Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Receptor-type tyrosine-protein phosphatase F

Gene

PTPRF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity.
The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei1516SubstrateBy similarity1
Active sitei1548Phosphocysteine intermediateCurated1
Binding sitei1592SubstrateBy similarity1
Active sitei1839Phosphocysteine intermediateBy similarity1

GO - Molecular functioni

  • chondroitin sulfate proteoglycan binding Source: Ensembl
  • heparin binding Source: UniProtKB-KW
  • protein tyrosine phosphatase activity Source: UniProtKB
  • transmembrane receptor protein tyrosine phosphatase activity Source: ProtInc

GO - Biological processi

  • cell adhesion Source: ProtInc
  • cell migration Source: UniProtKB
  • chemical synaptic transmission Source: Reactome
  • negative regulation of receptor binding Source: UniProtKB
  • neuron projection regeneration Source: Ensembl
  • peptidyl-tyrosine dephosphorylation Source: UniProtKB
  • regulation of axon regeneration Source: Ensembl
  • transmembrane receptor protein tyrosine phosphatase signaling pathway Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase, Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Heparin-binding

Enzyme and pathway databases

BioCyciZFISH:HS06974-MONOMER.
BRENDAi3.1.3.48. 2681.
ReactomeiR-HSA-8849932. SALM protein interactions at the synapses.
SignaLinkiP10586.
SIGNORiP10586.

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase F (EC:3.1.3.48)
Alternative name(s):
Leukocyte common antigen related
Short name:
LAR
Gene namesi
Name:PTPRF
Synonyms:LAR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:9670. PTPRF.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 1263ExtracellularSequence analysisAdd BLAST1234
Transmembranei1264 – 1284HelicalSequence analysisAdd BLAST21
Topological domaini1285 – 1907CytoplasmicSequence analysisAdd BLAST623

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • neuronal cell body Source: Ensembl
  • neuron projection Source: Ensembl
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Aplasia or hypoplasia of the breasts and/or nipples 2 (BNAH2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA group of congenital deformities encompassing total absence of breasts and nipple (amastia), absence of the nipple (athelia), and absence of the mammary gland (amazia).
See also OMIM:616001

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi1548C → S: Loss of activity. 1 Publication1

Organism-specific databases

DisGeNETi5792.
MalaCardsiPTPRF.
MIMi616001. phenotype.
OpenTargetsiENSG00000142949.
Orphaneti180188. Isolated breast aplasia.
PharmGKBiPA34015.

Chemistry databases

ChEMBLiCHEMBL3521.
GuidetoPHARMACOLOGYi1855.

Polymorphism and mutation databases

BioMutaiPTPRF.
DMDMi226709091.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000002543230 – 1907Receptor-type tyrosine-protein phosphatase FAdd BLAST1878

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi54 ↔ 107PROSITE-ProRule annotation
Glycosylationi117N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi156 ↔ 207PROSITE-ProRule annotation
Glycosylationi250N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi253 ↔ 298PROSITE-ProRule annotation
Glycosylationi295N-linked (GlcNAc...)Sequence analysis1
Glycosylationi721N-linked (GlcNAc...)Sequence analysis1
Glycosylationi959N-linked (GlcNAc...); atypical1 Publication1
Glycosylationi966N-linked (GlcNAc...)2 Publications1
Modified residuei1305PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP10586.
MaxQBiP10586.
PaxDbiP10586.
PeptideAtlasiP10586.
PRIDEiP10586.

PTM databases

DEPODiP10586.
iPTMnetiP10586.
PhosphoSitePlusiP10586.
SwissPalmiP10586.

Miscellaneous databases

PMAP-CutDBQ5T022.

Expressioni

Gene expression databases

BgeeiENSG00000142949.
CleanExiHS_PTPRF.
ExpressionAtlasiP10586. baseline and differential.
GenevisibleiP10586. HS.

Organism-specific databases

HPAiHPA012710.

Interactioni

Subunit structurei

Interacts with GRIP1 (By similarity). Interacts with PPFIA1, PPFIA2 and PPFIA3. Interacts with INSR.By similarity2 Publications

Protein-protein interaction databases

BioGridi111756. 49 interactors.
IntActiP10586. 9 interactors.
MINTiMINT-1189049.
STRINGi9606.ENSP00000353030.

Chemistry databases

BindingDBiP10586.

Structurei

Secondary structure

11907
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi31 – 37Combined sources7
Beta strandi42 – 45Combined sources4
Beta strandi50 – 60Combined sources11
Beta strandi63 – 68Combined sources6
Turni75 – 77Combined sources3
Beta strandi78 – 83Combined sources6
Helixi84 – 86Combined sources3
Beta strandi88 – 93Combined sources6
Helixi98 – 101Combined sources4
Beta strandi103 – 111Combined sources9
Beta strandi114 – 125Combined sources12
Helixi127 – 129Combined sources3
Beta strandi136 – 139Combined sources4
Beta strandi144 – 147Combined sources4
Beta strandi152 – 154Combined sources3
Beta strandi157 – 159Combined sources3
Beta strandi165 – 170Combined sources6
Helixi177 – 179Combined sources3
Beta strandi183 – 186Combined sources4
Beta strandi192 – 194Combined sources3
Helixi199 – 201Combined sources3
Beta strandi203 – 211Combined sources9
Beta strandi214 – 217Combined sources4
Beta strandi221 – 226Combined sources6
Beta strandi323 – 331Combined sources9
Beta strandi334 – 340Combined sources7
Beta strandi348 – 356Combined sources9
Beta strandi371 – 378Combined sources8
Beta strandi384 – 392Combined sources9
Beta strandi404 – 407Combined sources4
Beta strandi611 – 619Combined sources9
Beta strandi622 – 628Combined sources7
Helixi632 – 634Combined sources3
Beta strandi639 – 652Combined sources14
Beta strandi657 – 663Combined sources7
Beta strandi667 – 671Combined sources5
Beta strandi679 – 690Combined sources12
Beta strandi692 – 695Combined sources4
Beta strandi699 – 702Combined sources4
Beta strandi825 – 830Combined sources6
Beta strandi835 – 841Combined sources7
Beta strandi852 – 859Combined sources8
Beta strandi866 – 871Combined sources6
Beta strandi876 – 880Combined sources5
Beta strandi887 – 896Combined sources10
Beta strandi899 – 909Combined sources11
Beta strandi920 – 923Combined sources4
Beta strandi925 – 927Combined sources3
Beta strandi935 – 937Combined sources3
Beta strandi950 – 957Combined sources8
Beta strandi963 – 971Combined sources9
Beta strandi984 – 987Combined sources4
Helixi1334 – 1344Combined sources11
Turni1347 – 1349Combined sources3
Helixi1350 – 1358Combined sources9
Helixi1368 – 1371Combined sources4
Turni1373 – 1375Combined sources3
Helixi1376 – 1378Combined sources3
Turni1388 – 1390Combined sources3
Turni1401 – 1404Combined sources4
Beta strandi1407 – 1413Combined sources7
Beta strandi1416 – 1423Combined sources8
Turni1428 – 1430Combined sources3
Helixi1431 – 1440Combined sources10
Beta strandi1445 – 1448Combined sources4
Beta strandi1452 – 1454Combined sources3
Beta strandi1466 – 1472Combined sources7
Beta strandi1475 – 1484Combined sources10
Beta strandi1486 – 1497Combined sources12
Beta strandi1503 – 1511Combined sources9
Beta strandi1516 – 1518Combined sources3
Helixi1524 – 1536Combined sources13
Beta strandi1544 – 1553Combined sources10
Helixi1554 – 1571Combined sources18
Helixi1576 – 1584Combined sources9
Helixi1594 – 1610Combined sources17
Helixi1617 – 1619Combined sources3
Helixi1620 – 1627Combined sources8
Helixi1638 – 1644Combined sources7
Turni1645 – 1647Combined sources3
Turni1657 – 1660Combined sources4
Helixi1662 – 1667Combined sources6
Turni1677 – 1679Combined sources3
Turni1690 – 1693Combined sources4
Beta strandi1696 – 1700Combined sources5
Beta strandi1703 – 1705Combined sources3
Beta strandi1709 – 1712Combined sources4
Helixi1717 – 1719Combined sources3
Helixi1720 – 1729Combined sources10
Beta strandi1734 – 1737Combined sources4
Beta strandi1741 – 1743Combined sources3
Beta strandi1746 – 1749Combined sources4
Beta strandi1755 – 1757Combined sources3
Beta strandi1759 – 1761Combined sources3
Beta strandi1764 – 1773Combined sources10
Beta strandi1775 – 1786Combined sources12
Turni1787 – 1789Combined sources3
Beta strandi1792 – 1800Combined sources9
Beta strandi1805 – 1807Combined sources3
Helixi1813 – 1828Combined sources16
Beta strandi1835 – 1844Combined sources10
Helixi1845 – 1862Combined sources18
Beta strandi1863 – 1865Combined sources3
Helixi1867 – 1874Combined sources8
Turni1875 – 1877Combined sources3
Helixi1885 – 1900Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LARX-ray2.00A/B1333-1907[»]
2DJUNMR-A319-411[»]
2DN7NMR-A821-914[»]
2EDXNMR-A596-716[»]
2EDYNMR-A915-1010[»]
2YD5X-ray2.20A29-231[»]
2YD8X-ray2.05A29-231[»]
4N5UX-ray1.46A601-705[»]
ProteinModelPortaliP10586.
SMRiP10586.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10586.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 123Ig-like C2-type 1Add BLAST91
Domaini135 – 224Ig-like C2-type 2Add BLAST90
Domaini232 – 314Ig-like C2-type 3Add BLAST83
Domaini321 – 411Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST91
Domaini416 – 510Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST95
Domaini514 – 604Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST91
Domaini609 – 706Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST98
Domaini711 – 819Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST109
Domaini820 – 914Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST95
Domaini918 – 1010Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST93
Domaini1014 – 1098Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST85
Domaini1352 – 1607Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd BLAST256
Domaini1639 – 1898Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd BLAST260

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni68 – 77Heparin-bindingBy similarity10
Regioni1548 – 1554Substrate bindingBy similarity7

Sequence similaritiesi

Contains 8 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 2 tyrosine-protein phosphatase domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4228. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00760000118900.
HOVERGENiHBG053758.
InParanoidiP10586.
KOiK05695.
OMAiMLTPRWS.
OrthoDBiEOG091G11WG.
PhylomeDBiP10586.
TreeFamiTF312900.

Family and domain databases

CDDicd00063. FN3. 8 hits.
Gene3Di2.60.40.10. 11 hits.
3.90.190.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00041. fn3. 7 hits.
PF07679. I-set. 3 hits.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 8 hits.
SM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
SM00194. PTPc. 2 hits.
SM00404. PTPc_motif. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF49265. SSF49265. 5 hits.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 8 hits.
PS50835. IG_LIKE. 3 hits.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P10586-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPEPAPGRT MVPLVPALVM LGLVAGAHGD SKPVFIKVPE DQTGLSGGVA
60 70 80 90 100
SFVCQATGEP KPRITWMKKG KKVSSQRFEV IEFDDGAGSV LRIQPLRVQR
110 120 130 140 150
DEAIYECTAT NSLGEINTSA KLSVLEEEQL PPGFPSIDMG PQLKVVEKAR
160 170 180 190 200
TATMLCAAGG NPDPEISWFK DFLPVDPATS NGRIKQLRSG ALQIESSEES
210 220 230 240 250
DQGKYECVAT NSAGTRYSAP ANLYVRVRRV APRFSIPPSS QEVMPGGSVN
260 270 280 290 300
LTCVAVGAPM PYVKWMMGAE ELTKEDEMPV GRNVLELSNV VRSANYTCVA
310 320 330 340 350
ISSLGMIEAT AQVTVKALPK PPIDLVVTET TATSVTLTWD SGNSEPVTYY
360 370 380 390 400
GIQYRAAGTE GPFQEVDGVA TTRYSIGGLS PFSEYAFRVL AVNSIGRGPP
410 420 430 440 450
SEAVRARTGE QAPSSPPRRV QARMLSASTM LVQWEPPEEP NGLVRGYRVY
460 470 480 490 500
YTPDSRRPPN AWHKHNTDAG LLTTVGSLLP GITYSLRVLA FTAVGDGPPS
510 520 530 540 550
PTIQVKTQQG VPAQPADFQA EVESDTRIQL SWLLPPQERI IMYELVYWAA
560 570 580 590 600
EDEDQQHKVT FDPTSSYTLE DLKPDTLYRF QLAARSDMGV GVFTPTIEAR
610 620 630 640 650
TAQSTPSAPP QKVMCVSMGS TTVRVSWVPP PADSRNGVIT QYSVAYEAVD
660 670 680 690 700
GEDRGRHVVD GISREHSSWD LVGLEKWTEY RVWVRAHTDV GPGPESSPVL
710 720 730 740 750
VRTDEDVPSG PPRKVEVEPL NSTAVHVYWK LPVPSKQHGQ IRGYQVTYVR
760 770 780 790 800
LENGEPRGLP IIQDVMLAEA QWRPEESEDY ETTISGLTPE TTYSVTVAAY
810 820 830 840 850
TTKGDGARSK PKIVTTTGAV PGRPTMMIST TAMNTALLQW HPPKELPGEL
860 870 880 890 900
LGYRLQYCRA DEARPNTIDF GKDDQHFTVT GLHKGTTYIF RLAAKNRAGL
910 920 930 940 950
GEEFEKEIRT PEDLPSGFPQ NLHVTGLTTS TTELAWDPPV LAERNGRIIS
960 970 980 990 1000
YTVVFRDINS QQELQNITTD TRFTLTGLKP DTTYDIKVRA WTSKGSGPLS
1010 1020 1030 1040 1050
PSIQSRTMPV EQVFAKNFRV AAAMKTSVLL SWEVPDSYKS AVPFKILYNG
1060 1070 1080 1090 1100
QSVEVDGHSM RKLIADLQPN TEYSFVLMNR GSSAGGLQHL VSIRTAPDLL
1110 1120 1130 1140 1150
PHKPLPASAY IEDGRFDLSM PHVQDPSLVR WFYIVVVPID RVGGSMLTPR
1160 1170 1180 1190 1200
WSTPEELELD ELLEAIEQGG EEQRRRRRQA ERLKPYVAAQ LDVLPETFTL
1210 1220 1230 1240 1250
GDKKNYRGFY NRPLSPDLSY QCFVLASLKE PMDQKRYASS PYSDEIVVQV
1260 1270 1280 1290 1300
TPAQQQEEPE MLWVTGPVLA VILIILIVIA ILLFKRKRTH SPSSKDEQSI
1310 1320 1330 1340 1350
GLKDSLLAHS SDPVEMRRLN YQTPGMRDHP PIPITDLADN IERLKANDGL
1360 1370 1380 1390 1400
KFSQEYESID PGQQFTWENS NLEVNKPKNR YANVIAYDHS RVILTSIDGV
1410 1420 1430 1440 1450
PGSDYINANY IDGYRKQNAY IATQGPLPET MGDFWRMVWE QRTATVVMMT
1460 1470 1480 1490 1500
RLEEKSRVKC DQYWPARGTE TCGLIQVTLL DTVELATYTV RTFALHKSGS
1510 1520 1530 1540 1550
SEKRELRQFQ FMAWPDHGVP EYPTPILAFL RRVKACNPLD AGPMVVHCSA
1560 1570 1580 1590 1600
GVGRTGCFIV IDAMLERMKH EKTVDIYGHV TCMRSQRNYM VQTEDQYVFI
1610 1620 1630 1640 1650
HEALLEAATC GHTEVPARNL YAHIQKLGQV PPGESVTAME LEFKLLASSK
1660 1670 1680 1690 1700
AHTSRFISAN LPCNKFKNRL VNIMPYELTR VCLQPIRGVE GSDYINASFL
1710 1720 1730 1740 1750
DGYRQQKAYI ATQGPLAEST EDFWRMLWEH NSTIIVMLTK LREMGREKCH
1760 1770 1780 1790 1800
QYWPAERSAR YQYFVVDPMA EYNMPQYILR EFKVTDARDG QSRTIRQFQF
1810 1820 1830 1840 1850
TDWPEQGVPK TGEGFIDFIG QVHKTKEQFG QDGPITVHCS AGVGRTGVFI
1860 1870 1880 1890 1900
TLSIVLERMR YEGVVDMFQT VKTLRTQRPA MVQTEDQYQL CYRAALEYLG

SFDHYAT
Length:1,907
Mass (Da):212,879
Last modified:March 24, 2009 - v2
Checksum:i4A7C14A2090EA88F
GO
Isoform 2 (identifier: P10586-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     772-780: Missing.

Show »
Length:1,898
Mass (Da):211,687
Checksum:i5138123452E59A4E
GO

Sequence cautioni

The sequence BAD66835 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA68754 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti646Y → H in CAA68754 (PubMed:2972792).Curated1
Sequence conflicti1421I → T in AAH48768 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054766412A → V.Corresponds to variant rs1065775dbSNPEnsembl.1
Natural variantiVAR_020299450Y → C.Corresponds to variant rs3748796dbSNPEnsembl.1
Natural variantiVAR_020300562D → N.Corresponds to variant rs3748800dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_036617772 – 780Missing in isoform 2. 2 Publications9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00815 mRNA. Translation: CAA68754.1. Different initiation.
AB177857 mRNA. Translation: BAD66835.1. Different initiation.
AL583862, AC092815 Genomic DNA. Translation: CAI14894.1.
AL583862, AC092815 Genomic DNA. Translation: CAI14895.1.
CH471059 Genomic DNA. Translation: EAX07086.1.
CH471059 Genomic DNA. Translation: EAX07087.1.
CH471059 Genomic DNA. Translation: EAX07088.1.
CH471059 Genomic DNA. Translation: EAX07089.1.
BC048768 mRNA. Translation: AAH48768.1.
CCDSiCCDS489.2. [P10586-1]
CCDS490.2. [P10586-2]
PIRiS03841. TDHULK.
RefSeqiNP_002831.2. NM_002840.4. [P10586-1]
NP_569707.2. NM_130440.3. [P10586-2]
UniGeneiHs.272062.

Genome annotation databases

EnsembliENST00000359947; ENSP00000353030; ENSG00000142949. [P10586-1]
ENST00000438120; ENSP00000398822; ENSG00000142949. [P10586-2]
GeneIDi5792.
KEGGihsa:5792.
UCSCiuc001cjr.4. human. [P10586-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00815 mRNA. Translation: CAA68754.1. Different initiation.
AB177857 mRNA. Translation: BAD66835.1. Different initiation.
AL583862, AC092815 Genomic DNA. Translation: CAI14894.1.
AL583862, AC092815 Genomic DNA. Translation: CAI14895.1.
CH471059 Genomic DNA. Translation: EAX07086.1.
CH471059 Genomic DNA. Translation: EAX07087.1.
CH471059 Genomic DNA. Translation: EAX07088.1.
CH471059 Genomic DNA. Translation: EAX07089.1.
BC048768 mRNA. Translation: AAH48768.1.
CCDSiCCDS489.2. [P10586-1]
CCDS490.2. [P10586-2]
PIRiS03841. TDHULK.
RefSeqiNP_002831.2. NM_002840.4. [P10586-1]
NP_569707.2. NM_130440.3. [P10586-2]
UniGeneiHs.272062.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LARX-ray2.00A/B1333-1907[»]
2DJUNMR-A319-411[»]
2DN7NMR-A821-914[»]
2EDXNMR-A596-716[»]
2EDYNMR-A915-1010[»]
2YD5X-ray2.20A29-231[»]
2YD8X-ray2.05A29-231[»]
4N5UX-ray1.46A601-705[»]
ProteinModelPortaliP10586.
SMRiP10586.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111756. 49 interactors.
IntActiP10586. 9 interactors.
MINTiMINT-1189049.
STRINGi9606.ENSP00000353030.

Chemistry databases

BindingDBiP10586.
ChEMBLiCHEMBL3521.
GuidetoPHARMACOLOGYi1855.

PTM databases

DEPODiP10586.
iPTMnetiP10586.
PhosphoSitePlusiP10586.
SwissPalmiP10586.

Polymorphism and mutation databases

BioMutaiPTPRF.
DMDMi226709091.

Proteomic databases

EPDiP10586.
MaxQBiP10586.
PaxDbiP10586.
PeptideAtlasiP10586.
PRIDEiP10586.

Protocols and materials databases

DNASUi5792.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359947; ENSP00000353030; ENSG00000142949. [P10586-1]
ENST00000438120; ENSP00000398822; ENSG00000142949. [P10586-2]
GeneIDi5792.
KEGGihsa:5792.
UCSCiuc001cjr.4. human. [P10586-1]

Organism-specific databases

CTDi5792.
DisGeNETi5792.
GeneCardsiPTPRF.
HGNCiHGNC:9670. PTPRF.
HPAiHPA012710.
MalaCardsiPTPRF.
MIMi179590. gene.
616001. phenotype.
neXtProtiNX_P10586.
OpenTargetsiENSG00000142949.
Orphaneti180188. Isolated breast aplasia.
PharmGKBiPA34015.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4228. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00760000118900.
HOVERGENiHBG053758.
InParanoidiP10586.
KOiK05695.
OMAiMLTPRWS.
OrthoDBiEOG091G11WG.
PhylomeDBiP10586.
TreeFamiTF312900.

Enzyme and pathway databases

BioCyciZFISH:HS06974-MONOMER.
BRENDAi3.1.3.48. 2681.
ReactomeiR-HSA-8849932. SALM protein interactions at the synapses.
SignaLinkiP10586.
SIGNORiP10586.

Miscellaneous databases

ChiTaRSiPTPRF. human.
EvolutionaryTraceiP10586.
GeneWikiiPTPRF.
GenomeRNAii5792.
PMAP-CutDBQ5T022.
PROiP10586.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000142949.
CleanExiHS_PTPRF.
ExpressionAtlasiP10586. baseline and differential.
GenevisibleiP10586. HS.

Family and domain databases

CDDicd00063. FN3. 8 hits.
Gene3Di2.60.40.10. 11 hits.
3.90.190.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00041. fn3. 7 hits.
PF07679. I-set. 3 hits.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 8 hits.
SM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
SM00194. PTPc. 2 hits.
SM00404. PTPc_motif. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF49265. SSF49265. 5 hits.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 8 hits.
PS50835. IG_LIKE. 3 hits.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTPRF_HUMAN
AccessioniPrimary (citable) accession number: P10586
Secondary accession number(s): D3DPX6
, D3DPX7, Q5T021, Q5T022, Q5W9G2, Q86WS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: March 24, 2009
Last modified: November 30, 2016
This is version 202 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.