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Protein

Protein kinase byr1

Gene

byr1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Serine/threonine protein kinase involved in conjugation and sporulation. It is thought that it is phosphorylated by the byr2 protein kinase and that it can phosphorylate the spk1 kinase. When bound to bob1, is involved in the regulation of sexual differentiation.2 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei93 – 931ATPPROSITE-ProRule annotation
Active sitei186 – 1861Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi72 – 809ATPPROSITE-ProRule annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • MAP kinase kinase activity Source: PomBase
  • protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

  • activation of MAPK activity Source: GOC
  • ascospore formation Source: PomBase
  • conjugation with cellular fusion Source: PomBase
  • MAPK cascade involved in ascospore formation Source: PomBase
  • MAPK cascade involved in conjugation with cellular fusion Source: PomBase
  • mitotic cell cycle arrest in response to pheromone Source: PomBase
  • pheromone-dependent signal transduction involved in conjugation with cellular fusion Source: PomBase
  • protein phosphorylation Source: PomBase
  • signal transduction involved in conjugation with cellular fusion Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Conjugation, Sporulation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.12.2. 5613.
ReactomeiR-SPO-110056. MAPK3 (ERK1) activation.
R-SPO-112411. MAPK1 (ERK2) activation.
R-SPO-445144. Signal transduction by L1.
R-SPO-5674135. MAP2K and MAPK activation.
R-SPO-5674499. Negative feedback regulation of MAPK pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kinase byr1 (EC:2.7.12.2)
Alternative name(s):
MAPK kinase
Short name:
MAPKK
Gene namesi
Name:byr1
Synonyms:ste1
ORF Names:SPAC1D4.13
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC1D4.13.
PomBaseiSPAC1D4.13. byr1.

Subcellular locationi

  • Cytoplasm 1 Publication

  • Note: Localizes to the cell tips and septum forming regions.

GO - Cellular componenti

  • cell division site Source: PomBase
  • cell tip Source: PomBase
  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 340340Protein kinase byr1PRO_0000085688Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei214 – 2141PhosphoserineBy similarity
Modified residuei218 – 2181PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP10506.

Interactioni

Subunit structurei

Interacts with bob1 and spk1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
bob1O943072EBI-2042633,EBI-2042611

Protein-protein interaction databases

BioGridi278613. 14 interactions.
IntActiP10506. 2 interactions.
MINTiMINT-4687177.

Structurei

3D structure databases

ProteinModelPortaliP10506.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini66 – 320255Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000234206.
InParanoidiP10506.
KOiK11226.
OMAiYIHHERR.
OrthoDBiEOG7380F1.
PhylomeDBiP10506.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10506-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKRRRNPKG LVLNPNASVK SSDNDHKEEL INNQKSFESN VEAFMEQCAH
60 70 80 90 100
MNRRPAWISD LDNSSLEVVR HLGEGNGGAV SLVKHRNIFM ARKTVYVGSD
110 120 130 140 150
SKLQKQILRE LGVLHHCRSP YIVGFYGAFQ YKNNISLCME YMDCGSLDAI
160 170 180 190 200
LREGGPIPLD ILGKIINSMV KGLIYLYNVL HIIHRDLKPS NVVVNSRGEI
210 220 230 240 250
KLCDFGVSGE LVNSVAQTFV GTSTYMSPER IRGGKYTVKS DIWSLGISII
260 270 280 290 300
ELATQELPWS FSNIDDSIGI LDLLHCIVQE EPPRLPSSFP EDLRLFVDAC
310 320 330 340
LHKDPTLRAS PQQLCAMPYF QQALMINVDL ASWASNFRSS
Length:340
Mass (Da):38,189
Last modified:July 1, 1989 - v1
Checksum:i2AC885AEE971DB8A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07445 Genomic DNA. Translation: CAA30326.1.
CU329670 Genomic DNA. Translation: CAA93222.1.
PIRiS00473. OKBYR1.
RefSeqiNP_593026.1. NM_001018425.2.

Genome annotation databases

EnsemblFungiiSPAC1D4.13.1; SPAC1D4.13.1:pep; SPAC1D4.13.
GeneIDi2542137.
KEGGispo:SPAC1D4.13.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07445 Genomic DNA. Translation: CAA30326.1.
CU329670 Genomic DNA. Translation: CAA93222.1.
PIRiS00473. OKBYR1.
RefSeqiNP_593026.1. NM_001018425.2.

3D structure databases

ProteinModelPortaliP10506.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278613. 14 interactions.
IntActiP10506. 2 interactions.
MINTiMINT-4687177.

Proteomic databases

MaxQBiP10506.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC1D4.13.1; SPAC1D4.13.1:pep; SPAC1D4.13.
GeneIDi2542137.
KEGGispo:SPAC1D4.13.

Organism-specific databases

EuPathDBiFungiDB:SPAC1D4.13.
PomBaseiSPAC1D4.13. byr1.

Phylogenomic databases

HOGENOMiHOG000234206.
InParanoidiP10506.
KOiK11226.
OMAiYIHHERR.
OrthoDBiEOG7380F1.
PhylomeDBiP10506.

Enzyme and pathway databases

BRENDAi2.7.12.2. 5613.
ReactomeiR-SPO-110056. MAPK3 (ERK1) activation.
R-SPO-112411. MAPK1 (ERK2) activation.
R-SPO-445144. Signal transduction by L1.
R-SPO-5674135. MAP2K and MAPK activation.
R-SPO-5674499. Negative feedback regulation of MAPK pathway.

Miscellaneous databases

NextBioi20803209.
PROiP10506.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A gene which encodes a predicted protein kinase can restore some functions of the ras gene in fission yeast."
    Nadin-Davis S.A., Nasim A.
    EMBO J. 7:985-993(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  3. "Bob1, a Gim5/MM-1/Pfd5 homolog, interacts with the MAP kinase kinase byr1 to regulate sexual differentiation in the fission yeast, Schizosaccharomyces pombe."
    Henkel J., Du H., Yang P., Qyang Y., Kansra S., Ko M., Kim H., Marcus S.
    Differentiation 67:98-106(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH BOB1 AND SPK1, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiBYR1_SCHPO
AccessioniPrimary (citable) accession number: P10506
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: May 11, 2016
This is version 145 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.