P10606 (COX5B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 5B, mitochondrial

Alternative name(s):
Cytochrome c oxidase polypeptide Vb

Gene names

Name:

COX5B

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	129 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
Subcellular location	Mitochondrion inner membrane.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 5B family.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transit peptide
Ligand	Metal-binding Zinc
PTM	Acetylation
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	respiratory electron transport chain Traceable author statement. Source: Reactome respiratory gaseous exchange Traceable author statement. Source: ProtInc
Cellular component	mitochondrial inner membrane Traceable author statement. Source: Reactome
Molecular function	cytochrome-c oxidase activity Traceable author statement. Source: ProtInc metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 31	31	Mitochondrion Ref.5
	Chain	32 – 129	98	Cytochrome c oxidase subunit 5B, mitochondrial		PRO_0000006109
Sites
	Metal binding	91	1	Zinc By similarity
	Metal binding	93	1	Zinc By similarity
	Metal binding	113	1	Zinc By similarity
	Metal binding	116	1	Zinc By similarity
Amino acid modifications
	Modified residue	121	1	N6-acetyllysine Ref.6
Experimental info
	Sequence conflict	36 – 37	2	GV → TR in AAB19185. Ref.4
	Sequence conflict	109	1	E → Q in AAA52061. Ref.1
	Sequence conflict	109	1	E → Q in AAA52060. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P10606 [UniParc]. Last modified April 3, 2002. Version 2. Checksum: 877BF4CD334AC931	FASTA	129	13,696
	10 20 30 40 50 60 MASRLLRGAG TLAAQALRAR GPSGAAAMRS MASGGGVPTD EEQATGLERE IMLAAKKGLD 70 80 90 100 110 120 PYNVLAPKGA SGTREDPNLV PSISNKRIVG CICEEDNTSV VWFWLHKGEA QRCPRCGAHY KLVPQQLAH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence of cDNAs encoding subunit Vb of human and bovine cytochrome c oxidase." Zeviani M., Sakoda S., Sherbany A., Nakase H., Rizzuto R., Samitt C.E., Dimauro S., Schon E.A. Gene 65:1-11(1988) [PubMed: 2840351] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Structure of the human cytochrome c oxidase subunit Vb gene and chromosomal mapping of the coding gene and of seven pseudogenes." Lomax M.I., Hsieh C.L., Darras B.T., Francke U. Genomics 10:1-9(1991) [PubMed: 1646156] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin.
[4]	"Phylogenetic footprinting of the human cytochrome c oxidase subunit VB promoter." Bachman N.J., Yang T.L., Dasen J.S., Ernst R.E., Lomax M.I. Arch. Biochem. Biophys. 333:152-162(1996) [PubMed: 8806766] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-37.
[5]	"Human liver protein map: update 1993." Hughes G.J., Frutiger S., Paquet N., Pasquali C., Sanchez J.-C., Tissot J.-D., Bairoch A., Appel R.D., Hochstrasser D.F. Electrophoresis 14:1216-1222(1993) [PubMed: 8313870] [Abstract] Cited for: PROTEIN SEQUENCE OF 32-44. Tissue: Liver.
[6]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-121, MASS SPECTROMETRY.
[7]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M19961 mRNA. Translation: AAA52061.1. M59250 Genomic DNA. Translation: AAA52060.1. BC006229 mRNA. Translation: AAH06229.1. U41284 Genomic DNA. Translation: AAB19185.1.
IPI	IPI00021785.
PIR	OTHU5B. JT0324.
RefSeq	NP_001853.2. NM_001862.2.
UniGene	Hs.1342.
3D structure databases
ProteinModelPortal	P10606.
SMR	P10606. Positions 32-129.
ModBase	Search...
Protein-protein interaction databases
IntAct	P10606. 1 interaction.
STRING	P10606.
Protein family/group databases
TCDB	3.D.4.11.1. proton-translocating cytochrome oxidase (COX) superfamily.
PTM databases
PhosphoSite	P10606.
Polymorphism databases
DMDM	20141332.
2D gel databases
SWISS-2DPAGE	P10606.
Proteomic databases
PeptideAtlas	P10606.
PRIDE	P10606.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000258424; ENSP00000258424; ENSG00000135940.
GeneID	1329.
KEGG	hsa:1329.
UCSC	uc002sya.1. human.
Organism-specific databases
CTD	1329.
GeneCards	GC02P098262.
H-InvDB	HIX0002290.
HGNC	HGNC:2269. COX5B.
HPA	HPA034517.
MIM	123866. gene.
neXtProt	NX_P10606.
PharmGKB	PA26786.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG20077.
HOGENOM	HBG748384.
HOVERGEN	HBG051089.
InParanoid	P10606.
OMA	CEEDQTY.
OrthoDB	EOG495ZT9.
PhylomeDB	P10606.
Enzyme and pathway databases
Reactome	REACT_111217. Metabolism.
Gene expression databases
ArrayExpress	P10606.
Bgee	P10606.
CleanEx	HS_COX5B.
Genevestigator	P10606.
GermOnline	ENSG00000135940. Homo sapiens.
Family and domain databases
InterPro	IPR002124. Cyt_c_oxidase_su5b. IPR020893. Cyt_c_oxidase_su5b_Zn_BS. [Graphical view]
Gene3D	G3DSA:2.60.11.10. COX5B. 1 hit.
KO	K02265.
PANTHER	PTHR10122. COX5B. 1 hit.
Pfam	PF01215. COX5B. 1 hit. [Graphical view]
ProDom	PD007270. Cyt_c_oxidase_su5b. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00848. COX5B_1. 1 hit. PS51359. COX5B_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	5413.
SOURCE	Search...

Entry information

Entry name

COX5B_HUMAN

Accession

Primary (citable) accession number: P10606
Secondary accession number(s): Q96J18, Q99610

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	April 3, 2002
Last modified:	January 25, 2012
This is version 122 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.