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Protein

COUP transcription factor 1

Gene

NR2F1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. Binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. Represses transcriptional activity of LHCG.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi83 – 158Nuclear receptorPROSITE-ProRule annotationAdd BLAST76
Zinc fingeri86 – 106NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri122 – 146NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

  • retinoic acid-responsive element binding Source: Ensembl
  • RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding Source: ProtInc
  • sequence-specific DNA binding Source: UniProtKB
  • steroid hormone receptor activity Source: InterPro
  • transcription coactivator activity Source: ProtInc
  • transcription factor activity, sequence-specific DNA binding Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Receptor, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000175745-MONOMER.
ReactomeiR-HSA-383280. Nuclear Receptor transcription pathway.
SignaLinkiP10589.
SIGNORiP10589.

Names & Taxonomyi

Protein namesi
Recommended name:
COUP transcription factor 1
Short name:
COUP-TF1
Alternative name(s):
COUP transcription factor I
Short name:
COUP-TF I
Nuclear receptor subfamily 2 group F member 1
V-erbA-related protein 3
Short name:
EAR-3
Gene namesi
Name:NR2F1
Synonyms:EAR3, ERBAL3, TFCOUP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:7975. NR2F1.

Subcellular locationi

GO - Cellular componenti

  • nucleoplasm Source: Reactome
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Bosch-Boonstra-Schaaf optic atrophy syndrome (BBSOAS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant disorder characterized by optic atrophy associated with developmental delay and intellectual disability. Most patients also have evidence of cerebral visual impairment.
See also OMIM:615722
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_071319112R → K in BBSOAS; decreases transcriptional activity. 1 PublicationCorresponds to variant rs587777277dbSNPEnsembl.1
Natural variantiVAR_071320113S → R in BBSOAS; decreases transcriptional activity. 1 PublicationCorresponds to variant rs587777275dbSNPEnsembl.1
Natural variantiVAR_071321115R → P in BBSOAS; decreases transcriptional activity. 1 PublicationCorresponds to variant rs587777274dbSNPEnsembl.1
Natural variantiVAR_071322252L → P in BBSOAS; decreases transcriptional activity. 1 PublicationCorresponds to variant rs587777276dbSNPEnsembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi7025.
MalaCardsiNR2F1.
MIMi615722. phenotype.
OpenTargetsiENSG00000175745.
Orphaneti401777. Optic atrophy-intellectual disability syndrome.
PharmGKBiPA31758.

Chemistry databases

ChEMBLiCHEMBL1961789.

Polymorphism and mutation databases

BioMutaiNR2F1.
DMDMi116959.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000536021 – 423COUP transcription factor 1Add BLAST423

Proteomic databases

MaxQBiP10589.
PaxDbiP10589.
PeptideAtlasiP10589.
PRIDEiP10589.

PTM databases

iPTMnetiP10589.
PhosphoSitePlusiP10589.

Expressioni

Inductioni

Inhibited by gonadotropin in granulosa cells.1 Publication

Gene expression databases

BgeeiENSG00000175745.
CleanExiHS_NR2F1.
ExpressionAtlasiP10589. baseline and differential.
GenevisibleiP10589. HS.

Organism-specific databases

HPAiCAB019281.

Interactioni

Subunit structurei

Binds DNA as dimer; homodimer and probable heterodimer with NR2F6. Interacts with COPS2.2 Publications

Protein-protein interaction databases

BioGridi112883. 27 interactors.
DIPiDIP-622N.
IntActiP10589. 8 interactors.
MINTiMINT-1514389.
STRINGi9606.ENSP00000325819.

Chemistry databases

BindingDBiP10589.

Structurei

Secondary structure

1423
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni87 – 89Combined sources3
Beta strandi95 – 97Combined sources3
Helixi104 – 114Combined sources11
Turni115 – 117Combined sources3
Beta strandi132 – 136Combined sources5
Helixi140 – 149Combined sources10
Helixi153 – 156Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EBLNMR-A84-159[»]
ProteinModelPortaliP10589.
SMRiP10589.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10589.

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi32 – 36Poly-Gly5

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri86 – 106NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri122 – 146NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
GeneTreeiENSGT00760000118948.
HOGENOMiHOG000260820.
HOVERGENiHBG005606.
InParanoidiP10589.
KOiK08547.
OMAiGDKGQSQ.
OrthoDBiEOG091G0YX6.
PhylomeDBiP10589.
TreeFamiTF352097.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR003068. COUP_TF.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01282. COUPTNFACTOR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10589-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMVVSSWRD PQDDVAGGNP GGPNPAAQAA RGGGGGAGEQ QQQAGSGAPH
60 70 80 90 100
TPQTPGQPGA PATPGTAGDK GQGPPGSGQS QQHIECVVCG DKSSGKHYGQ
110 120 130 140 150
FTCEGCKSFF KRSVRRNLTY TCRANRNCPI DQHHRNQCQY CRLKKCLKVG
160 170 180 190 200
MRREAVQRGR MPPTQPNPGQ YALTNGDPLN GHCYLSGYIS LLLRAEPYPT
210 220 230 240 250
SRYGSQCMQP NNIMGIENIC ELAARLLFSA VEWARNIPFF PDLQITDQVS
260 270 280 290 300
LLRLTWSELF VLNAAQCSMP LHVAPLLAAA GLHASPMSAD RVVAFMDHIR
310 320 330 340 350
IFQEQVEKLK ALHVDSAEYS CLKAIVLFTS DACGLSDAAH IESLQEKSQC
360 370 380 390 400
ALEEYVRSQY PNQPSRFGKL LLRLPSLRTV SSSVIEQLFF VRLVGKTPIE
410 420
TLIRDMLLSG SSFNWPYMSI QCS
Length:423
Mass (Da):46,156
Last modified:July 1, 1989 - v1
Checksum:i6EE634BE96242731
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_071319112R → K in BBSOAS; decreases transcriptional activity. 1 PublicationCorresponds to variant rs587777277dbSNPEnsembl.1
Natural variantiVAR_071320113S → R in BBSOAS; decreases transcriptional activity. 1 PublicationCorresponds to variant rs587777275dbSNPEnsembl.1
Natural variantiVAR_071321115R → P in BBSOAS; decreases transcriptional activity. 1 PublicationCorresponds to variant rs587777274dbSNPEnsembl.1
Natural variantiVAR_071322252L → P in BBSOAS; decreases transcriptional activity. 1 PublicationCorresponds to variant rs587777276dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16155 mRNA. Translation: CAA34277.1.
X12795 Genomic DNA. Translation: CAA31283.1.
BC004154 mRNA. Translation: AAH04154.1.
BC017493 mRNA. Translation: AAH17493.1.
CCDSiCCDS4068.1.
PIRiS02710.
RefSeqiNP_005645.1. NM_005654.5.
UniGeneiHs.519445.

Genome annotation databases

EnsembliENST00000327111; ENSP00000325819; ENSG00000175745.
GeneIDi7025.
KEGGihsa:7025.
UCSCiuc003kkj.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16155 mRNA. Translation: CAA34277.1.
X12795 Genomic DNA. Translation: CAA31283.1.
BC004154 mRNA. Translation: AAH04154.1.
BC017493 mRNA. Translation: AAH17493.1.
CCDSiCCDS4068.1.
PIRiS02710.
RefSeqiNP_005645.1. NM_005654.5.
UniGeneiHs.519445.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EBLNMR-A84-159[»]
ProteinModelPortaliP10589.
SMRiP10589.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112883. 27 interactors.
DIPiDIP-622N.
IntActiP10589. 8 interactors.
MINTiMINT-1514389.
STRINGi9606.ENSP00000325819.

Chemistry databases

BindingDBiP10589.
ChEMBLiCHEMBL1961789.

PTM databases

iPTMnetiP10589.
PhosphoSitePlusiP10589.

Polymorphism and mutation databases

BioMutaiNR2F1.
DMDMi116959.

Proteomic databases

MaxQBiP10589.
PaxDbiP10589.
PeptideAtlasiP10589.
PRIDEiP10589.

Protocols and materials databases

DNASUi7025.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000327111; ENSP00000325819; ENSG00000175745.
GeneIDi7025.
KEGGihsa:7025.
UCSCiuc003kkj.4. human.

Organism-specific databases

CTDi7025.
DisGeNETi7025.
GeneCardsiNR2F1.
HGNCiHGNC:7975. NR2F1.
HPAiCAB019281.
MalaCardsiNR2F1.
MIMi132890. gene.
615722. phenotype.
neXtProtiNX_P10589.
OpenTargetsiENSG00000175745.
Orphaneti401777. Optic atrophy-intellectual disability syndrome.
PharmGKBiPA31758.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
GeneTreeiENSGT00760000118948.
HOGENOMiHOG000260820.
HOVERGENiHBG005606.
InParanoidiP10589.
KOiK08547.
OMAiGDKGQSQ.
OrthoDBiEOG091G0YX6.
PhylomeDBiP10589.
TreeFamiTF352097.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000175745-MONOMER.
ReactomeiR-HSA-383280. Nuclear Receptor transcription pathway.
SignaLinkiP10589.
SIGNORiP10589.

Miscellaneous databases

ChiTaRSiNR2F1. human.
EvolutionaryTraceiP10589.
GeneWikiiCOUP-TFI.
GenomeRNAii7025.
PROiP10589.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000175745.
CleanExiHS_NR2F1.
ExpressionAtlasiP10589. baseline and differential.
GenevisibleiP10589. HS.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR003068. COUP_TF.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01282. COUPTNFACTOR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOT1_HUMAN
AccessioniPrimary (citable) accession number: P10589
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 2, 2016
This is version 176 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.