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Protein

Invertase 1

Gene

SUC1

Organism
Saccharomyces cerevisiae (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-fructofuranoside residues in beta-D-fructofuranosides.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei42PROSITE-ProRule annotation1
Binding sitei60SubstrateBy similarity1
Binding sitei223SubstrateBy similarity1
Binding sitei311SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH32. Glycoside Hydrolase Family 32.
mycoCLAPiSUC32A_YEAST.

Names & Taxonomyi

Protein namesi
Recommended name:
Invertase 1 (EC:3.2.1.26)
Alternative name(s):
Beta-fructofuranosidase 1
Saccharase
Gene namesi
Name:SUC1
OrganismiSaccharomyces cerevisiae (Baker's yeast)
Taxonomic identifieri4932 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Organism-specific databases

SGDiS000029531. SUC1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei8263. Sac c Invertase.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Add BLAST19
ChainiPRO_000003339820 – 532Invertase 1Add BLAST513

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi23N-linked (GlcNAc...); in isoform SecretedSequence analysis1
Glycosylationi64N-linked (GlcNAc...); in isoform SecretedSequence analysis1
Glycosylationi111N-linked (GlcNAc...); in isoform SecretedSequence analysis1
Glycosylationi112N-linked (GlcNAc...); in isoform SecretedSequence analysis1
Glycosylationi118N-linked (GlcNAc...); in isoform SecretedSequence analysis1
Glycosylationi165N-linked (GlcNAc...); in isoform SecretedSequence analysis1
Glycosylationi275N-linked (GlcNAc...); in isoform SecretedSequence analysis1
Glycosylationi356N-linked (GlcNAc...); in isoform SecretedSequence analysis1
Glycosylationi369N-linked (GlcNAc...); in isoform SecretedSequence analysis1
Glycosylationi384N-linked (GlcNAc...); in isoform SecretedSequence analysis1
Glycosylationi398N-linked (GlcNAc...); in isoform SecretedSequence analysis1
Glycosylationi512N-linked (GlcNAc...); in isoform SecretedSequence analysis1

Post-translational modificationi

Isoform Secreted is glycosylated. Isoform Intracellular is not glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP10594.
PRIDEiP10594.

Interactioni

Protein-protein interaction databases

STRINGi4932.YIL162W.

Structurei

3D structure databases

ProteinModelPortaliP10594.
SMRiP10594.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni39 – 42Substrate bindingBy similarity4
Regioni102 – 103Substrate bindingBy similarity2
Regioni170 – 171Substrate bindingBy similarity2

Sequence similaritiesi

Belongs to the glycosyl hydrolase 32 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0228. Eukaryota.
COG1621. LUCA.

Family and domain databases

Gene3Di2.120.10.10. 2 hits.
2.60.120.560. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001362. Glyco_hydro_32.
IPR018053. Glyco_hydro_32_AS.
IPR013189. Glyco_hydro_32_C.
IPR013148. Glyco_hydro_32_N.
IPR023296. Glyco_hydro_beta-prop.
IPR011040. Sialidases.
[Graphical view]
PfamiPF08244. Glyco_hydro_32C. 1 hit.
PF00251. Glyco_hydro_32N. 1 hit.
[Graphical view]
SMARTiSM00640. Glyco_32. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF75005. SSF75005. 1 hit.
PROSITEiPS00609. GLYCOSYL_HYDROL_F32. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket

Isoform Secreted (identifier: P10594-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLQAFLFLL AGFAAKISAS MTNETSDRPL VHFTPNKGWM NDPNGLWYDA
60 70 80 90 100
KEGKWHLYFQ YNPNDTVWGL PLFWGHATSD DLTHWQDEPV AIAPKRKDSG
110 120 130 140 150
AYSGSMVIDY NNTSGFFNDT IDPRQRCVAI WTYNTPESEE QYISYSLDGG
160 170 180 190 200
YTFTEYQKNP VLAANSTQFR DPKVFWYEPS KKWIMTAAKS QDYKIEIYSS
210 220 230 240 250
DDLKSWKLES AFANEGFLGY QYECPGLIEV PSEQDPSKSH WVMFISINPG
260 270 280 290 300
APAGGSFNQY FVGSFNGHHF EAFDNQSRVV DFGKDYYALQ TFFNTDPTYG
310 320 330 340 350
SALGIAWASN WEYSAFVPSN PWRSSMSLVR PFSLNTEYQA NPETELINLK
360 370 380 390 400
AEPILNISSA GPWSRFATNT TLTKANSYNV DLSNSTGTLE FELVYAVNTT
410 420 430 440 450
QTISKSVFAD LSLWFKGLED PEEYLRMGFE VSASSFFLDR GNSKVKFVKE
460 470 480 490 500
NPYFTNRMSV NNQPFKSEND LSYYKVYGLL DQNILELYFN DGDVVSTNTY
510 520 530
FMTTGNALGS VNMTTGVDNL FYIDKFQVRE VK
Length:532
Mass (Da):60,570
Last modified:July 1, 1989 - v1
Checksum:i3280EF260EA01606
GO
Isoform Intracellular (identifier: P10594-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: Missing.

Note: Produced by alternative initiation at Met-21 of isoform Secreted.
Show »
Length:512
Mass (Da):58,476
Checksum:iA372DE49187249A1
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0196101 – 20Missing in isoform Intracellular. CuratedAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07570 Genomic DNA. Translation: CAA30457.1.
PIRiS27372.

Keywords - Coding sequence diversityi

Alternative initiation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07570 Genomic DNA. Translation: CAA30457.1.
PIRiS27372.

3D structure databases

ProteinModelPortaliP10594.
SMRiP10594.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4932.YIL162W.

Protein family/group databases

Allergomei8263. Sac c Invertase.
CAZyiGH32. Glycoside Hydrolase Family 32.
mycoCLAPiSUC32A_YEAST.

Proteomic databases

PaxDbiP10594.
PRIDEiP10594.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

SGDiS000029531. SUC1.

Phylogenomic databases

eggNOGiKOG0228. Eukaryota.
COG1621. LUCA.

Family and domain databases

Gene3Di2.120.10.10. 2 hits.
2.60.120.560. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001362. Glyco_hydro_32.
IPR018053. Glyco_hydro_32_AS.
IPR013189. Glyco_hydro_32_C.
IPR013148. Glyco_hydro_32_N.
IPR023296. Glyco_hydro_beta-prop.
IPR011040. Sialidases.
[Graphical view]
PfamiPF08244. Glyco_hydro_32C. 1 hit.
PF00251. Glyco_hydro_32N. 1 hit.
[Graphical view]
SMARTiSM00640. Glyco_32. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF75005. SSF75005. 1 hit.
PROSITEiPS00609. GLYCOSYL_HYDROL_F32. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiINV1_YEASX
AccessioniPrimary (citable) accession number: P10594
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 2, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.