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Protein

Streptokinase G

Gene

skg

Organism
Streptococcus sp. (strain 19909)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

This protein is not a protease, but it activates plasminogen by complexing with it. As a potential virulence factor, it is thought to prevent the formation of effective fibrin barriers around the site of infection, thereby contributing to the invasiveness of the cells.

GO - Biological processi

Keywordsi

Biological processPlasminogen activation, Virulence

Names & Taxonomyi

Protein namesi
Recommended name:
Streptokinase G
Gene namesi
Name:skg
OrganismiStreptococcus sp. (strain 19909)
Taxonomic identifieri69017 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Add BLAST26
ChainiPRO_000002243027 – 440Streptokinase GAdd BLAST414

Structurei

3D structure databases

ProteinModelPortaliP10519.
SMRiP10519.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR004093. SAK/SK.
IPR036120. SAK/SK_sf.
IPR008124. SK.
PfamiView protein in Pfam
PF02821. Staphylokinase. 3 hits.
PRINTSiPR01753. STREPKINASE.
SUPFAMiSSF54328. SSF54328. 3 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10519-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNYLSFGMF ALLFALTFGT VNSVQAIAGP EWLLDRPSVN NSQLVVSVAG
60 70 80 90 100
TVEGTNQDIS LKFFEIDLTS RPAHGGKTEQ GLSPKSKLFA TDSGAMPHKL
110 120 130 140 150
EKADLLKAIQ EQLIANVHSN DDYFEVIDFA SDATITDRNG KVYFADKDGS
160 170 180 190 200
VTLPIQPVQE FLLKGHVRVR PYKEKPVQNQ AKSVDVEYTV QFTPLNPDDD
210 220 230 240 250
FRPALKDTKL LKTLAIGDTI TSQELLAQAQ SILNKNHPGY TIYERDSSIV
260 270 280 290 300
THDNDIFRTI LPMDQEFTYH VKNREQAYRI NKKSGLNEEI NNTDLISEKY
310 320 330 340 350
YVLKKGEKPY DPFDRSHLKL FTIKYVDVNT NELLKSEQLL TASERNLDFR
360 370 380 390 400
DLYDPRDKAK LLYNNLDAFG IMDYTLTGKV EDNHDDTNRI ITVYMGKRPE
410 420 430 440
GENASYHLAY DKDRYTEEER EVYSYLRYTG TPIPDNPNDK
Length:440
Mass (Da):50,199
Last modified:July 1, 1989 - v1
Checksum:i5521F8825FE1B6EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13400 Genomic DNA. Translation: CAA31766.1.
PIRiS02723.

Similar proteinsi

Entry informationi

Entry nameiSTRP_STRS1
AccessioniPrimary (citable) accession number: P10519
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 25, 2017
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program