Reviewed, UniProtKB/Swiss-Prot P10575 (GLRX1_BOVIN)

Names and origin

Protein names

Recommended name:
    Glutaredoxin-1
Alternative name(s):
    Thioltransferase
      Short name=TTase

Gene names

Name:	GLRX
Synonyms:	GRX

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	106 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the glutaredoxin family. Contains 1 glutaredoxin domain.

Ontologies

Keywords
Biological process	Electron transport Transport
Cellular component	Cytoplasm
Domain	Redox-active center
PTM	Acetylation Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro protein disulfide oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.2
	Chain	2 – 106	105	Glutaredoxin-1		PRO_0000141599
Regions
	Domain	3 – 106	104	Glutaredoxin
Amino acid modifications
	Modified residue	2	1	N-acetylalanine Ref.3
	Disulfide bond	23 ↔ 26		Redox-active
	Disulfide bond	79 ↔ 83

Sequences

	Sequence		Length	Mass (Da)
	P10575-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 99E1C2260E9D02BF	FASTA	106	11,783
	10 20 30 40 50 60 MAQAFVNSKI QPGKVVVFIK PTCPYCRKTQ ELLSQLPFKQ GLLEFVDITA AGNISEIQDY 70 80 90 100 LQQLTGARTV PRVFIGQECI GGCTDLVNMH ERGELLTRLK QMGALQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Liver.
[2]	"The primary structure of calf thymus glutaredoxin. Homology with the corresponding Escherichia coli protein but elongation at both ends and with an additional half-cystine/cysteine pair." Klintrot I.-M., Hoeoeg J.-O., Joernvall H., Holmgren A., Luthman M. Eur. J. Biochem. 144:417-423(1984) [PubMed: 6386471] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-106. Tissue: Thymus.
[3]	"A revised sequence of calf thymus glutaredoxin." Papayannopoulos I.A., Gan Z.-R., Wells W.W., Biemann K. Biochem. Biophys. Res. Commun. 159:1448-1454(1989) [PubMed: 2930571] [Abstract] Cited for: SEQUENCE REVISION TO 1-3 AND 69-72. Tissue: Thymus.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC109978 mRNA. Translation: AAI09979.1.
IPI	IPI00687478.
PIR	GDBO. A30164.
RefSeq	NP_001032693.1.
UniGene	Bt.2877
3D structure databases
HSSP	HSSP built from PDB template 1KTE based on UniProtKB P12309.
SMR	P10575. Positions 2-106.
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAG00000038186. Bos taurus. [Contig view]
GeneID	515416.
KEGG	bta:515416.
Phylogenomic databases
HOVERGEN	P10575.
OMA	P10575. DITASNH.
Family and domain databases
InterPro	IPR011767. GLR_AS. IPR002109. Glutaredoxin. IPR014025. Glutaredoxin_sub. IPR011899. GRX_euk. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
Pfam	PF00462. Glutaredoxin. 1 hit. [Graphical view]
PRINTS	PR00160. GLUTAREDOXIN.
TIGRFAMs	TIGR02180. GRX_euk. 1 hit.
PROSITE	PS00195. GLUTAREDOXIN_1. 1 hit. PS51354. GLUTAREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLRX1_BOVIN

Accession

Primary (citable) accession number: P10575
Secondary accession number(s): Q32KQ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	January 23, 2007
Last modified:	June 16, 2009
This is version 76 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)