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Protein

Glutaredoxin-1

Gene

GLRX

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Enzyme and pathway databases

ReactomeiR-BTA-499943. Synthesis and interconversion of nucleotide di- and triphosphates.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaredoxin-1
Alternative name(s):
Thioltransferase
Short name:
TTase
Gene namesi
Name:GLRX
Synonyms:GRX
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 106105Glutaredoxin-1PRO_0000141599Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei9 – 91N6-succinyllysineBy similarity
Disulfide bondi23 ↔ 26Redox-active
Disulfide bondi79 ↔ 83

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

PaxDbiP10575.
PeptideAtlasiP10575.
PRIDEiP10575.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000051774.

Structurei

3D structure databases

ProteinModelPortaliP10575.
SMRiP10575. Positions 2-106.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 106104GlutaredoxinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the glutaredoxin family.Curated
Contains 1 glutaredoxin domain.PROSITE-ProRule annotation

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiKOG1752. Eukaryota.
COG0695. LUCA.
GeneTreeiENSGT00390000003677.
HOGENOMiHOG000095204.
HOVERGENiHBG000283.
InParanoidiP10575.
KOiK03676.
OMAiVNCKFPS.
OrthoDBiEOG7QRQWZ.
TreeFamiTF326994.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR011767. GLR_AS.
IPR002109. Glutaredoxin.
IPR011899. Glutaredoxin_euk/vir.
IPR014025. Glutaredoxin_subgr.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00462. Glutaredoxin. 1 hit.
[Graphical view]
PRINTSiPR00160. GLUTAREDOXIN.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR02180. GRX_euk. 1 hit.
PROSITEiPS00195. GLUTAREDOXIN_1. 1 hit.
PS51354. GLUTAREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10575-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQAFVNSKI QPGKVVVFIK PTCPYCRKTQ ELLSQLPFKQ GLLEFVDITA
60 70 80 90 100
AGNISEIQDY LQQLTGARTV PRVFIGQECI GGCTDLVNMH ERGELLTRLK

QMGALQ
Length:106
Mass (Da):11,783
Last modified:January 23, 2007 - v3
Checksum:i99E1C2260E9D02BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109978 mRNA. Translation: AAI09979.1.
PIRiA30164. GDBO.
RefSeqiNP_001032693.1. NM_001037604.2.
UniGeneiBt.2877.

Genome annotation databases

EnsembliENSBTAT00000054658; ENSBTAP00000051774; ENSBTAG00000038186.
GeneIDi515416.
KEGGibta:515416.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109978 mRNA. Translation: AAI09979.1.
PIRiA30164. GDBO.
RefSeqiNP_001032693.1. NM_001037604.2.
UniGeneiBt.2877.

3D structure databases

ProteinModelPortaliP10575.
SMRiP10575. Positions 2-106.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000051774.

Proteomic databases

PaxDbiP10575.
PeptideAtlasiP10575.
PRIDEiP10575.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000054658; ENSBTAP00000051774; ENSBTAG00000038186.
GeneIDi515416.
KEGGibta:515416.

Organism-specific databases

CTDi2745.

Phylogenomic databases

eggNOGiKOG1752. Eukaryota.
COG0695. LUCA.
GeneTreeiENSGT00390000003677.
HOGENOMiHOG000095204.
HOVERGENiHBG000283.
InParanoidiP10575.
KOiK03676.
OMAiVNCKFPS.
OrthoDBiEOG7QRQWZ.
TreeFamiTF326994.

Enzyme and pathway databases

ReactomeiR-BTA-499943. Synthesis and interconversion of nucleotide di- and triphosphates.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR011767. GLR_AS.
IPR002109. Glutaredoxin.
IPR011899. Glutaredoxin_euk/vir.
IPR014025. Glutaredoxin_subgr.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00462. Glutaredoxin. 1 hit.
[Graphical view]
PRINTSiPR00160. GLUTAREDOXIN.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR02180. GRX_euk. 1 hit.
PROSITEiPS00195. GLUTAREDOXIN_1. 1 hit.
PS51354. GLUTAREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Liver.
  2. "The primary structure of calf thymus glutaredoxin. Homology with the corresponding Escherichia coli protein but elongation at both ends and with an additional half-cystine/cysteine pair."
    Klintrot I.-M., Hoeoeg J.-O., Joernvall H., Holmgren A., Luthman M.
    Eur. J. Biochem. 144:417-423(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-106.
    Tissue: Thymus.
  3. Cited for: SEQUENCE REVISION TO 1-3 AND 69-72, ACETYLATION AT ALA-2.
    Tissue: Thymus.

Entry informationi

Entry nameiGLRX1_BOVIN
AccessioniPrimary (citable) accession number: P10575
Secondary accession number(s): Q32KQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: July 6, 2016
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.