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P10606

- COX5B_HUMAN

UniProt

P10606 - COX5B_HUMAN

Protein

Cytochrome c oxidase subunit 5B, mitochondrial

Gene

COX5B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi91 – 911ZincPROSITE-ProRule annotation
    Metal bindingi93 – 931ZincPROSITE-ProRule annotation
    Metal bindingi113 – 1131ZincPROSITE-ProRule annotation
    Metal bindingi116 – 1161ZincPROSITE-ProRule annotation

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: ProtInc
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cellular metabolic process Source: Reactome
    2. hydrogen ion transmembrane transport Source: GOC
    3. respiratory electron transport chain Source: Reactome
    4. respiratory gaseous exchange Source: ProtInc
    5. small molecule metabolic process Source: Reactome

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_22393. Respiratory electron transport.

    Protein family/group databases

    TCDBi3.D.4.11.1. the proton-translocating cytochrome oxidase (cox) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 5B, mitochondrial
    Alternative name(s):
    Cytochrome c oxidase polypeptide Vb
    Gene namesi
    Name:COX5B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:2269. COX5B.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. mitochondrial inner membrane Source: Reactome
    3. mitochondrion Source: HPA

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26786.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3131Mitochondrion1 PublicationAdd
    BLAST
    Chaini32 – 12998Cytochrome c oxidase subunit 5B, mitochondrialPRO_0000006109Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei68 – 681N6-acetyllysineBy similarity
    Modified residuei86 – 861N6-acetyllysineBy similarity
    Modified residuei121 – 1211N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP10606.
    PaxDbiP10606.
    PeptideAtlasiP10606.
    PRIDEiP10606.

    2D gel databases

    SWISS-2DPAGEP10606.

    PTM databases

    PhosphoSiteiP10606.

    Expressioni

    Gene expression databases

    BgeeiP10606.
    CleanExiHS_COX5B.
    GenevestigatoriP10606.

    Organism-specific databases

    HPAiHPA034517.

    Interactioni

    Protein-protein interaction databases

    BioGridi107722. 10 interactions.
    IntActiP10606. 7 interactions.
    MINTiMINT-3007350.
    STRINGi9606.ENSP00000258424.

    Structurei

    3D structure databases

    ProteinModelPortaliP10606.
    SMRiP10606. Positions 32-129.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiNOG316751.
    HOGENOMiHOG000184129.
    HOVERGENiHBG051089.
    InParanoidiP10606.
    KOiK02265.
    OMAiNDADMER.
    OrthoDBiEOG7D85ZC.
    PhylomeDBiP10606.
    TreeFamiTF105063.

    Family and domain databases

    Gene3Di2.60.11.10. 1 hit.
    InterProiIPR002124. Cyt_c_oxidase_su5b.
    IPR020893. Cyt_c_oxidase_su5b_Zn_BS.
    [Graphical view]
    PANTHERiPTHR10122. PTHR10122. 1 hit.
    PfamiPF01215. COX5B. 1 hit.
    [Graphical view]
    ProDomiPD007270. Cyt_c_oxidase_su5b. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    PROSITEiPS00848. COX5B_1. 1 hit.
    PS51359. COX5B_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P10606-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASRLLRGAG TLAAQALRAR GPSGAAAMRS MASGGGVPTD EEQATGLERE    50
    IMLAAKKGLD PYNVLAPKGA SGTREDPNLV PSISNKRIVG CICEEDNTSV 100
    VWFWLHKGEA QRCPRCGAHY KLVPQQLAH 129
    Length:129
    Mass (Da):13,696
    Last modified:April 3, 2002 - v2
    Checksum:i877BF4CD334AC931
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti36 – 372GV → TR in AAB19185. (PubMed:8806766)Curated
    Sequence conflicti109 – 1091E → Q in AAA52061. (PubMed:2840351)Curated
    Sequence conflicti109 – 1091E → Q in AAA52060. (PubMed:2840351)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M19961 mRNA. Translation: AAA52061.1.
    M59250 Genomic DNA. Translation: AAA52060.1.
    BT006742 mRNA. Translation: AAP35388.1.
    AC017099 Genomic DNA. Translation: AAY24279.1.
    BC006229 mRNA. Translation: AAH06229.1.
    U41284 Genomic DNA. Translation: AAB19185.1.
    CCDSiCCDS2032.1.
    PIRiJT0324. OTHU5B.
    RefSeqiNP_001853.2. NM_001862.2.
    UniGeneiHs.1342.

    Genome annotation databases

    EnsembliENST00000258424; ENSP00000258424; ENSG00000135940.
    GeneIDi1329.
    KEGGihsa:1329.
    UCSCiuc002sya.3. human.

    Polymorphism databases

    DMDMi20141332.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M19961 mRNA. Translation: AAA52061.1 .
    M59250 Genomic DNA. Translation: AAA52060.1 .
    BT006742 mRNA. Translation: AAP35388.1 .
    AC017099 Genomic DNA. Translation: AAY24279.1 .
    BC006229 mRNA. Translation: AAH06229.1 .
    U41284 Genomic DNA. Translation: AAB19185.1 .
    CCDSi CCDS2032.1.
    PIRi JT0324. OTHU5B.
    RefSeqi NP_001853.2. NM_001862.2.
    UniGenei Hs.1342.

    3D structure databases

    ProteinModelPortali P10606.
    SMRi P10606. Positions 32-129.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107722. 10 interactions.
    IntActi P10606. 7 interactions.
    MINTi MINT-3007350.
    STRINGi 9606.ENSP00000258424.

    Protein family/group databases

    TCDBi 3.D.4.11.1. the proton-translocating cytochrome oxidase (cox) superfamily.

    PTM databases

    PhosphoSitei P10606.

    Polymorphism databases

    DMDMi 20141332.

    2D gel databases

    SWISS-2DPAGE P10606.

    Proteomic databases

    MaxQBi P10606.
    PaxDbi P10606.
    PeptideAtlasi P10606.
    PRIDEi P10606.

    Protocols and materials databases

    DNASUi 1329.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000258424 ; ENSP00000258424 ; ENSG00000135940 .
    GeneIDi 1329.
    KEGGi hsa:1329.
    UCSCi uc002sya.3. human.

    Organism-specific databases

    CTDi 1329.
    GeneCardsi GC02P098262.
    HGNCi HGNC:2269. COX5B.
    HPAi HPA034517.
    MIMi 123866. gene.
    neXtProti NX_P10606.
    PharmGKBi PA26786.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG316751.
    HOGENOMi HOG000184129.
    HOVERGENi HBG051089.
    InParanoidi P10606.
    KOi K02265.
    OMAi NDADMER.
    OrthoDBi EOG7D85ZC.
    PhylomeDBi P10606.
    TreeFami TF105063.

    Enzyme and pathway databases

    Reactomei REACT_22393. Respiratory electron transport.

    Miscellaneous databases

    ChiTaRSi COX5B. human.
    GeneWikii COX5B.
    GenomeRNAii 1329.
    NextBioi 5413.
    PROi P10606.
    SOURCEi Search...

    Gene expression databases

    Bgeei P10606.
    CleanExi HS_COX5B.
    Genevestigatori P10606.

    Family and domain databases

    Gene3Di 2.60.11.10. 1 hit.
    InterProi IPR002124. Cyt_c_oxidase_su5b.
    IPR020893. Cyt_c_oxidase_su5b_Zn_BS.
    [Graphical view ]
    PANTHERi PTHR10122. PTHR10122. 1 hit.
    Pfami PF01215. COX5B. 1 hit.
    [Graphical view ]
    ProDomi PD007270. Cyt_c_oxidase_su5b. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    PROSITEi PS00848. COX5B_1. 1 hit.
    PS51359. COX5B_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence of cDNAs encoding subunit Vb of human and bovine cytochrome c oxidase."
      Zeviani M., Sakoda S., Sherbany A., Nakase H., Rizzuto R., Samitt C.E., Dimauro S., Schon E.A.
      Gene 65:1-11(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Structure of the human cytochrome c oxidase subunit Vb gene and chromosomal mapping of the coding gene and of seven pseudogenes."
      Lomax M.I., Hsieh C.L., Darras B.T., Francke U.
      Genomics 10:1-9(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skin.
    6. "Phylogenetic footprinting of the human cytochrome c oxidase subunit VB promoter."
      Bachman N.J., Yang T.L., Dasen J.S., Ernst R.E., Lomax M.I.
      Arch. Biochem. Biophys. 333:152-162(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-37.
    7. Cited for: PROTEIN SEQUENCE OF 32-44.
      Tissue: Liver.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCOX5B_HUMAN
    AccessioniPrimary (citable) accession number: P10606
    Secondary accession number(s): Q53YB7, Q96J18, Q99610
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: April 3, 2002
    Last modified: October 1, 2014
    This is version 147 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3