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Protein

Beta-casein

Gene

Csn2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Important role in determination of the surface properties of the casein micelles.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Milk protein

Enzyme and pathway databases

ReactomeiREACT_345486. Nuclear signaling by ERBB4.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-casein
Gene namesi
Name:Csn2
Synonyms:Csnb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:88541. Csn2.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: MGI
  • extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515By similarityAdd
BLAST
Chaini16 – 231216Beta-caseinPRO_0000004477Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei23 – 231PhosphoserineBy similarity
Modified residuei26 – 261PhosphothreonineBy similarity
Modified residuei28 – 281PhosphoserineBy similarity
Modified residuei30 – 301PhosphoserineBy similarity
Modified residuei31 – 311PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP10598.
PRIDEiP10598.

PTM databases

PhosphoSiteiP10598.

Expressioni

Tissue specificityi

Mammary gland specific. Secreted in milk.

Gene expression databases

BgeeiP10598.
CleanExiMM_CSN2.
ExpressionAtlasiP10598. baseline and differential.
GenevisibleiP10598. MM.

Interactioni

Protein-protein interaction databases

BioGridi198938. 2 interactions.
STRINGi10090.ENSMUSP00000080976.

Structurei

3D structure databases

ProteinModelPortaliP10598.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-casein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG45871.
GeneTreeiENSGT00390000001890.
HOVERGENiHBG004973.
InParanoidiP10598.
KOiK17107.
OMAiEIMEVPK.
OrthoDBiEOG7W6WP2.
PhylomeDBiP10598.
TreeFamiTF336929.

Family and domain databases

InterProiIPR001588. Casein.
IPR016345. Casein_beta.
[Graphical view]
PANTHERiPTHR11500. PTHR11500. 1 hit.
PfamiPF00363. Casein. 1 hit.
[Graphical view]
PIRSFiPIRSF002372. Beta-casein. 1 hit.
PROSITEiPS00306. CASEIN_ALPHA_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10598-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVFILACLV ALALARETTF TVSSETDSIS SEESVEHINE QKLQKVNLMG
60 70 80 90 100
QLQAEDVLQA KVHSSIQSQP QAFPYAQAQT ISCNPVPQNI QPIAQPPVVP
110 120 130 140 150
SLGPVISPEL ESFLKAKATI LPKHKQMPLL NSETVLRLIN SQIPSLASLA
160 170 180 190 200
NLHLPQSLVQ LLAQVVQAFP QTHLVSSQTQ LSLPQSKVLY FLQQVAPFLP
210 220 230
QDMSVQDLLQ YLELLNPTVQ FPATPQHSVS V
Length:231
Mass (Da):25,337
Last modified:July 1, 1989 - v1
Checksum:i7DD7DFF0766A9422
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31V → T in AAH19189 (PubMed:15489334).Curated
Sequence conflicti41 – 411Missing in BAB32374 (PubMed:16141072).Curated
Sequence conflicti41 – 411Missing in BAB32375 (PubMed:16141072).Curated
Sequence conflicti41 – 411Missing in AAH19114 (PubMed:15489334).Curated
Sequence conflicti41 – 411Missing in AAH19189 (PubMed:15489334).Curated
Sequence conflicti145 – 1451S → C in BAB32374 (PubMed:16141072).Curated
Sequence conflicti156 – 1561Q → R in AAH13332 (PubMed:15489334).Curated
Sequence conflicti165 – 1662VV → GG in BAB32375 (PubMed:16141072).Curated
Sequence conflicti192 – 1921L → V in BAB32374 (PubMed:16141072).Curated
Sequence conflicti218 – 2181T → P in BAB32374 (PubMed:16141072).Curated
Sequence conflicti218 – 2181T → P in BAB32375 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04490 mRNA. Translation: CAA28178.1.
X13484 Genomic DNA. Translation: CAA31840.1.
AK021324 mRNA. Translation: BAB32374.1.
AK021328 mRNA. Translation: BAB32375.1.
AK052803 mRNA. Translation: BAC35152.1.
AK052805 mRNA. Translation: BAC35153.1.
AK085694 mRNA. Translation: BAC39508.1.
AK085729 mRNA. Translation: BAC39522.1.
AK142616 mRNA. Translation: BAE25131.1.
AK142620 mRNA. Translation: BAE25133.1.
AK142635 mRNA. Translation: BAE25141.1.
AK164747 mRNA. Translation: BAE37898.1.
AK164791 mRNA. Translation: BAE37917.1.
AK164792 mRNA. Translation: BAE37918.1.
AK164793 mRNA. Translation: BAE37919.1.
AK164794 mRNA. Translation: BAE37920.1.
BC013332 mRNA. Translation: AAH13332.1.
BC019114 mRNA. Translation: AAH19114.1.
BC019189 mRNA. Translation: AAH19189.1.
BC021153 mRNA. Translation: AAH21153.1.
CCDSiCCDS39131.1.
PIRiJU0061.
RefSeqiNP_001272949.1. NM_001286020.1.
NP_001272950.1. NM_001286021.1.
NP_001272952.1. NM_001286023.1.
NP_034102.1. NM_009972.2.
UniGeneiMm.268737.

Genome annotation databases

EnsembliENSMUST00000082370; ENSMUSP00000080976; ENSMUSG00000063157.
GeneIDi12991.
KEGGimmu:12991.
UCSCiuc008xyu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04490 mRNA. Translation: CAA28178.1.
X13484 Genomic DNA. Translation: CAA31840.1.
AK021324 mRNA. Translation: BAB32374.1.
AK021328 mRNA. Translation: BAB32375.1.
AK052803 mRNA. Translation: BAC35152.1.
AK052805 mRNA. Translation: BAC35153.1.
AK085694 mRNA. Translation: BAC39508.1.
AK085729 mRNA. Translation: BAC39522.1.
AK142616 mRNA. Translation: BAE25131.1.
AK142620 mRNA. Translation: BAE25133.1.
AK142635 mRNA. Translation: BAE25141.1.
AK164747 mRNA. Translation: BAE37898.1.
AK164791 mRNA. Translation: BAE37917.1.
AK164792 mRNA. Translation: BAE37918.1.
AK164793 mRNA. Translation: BAE37919.1.
AK164794 mRNA. Translation: BAE37920.1.
BC013332 mRNA. Translation: AAH13332.1.
BC019114 mRNA. Translation: AAH19114.1.
BC019189 mRNA. Translation: AAH19189.1.
BC021153 mRNA. Translation: AAH21153.1.
CCDSiCCDS39131.1.
PIRiJU0061.
RefSeqiNP_001272949.1. NM_001286020.1.
NP_001272950.1. NM_001286021.1.
NP_001272952.1. NM_001286023.1.
NP_034102.1. NM_009972.2.
UniGeneiMm.268737.

3D structure databases

ProteinModelPortaliP10598.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198938. 2 interactions.
STRINGi10090.ENSMUSP00000080976.

PTM databases

PhosphoSiteiP10598.

Proteomic databases

PaxDbiP10598.
PRIDEiP10598.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000082370; ENSMUSP00000080976; ENSMUSG00000063157.
GeneIDi12991.
KEGGimmu:12991.
UCSCiuc008xyu.1. mouse.

Organism-specific databases

CTDi1447.
MGIiMGI:88541. Csn2.

Phylogenomic databases

eggNOGiNOG45871.
GeneTreeiENSGT00390000001890.
HOVERGENiHBG004973.
InParanoidiP10598.
KOiK17107.
OMAiEIMEVPK.
OrthoDBiEOG7W6WP2.
PhylomeDBiP10598.
TreeFamiTF336929.

Enzyme and pathway databases

ReactomeiREACT_345486. Nuclear signaling by ERBB4.

Miscellaneous databases

ChiTaRSiCsn2. mouse.
NextBioi282788.
PROiP10598.
SOURCEiSearch...

Gene expression databases

BgeeiP10598.
CleanExiMM_CSN2.
ExpressionAtlasiP10598. baseline and differential.
GenevisibleiP10598. MM.

Family and domain databases

InterProiIPR001588. Casein.
IPR016345. Casein_beta.
[Graphical view]
PANTHERiPTHR11500. PTHR11500. 1 hit.
PfamiPF00363. Casein. 1 hit.
[Graphical view]
PIRSFiPIRSF002372. Beta-casein. 1 hit.
PROSITEiPS00306. CASEIN_ALPHA_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of a cDNA encoding mouse beta casein."
    Yoshimura M., Banerjee M.R., Oka T.
    Nucleic Acids Res. 14:8224-8224(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Isolation and structural analysis of the mouse beta-casein gene."
    Yoshimura M., Oka T.
    Gene 78:267-275(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Transfection of beta-casein chimeric gene and hormonal induction of its expression in primary murine mammary epithelial cells."
    Yoshimura M., Oka T.
    Proc. Natl. Acad. Sci. U.S.A. 87:3670-3674(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C3H/HeN.
    Tissue: Liver.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.

Entry informationi

Entry nameiCASB_MOUSE
AccessioniPrimary (citable) accession number: P10598
Secondary accession number(s): Q543D9
, Q8VCT6, Q8VCU8, Q91VI5, Q922Y5, Q9D1U6, Q9D1U7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: June 24, 2015
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.