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Protein

Glutaredoxin-1

Gene

GLRX

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Transport

Enzyme and pathway databases

ReactomeiR-BTA-499943. Interconversion of nucleotide di- and triphosphates.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaredoxin-1
Alternative name(s):
Thioltransferase
Short name:
TTase
Gene namesi
Name:GLRX
Synonyms:GRX
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001415992 – 106Glutaredoxin-1Add BLAST105

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1
Modified residuei9N6-succinyllysineBy similarity1
Disulfide bondi23 ↔ 26Redox-active
Disulfide bondi79 ↔ 83

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

PaxDbiP10575.
PeptideAtlasiP10575.
PRIDEiP10575.

Expressioni

Gene expression databases

BgeeiENSBTAG00000038186.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000051774.

Structurei

3D structure databases

ProteinModelPortaliP10575.
SMRiP10575.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 106GlutaredoxinPROSITE-ProRule annotationAdd BLAST104

Sequence similaritiesi

Belongs to the glutaredoxin family.Curated

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiKOG1752. Eukaryota.
COG0695. LUCA.
GeneTreeiENSGT00390000003677.
HOGENOMiHOG000095204.
HOVERGENiHBG000283.
InParanoidiP10575.
KOiK03676.
OMAiYCGYCKR.
OrthoDBiEOG091G0WLY.
TreeFamiTF326994.

Family and domain databases

InterProiView protein in InterPro
IPR011767. GLR_AS.
IPR002109. Glutaredoxin.
IPR011899. Glutaredoxin_euk/vir.
IPR014025. Glutaredoxin_subgr.
IPR012336. Thioredoxin-like_fold.
PfamiView protein in Pfam
PF00462. Glutaredoxin. 1 hit.
PRINTSiPR00160. GLUTAREDOXIN.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR02180. GRX_euk. 1 hit.
PROSITEiView protein in PROSITE
PS00195. GLUTAREDOXIN_1. 1 hit.
PS51354. GLUTAREDOXIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10575-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQAFVNSKI QPGKVVVFIK PTCPYCRKTQ ELLSQLPFKQ GLLEFVDITA
60 70 80 90 100
AGNISEIQDY LQQLTGARTV PRVFIGQECI GGCTDLVNMH ERGELLTRLK

QMGALQ
Length:106
Mass (Da):11,783
Last modified:January 23, 2007 - v3
Checksum:i99E1C2260E9D02BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109978 mRNA. Translation: AAI09979.1.
PIRiA30164. GDBO.
RefSeqiNP_001032693.1. NM_001037604.2.
UniGeneiBt.2877.

Genome annotation databases

EnsembliENSBTAT00000054658; ENSBTAP00000051774; ENSBTAG00000038186.
GeneIDi515416.
KEGGibta:515416.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiGLRX1_BOVIN
AccessioniPrimary (citable) accession number: P10575
Secondary accession number(s): Q32KQ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: June 7, 2017
This is version 131 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families