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P10536

- RAB1B_RAT

UniProt

P10536 - RAB1B_RAT

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Protein
Ras-related protein Rab-1B
Gene
Rab1b
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Protein transport. Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 228GTP By similarity
Nucleotide bindingi63 – 675GTP By similarity
Nucleotide bindingi121 – 1244GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB

GO - Biological processi

  1. protein transport Source: UniProtKB-KW
  2. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-1B
Gene namesi
Name:Rab1b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi1359415. MGC105830.

Subcellular locationi

Membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm
Note: Targeted by REP1 to membranes of specific subcellular compartments including endoplasmic reticulum, Golgi apparatus, and intermediate vesicles between these two compartments. In the GDP-form, colocalizes with GDI in the cytoplasm.1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi21 – 211K → M: Abolishes GTP-binding. 1 Publication
Mutagenesisi65 – 651A → T: Reduced GTPase activity. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 201201Ras-related protein Rab-1B
PRO_0000121063Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity
Modified residuei76 – 761O-(2-cholinephosphoryl)serine By similarity
Lipidationi200 – 2001S-geranylgeranyl cysteine1 Publication
Modified residuei201 – 2011Cysteine methyl ester Reviewed prediction
Lipidationi201 – 2011S-geranylgeranyl cysteine1 Publication

Post-translational modificationi

Prenylated; by GGTase II, only after interaction of the substrate with Rab escort protein 1 (REP1) By similarity.

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

PaxDbiP10536.
PRIDEiP10536.

PTM databases

PhosphoSiteiP10536.

Expressioni

Gene expression databases

GenevestigatoriP10536.

Interactioni

Subunit structurei

Interacts with MICAL1, MICAL2 and MICAL3. Interacts with GDI1; the interaction requires the GDP-bound state. Interacts with CHM/REP1; the interaction requires the GDP-bound form and is necessary for prenylation by GGTase II By similarity.

Protein-protein interaction databases

IntActiP10536. 1 interaction.
MINTiMINT-4577563.
STRINGi10116.ENSRNOP00000027486.

Structurei

3D structure databases

ProteinModelPortaliP10536.
SMRiP10536. Positions 5-173.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni64 – 8320Switch 2 region; required for interaction with REP1/CHM By similarity
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi37 – 459Effector region By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1100.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP10536.
PhylomeDBiP10536.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10536-1 [UniParc]FASTAAdd to Basket

« Hide

MNPEYDYLFK LLLIGDSGVG KSCLLLRFAD DTYTESYIST IGVDFKIRTI    50
ELDGKTIKLQ IWDTAGQERF RTVTSSYYRG AHGIIVVYDV TDQESYANVK 100
QWLQEIDRYA SENVNKLLVG NKSDLTTKKV VDNTTAKEFA DSLGVPFLET 150
SAKNATNVEQ AFMTMAAEIK KRMGPGAASG GERPNLKIDS TPVKSASGGC 200
C 201
Length:201
Mass (Da):22,163
Last modified:July 1, 1989 - v1
Checksum:i8D3EEDC2AEF4A2FE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X13905 mRNA. Translation: CAA32105.1.
PIRiS06147.
UniGeneiRn.155100.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X13905 mRNA. Translation: CAA32105.1 .
PIRi S06147.
UniGenei Rn.155100.

3D structure databases

ProteinModelPortali P10536.
SMRi P10536. Positions 5-173.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P10536. 1 interaction.
MINTi MINT-4577563.
STRINGi 10116.ENSRNOP00000027486.

PTM databases

PhosphoSitei P10536.

Proteomic databases

PaxDbi P10536.
PRIDEi P10536.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

RGDi 1359415. MGC105830.

Phylogenomic databases

eggNOGi COG1100.
HOGENOMi HOG000233968.
HOVERGENi HBG009351.
InParanoidi P10536.
PhylomeDBi P10536.

Gene expression databases

Genevestigatori P10536.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00175. RAB. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51419. RAB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of a rat cDNA: rab1B, encoding a rab1-YPT related protein."
    Zahraoui A., Touchot N., Chardin P., Tavitian A.
    Nucleic Acids Res. 17:1770-1770(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Biochemical properties of the YPT-related rab1B protein. Comparison with rab1A."
    Touchot N., Zahraoui A., Vielh E., Tavitian A.
    FEBS Lett. 256:79-84(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION, MUTAGENESIS OF LYS-21 AND ALA-65.
  3. "Rab1b regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments."
    Plutner H., Cox A.D., Pind S., Khosravi-Far R., Bourne J.R., Schwaninger R., Der C.J., Balch W.E.
    J. Cell Biol. 115:31-43(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, FUNCTION.
  4. Cited for: ISOPRENYLATION AT CYS-200 AND CYS-201.

Entry informationi

Entry nameiRAB1B_RAT
AccessioniPrimary (citable) accession number: P10536
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: April 16, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Rab-1B binds GTP and GDP and possesses intrinsic GTPase activity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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