Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P10509 (BLAC_STRAU) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-lactamase

EC=3.5.2.6
Alternative name(s):
Penicillinase
Gene names
Name:bla
OrganismStreptomyces aureofaciens
Taxonomic identifier1894 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

A beta-lactam + H2O = a substituted beta-amino acid.

Post-translational modification

Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

Sequence similarities

Belongs to the class-A beta-lactamase family.

Ontologies

Keywords
   Biological processAntibiotic resistance
   DomainSignal
   Molecular functionHydrolase
Gene Ontology (GO)
   Biological_processbeta-lactam antibiotic catabolic process

Inferred from electronic annotation. Source: InterPro

response to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionbeta-lactamase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3434Tat-type signal Potential
Chain35 – 311277Beta-lactamase
PRO_0000017013

Regions

Region255 – 2573Substrate binding By similarity

Sites

Active site871Acyl-ester intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
P10509 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: 6FC8F4E5CD4C1DFA

FASTA31132,486
        10         20         30         40         50         60 
MRLTQAPPSR RTLMTLGAGA TMAALLPAGG AAYASTSTAK APAAEGISGR LRALEKQYAA 

        70         80         90        100        110        120 
RLGVFALDTG TGAGRSYRAG ERFPMCSVFK ALAAAAVLRD VDARREFLTK RIHYTEKFVK 

       130        140        150        160        170        180 
DAGYIPVTGK PENIAGGMTG AELCAAAVSE SDNGAGNLLL RELDGPTGIT RFCRSLGDTT 

       190        200        210        220        230        240 
TRLDRWEPAL NSAEPDRVTD TTSPGAIGRT FGRLIVGSAL RAGDRKRLTG WLVANTTNRP 

       250        260        270        280        290        300 
TFRAGLPDDW VLADKTGGGE QYGVANDVGV VQPPGRAPLV LSVLSTKFDP KGPTDNPLVA 

       310 
KAAALVAGEL T 

« Hide

References

[1]Reynes J.-P., Drocourt D., Tiraby G.
Submitted (NOV-1988) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X13597 Genomic DNA. Translation: CAA31933.1.
PIRS02714.

3D structure databases

ProteinModelPortalP10509.
SMRP10509. Positions 50-310.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.710.10. 1 hit.
InterProIPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
IPR006311. TAT_signal.
[Graphical view]
PfamPF00144. Beta-lactamase. 1 hit.
[Graphical view]
PRINTSPR00118. BLACTAMASEA.
SUPFAMSSF56601. SSF56601. 1 hit.
PROSITEPS00146. BETA_LACTAMASE_A. 1 hit.
PS51318. TAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBLAC_STRAU
AccessionPrimary (citable) accession number: P10509
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 16, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families