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Protein

Cytochrome c oxidase subunit 5B, mitochondrial

Gene

COX5B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi91ZincPROSITE-ProRule annotation1
Metal bindingi93ZincPROSITE-ProRule annotation1
Metal bindingi113ZincPROSITE-ProRule annotation1
Metal bindingi116ZincPROSITE-ProRule annotation1

GO - Molecular functioni

  • cytochrome-c oxidase activity Source: ProtInc
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:HS06090-MONOMER.
ReactomeiR-HSA-5628897. TP53 Regulates Metabolic Genes.
R-HSA-611105. Respiratory electron transport.

Protein family/group databases

TCDBi3.D.4.11.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 5B, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide Vb
Gene namesi
Name:COX5B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:2269. COX5B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1329.
OpenTargetsiENSG00000135940.
PharmGKBiPA26786.

Chemistry databases

DrugBankiDB02659. Cholic Acid.

Polymorphism and mutation databases

BioMutaiCOX5B.
DMDMi20141332.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 31MitochondrionCombined sources1 PublicationAdd BLAST31
ChainiPRO_000000610932 – 129Cytochrome c oxidase subunit 5B, mitochondrialAdd BLAST98

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei68N6-acetyllysineBy similarity1
Modified residuei86N6-acetyllysineBy similarity1
Modified residuei121N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP10606.
PaxDbiP10606.
PeptideAtlasiP10606.
PRIDEiP10606.
TopDownProteomicsiP10606.

2D gel databases

SWISS-2DPAGEP10606.

PTM databases

iPTMnetiP10606.
PhosphoSitePlusiP10606.

Expressioni

Gene expression databases

BgeeiENSG00000135940.
CleanExiHS_COX5B.
GenevisibleiP10606. HS.

Organism-specific databases

HPAiHPA034517.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BHLHE40O145033EBI-1053725,EBI-711810
CCDC36Q8IYA84EBI-1053725,EBI-8638439
CDR2Q018505EBI-1053725,EBI-1181367
KRT15P190123EBI-1053725,EBI-739566
KRT31Q153233EBI-1053725,EBI-948001
PNMA1Q8ND903EBI-1053725,EBI-302345
TFIP11Q9UBB93EBI-1053725,EBI-1105213
TRAF1Q130773EBI-1053725,EBI-359224
TRIM23P364064EBI-1053725,EBI-740098

Protein-protein interaction databases

BioGridi107722. 39 interactors.
IntActiP10606. 28 interactors.
MINTiMINT-3007350.
STRINGi9606.ENSP00000258424.

Structurei

3D structure databases

ProteinModelPortaliP10606.
SMRiP10606.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3352. Eukaryota.
ENOG4111XEM. LUCA.
GeneTreeiENSGT00390000011010.
HOGENOMiHOG000184129.
HOVERGENiHBG051089.
InParanoidiP10606.
KOiK02265.
OMAiPYNMLPP.
OrthoDBiEOG091G0S9L.
PhylomeDBiP10606.
TreeFamiTF105063.

Family and domain databases

CDDicd00924. Cyt_c_Oxidase_Vb. 1 hit.
Gene3Di2.60.11.10. 1 hit.
InterProiIPR002124. Cyt_c_oxidase_su5b.
IPR020893. Cyt_c_oxidase_su5b_Zn_BS.
[Graphical view]
PANTHERiPTHR10122. PTHR10122. 1 hit.
PfamiPF01215. COX5B. 1 hit.
[Graphical view]
ProDomiPD007270. Cyt_c_oxidase_su5b. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00848. COX5B_1. 1 hit.
PS51359. COX5B_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10606-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRLLRGAG TLAAQALRAR GPSGAAAMRS MASGGGVPTD EEQATGLERE
60 70 80 90 100
IMLAAKKGLD PYNVLAPKGA SGTREDPNLV PSISNKRIVG CICEEDNTSV
110 120
VWFWLHKGEA QRCPRCGAHY KLVPQQLAH
Length:129
Mass (Da):13,696
Last modified:April 3, 2002 - v2
Checksum:i877BF4CD334AC931
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti36 – 37GV → TR in AAB19185 (PubMed:8806766).Curated2
Sequence conflicti109E → Q in AAA52061 (PubMed:2840351).Curated1
Sequence conflicti109E → Q in AAA52060 (PubMed:2840351).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19961 mRNA. Translation: AAA52061.1.
M59250 Genomic DNA. Translation: AAA52060.1.
BT006742 mRNA. Translation: AAP35388.1.
AC017099 Genomic DNA. Translation: AAY24279.1.
BC006229 mRNA. Translation: AAH06229.1.
U41284 Genomic DNA. Translation: AAB19185.1.
CCDSiCCDS2032.1.
PIRiJT0324. OTHU5B.
RefSeqiNP_001853.2. NM_001862.2.
UniGeneiHs.1342.

Genome annotation databases

EnsembliENST00000258424; ENSP00000258424; ENSG00000135940.
GeneIDi1329.
KEGGihsa:1329.
UCSCiuc002sya.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19961 mRNA. Translation: AAA52061.1.
M59250 Genomic DNA. Translation: AAA52060.1.
BT006742 mRNA. Translation: AAP35388.1.
AC017099 Genomic DNA. Translation: AAY24279.1.
BC006229 mRNA. Translation: AAH06229.1.
U41284 Genomic DNA. Translation: AAB19185.1.
CCDSiCCDS2032.1.
PIRiJT0324. OTHU5B.
RefSeqiNP_001853.2. NM_001862.2.
UniGeneiHs.1342.

3D structure databases

ProteinModelPortaliP10606.
SMRiP10606.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107722. 39 interactors.
IntActiP10606. 28 interactors.
MINTiMINT-3007350.
STRINGi9606.ENSP00000258424.

Chemistry databases

DrugBankiDB02659. Cholic Acid.

Protein family/group databases

TCDBi3.D.4.11.1. the proton-translocating cytochrome oxidase (cox) superfamily.

PTM databases

iPTMnetiP10606.
PhosphoSitePlusiP10606.

Polymorphism and mutation databases

BioMutaiCOX5B.
DMDMi20141332.

2D gel databases

SWISS-2DPAGEP10606.

Proteomic databases

EPDiP10606.
PaxDbiP10606.
PeptideAtlasiP10606.
PRIDEiP10606.
TopDownProteomicsiP10606.

Protocols and materials databases

DNASUi1329.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258424; ENSP00000258424; ENSG00000135940.
GeneIDi1329.
KEGGihsa:1329.
UCSCiuc002sya.4. human.

Organism-specific databases

CTDi1329.
DisGeNETi1329.
GeneCardsiCOX5B.
HGNCiHGNC:2269. COX5B.
HPAiHPA034517.
MIMi123866. gene.
neXtProtiNX_P10606.
OpenTargetsiENSG00000135940.
PharmGKBiPA26786.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3352. Eukaryota.
ENOG4111XEM. LUCA.
GeneTreeiENSGT00390000011010.
HOGENOMiHOG000184129.
HOVERGENiHBG051089.
InParanoidiP10606.
KOiK02265.
OMAiPYNMLPP.
OrthoDBiEOG091G0S9L.
PhylomeDBiP10606.
TreeFamiTF105063.

Enzyme and pathway databases

BioCyciZFISH:HS06090-MONOMER.
ReactomeiR-HSA-5628897. TP53 Regulates Metabolic Genes.
R-HSA-611105. Respiratory electron transport.

Miscellaneous databases

ChiTaRSiCOX5B. human.
GeneWikiiCOX5B.
GenomeRNAii1329.
PROiP10606.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135940.
CleanExiHS_COX5B.
GenevisibleiP10606. HS.

Family and domain databases

CDDicd00924. Cyt_c_Oxidase_Vb. 1 hit.
Gene3Di2.60.11.10. 1 hit.
InterProiIPR002124. Cyt_c_oxidase_su5b.
IPR020893. Cyt_c_oxidase_su5b_Zn_BS.
[Graphical view]
PANTHERiPTHR10122. PTHR10122. 1 hit.
PfamiPF01215. COX5B. 1 hit.
[Graphical view]
ProDomiPD007270. Cyt_c_oxidase_su5b. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00848. COX5B_1. 1 hit.
PS51359. COX5B_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX5B_HUMAN
AccessioniPrimary (citable) accession number: P10606
Secondary accession number(s): Q53YB7, Q96J18, Q99610
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: April 3, 2002
Last modified: November 30, 2016
This is version 171 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.