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Protein

Pancreatic prohormone

Gene

Ppy

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions.

GO - Molecular functioni

  • G-protein coupled receptor binding Source: MGI
  • neuropeptide hormone activity Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Pancreatic prohormone
Alternative name(s):
Pancreatic polypeptide
Short name:
PP
Cleaved into the following 2 chains:
Gene namesi
Name:Ppy
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:97753. Ppy.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Add BLAST29
PeptideiPRO_000002536830 – 65Pancreatic hormoneAdd BLAST36
PeptideiPRO_000002536969 – 100C-terminal peptideAdd BLAST32

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei65Tyrosine amideBy similarity1

Post-translational modificationi

No icosapeptide-like peptide is cleaved from the C-terminal.

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiP10601.
PRIDEiP10601.

Expressioni

Gene expression databases

BgeeiENSMUSG00000017316.
CleanExiMM_PPY.
ExpressionAtlasiP10601. baseline and differential.
GenevisibleiP10601. MM.

Interactioni

GO - Molecular functioni

  • G-protein coupled receptor binding Source: MGI
  • neuropeptide hormone activity Source: GO_Central

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000017460.

Structurei

3D structure databases

ProteinModelPortaliP10601.
SMRiP10601.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NPY family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J7V9. Eukaryota.
ENOG41115N2. LUCA.
GeneTreeiENSGT00530000064295.
HOGENOMiHOG000252942.
HOVERGENiHBG008147.
InParanoidiP10601.
KOiK05234.
OMAiLRRYINT.
OrthoDBiEOG091G15HI.
PhylomeDBiP10601.
TreeFamiTF332778.

Family and domain databases

CDDicd00126. PAH. 1 hit.
InterProiIPR015480. Pancreatic_hormone.
IPR001955. Pancreatic_hormone-like.
IPR020392. Pancreatic_hormone-like_CS.
[Graphical view]
PANTHERiPTHR10533. PTHR10533. 1 hit.
PTHR10533:SF2. PTHR10533:SF2. 1 hit.
PfamiPF00159. Hormone_3. 1 hit.
[Graphical view]
PRINTSiPR00278. PANCHORMONE.
ProDomiPD001267. Pancreatic_hormone-like. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00309. PAH. 1 hit.
[Graphical view]
PROSITEiPS00265. PANCREATIC_HORMONE_1. 1 hit.
PS50276. PANCREATIC_HORMONE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10601-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVAYCCLSL FLVSTWVALL LQPLQGTWGA PLEPMYPGDY ATPEQMAQYE
60 70 80 90 100
TQLRRYINTL TRPRYGKRAE EENTGGLPGV QLSPCTSPPV GLIPCSAPWS
Length:100
Mass (Da):11,020
Last modified:July 1, 1989 - v1
Checksum:iA0D0D04FB7DFB9D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18208 mRNA. Translation: AAA39967.1.
CCDSiCCDS25486.1.
PIRiB28261.
RefSeqiNP_032944.1. NM_008918.1.
UniGeneiMm.1269.

Genome annotation databases

EnsembliENSMUST00000017460; ENSMUSP00000017460; ENSMUSG00000017316.
ENSMUST00000170554; ENSMUSP00000126798; ENSMUSG00000017316.
GeneIDi19064.
KEGGimmu:19064.
UCSCiuc007lqm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18208 mRNA. Translation: AAA39967.1.
CCDSiCCDS25486.1.
PIRiB28261.
RefSeqiNP_032944.1. NM_008918.1.
UniGeneiMm.1269.

3D structure databases

ProteinModelPortaliP10601.
SMRiP10601.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000017460.

Proteomic databases

PaxDbiP10601.
PRIDEiP10601.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000017460; ENSMUSP00000017460; ENSMUSG00000017316.
ENSMUST00000170554; ENSMUSP00000126798; ENSMUSG00000017316.
GeneIDi19064.
KEGGimmu:19064.
UCSCiuc007lqm.1. mouse.

Organism-specific databases

CTDi5539.
MGIiMGI:97753. Ppy.

Phylogenomic databases

eggNOGiENOG410J7V9. Eukaryota.
ENOG41115N2. LUCA.
GeneTreeiENSGT00530000064295.
HOGENOMiHOG000252942.
HOVERGENiHBG008147.
InParanoidiP10601.
KOiK05234.
OMAiLRRYINT.
OrthoDBiEOG091G15HI.
PhylomeDBiP10601.
TreeFamiTF332778.

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiP10601.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000017316.
CleanExiMM_PPY.
ExpressionAtlasiP10601. baseline and differential.
GenevisibleiP10601. MM.

Family and domain databases

CDDicd00126. PAH. 1 hit.
InterProiIPR015480. Pancreatic_hormone.
IPR001955. Pancreatic_hormone-like.
IPR020392. Pancreatic_hormone-like_CS.
[Graphical view]
PANTHERiPTHR10533. PTHR10533. 1 hit.
PTHR10533:SF2. PTHR10533:SF2. 1 hit.
PfamiPF00159. Hormone_3. 1 hit.
[Graphical view]
PRINTSiPR00278. PANCHORMONE.
ProDomiPD001267. Pancreatic_hormone-like. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00309. PAH. 1 hit.
[Graphical view]
PROSITEiPS00265. PANCREATIC_HORMONE_1. 1 hit.
PS50276. PANCREATIC_HORMONE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPAHO_MOUSE
AccessioniPrimary (citable) accession number: P10601
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 30, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.