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P10600

- TGFB3_HUMAN

UniProt

P10600 - TGFB3_HUMAN

Protein

Transforming growth factor beta-3

Gene

TGFB3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 169 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
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    Functioni

    Involved in embryogenesis and cell differentiation.

    GO - Molecular functioni

    1. identical protein binding Source: BHF-UCL
    2. protein binding Source: UniProtKB
    3. transforming growth factor beta binding Source: BHF-UCL
    4. type II transforming growth factor beta receptor binding Source: BHF-UCL
    5. type I transforming growth factor beta receptor binding Source: BHF-UCL

    GO - Biological processi

    1. activation of MAPK activity Source: Ensembl
    2. aging Source: Ensembl
    3. blood coagulation Source: Reactome
    4. cell-cell junction organization Source: BHF-UCL
    5. cell growth Source: InterPro
    6. detection of hypoxia Source: BHF-UCL
    7. digestive tract development Source: Ensembl
    8. embryonic neurocranium morphogenesis Source: Ensembl
    9. extracellular matrix organization Source: Reactome
    10. face morphogenesis Source: BHF-UCL
    11. female pregnancy Source: Ensembl
    12. frontal suture morphogenesis Source: Ensembl
    13. inner ear development Source: Ensembl
    14. in utero embryonic development Source: BHF-UCL
    15. lung alveolus development Source: BHF-UCL
    16. mammary gland development Source: BHF-UCL
    17. menstrual cycle phase Source: BHF-UCL
    18. negative regulation of cell proliferation Source: BHF-UCL
    19. negative regulation of DNA replication Source: BHF-UCL
    20. negative regulation of macrophage cytokine production Source: DFLAT
    21. negative regulation of neuron apoptotic process Source: BHF-UCL
    22. negative regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
    23. odontogenesis Source: BHF-UCL
    24. ossification involved in bone remodeling Source: BHF-UCL
    25. palate development Source: BHF-UCL
    26. platelet activation Source: Reactome
    27. platelet degranulation Source: Reactome
    28. positive regulation of apoptotic process Source: BHF-UCL
    29. positive regulation of bone mineralization Source: BHF-UCL
    30. positive regulation of cell division Source: UniProtKB-KW
    31. positive regulation of collagen biosynthetic process Source: BHF-UCL
    32. positive regulation of DNA replication Source: BHF-UCL
    33. positive regulation of epithelial to mesenchymal transition Source: BHF-UCL
    34. positive regulation of filopodium assembly Source: BHF-UCL
    35. positive regulation of pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
    36. positive regulation of protein secretion Source: BHF-UCL
    37. positive regulation of SMAD protein import into nucleus Source: BHF-UCL
    38. positive regulation of transcription, DNA-templated Source: BHF-UCL
    39. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    40. response to estrogen Source: Ensembl
    41. response to hypoxia Source: BHF-UCL
    42. response to laminar fluid shear stress Source: Ensembl
    43. response to progesterone Source: BHF-UCL
    44. salivary gland morphogenesis Source: BHF-UCL
    45. SMAD protein import into nucleus Source: Ensembl
    46. transforming growth factor beta receptor signaling pathway Source: BHF-UCL

    Keywords - Molecular functioni

    Growth factor, Mitogen

    Enzyme and pathway databases

    ReactomeiREACT_150331. Molecules associated with elastic fibres.
    REACT_163906. ECM proteoglycans.
    SignaLinkiP10600.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transforming growth factor beta-3
    Short name:
    TGF-beta-3
    Cleaved into the following chain:
    Gene namesi
    Name:TGFB3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:11769. TGFB3.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. extracellular matrix Source: BHF-UCL
    3. extracellular region Source: Reactome
    4. extracellular space Source: Ensembl
    5. neuronal cell body Source: Ensembl
    6. nucleus Source: Ensembl
    7. plasma membrane Source: BHF-UCL
    8. platelet alpha granule lumen Source: Reactome
    9. T-tubule Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Involvement in diseasei

    Arrhythmogenic right ventricular dysplasia, familial, 1 (ARVD1) [MIM:107970]: A congenital heart disease characterized by infiltration of adipose and fibrous tissue into the right ventricle and loss of myocardial cells, resulting in ventricular and supraventricular arrhythmias.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Rienhoff syndrome (RNHF) [MIM:615582]: A congenital syndrome characterized by abnormal development of several mesenchymal-derived tissues, including muscle and craniopalatofacial structures, accompanied by low muscle mass, growth retardation, distal arthrogryposis. Additional clinical features include arachnodactyly, pectus excavatum, pes planus, and hyperextensible large joints, as well as hypertelorism and bifid uvula. There is no evidence of vascular disease.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti409 – 4091C → Y in RNHF; hypomorphic mutation; results in impaired TGF-beta signaling. 1 Publication
    VAR_070924

    Keywords - Diseasei

    Cardiomyopathy, Disease mutation

    Organism-specific databases

    MIMi107970. phenotype.
    615582. phenotype.
    Orphaneti293899. Familial isolated arrhythmogenic ventricular dysplasia, biventricular form.
    293888. Familial isolated arrhythmogenic ventricular dysplasia, left dominant form.
    293910. Familial isolated arrhythmogenic ventricular dysplasia, right dominant form.
    PharmGKBiPA36483.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 300277Latency-associated peptidePRO_0000033796Add
    BLAST
    Chaini301 – 412112Transforming growth factor beta-3PRO_0000033797Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi74 – 741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi135 – 1351N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi142 – 1421N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi307 ↔ 316
    Disulfide bondi315 ↔ 378
    Disulfide bondi344 ↔ 409
    Disulfide bondi348 ↔ 411
    Disulfide bondi377 – 377InterchainBy similarity

    Post-translational modificationi

    The precursor is cleaved into mature TGF-beta-3 and LAP, which remains non-covalently linked to mature TGF-beta-3 rendering it inactive.By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP10600.
    PRIDEiP10600.

    PTM databases

    PhosphoSiteiP10600.

    Miscellaneous databases

    PMAP-CutDBP10600.

    Expressioni

    Gene expression databases

    ArrayExpressiP10600.
    BgeeiP10600.
    CleanExiHS_TGFB3.
    GenevestigatoriP10600.

    Organism-specific databases

    HPAiCAB018337.
    HPA027923.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked. Interacts with ASPN.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    TGFBR2P371738EBI-1033020,EBI-296151

    Protein-protein interaction databases

    BioGridi112901. 7 interactions.
    DIPiDIP-5937N.
    IntActiP10600. 6 interactions.
    MINTiMINT-8177755.
    STRINGi9606.ENSP00000238682.

    Structurei

    Secondary structure

    1
    412
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi304 – 3096
    Beta strandi314 – 3185
    Beta strandi321 – 3233
    Helixi324 – 3285
    Beta strandi333 – 3353
    Beta strandi337 – 3404
    Beta strandi343 – 3464
    Turni350 – 3534
    Helixi357 – 36812
    Helixi370 – 3723
    Beta strandi377 – 3804
    Beta strandi382 – 39211
    Beta strandi395 – 40612
    Beta strandi408 – 4125

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1KTZX-ray2.15A301-412[»]
    1TGJX-ray2.00A301-412[»]
    1TGKX-ray3.30A301-412[»]
    2PJYX-ray3.00A301-412[»]
    3EO1X-ray3.10C/F/I/L301-412[»]
    ProteinModelPortaliP10600.
    SMRiP10600. Positions 24-412.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP10600.

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi261 – 2633Cell attachment siteSequence Analysis

    Sequence similaritiesi

    Belongs to the TGF-beta family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG269146.
    HOGENOMiHOG000290198.
    HOVERGENiHBG074115.
    InParanoidiP10600.
    KOiK13377.
    OMAiPEPSVMT.
    OrthoDBiEOG70GMFT.
    PhylomeDBiP10600.
    TreeFamiTF351793.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR016319. TGF-beta.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    IPR015618. Transform_grow_fac_b3.
    [Graphical view]
    PANTHERiPTHR11848. PTHR11848. 1 hit.
    PfamiPF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001787. TGF-beta. 1 hit.
    PRINTSiPR01423. TGFBETA.
    PR01426. TGFBETA3.
    SMARTiSM00204. TGFB. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P10600-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKMHLQRALV VLALLNFATV SLSLSTCTTL DFGHIKKKRV EAIRGQILSK    50
    LRLTSPPEPT VMTHVPYQVL ALYNSTRELL EEMHGEREEG CTQENTESEY 100
    YAKEIHKFDM IQGLAEHNEL AVCPKGITSK VFRFNVSSVE KNRTNLFRAE 150
    FRVLRVPNPS SKRNEQRIEL FQILRPDEHI AKQRYIGGKN LPTRGTAEWL 200
    SFDVTDTVRE WLLRRESNLG LEISIHCPCH TFQPNGDILE NIHEVMEIKF 250
    KGVDNEDDHG RGDLGRLKKQ KDHHNPHLIL MMIPPHRLDN PGQGGQRKKR 300
    ALDTNYCFRN LEENCCVRPL YIDFRQDLGW KWVHEPKGYY ANFCSGPCPY 350
    LRSADTTHST VLGLYNTLNP EASASPCCVP QDLEPLTILY YVGRTPKVEQ 400
    LSNMVVKSCK CS 412
    Length:412
    Mass (Da):47,328
    Last modified:July 1, 1989 - v1
    Checksum:i3CAD3548D3AEA178
    GO
    Isoform 2 (identifier: P10600-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         310-412: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:309
    Mass (Da):35,708
    Checksum:i30F7A936E9467729
    GO

    Sequence cautioni

    The sequence CAA33024.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti60 – 601T → M.1 Publication
    Corresponds to variant rs4252315 [ dbSNP | Ensembl ].
    VAR_016315
    Natural varianti409 – 4091C → Y in RNHF; hypomorphic mutation; results in impaired TGF-beta signaling. 1 Publication
    VAR_070924

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei310 – 412103Missing in isoform 2. 2 PublicationsVSP_056285Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J03241 mRNA. Translation: AAA61161.1.
    X14149 mRNA. Translation: CAA32362.1.
    X14885
    , X14886, X14887, X14888, X14889, X14890, X14891 Genomic DNA. Translation: CAA33024.1. Different initiation.
    AY140241 Genomic DNA. Translation: AAM96819.1.
    AY208161 Genomic DNA. Translation: AAO13495.1.
    BT007287 mRNA. Translation: AAP35951.1.
    AF107885 Genomic DNA. Translation: AAC79727.1.
    BC018503 mRNA. Translation: AAH18503.1.
    CCDSiCCDS9846.1.
    PIRiA36169.
    RefSeqiNP_003230.1. NM_003239.2.
    XP_005268085.1. XM_005268028.1.
    UniGeneiHs.592317.

    Genome annotation databases

    EnsembliENST00000238682; ENSP00000238682; ENSG00000119699.
    ENST00000556285; ENSP00000451110; ENSG00000119699.
    GeneIDi7043.
    KEGGihsa:7043.
    UCSCiuc001xsc.2. human.

    Polymorphism databases

    DMDMi135684.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs
    SeattleSNPs
    Wikipedia

    TGF beta-3 entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J03241 mRNA. Translation: AAA61161.1 .
    X14149 mRNA. Translation: CAA32362.1 .
    X14885
    , X14886 , X14887 , X14888 , X14889 , X14890 , X14891 Genomic DNA. Translation: CAA33024.1 . Different initiation.
    AY140241 Genomic DNA. Translation: AAM96819.1 .
    AY208161 Genomic DNA. Translation: AAO13495.1 .
    BT007287 mRNA. Translation: AAP35951.1 .
    AF107885 Genomic DNA. Translation: AAC79727.1 .
    BC018503 mRNA. Translation: AAH18503.1 .
    CCDSi CCDS9846.1.
    PIRi A36169.
    RefSeqi NP_003230.1. NM_003239.2.
    XP_005268085.1. XM_005268028.1.
    UniGenei Hs.592317.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1KTZ X-ray 2.15 A 301-412 [» ]
    1TGJ X-ray 2.00 A 301-412 [» ]
    1TGK X-ray 3.30 A 301-412 [» ]
    2PJY X-ray 3.00 A 301-412 [» ]
    3EO1 X-ray 3.10 C/F/I/L 301-412 [» ]
    ProteinModelPortali P10600.
    SMRi P10600. Positions 24-412.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112901. 7 interactions.
    DIPi DIP-5937N.
    IntActi P10600. 6 interactions.
    MINTi MINT-8177755.
    STRINGi 9606.ENSP00000238682.

    PTM databases

    PhosphoSitei P10600.

    Polymorphism databases

    DMDMi 135684.

    Proteomic databases

    PaxDbi P10600.
    PRIDEi P10600.

    Protocols and materials databases

    DNASUi 7043.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000238682 ; ENSP00000238682 ; ENSG00000119699 .
    ENST00000556285 ; ENSP00000451110 ; ENSG00000119699 .
    GeneIDi 7043.
    KEGGi hsa:7043.
    UCSCi uc001xsc.2. human.

    Organism-specific databases

    CTDi 7043.
    GeneCardsi GC14M076424.
    GeneReviewsi TGFB3.
    HGNCi HGNC:11769. TGFB3.
    HPAi CAB018337.
    HPA027923.
    MIMi 107970. phenotype.
    190230. gene.
    615582. phenotype.
    neXtProti NX_P10600.
    Orphaneti 293899. Familial isolated arrhythmogenic ventricular dysplasia, biventricular form.
    293888. Familial isolated arrhythmogenic ventricular dysplasia, left dominant form.
    293910. Familial isolated arrhythmogenic ventricular dysplasia, right dominant form.
    PharmGKBi PA36483.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG269146.
    HOGENOMi HOG000290198.
    HOVERGENi HBG074115.
    InParanoidi P10600.
    KOi K13377.
    OMAi PEPSVMT.
    OrthoDBi EOG70GMFT.
    PhylomeDBi P10600.
    TreeFami TF351793.

    Enzyme and pathway databases

    Reactomei REACT_150331. Molecules associated with elastic fibres.
    REACT_163906. ECM proteoglycans.
    SignaLinki P10600.

    Miscellaneous databases

    ChiTaRSi TGFB3. human.
    EvolutionaryTracei P10600.
    GeneWikii Transforming_growth_factor,_beta_3.
    GenomeRNAii 7043.
    NextBioi 27521.
    PMAP-CutDB P10600.
    PROi P10600.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P10600.
    Bgeei P10600.
    CleanExi HS_TGFB3.
    Genevestigatori P10600.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR016319. TGF-beta.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    IPR015618. Transform_grow_fac_b3.
    [Graphical view ]
    PANTHERi PTHR11848. PTHR11848. 1 hit.
    Pfami PF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001787. TGF-beta. 1 hit.
    PRINTSi PR01423. TGFBETA.
    PR01426. TGFBETA3.
    SMARTi SM00204. TGFB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of another member of the transforming growth factor type beta gene family."
      ten Dijke P., Hansen P., Iwata K., Pieler C., Foulkes J.G.
      Proc. Natl. Acad. Sci. U.S.A. 85:4715-4719(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "A new type of transforming growth factor-beta, TGF-beta 3."
      Derynck R., Lindquist P.B., Lee A., Wen D., Tamm J., Graycar J.L., Rhee L., Mason A.J., Miller D.A., Coffey R.J., Moses H.L., Chen E.Y.
      EMBO J. 7:3737-3743(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Placenta.
    3. "Complete genomic sequence of human transforming growth factor-beta 3."
      Madan A., Rowen L., Qin S., Dickhoff R., Shaffer T., James R., Abbasi N., Loretz C., Madan A., Dors M., Dahl T., Hall J., Lasky S., Hood L.
      Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. NIEHS SNPs program
      Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. SeattleSNPs variation discovery resource
      Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT MET-60.
    6. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    7. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Prostate.
    9. "Inhibition of translation of transforming growth factor-beta 3 mRNA by its 5' untranslated region."
      Arrick B.A., Lee A.L., Grendell R.L., Derynck R.
      Mol. Cell. Biol. 11:4306-4313(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-48 (ISOFORM 1/2).
    10. "Mechanisms for asporin function and regulation in articular cartilage."
      Nakajima M., Kizawa H., Saitoh M., Kou I., Miyazono K., Ikegawa S.
      J. Biol. Chem. 282:32185-32192(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ASPN.
    11. "The crystal structure of TGF-beta 3 and comparison to TGF-beta 2: implications for receptor binding."
      Mittl P.R.E., Priestle J.P., Cox D.A., McMaster G., Cerletti N., Gruetter M.G.
      Protein Sci. 5:1261-1271(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 301-412.
    12. "Regulatory mutations in transforming growth factor-beta3 gene cause arrhythmogenic right ventricular cardiomyopathy type 1."
      Beffagna G., Occhi G., Nava A., Vitiello L., Ditadi A., Basso C., Bauce B., Carraro G., Thiene G., Towbin J.A., Danieli G.A., Rampazzo A.
      Cardiovasc. Res. 65:366-373(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN ARVD1.
    13. "A mutation in TGFB3 associated with a syndrome of low muscle mass, growth retardation, distal arthrogryposis and clinical features overlapping with Marfan and Loeys-Dietz syndrome."
      Rienhoff H.Y. Jr., Yeo C.Y., Morissette R., Khrebtukova I., Melnick J., Luo S., Leng N., Kim Y.J., Schroth G., Westwick J., Vogel H., McDonnell N., Hall J.G., Whitman M.
      Am. J. Med. Genet. A 161A:2040-2046(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT RNHF TYR-409, CHARACTERIZATION OF VARIANT RNHF TYR-409.

    Entry informationi

    Entry nameiTGFB3_HUMAN
    AccessioniPrimary (citable) accession number: P10600
    Secondary accession number(s): Q8WV88
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 169 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3