mitochondrial
PRO_0000006109

Sites

Metal binding911Zinc By similarity
Metal binding931Zinc By similarity
Metal binding1131Zinc By similarity
Metal binding1161Zinc By similarity

Amino acid modifications

Modified residue681N6-acetyllysine By similarity
Modified residue861N6-acetyllysine By similarity
Modified residue1211N6-acetyllysine By similarity

Experimental info

Sequence conflict36 – 372GV → TR in AAB19185. Ref.6
Sequence conflict1091E → Q in AAA52061. Ref.1
Sequence conflict1091E → Q in AAA52060. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P10606 [UniParc].

Last modified April 3, 2002. Version 2.
Checksum: 877BF4CD334AC931

FASTA12913,696
        10         20         30         40         50         60 
MASRLLRGAG TLAAQALRAR GPSGAAAMRS MASGGGVPTD EEQATGLERE IMLAAKKGLD 

        70         80         90        100        110        120 
PYNVLAPKGA SGTREDPNLV PSISNKRIVG CICEEDNTSV VWFWLHKGEA QRCPRCGAHY 


KLVPQQLAH 

« Hide

References

« Hide 'large scale' references
[1]"Sequence of cDNAs encoding subunit Vb of human and bovine cytochrome c oxidase."
Zeviani M., Sakoda S., Sherbany A., Nakase H., Rizzuto R., Samitt C.E., Dimauro S., Schon E.A.
Gene 65:1-11(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Structure of the human cytochrome c oxidase subunit Vb gene and chromosomal mapping of the coding gene and of seven pseudogenes."
Lomax M.I., Hsieh C.L., Darras B.T., Francke U.
Genomics 10:1-9(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Skin.
[6]"Phylogenetic footprinting of the human cytochrome c oxidase subunit VB promoter."
Bachman N.J., Yang T.L., Dasen J.S., Ernst R.E., Lomax M.I.
Arch. Biochem. Biophys. 333:152-162(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-37.
[7]"Human liver protein map: update 1993."
Hughes G.J., Frutiger S., Paquet N., Pasquali C., Sanchez J.-C., Tissot J.-D., Bairoch A., Appel R.D., Hochstrasser D.F.
Electrophoresis 14:1216-1222(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 32-44.
Tissue: Liver.
[8]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M19961 mRNA. Translation: AAA52061.1.
M59250 Genomic DNA. Translation: AAA52060.1.
BT006742 mRNA. Translation: AAP35388.1.
AC017099 Genomic DNA. Translation: AAY24279.1.
BC006229 mRNA. Translation: AAH06229.1.
U41284 Genomic DNA. Translation: AAB19185.1.
CCDSCCDS2032.1.
PIROTHU5B. JT0324.
RefSeqNP_001853.2. NM_001862.2.
UniGeneHs.1342.

3D structure databases

ProteinModelPortalP10606.
SMRP10606. Positions 32-129.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107722. 9 interactions.
IntActP10606. 7 interactions.
MINTMINT-3007350.
STRING9606.ENSP00000258424.

Protein family/group databases

TCDB3.D.4.11.1. the proton-translocating cytochrome oxidase (cox) superfamily.

PTM databases

PhosphoSiteP10606.

Polymorphism databases

DMDM20141332.

2D gel databases

SWISS-2DPAGEP10606.

Proteomic databases

MaxQBP10606.
PaxDbP10606.
PeptideAtlasP10606.
PRIDEP10606.

Protocols and materials databases

DNASU1329.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000258424; ENSP00000258424; ENSG00000135940.
GeneID1329.
KEGGhsa:1329.
UCSCuc002sya.3. human.

Organism-specific databases

CTD1329.
GeneCardsGC02P098262.
HGNCHGNC:2269. COX5B.
HPAHPA034517.
MIM123866. gene.
neXtProtNX_P10606.
PharmGKBPA26786.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG316751.
HOGENOMHOG000184129.
HOVERGENHBG051089.
InParanoidP10606.
KOK02265.
OMANDADMER.
OrthoDBEOG7D85ZC.
PhylomeDBP10606.
TreeFamTF105063.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.

Gene expression databases

BgeeP10606.
CleanExHS_COX5B.
GenevestigatorP10606.

Family and domain databases

Gene3D2.60.11.10. 1 hit.
InterProIPR002124. Cyt_c_oxidase_su5b.
IPR020893. Cyt_c_oxidase_su5b_Zn_BS.
[Graphical view]
PANTHERPTHR10122. PTHR10122. 1 hit.
PfamPF01215. COX5B. 1 hit.
[Graphical view]
ProDomPD007270. Cyt_c_oxidase_su5b. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEPS00848. COX5B_1. 1 hit.
PS51359. COX5B_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCOX5B. human.
GeneWikiCOX5B.
GenomeRNAi1329.
NextBio5413.
PROP10606.
SOURCESearch...

Entry information

Entry nameCOX5B_HUMAN
AccessionPrimary (citable) accession number: P10606
Secondary accession number(s): Q53YB7, Q96J18, Q99610
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: April 3, 2002
Last modified: July 9, 2014
This is version 145 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM