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P10589

- COT1_HUMAN

UniProt

P10589 - COT1_HUMAN

Protein

COUP transcription factor 1

Gene

NR2F1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 156 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
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    Functioni

    Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. Binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. Represses transcriptional activity of LHCG.2 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi83 – 15876Nuclear receptorPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri86 – 10621NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri122 – 14625NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: ProtInc
    2. protein binding Source: BHF-UCL
    3. retinoic acid-responsive element binding Source: Ensembl
    4. sequence-specific DNA binding Source: UniProtKB
    5. sequence-specific DNA binding transcription factor activity Source: UniProtKB
    6. steroid hormone receptor activity Source: InterPro
    7. transcription coactivator activity Source: ProtInc
    8. zinc ion binding Source: InterPro

    GO - Biological processi

    1. cerebral cortex regionalization Source: Ensembl
    2. gene expression Source: Reactome
    3. intracellular receptor signaling pathway Source: GOC
    4. negative regulation of neuron projection development Source: Ensembl
    5. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    6. neuron migration Source: Ensembl
    7. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    8. signal transduction Source: ProtInc
    9. transcription initiation from RNA polymerase II promoter Source: Reactome

    Keywords - Molecular functioni

    Activator, Receptor, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_15525. Nuclear Receptor transcription pathway.
    SignaLinkiP10589.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    COUP transcription factor 1
    Short name:
    COUP-TF1
    Alternative name(s):
    COUP transcription factor I
    Short name:
    COUP-TF I
    Nuclear receptor subfamily 2 group F member 1
    V-erbA-related protein 3
    Short name:
    EAR-3
    Gene namesi
    Name:NR2F1
    Synonyms:EAR3, ERBAL3, TFCOUP1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:7975. NR2F1.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleoplasm Source: Reactome
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31758.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 423423COUP transcription factor 1PRO_0000053602Add
    BLAST

    Proteomic databases

    MaxQBiP10589.
    PaxDbiP10589.
    PRIDEiP10589.

    PTM databases

    PhosphoSiteiP10589.

    Expressioni

    Inductioni

    Inhibited by gonadotropin in granulosa cells.1 Publication

    Gene expression databases

    BgeeiP10589.
    CleanExiHS_NR2F1.
    GenevestigatoriP10589.

    Organism-specific databases

    HPAiCAB019281.

    Interactioni

    Subunit structurei

    Binds DNA as dimer; homodimer and probable heterodimer with NR2F6. Interacts with COPS2.2 Publications

    Protein-protein interaction databases

    BioGridi112883. 17 interactions.
    DIPiDIP-622N.
    IntActiP10589. 1 interaction.
    MINTiMINT-1514389.
    STRINGi9606.ENSP00000325819.

    Structurei

    Secondary structure

    1
    423
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni87 – 893
    Beta strandi95 – 973
    Helixi104 – 11411
    Turni115 – 1173
    Beta strandi132 – 1365
    Helixi140 – 14910
    Helixi153 – 1564

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2EBLNMR-A84-159[»]
    ProteinModelPortaliP10589.
    SMRiP10589. Positions 82-414.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP10589.

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi32 – 365Poly-Gly

    Sequence similaritiesi

    Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri86 – 10621NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri122 – 14625NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG327099.
    HOGENOMiHOG000260820.
    HOVERGENiHBG005606.
    InParanoidiP10589.
    KOiK08547.
    OMAiDSAHIES.
    OrthoDBiEOG72RMZ5.
    PhylomeDBiP10589.
    TreeFamiTF352097.

    Family and domain databases

    Gene3Di1.10.565.10. 1 hit.
    3.30.50.10. 1 hit.
    InterProiIPR003068. COUP_TF.
    IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PfamiPF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view]
    PRINTSiPR01282. COUPTNFACTOR.
    PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTiSM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view]
    SUPFAMiSSF48508. SSF48508. 1 hit.
    PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P10589-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAMVVSSWRD PQDDVAGGNP GGPNPAAQAA RGGGGGAGEQ QQQAGSGAPH    50
    TPQTPGQPGA PATPGTAGDK GQGPPGSGQS QQHIECVVCG DKSSGKHYGQ 100
    FTCEGCKSFF KRSVRRNLTY TCRANRNCPI DQHHRNQCQY CRLKKCLKVG 150
    MRREAVQRGR MPPTQPNPGQ YALTNGDPLN GHCYLSGYIS LLLRAEPYPT 200
    SRYGSQCMQP NNIMGIENIC ELAARLLFSA VEWARNIPFF PDLQITDQVS 250
    LLRLTWSELF VLNAAQCSMP LHVAPLLAAA GLHASPMSAD RVVAFMDHIR 300
    IFQEQVEKLK ALHVDSAEYS CLKAIVLFTS DACGLSDAAH IESLQEKSQC 350
    ALEEYVRSQY PNQPSRFGKL LLRLPSLRTV SSSVIEQLFF VRLVGKTPIE 400
    TLIRDMLLSG SSFNWPYMSI QCS 423
    Length:423
    Mass (Da):46,156
    Last modified:July 1, 1989 - v1
    Checksum:i6EE634BE96242731
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X16155 mRNA. Translation: CAA34277.1.
    X12795 Genomic DNA. Translation: CAA31283.1.
    BC004154 mRNA. Translation: AAH04154.1.
    BC017493 mRNA. Translation: AAH17493.1.
    CCDSiCCDS4068.1.
    PIRiS02710.
    RefSeqiNP_005645.1. NM_005654.5.
    UniGeneiHs.519445.

    Genome annotation databases

    EnsembliENST00000327111; ENSP00000325819; ENSG00000175745.
    GeneIDi7025.
    KEGGihsa:7025.
    UCSCiuc003kkj.3. human.

    Polymorphism databases

    DMDMi116959.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X16155 mRNA. Translation: CAA34277.1 .
    X12795 Genomic DNA. Translation: CAA31283.1 .
    BC004154 mRNA. Translation: AAH04154.1 .
    BC017493 mRNA. Translation: AAH17493.1 .
    CCDSi CCDS4068.1.
    PIRi S02710.
    RefSeqi NP_005645.1. NM_005654.5.
    UniGenei Hs.519445.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2EBL NMR - A 84-159 [» ]
    ProteinModelPortali P10589.
    SMRi P10589. Positions 82-414.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112883. 17 interactions.
    DIPi DIP-622N.
    IntActi P10589. 1 interaction.
    MINTi MINT-1514389.
    STRINGi 9606.ENSP00000325819.

    Chemistry

    ChEMBLi CHEMBL1961789.

    PTM databases

    PhosphoSitei P10589.

    Polymorphism databases

    DMDMi 116959.

    Proteomic databases

    MaxQBi P10589.
    PaxDbi P10589.
    PRIDEi P10589.

    Protocols and materials databases

    DNASUi 7025.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000327111 ; ENSP00000325819 ; ENSG00000175745 .
    GeneIDi 7025.
    KEGGi hsa:7025.
    UCSCi uc003kkj.3. human.

    Organism-specific databases

    CTDi 7025.
    GeneCardsi GC05P092920.
    HGNCi HGNC:7975. NR2F1.
    HPAi CAB019281.
    MIMi 132890. gene.
    neXtProti NX_P10589.
    PharmGKBi PA31758.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG327099.
    HOGENOMi HOG000260820.
    HOVERGENi HBG005606.
    InParanoidi P10589.
    KOi K08547.
    OMAi DSAHIES.
    OrthoDBi EOG72RMZ5.
    PhylomeDBi P10589.
    TreeFami TF352097.

    Enzyme and pathway databases

    Reactomei REACT_15525. Nuclear Receptor transcription pathway.
    SignaLinki P10589.

    Miscellaneous databases

    ChiTaRSi NR2F1. human.
    EvolutionaryTracei P10589.
    GeneWikii COUP-TFI.
    GenomeRNAii 7025.
    NextBioi 27447.
    PROi P10589.
    SOURCEi Search...

    Gene expression databases

    Bgeei P10589.
    CleanExi HS_NR2F1.
    Genevestigatori P10589.

    Family and domain databases

    Gene3Di 1.10.565.10. 1 hit.
    3.30.50.10. 1 hit.
    InterProi IPR003068. COUP_TF.
    IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    Pfami PF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view ]
    PRINTSi PR01282. COUPTNFACTOR.
    PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTi SM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48508. SSF48508. 1 hit.
    PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "COUP transcription factor is a member of the steroid receptor superfamily."
      Wang L.-H., Tsai S.Y., Cook R.G., Beattie W.G., Tsai M.-J., O'Malley B.W.
      Nature 340:163-166(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-423, PARTIAL PROTEIN SEQUENCE.
    2. "Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other."
      Miyajima N., Kadowaki Y., Fukushige S., Shimizu S., Semba K., Yamanashi Y., Matsubara K., Toyoshima K., Yamamoto T.
      Nucleic Acids Res. 16:11057-11074(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Lung.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung and Uterus.
    4. "Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily."
      Dressel U., Thormeyer D., Altincicek B., Paululat A., Eggert M., Schneider S., Tenbaum S.P., Renkawitz R., Baniahmad A.
      Mol. Cell. Biol. 19:3383-3394(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH COPS2.
    5. "Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor."
      Zhang Y., Dufau M.L.
      J. Biol. Chem. 275:2763-2770(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. "EAR2 and EAR3/COUP-TFI regulate transcription of the rat LH receptor."
      Zhang Y., Dufau M.L.
      Mol. Endocrinol. 15:1891-1905(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBUNIT, INDUCTION BY GONADOTROPIN.
    7. "Solution structure of the zinc finger, C4-type domain of human COUP transcription factor 1."
      RIKEN structural genomics initiative (RSGI)
      Submitted (FEB-2008) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 84-162.

    Entry informationi

    Entry nameiCOT1_HUMAN
    AccessioniPrimary (citable) accession number: P10589
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 156 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3