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Protein

Glutaredoxin-1

Gene

GLRX

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Transport

Enzyme and pathway databases

ReactomeiR-BTA-499943 Interconversion of nucleotide di- and triphosphates

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaredoxin-1
Alternative name(s):
Thioltransferase
Short name:
TTase
Gene namesi
Name:GLRX
Synonyms:GRX
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001415992 – 106Glutaredoxin-1Add BLAST105

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1
Modified residuei9N6-succinyllysineBy similarity1
Disulfide bondi23 ↔ 26Redox-active
Disulfide bondi79 ↔ 83

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

PaxDbiP10575
PeptideAtlasiP10575
PRIDEiP10575

PTM databases

iPTMnetiP10575

Expressioni

Gene expression databases

BgeeiENSBTAG00000038186

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000051774

Structurei

3D structure databases

ProteinModelPortaliP10575
SMRiP10575
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 106GlutaredoxinPROSITE-ProRule annotationAdd BLAST104

Sequence similaritiesi

Belongs to the glutaredoxin family.Curated

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiKOG1752 Eukaryota
COG0695 LUCA
GeneTreeiENSGT00900000141068
HOGENOMiHOG000095204
HOVERGENiHBG000283
InParanoidiP10575
KOiK03676
OMAiCKMAKEP
OrthoDBiEOG091G0WLY
TreeFamiTF326994

Family and domain databases

InterProiView protein in InterPro
IPR011767 GLR_AS
IPR002109 Glutaredoxin
IPR011899 Glutaredoxin_euk/vir
IPR014025 Glutaredoxin_subgr
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF00462 Glutaredoxin, 1 hit
PRINTSiPR00160 GLUTAREDOXIN
SUPFAMiSSF52833 SSF52833, 1 hit
TIGRFAMsiTIGR02180 GRX_euk, 1 hit
PROSITEiView protein in PROSITE
PS00195 GLUTAREDOXIN_1, 1 hit
PS51354 GLUTAREDOXIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10575-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQAFVNSKI QPGKVVVFIK PTCPYCRKTQ ELLSQLPFKQ GLLEFVDITA
60 70 80 90 100
AGNISEIQDY LQQLTGARTV PRVFIGQECI GGCTDLVNMH ERGELLTRLK

QMGALQ
Length:106
Mass (Da):11,783
Last modified:January 23, 2007 - v3
Checksum:i99E1C2260E9D02BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109978 mRNA Translation: AAI09979.1
PIRiA30164 GDBO
RefSeqiNP_001032693.1, NM_001037604.2
UniGeneiBt.2877

Genome annotation databases

EnsembliENSBTAT00000054658; ENSBTAP00000051774; ENSBTAG00000038186
GeneIDi515416
KEGGibta:515416

Similar proteinsi

Entry informationi

Entry nameiGLRX1_BOVIN
AccessioniPrimary (citable) accession number: P10575
Secondary accession number(s): Q32KQ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 134 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health