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Protein

Pancreatic prohormone

Gene

Ppy

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions.

GO - Molecular functioni

  • G-protein coupled receptor binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Pancreatic prohormone
Alternative name(s):
Pancreatic polypeptide
Short name:
PP
Cleaved into the following 2 chains:
Gene namesi
Name:Ppy
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:97753. Ppy.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Add
BLAST
Peptidei30 – 6536Pancreatic hormonePRO_0000025368Add
BLAST
Peptidei69 – 10032C-terminal peptidePRO_0000025369Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei65 – 651Tyrosine amideBy similarity

Post-translational modificationi

No icosapeptide-like peptide is cleaved from the C-terminal.

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiP10601.
PRIDEiP10601.

Expressioni

Gene expression databases

BgeeiP10601.
CleanExiMM_PPY.
ExpressionAtlasiP10601. baseline and differential.
GenevisibleiP10601. MM.

Interactioni

GO - Molecular functioni

  • G-protein coupled receptor binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000017460.

Structurei

3D structure databases

ProteinModelPortaliP10601.
SMRiP10601. Positions 30-65.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NPY family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J7V9. Eukaryota.
ENOG41115N2. LUCA.
HOGENOMiHOG000252942.
HOVERGENiHBG008147.
InParanoidiP10601.
KOiK05234.
OMAiLRRYINT.
OrthoDBiEOG7KDFDF.
PhylomeDBiP10601.
TreeFamiTF332778.

Family and domain databases

InterProiIPR015480. Pancreatic_hormone.
IPR001955. Pancreatic_hormone-like.
IPR020392. Pancreatic_hormone-like_CS.
[Graphical view]
PANTHERiPTHR10533. PTHR10533. 1 hit.
PTHR10533:SF2. PTHR10533:SF2. 1 hit.
PfamiPF00159. Hormone_3. 1 hit.
[Graphical view]
PRINTSiPR00278. PANCHORMONE.
ProDomiPD001267. Pancreatic_hormone-like. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00309. PAH. 1 hit.
[Graphical view]
PROSITEiPS00265. PANCREATIC_HORMONE_1. 1 hit.
PS50276. PANCREATIC_HORMONE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10601-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVAYCCLSL FLVSTWVALL LQPLQGTWGA PLEPMYPGDY ATPEQMAQYE
60 70 80 90 100
TQLRRYINTL TRPRYGKRAE EENTGGLPGV QLSPCTSPPV GLIPCSAPWS
Length:100
Mass (Da):11,020
Last modified:July 1, 1989 - v1
Checksum:iA0D0D04FB7DFB9D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18208 mRNA. Translation: AAA39967.1.
CCDSiCCDS25486.1.
PIRiB28261.
RefSeqiNP_032944.1. NM_008918.1.
XP_011247102.1. XM_011248800.1.
UniGeneiMm.1269.

Genome annotation databases

EnsembliENSMUST00000017460; ENSMUSP00000017460; ENSMUSG00000017316.
ENSMUST00000170554; ENSMUSP00000126798; ENSMUSG00000017316.
GeneIDi19064.
KEGGimmu:19064.
UCSCiuc007lqm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18208 mRNA. Translation: AAA39967.1.
CCDSiCCDS25486.1.
PIRiB28261.
RefSeqiNP_032944.1. NM_008918.1.
XP_011247102.1. XM_011248800.1.
UniGeneiMm.1269.

3D structure databases

ProteinModelPortaliP10601.
SMRiP10601. Positions 30-65.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000017460.

Proteomic databases

PaxDbiP10601.
PRIDEiP10601.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000017460; ENSMUSP00000017460; ENSMUSG00000017316.
ENSMUST00000170554; ENSMUSP00000126798; ENSMUSG00000017316.
GeneIDi19064.
KEGGimmu:19064.
UCSCiuc007lqm.1. mouse.

Organism-specific databases

CTDi5539.
MGIiMGI:97753. Ppy.

Phylogenomic databases

eggNOGiENOG410J7V9. Eukaryota.
ENOG41115N2. LUCA.
HOGENOMiHOG000252942.
HOVERGENiHBG008147.
InParanoidiP10601.
KOiK05234.
OMAiLRRYINT.
OrthoDBiEOG7KDFDF.
PhylomeDBiP10601.
TreeFamiTF332778.

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-418594. G alpha (i) signalling events.

Miscellaneous databases

NextBioi295574.
PROiP10601.
SOURCEiSearch...

Gene expression databases

BgeeiP10601.
CleanExiMM_PPY.
ExpressionAtlasiP10601. baseline and differential.
GenevisibleiP10601. MM.

Family and domain databases

InterProiIPR015480. Pancreatic_hormone.
IPR001955. Pancreatic_hormone-like.
IPR020392. Pancreatic_hormone-like_CS.
[Graphical view]
PANTHERiPTHR10533. PTHR10533. 1 hit.
PTHR10533:SF2. PTHR10533:SF2. 1 hit.
PfamiPF00159. Hormone_3. 1 hit.
[Graphical view]
PRINTSiPR00278. PANCHORMONE.
ProDomiPD001267. Pancreatic_hormone-like. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00309. PAH. 1 hit.
[Graphical view]
PROSITEiPS00265. PANCREATIC_HORMONE_1. 1 hit.
PS50276. PANCREATIC_HORMONE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Mosaic evolution of prepropancreatic polypeptide. II. Structural conservation and divergence in pancreatic polypeptide gene."
    Yonekura H., Nata K., Watanabe T., Kurashina Y., Yamamoto H., Okamoto H.
    J. Biol. Chem. 263:2990-2997(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Tissue: Pancreas.

Entry informationi

Entry nameiPAHO_MOUSE
AccessioniPrimary (citable) accession number: P10601
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: May 11, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.