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P10598

- CASB_MOUSE

UniProt

P10598 - CASB_MOUSE

Protein

Beta-casein

Gene

Csn2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
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    Functioni

    Important role in determination of the surface properties of the casein micelles.

    GO - Molecular functioni

    1. transporter activity Source: InterPro

    Keywords - Molecular functioni

    Milk protein

    Enzyme and pathway databases

    ReactomeiREACT_198574. Nuclear signaling by ERBB4.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-casein
    Gene namesi
    Name:Csn2
    Synonyms:Csnb
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:88541. Csn2.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: MGI

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1515By similarityAdd
    BLAST
    Chaini16 – 231216Beta-caseinPRO_0000004477Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei23 – 231PhosphoserineBy similarity
    Modified residuei26 – 261PhosphothreonineBy similarity
    Modified residuei28 – 281PhosphoserineBy similarity
    Modified residuei30 – 301PhosphoserineBy similarity
    Modified residuei31 – 311PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP10598.
    PRIDEiP10598.

    PTM databases

    PhosphoSiteiP10598.

    Expressioni

    Tissue specificityi

    Mammary gland specific. Secreted in milk.

    Gene expression databases

    BgeeiP10598.
    CleanExiMM_CSN2.
    GenevestigatoriP10598.

    Interactioni

    Protein-protein interaction databases

    BioGridi198938. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP10598.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the beta-casein family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG45871.
    GeneTreeiENSGT00390000001890.
    HOVERGENiHBG004973.
    InParanoidiP10598.
    KOiK17107.
    OMAiEIMEVPK.
    OrthoDBiEOG7W6WP2.
    PhylomeDBiP10598.
    TreeFamiTF336929.

    Family and domain databases

    InterProiIPR001588. Casein.
    IPR016345. Casein_beta.
    [Graphical view]
    PANTHERiPTHR11500. PTHR11500. 1 hit.
    PfamiPF00363. Casein. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002372. Beta-casein. 1 hit.
    PROSITEiPS00306. CASEIN_ALPHA_BETA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P10598-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVFILACLV ALALARETTF TVSSETDSIS SEESVEHINE QKLQKVNLMG    50
    QLQAEDVLQA KVHSSIQSQP QAFPYAQAQT ISCNPVPQNI QPIAQPPVVP 100
    SLGPVISPEL ESFLKAKATI LPKHKQMPLL NSETVLRLIN SQIPSLASLA 150
    NLHLPQSLVQ LLAQVVQAFP QTHLVSSQTQ LSLPQSKVLY FLQQVAPFLP 200
    QDMSVQDLLQ YLELLNPTVQ FPATPQHSVS V 231
    Length:231
    Mass (Da):25,337
    Last modified:July 1, 1989 - v1
    Checksum:i7DD7DFF0766A9422
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti3 – 31V → T in AAH19189. (PubMed:15489334)Curated
    Sequence conflicti41 – 411Missing in BAB32374. (PubMed:16141072)Curated
    Sequence conflicti41 – 411Missing in BAB32375. (PubMed:16141072)Curated
    Sequence conflicti41 – 411Missing in AAH19114. (PubMed:15489334)Curated
    Sequence conflicti41 – 411Missing in AAH19189. (PubMed:15489334)Curated
    Sequence conflicti145 – 1451S → C in BAB32374. (PubMed:16141072)Curated
    Sequence conflicti156 – 1561Q → R in AAH13332. (PubMed:15489334)Curated
    Sequence conflicti165 – 1662VV → GG in BAB32375. (PubMed:16141072)Curated
    Sequence conflicti192 – 1921L → V in BAB32374. (PubMed:16141072)Curated
    Sequence conflicti218 – 2181T → P in BAB32374. (PubMed:16141072)Curated
    Sequence conflicti218 – 2181T → P in BAB32375. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X04490 mRNA. Translation: CAA28178.1.
    X13484 Genomic DNA. Translation: CAA31840.1.
    AK021324 mRNA. Translation: BAB32374.1.
    AK021328 mRNA. Translation: BAB32375.1.
    AK052803 mRNA. Translation: BAC35152.1.
    AK052805 mRNA. Translation: BAC35153.1.
    AK085694 mRNA. Translation: BAC39508.1.
    AK085729 mRNA. Translation: BAC39522.1.
    AK142616 mRNA. Translation: BAE25131.1.
    AK142620 mRNA. Translation: BAE25133.1.
    AK142635 mRNA. Translation: BAE25141.1.
    AK164747 mRNA. Translation: BAE37898.1.
    AK164791 mRNA. Translation: BAE37917.1.
    AK164792 mRNA. Translation: BAE37918.1.
    AK164793 mRNA. Translation: BAE37919.1.
    AK164794 mRNA. Translation: BAE37920.1.
    BC013332 mRNA. Translation: AAH13332.1.
    BC019114 mRNA. Translation: AAH19114.1.
    BC019189 mRNA. Translation: AAH19189.1.
    BC021153 mRNA. Translation: AAH21153.1.
    CCDSiCCDS39131.1.
    PIRiJU0061.
    RefSeqiNP_001272949.1. NM_001286020.1.
    NP_001272950.1. NM_001286021.1.
    NP_001272952.1. NM_001286023.1.
    NP_034102.1. NM_009972.2.
    UniGeneiMm.268737.

    Genome annotation databases

    EnsembliENSMUST00000082370; ENSMUSP00000080976; ENSMUSG00000063157.
    GeneIDi12991.
    KEGGimmu:12991.
    UCSCiuc008xyu.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X04490 mRNA. Translation: CAA28178.1 .
    X13484 Genomic DNA. Translation: CAA31840.1 .
    AK021324 mRNA. Translation: BAB32374.1 .
    AK021328 mRNA. Translation: BAB32375.1 .
    AK052803 mRNA. Translation: BAC35152.1 .
    AK052805 mRNA. Translation: BAC35153.1 .
    AK085694 mRNA. Translation: BAC39508.1 .
    AK085729 mRNA. Translation: BAC39522.1 .
    AK142616 mRNA. Translation: BAE25131.1 .
    AK142620 mRNA. Translation: BAE25133.1 .
    AK142635 mRNA. Translation: BAE25141.1 .
    AK164747 mRNA. Translation: BAE37898.1 .
    AK164791 mRNA. Translation: BAE37917.1 .
    AK164792 mRNA. Translation: BAE37918.1 .
    AK164793 mRNA. Translation: BAE37919.1 .
    AK164794 mRNA. Translation: BAE37920.1 .
    BC013332 mRNA. Translation: AAH13332.1 .
    BC019114 mRNA. Translation: AAH19114.1 .
    BC019189 mRNA. Translation: AAH19189.1 .
    BC021153 mRNA. Translation: AAH21153.1 .
    CCDSi CCDS39131.1.
    PIRi JU0061.
    RefSeqi NP_001272949.1. NM_001286020.1.
    NP_001272950.1. NM_001286021.1.
    NP_001272952.1. NM_001286023.1.
    NP_034102.1. NM_009972.2.
    UniGenei Mm.268737.

    3D structure databases

    ProteinModelPortali P10598.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198938. 2 interactions.

    PTM databases

    PhosphoSitei P10598.

    Proteomic databases

    PaxDbi P10598.
    PRIDEi P10598.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000082370 ; ENSMUSP00000080976 ; ENSMUSG00000063157 .
    GeneIDi 12991.
    KEGGi mmu:12991.
    UCSCi uc008xyu.1. mouse.

    Organism-specific databases

    CTDi 1447.
    MGIi MGI:88541. Csn2.

    Phylogenomic databases

    eggNOGi NOG45871.
    GeneTreei ENSGT00390000001890.
    HOVERGENi HBG004973.
    InParanoidi P10598.
    KOi K17107.
    OMAi EIMEVPK.
    OrthoDBi EOG7W6WP2.
    PhylomeDBi P10598.
    TreeFami TF336929.

    Enzyme and pathway databases

    Reactomei REACT_198574. Nuclear signaling by ERBB4.

    Miscellaneous databases

    ChiTaRSi CSN2. mouse.
    NextBioi 282788.
    PROi P10598.
    SOURCEi Search...

    Gene expression databases

    Bgeei P10598.
    CleanExi MM_CSN2.
    Genevestigatori P10598.

    Family and domain databases

    InterProi IPR001588. Casein.
    IPR016345. Casein_beta.
    [Graphical view ]
    PANTHERi PTHR11500. PTHR11500. 1 hit.
    Pfami PF00363. Casein. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002372. Beta-casein. 1 hit.
    PROSITEi PS00306. CASEIN_ALPHA_BETA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of a cDNA encoding mouse beta casein."
      Yoshimura M., Banerjee M.R., Oka T.
      Nucleic Acids Res. 14:8224-8224(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Isolation and structural analysis of the mouse beta-casein gene."
      Yoshimura M., Oka T.
      Gene 78:267-275(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    3. "Transfection of beta-casein chimeric gene and hormonal induction of its expression in primary murine mammary epithelial cells."
      Yoshimura M., Oka T.
      Proc. Natl. Acad. Sci. U.S.A. 87:3670-3674(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: C3H/HeN.
      Tissue: Liver.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Mammary gland.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiCASB_MOUSE
    AccessioniPrimary (citable) accession number: P10598
    Secondary accession number(s): Q543D9
    , Q8VCT6, Q8VCU8, Q91VI5, Q922Y5, Q9D1U6, Q9D1U7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3