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Protein

Myosin-11

Gene

MYH11

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Muscle contraction.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi177 – 1848ATP

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Muscle protein, Myosin

Keywords - Ligandi

Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

Enzyme and pathway databases

SABIO-RKP10587.

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-11
Alternative name(s):
Myosin heavy chain 11
Myosin heavy chain, gizzard smooth muscle
Gene namesi
Name:MYH11
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Thick filament

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 19791978Myosin-11PRO_0000123429Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21Blocked amino end (Ser)1 Publication
Modified residuei128 – 1281N6,N6,N6-trimethyllysine1 Publication

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiP10587.
PRIDEiP10587.

Interactioni

Subunit structurei

Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).

Binary interactionsi

WithEntry#Exp.IntActNotes
MYL6P026072EBI-1027098,EBI-1027073

Protein-protein interaction databases

IntActiP10587. 1 interaction.
STRINGi9031.ENSGALP00000032964.

Structurei

Secondary structure

1
1979
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi10 – 123Combined sources
Helixi23 – 286Combined sources
Beta strandi35 – 384Combined sources
Beta strandi40 – 489Combined sources
Beta strandi57 – 648Combined sources
Beta strandi67 – 704Combined sources
Helixi81 – 833Combined sources
Beta strandi91 – 933Combined sources
Helixi97 – 10913Combined sources
Beta strandi114 – 1163Combined sources
Beta strandi118 – 1247Combined sources
Helixi135 – 1406Combined sources
Turni141 – 1433Combined sources
Helixi146 – 1483Combined sources
Helixi153 – 16715Combined sources
Beta strandi171 – 1766Combined sources
Helixi183 – 19816Combined sources
Helixi219 – 2246Combined sources
Helixi227 – 2359Combined sources
Beta strandi236 – 2394Combined sources
Beta strandi245 – 25612Combined sources
Beta strandi258 – 2603Combined sources
Beta strandi262 – 2709Combined sources
Helixi274 – 2774Combined sources
Helixi288 – 2969Combined sources
Helixi299 – 3024Combined sources
Turni303 – 3064Combined sources
Turni310 – 3123Combined sources
Helixi328 – 34215Combined sources
Helixi346 – 36419Combined sources
Turni371 – 3733Combined sources
Helixi382 – 39110Combined sources
Helixi395 – 4039Combined sources
Helixi420 – 45031Combined sources
Beta strandi459 – 4657Combined sources
Beta strandi473 – 4753Combined sources
Helixi477 – 50731Combined sources
Helixi522 – 5298Combined sources
Beta strandi532 – 5343Combined sources
Helixi537 – 5448Combined sources
Helixi552 – 56211Combined sources
Turni563 – 5653Combined sources
Beta strandi569 – 5713Combined sources
Turni576 – 5783Combined sources
Beta strandi580 – 5856Combined sources
Beta strandi588 – 5936Combined sources
Helixi597 – 6026Combined sources
Helixi607 – 6148Combined sources
Helixi619 – 6246Combined sources
Helixi659 – 67517Combined sources
Beta strandi677 – 6859Combined sources
Helixi698 – 70710Combined sources
Helixi710 – 71910Combined sources
Beta strandi723 – 7264Combined sources
Helixi727 – 7348Combined sources
Helixi735 – 7384Combined sources
Turni739 – 7413Combined sources
Helixi749 – 76012Combined sources
Helixi764 – 7663Combined sources
Beta strandi767 – 7693Combined sources
Beta strandi771 – 7766Combined sources
Helixi780 – 7889Combined sources
Helixi793 – 81927Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BR1X-ray3.50A/C/E/G3-819[»]
1BR2X-ray2.90A/B/C/D/E/F3-792[»]
1BR4X-ray3.62A/C/E/G3-819[»]
1I84electron microscopy20.00S/V2-1175[»]
3DTPelectron microscopy20.00A/B3-852[»]
3J04electron microscopy-A/D2-910[»]
DisProtiDP00102.
ProteinModelPortaliP10587.
SMRiP10587. Positions 2-819.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10587.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini84 – 789706Myosin motorAdd
BLAST
Domaini792 – 82130IQPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni667 – 68923Actin-bindingAdd
BLAST
Regioni768 – 78215Actin-bindingAdd
BLAST
Regioni850 – 19791130Rodlike tail (S2 and LMM domains)Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili850 – 19791130Sequence analysisAdd
BLAST

Domaini

The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).Curated

Sequence similaritiesi

Contains 1 IQ domain.PROSITE-ProRule annotation
Contains 1 myosin motor domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0161. Eukaryota.
COG5022. LUCA.
HOGENOMiHOG000173958.
HOVERGENiHBG004704.
InParanoidiP10587.
PhylomeDBiP10587.
TreeFamiTF333601.

Family and domain databases

Gene3Di4.10.270.10. 1 hit.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10587-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQKPLSDDE KFLFVDKNFV NNPLAQADWS AKKLVWVPSE KHGFEAASIK
60 70 80 90 100
EEKGDEVTVE LQENGKKVTL SKDDIQKMNP PKFSKVEDMA ELTCLNEASV
110 120 130 140 150
LHNLRERYFS GLIYTYSGLF CVVINPYKQL PIYSEKIIDM YKGKKRHEMP
160 170 180 190 200
PHIYAIADTA YRSMLQDRED QSILCTGESG AGKTENTKKV IQYLAVVASS
210 220 230 240 250
HKGKKDTSIT QGPSFSYGEL EKQLLQANPI LEAFGNAKTV KNDNSSRFGK
260 270 280 290 300
FIRINFDVTG YIVGANIETY LLEKSRAIRQ AKDERTFHIF YYLIAGASEQ
310 320 330 340 350
MRNDLLLEGF NNYTFLSNGH VPIPAQQDDE MFQETLEAMT IMGFTEEEQT
360 370 380 390 400
SILRVVSSVL QLGNIVFKKE RNTDQASMPD NTAAQKVCHL MGINVTDFTR
410 420 430 440 450
SILTPRIKVG RDVVQKAQTK EQADFAIEAL AKAKFERLFR WILTRVNKAL
460 470 480 490 500
DKTKRQGASF LGILDIAGFE IFEINSFEQL CINYTNEKLQ QLFNHTMFIL
510 520 530 540 550
EQEEYQREGI EWNFIDFGLD LQPCIELIER PTNPPGVLAL LDEECWFPKA
560 570 580 590 600
TDTSFVEKLI QEQGNHAKFQ KSKQLKDKTE FCILHYAGKV TYNASAWLTK
610 620 630 640 650
NMDPLNDNVT SLLNQSSDKF VADLWKDVDR IVGLDQMAKM TESSLPSASK
660 670 680 690 700
TKKGMFRTVG QLYKEQLTKL MTTLRNTNPN FVRCIIPNHE KRAGKLDAHL
710 720 730 740 750
VLEQLRCNGV LEGIRICRQG FPNRIVFQEF RQRYEILAAN AIPKGFMDGK
760 770 780 790 800
QACILMIKAL ELDPNLYRIG QSKIFFRTGV LAHLEEERDL KITDVIIAFQ
810 820 830 840 850
AQCRGYLARK AFAKRQQQLT AMKVIQRNCA AYLKLRNWQW WRLFTKVKPL
860 870 880 890 900
LQVTRQEEEM QAKDEELQRT KERQQKAEAE LKELEQKHTQ LCEEKNLLQE
910 920 930 940 950
KLQAETELYA EAEEMRVRLA AKKQELEEIL HEMEARIEEE EERSQQLQAE
960 970 980 990 1000
KKKMQQQMLD LEEQLEEEEA ARQKLQLEKV TADGKIKKME DDILIMEDQN
1010 1020 1030 1040 1050
NKLTKERKLL EERVSDLTTN LAEEEEKAKN LTKLKNKHES MISELEVRLK
1060 1070 1080 1090 1100
KEEKSRQELE KIKRKLEGES SDLHEQIAEL QAQIAELKAQ LAKKEEELQA
1110 1120 1130 1140 1150
ALARLEDETS QKNNALKKIR ELESHISDLQ EDLESEKAAR NKAEKQKRDL
1160 1170 1180 1190 1200
SEELEALKTE LEDTLDTTAT QQELRAKREQ EVTVLKRALE EETRTHEAQV
1210 1220 1230 1240 1250
QEMRQKHTQA VEELTEQLEQ FKRAKANLDK TKQTLEKDNA DLANEIRSLS
1260 1270 1280 1290 1300
QAKQDVEHKK KKLEVQLQDL QSKYSDGERV RTELNEKVHK LQIEVENVTS
1310 1320 1330 1340 1350
LLNEAESKNI KLTKDVATLG SQLQDTQELL QEETRQKLNV TTKLRQLEDD
1360 1370 1380 1390 1400
KNSLQEQLDE EVEAKQNLER HISTLTIQLS DSKKKLQEFT ATVETMEEGK
1410 1420 1430 1440 1450
KKLQREIESL TQQFEEKAAS YDKLEKTKNR LQQELDDLVV DLDNQRQLVS
1460 1470 1480 1490 1500
NLEKKQKKFD QMLAEEKNIS SKYADERDRA EAEAREKETK ALSLARALEE
1510 1520 1530 1540 1550
ALEAKEELER TNKMLKAEME DLVSSKDDVG KNVHELEKSK RTLEQQVEEM
1560 1570 1580 1590 1600
KTQLEELEDE LQAAEDAKLR LEVNMQAMKS QFERDLQARD EQNEEKRRQL
1610 1620 1630 1640 1650
LKQLHEHETE LEDERKQRAL AAAAKKKLEV DVKDLESQVD SANKAREEAI
1660 1670 1680 1690 1700
KQLRKLQAQM KDYQRDLDDA RAAREEIFAT ARENEKKAKN LEAELIQLQE
1710 1720 1730 1740 1750
DLAAAERARK QADLEKEEMA EELASANSGR TSLQDEKRRL EARIAQLEEE
1760 1770 1780 1790 1800
LDEEHSNIET MSDRMRKAVQ QAEQLNNELA TERATAQKNE NARQQLERQN
1810 1820 1830 1840 1850
KELRSKLQEM EGAVKSKFKS TIAALEAKIA SLEEQLEQEA REKQAAAKTL
1860 1870 1880 1890 1900
RQKDKKLKDA LLQVEDERKQ AEQYKDQAEK GNLRLKQLKR QLEEAEEESQ
1910 1920 1930 1940 1950
RINANRRKLQ RELDEATESN DALGREVAAL KSKLRRGNEP VSFAPPRRSG
1960 1970
GRRVIENATD GGEEEIDGRD GDFNGKASE
Length:1,979
Mass (Da):228,796
Last modified:January 23, 2007 - v4
Checksum:i2F583CDDD4D9557D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti205 – 21612KDTSI…GPSFS → RTPASLKVHLFP in CAA29793 (PubMed:2892941).CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06546 mRNA. Translation: CAA29793.1.
PIRiS03166.
UniGeneiGga.3225.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06546 mRNA. Translation: CAA29793.1.
PIRiS03166.
UniGeneiGga.3225.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BR1X-ray3.50A/C/E/G3-819[»]
1BR2X-ray2.90A/B/C/D/E/F3-792[»]
1BR4X-ray3.62A/C/E/G3-819[»]
1I84electron microscopy20.00S/V2-1175[»]
3DTPelectron microscopy20.00A/B3-852[»]
3J04electron microscopy-A/D2-910[»]
DisProtiDP00102.
ProteinModelPortaliP10587.
SMRiP10587. Positions 2-819.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP10587. 1 interaction.
STRINGi9031.ENSGALP00000032964.

Proteomic databases

PaxDbiP10587.
PRIDEiP10587.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0161. Eukaryota.
COG5022. LUCA.
HOGENOMiHOG000173958.
HOVERGENiHBG004704.
InParanoidiP10587.
PhylomeDBiP10587.
TreeFamiTF333601.

Enzyme and pathway databases

SABIO-RKP10587.

Miscellaneous databases

EvolutionaryTraceiP10587.

Family and domain databases

Gene3Di4.10.270.10. 1 hit.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYH11_CHICK
AccessioniPrimary (citable) accession number: P10587
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: June 8, 2016
This is version 152 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.