Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cytochrome c oxidase subunit 5B, mitochondrial

Gene

COX5B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi91ZincPROSITE-ProRule annotation1
Metal bindingi93ZincPROSITE-ProRule annotation1
Metal bindingi113ZincPROSITE-ProRule annotation1
Metal bindingi116ZincPROSITE-ProRule annotation1

GO - Molecular functioni

  • cytochrome-c oxidase activity Source: ProtInc
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-611105 Respiratory electron transport
SIGNORiP10606

Protein family/group databases

TCDBi3.D.4.11.1 the proton-translocating cytochrome oxidase (cox) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 5B, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide Vb
Gene namesi
Name:COX5B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000135940.6
HGNCiHGNC:2269 COX5B
MIMi123866 gene
neXtProtiNX_P10606

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1329
OpenTargetsiENSG00000135940
PharmGKBiPA26786

Chemistry databases

DrugBankiDB02659 Cholic Acid
DB04464 N-Formylmethionine

Polymorphism and mutation databases

BioMutaiCOX5B
DMDMi20141332

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 31MitochondrionCombined sources1 PublicationAdd BLAST31
ChainiPRO_000000610932 – 129Cytochrome c oxidase subunit 5B, mitochondrialAdd BLAST98

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei68N6-acetyllysineBy similarity1
Modified residuei86N6-acetyllysineBy similarity1
Modified residuei121N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP10606
PaxDbiP10606
PeptideAtlasiP10606
PRIDEiP10606
ProteomicsDBi52618
TopDownProteomicsiP10606

2D gel databases

SWISS-2DPAGEiP10606

PTM databases

iPTMnetiP10606
PhosphoSitePlusiP10606

Expressioni

Gene expression databases

BgeeiENSG00000135940
CleanExiHS_COX5B
GenevisibleiP10606 HS

Organism-specific databases

HPAiHPA034517

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi107722, 42 interactors
IntActiP10606, 47 interactors
MINTiP10606
STRINGi9606.ENSP00000258424

Structurei

3D structure databases

ProteinModelPortaliP10606
SMRiP10606
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3352 Eukaryota
ENOG4111XEM LUCA
GeneTreeiENSGT00390000011010
HOGENOMiHOG000184129
HOVERGENiHBG051089
InParanoidiP10606
KOiK02265
OMAiKLVPHNL
OrthoDBiEOG091G0S9L
PhylomeDBiP10606
TreeFamiTF105063

Family and domain databases

CDDicd00924 Cyt_c_Oxidase_Vb, 1 hit
Gene3Di2.60.11.10, 1 hit
InterProiView protein in InterPro
IPR002124 Cyt_c_oxidase_su5b
IPR036972 Cyt_c_oxidase_su5b_sf
IPR020893 Cyt_c_oxidase_su5b_Zn_BS
PANTHERiPTHR10122 PTHR10122, 1 hit
PfamiView protein in Pfam
PF01215 COX5B, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD007270 Cyt_c_oxidase_su5b, 1 hit
PROSITEiView protein in PROSITE
PS00848 COX5B_1, 1 hit
PS51359 COX5B_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10606-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRLLRGAG TLAAQALRAR GPSGAAAMRS MASGGGVPTD EEQATGLERE
60 70 80 90 100
IMLAAKKGLD PYNVLAPKGA SGTREDPNLV PSISNKRIVG CICEEDNTSV
110 120
VWFWLHKGEA QRCPRCGAHY KLVPQQLAH
Length:129
Mass (Da):13,696
Last modified:April 3, 2002 - v2
Checksum:i877BF4CD334AC931
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti36 – 37GV → TR in AAB19185 (PubMed:8806766).Curated2
Sequence conflicti109E → Q in AAA52061 (PubMed:2840351).Curated1
Sequence conflicti109E → Q in AAA52060 (PubMed:2840351).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19961 mRNA Translation: AAA52061.1
M59250 Genomic DNA Translation: AAA52060.1
BT006742 mRNA Translation: AAP35388.1
AC017099 Genomic DNA Translation: AAY24279.1
BC006229 mRNA Translation: AAH06229.1
U41284 Genomic DNA Translation: AAB19185.1
CCDSiCCDS2032.1
PIRiJT0324 OTHU5B
RefSeqiNP_001853.2, NM_001862.2
UniGeneiHs.1342

Genome annotation databases

EnsembliENST00000258424; ENSP00000258424; ENSG00000135940
GeneIDi1329
KEGGihsa:1329
UCSCiuc002sya.4 human

Similar proteinsi

Entry informationi

Entry nameiCOX5B_HUMAN
AccessioniPrimary (citable) accession number: P10606
Secondary accession number(s): Q53YB7, Q96J18, Q99610
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: April 3, 2002
Last modified: June 20, 2018
This is version 184 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health