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Protein

Cytochrome c oxidase subunit 5B, mitochondrial

Gene

COX5B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi91 – 911ZincPROSITE-ProRule annotation
Metal bindingi93 – 931ZincPROSITE-ProRule annotation
Metal bindingi113 – 1131ZincPROSITE-ProRule annotation
Metal bindingi116 – 1161ZincPROSITE-ProRule annotation

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: ProtInc
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cellular metabolic process Source: Reactome
  2. hydrogen ion transmembrane transport Source: GOC
  3. respiratory electron transport chain Source: Reactome
  4. respiratory gaseous exchange Source: ProtInc
  5. small molecule metabolic process Source: Reactome
  6. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_22393. Respiratory electron transport.
REACT_268444. Orphan transporters.

Protein family/group databases

TCDBi3.D.4.11.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 5B, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide Vb
Gene namesi
Name:COX5B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:2269. COX5B.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
  2. mitochondrial inner membrane Source: Reactome
  3. mitochondrion Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26786.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3131Mitochondrion1 PublicationAdd
BLAST
Chaini32 – 12998Cytochrome c oxidase subunit 5B, mitochondrialPRO_0000006109Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei68 – 681N6-acetyllysineBy similarity
Modified residuei86 – 861N6-acetyllysineBy similarity
Modified residuei121 – 1211N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP10606.
PaxDbiP10606.
PeptideAtlasiP10606.
PRIDEiP10606.

2D gel databases

SWISS-2DPAGEP10606.

PTM databases

PhosphoSiteiP10606.

Expressioni

Gene expression databases

BgeeiP10606.
CleanExiHS_COX5B.
GenevestigatoriP10606.

Organism-specific databases

HPAiHPA034517.

Interactioni

Protein-protein interaction databases

BioGridi107722. 21 interactions.
IntActiP10606. 7 interactions.
MINTiMINT-3007350.
STRINGi9606.ENSP00000258424.

Structurei

3D structure databases

ProteinModelPortaliP10606.
SMRiP10606. Positions 32-129.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG316751.
GeneTreeiENSGT00390000011010.
HOGENOMiHOG000184129.
HOVERGENiHBG051089.
InParanoidiP10606.
KOiK02265.
OMAiHWFKLVE.
OrthoDBiEOG7D85ZC.
PhylomeDBiP10606.
TreeFamiTF105063.

Family and domain databases

Gene3Di2.60.11.10. 1 hit.
InterProiIPR002124. Cyt_c_oxidase_su5b.
IPR020893. Cyt_c_oxidase_su5b_Zn_BS.
[Graphical view]
PANTHERiPTHR10122. PTHR10122. 1 hit.
PfamiPF01215. COX5B. 1 hit.
[Graphical view]
ProDomiPD007270. Cyt_c_oxidase_su5b. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00848. COX5B_1. 1 hit.
PS51359. COX5B_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10606-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRLLRGAG TLAAQALRAR GPSGAAAMRS MASGGGVPTD EEQATGLERE
60 70 80 90 100
IMLAAKKGLD PYNVLAPKGA SGTREDPNLV PSISNKRIVG CICEEDNTSV
110 120
VWFWLHKGEA QRCPRCGAHY KLVPQQLAH
Length:129
Mass (Da):13,696
Last modified:April 2, 2002 - v2
Checksum:i877BF4CD334AC931
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti36 – 372GV → TR in AAB19185 (PubMed:8806766).Curated
Sequence conflicti109 – 1091E → Q in AAA52061 (PubMed:2840351).Curated
Sequence conflicti109 – 1091E → Q in AAA52060 (PubMed:2840351).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19961 mRNA. Translation: AAA52061.1.
M59250 Genomic DNA. Translation: AAA52060.1.
BT006742 mRNA. Translation: AAP35388.1.
AC017099 Genomic DNA. Translation: AAY24279.1.
BC006229 mRNA. Translation: AAH06229.1.
U41284 Genomic DNA. Translation: AAB19185.1.
CCDSiCCDS2032.1.
PIRiJT0324. OTHU5B.
RefSeqiNP_001853.2. NM_001862.2.
UniGeneiHs.1342.

Genome annotation databases

EnsembliENST00000258424; ENSP00000258424; ENSG00000135940.
GeneIDi1329.
KEGGihsa:1329.
UCSCiuc002sya.3. human.

Polymorphism databases

DMDMi20141332.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19961 mRNA. Translation: AAA52061.1.
M59250 Genomic DNA. Translation: AAA52060.1.
BT006742 mRNA. Translation: AAP35388.1.
AC017099 Genomic DNA. Translation: AAY24279.1.
BC006229 mRNA. Translation: AAH06229.1.
U41284 Genomic DNA. Translation: AAB19185.1.
CCDSiCCDS2032.1.
PIRiJT0324. OTHU5B.
RefSeqiNP_001853.2. NM_001862.2.
UniGeneiHs.1342.

3D structure databases

ProteinModelPortaliP10606.
SMRiP10606. Positions 32-129.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107722. 21 interactions.
IntActiP10606. 7 interactions.
MINTiMINT-3007350.
STRINGi9606.ENSP00000258424.

Protein family/group databases

TCDBi3.D.4.11.1. the proton-translocating cytochrome oxidase (cox) superfamily.

PTM databases

PhosphoSiteiP10606.

Polymorphism databases

DMDMi20141332.

2D gel databases

SWISS-2DPAGEP10606.

Proteomic databases

MaxQBiP10606.
PaxDbiP10606.
PeptideAtlasiP10606.
PRIDEiP10606.

Protocols and materials databases

DNASUi1329.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258424; ENSP00000258424; ENSG00000135940.
GeneIDi1329.
KEGGihsa:1329.
UCSCiuc002sya.3. human.

Organism-specific databases

CTDi1329.
GeneCardsiGC02P098262.
HGNCiHGNC:2269. COX5B.
HPAiHPA034517.
MIMi123866. gene.
neXtProtiNX_P10606.
PharmGKBiPA26786.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG316751.
GeneTreeiENSGT00390000011010.
HOGENOMiHOG000184129.
HOVERGENiHBG051089.
InParanoidiP10606.
KOiK02265.
OMAiHWFKLVE.
OrthoDBiEOG7D85ZC.
PhylomeDBiP10606.
TreeFamiTF105063.

Enzyme and pathway databases

ReactomeiREACT_22393. Respiratory electron transport.
REACT_268444. Orphan transporters.

Miscellaneous databases

ChiTaRSiCOX5B. human.
GeneWikiiCOX5B.
GenomeRNAii1329.
NextBioi5413.
PROiP10606.
SOURCEiSearch...

Gene expression databases

BgeeiP10606.
CleanExiHS_COX5B.
GenevestigatoriP10606.

Family and domain databases

Gene3Di2.60.11.10. 1 hit.
InterProiIPR002124. Cyt_c_oxidase_su5b.
IPR020893. Cyt_c_oxidase_su5b_Zn_BS.
[Graphical view]
PANTHERiPTHR10122. PTHR10122. 1 hit.
PfamiPF01215. COX5B. 1 hit.
[Graphical view]
ProDomiPD007270. Cyt_c_oxidase_su5b. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00848. COX5B_1. 1 hit.
PS51359. COX5B_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of cDNAs encoding subunit Vb of human and bovine cytochrome c oxidase."
    Zeviani M., Sakoda S., Sherbany A., Nakase H., Rizzuto R., Samitt C.E., Dimauro S., Schon E.A.
    Gene 65:1-11(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Structure of the human cytochrome c oxidase subunit Vb gene and chromosomal mapping of the coding gene and of seven pseudogenes."
    Lomax M.I., Hsieh C.L., Darras B.T., Francke U.
    Genomics 10:1-9(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  6. "Phylogenetic footprinting of the human cytochrome c oxidase subunit VB promoter."
    Bachman N.J., Yang T.L., Dasen J.S., Ernst R.E., Lomax M.I.
    Arch. Biochem. Biophys. 333:152-162(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-37.
  7. Cited for: PROTEIN SEQUENCE OF 32-44.
    Tissue: Liver.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiCOX5B_HUMAN
AccessioniPrimary (citable) accession number: P10606
Secondary accession number(s): Q53YB7, Q96J18, Q99610
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 30, 1989
Last sequence update: April 2, 2002
Last modified: March 31, 2015
This is version 153 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.