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Protein

Invertase 1

Gene

SUC1

Organism
Saccharomyces cerevisiae (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-fructofuranoside residues in beta-D-fructofuranosides.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei42PROSITE-ProRule annotation1
Binding sitei60SubstrateBy similarity1
Binding sitei223SubstrateBy similarity1
Binding sitei311SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase

Protein family/group databases

CAZyiGH32 Glycoside Hydrolase Family 32
mycoCLAPiSUC32A_YEAST

Names & Taxonomyi

Protein namesi
Recommended name:
Invertase 1 (EC:3.2.1.26)
Alternative name(s):
Beta-fructofuranosidase 1
Saccharase
Gene namesi
Name:SUC1
OrganismiSaccharomyces cerevisiae (Baker's yeast)
Taxonomic identifieri4932 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Organism-specific databases

SGDiS000029531 SUC1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei8263 Sac c Invertase

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Add BLAST19
ChainiPRO_000003339820 – 532Invertase 1Add BLAST513

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi23N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi64N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi111N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi112N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi118N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi165N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi275N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi356N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi369N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi384N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi398N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi512N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Isoform Secreted is glycosylated. Isoform Intracellular is not glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP10594

Structurei

3D structure databases

ProteinModelPortaliP10594
SMRiP10594
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni39 – 42Substrate bindingBy similarity4
Regioni102 – 103Substrate bindingBy similarity2
Regioni170 – 171Substrate bindingBy similarity2

Sequence similaritiesi

Belongs to the glycosyl hydrolase 32 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0228 Eukaryota
COG1621 LUCA

Family and domain databases

Gene3Di2.115.10.20, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001362 Glyco_hydro_32
IPR018053 Glyco_hydro_32_AS
IPR013189 Glyco_hydro_32_C
IPR013148 Glyco_hydro_32_N
IPR023296 Glyco_hydro_beta-prop_sf
PfamiView protein in Pfam
PF08244 Glyco_hydro_32C, 1 hit
PF00251 Glyco_hydro_32N, 1 hit
SMARTiView protein in SMART
SM00640 Glyco_32, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
SSF75005 SSF75005, 1 hit
PROSITEiView protein in PROSITE
PS00609 GLYCOSYL_HYDROL_F32, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket

Isoform Secreted (identifier: P10594-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLQAFLFLL AGFAAKISAS MTNETSDRPL VHFTPNKGWM NDPNGLWYDA
60 70 80 90 100
KEGKWHLYFQ YNPNDTVWGL PLFWGHATSD DLTHWQDEPV AIAPKRKDSG
110 120 130 140 150
AYSGSMVIDY NNTSGFFNDT IDPRQRCVAI WTYNTPESEE QYISYSLDGG
160 170 180 190 200
YTFTEYQKNP VLAANSTQFR DPKVFWYEPS KKWIMTAAKS QDYKIEIYSS
210 220 230 240 250
DDLKSWKLES AFANEGFLGY QYECPGLIEV PSEQDPSKSH WVMFISINPG
260 270 280 290 300
APAGGSFNQY FVGSFNGHHF EAFDNQSRVV DFGKDYYALQ TFFNTDPTYG
310 320 330 340 350
SALGIAWASN WEYSAFVPSN PWRSSMSLVR PFSLNTEYQA NPETELINLK
360 370 380 390 400
AEPILNISSA GPWSRFATNT TLTKANSYNV DLSNSTGTLE FELVYAVNTT
410 420 430 440 450
QTISKSVFAD LSLWFKGLED PEEYLRMGFE VSASSFFLDR GNSKVKFVKE
460 470 480 490 500
NPYFTNRMSV NNQPFKSEND LSYYKVYGLL DQNILELYFN DGDVVSTNTY
510 520 530
FMTTGNALGS VNMTTGVDNL FYIDKFQVRE VK
Length:532
Mass (Da):60,570
Last modified:July 1, 1989 - v1
Checksum:i3280EF260EA01606
GO
Isoform Intracellular (identifier: P10594-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: Missing.

Note: Produced by alternative initiation at Met-21 of isoform Secreted.
Show »
Length:512
Mass (Da):58,476
Checksum:iA372DE49187249A1
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0196101 – 20Missing in isoform Intracellular. CuratedAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07570 Genomic DNA Translation: CAA30457.1
PIRiS27372

Keywords - Coding sequence diversityi

Alternative initiation

Similar proteinsi

Entry informationi

Entry nameiINV1_YEASX
AccessioniPrimary (citable) accession number: P10594
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: March 28, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health