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Protein

Protein kinase byr1

Gene

byr1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serine/threonine protein kinase involved in conjugation and sporulation. It is thought that it is phosphorylated by the byr2 protein kinase and that it can phosphorylate the spk1 kinase. When bound to bob1, is involved in the regulation of sexual differentiation.2 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei93ATPPROSITE-ProRule annotation1
Active sitei186Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi72 – 80ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • MAP kinase kinase activity Source: PomBase
  • protein serine/threonine kinase activity Source: GO_Central

GO - Biological processi

  • conjugation with cellular fusion Source: PomBase
  • MAPK cascade Source: PomBase
  • pheromone-dependent signal transduction involved in conjugation with cellular fusion Source: PomBase
  • regulation of apoptotic process Source: GO_Central
  • regulation of ascospore formation Source: PomBase
  • regulation of conjugation with cellular fusion Source: PomBase
  • sporulation resulting in formation of a cellular spore Source: UniProtKB-KW
  • stress-activated protein kinase signaling cascade Source: GO_Central

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processConjugation, Sporulation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.12.2 5613
ReactomeiR-SPO-110056 MAPK3 (ERK1) activation
R-SPO-112411 MAPK1 (ERK2) activation
R-SPO-445144 Signal transduction by L1
R-SPO-5674135 MAP2K and MAPK activation
R-SPO-5674499 Negative feedback regulation of MAPK pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kinase byr1 (EC:2.7.12.2)
Alternative name(s):
MAPK kinase
Short name:
MAPKK
Gene namesi
Name:byr1
Synonyms:ste1
ORF Names:SPAC1D4.13
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC1D4.13
PomBaseiSPAC1D4.13 byr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000856881 – 340Protein kinase byr1Add BLAST340

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei214PhosphoserineBy similarity1
Modified residuei218PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP10506
PaxDbiP10506
PRIDEiP10506

Interactioni

Subunit structurei

Interacts with bob1 and spk1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
bob1O943072EBI-2042633,EBI-2042611

Protein-protein interaction databases

BioGridi278613, 14 interactors
IntActiP10506, 2 interactors
STRINGi4896.SPAC1D4.13.1

Structurei

3D structure databases

ProteinModelPortaliP10506
SMRiP10506
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini66 – 320Protein kinasePROSITE-ProRule annotationAdd BLAST255

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000234206
InParanoidiP10506
KOiK11226
OMAiGHGPVMA
OrthoDBiEOG092C3RSG
PhylomeDBiP10506

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

P10506-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKRRRNPKG LVLNPNASVK SSDNDHKEEL INNQKSFESN VEAFMEQCAH
60 70 80 90 100
MNRRPAWISD LDNSSLEVVR HLGEGNGGAV SLVKHRNIFM ARKTVYVGSD
110 120 130 140 150
SKLQKQILRE LGVLHHCRSP YIVGFYGAFQ YKNNISLCME YMDCGSLDAI
160 170 180 190 200
LREGGPIPLD ILGKIINSMV KGLIYLYNVL HIIHRDLKPS NVVVNSRGEI
210 220 230 240 250
KLCDFGVSGE LVNSVAQTFV GTSTYMSPER IRGGKYTVKS DIWSLGISII
260 270 280 290 300
ELATQELPWS FSNIDDSIGI LDLLHCIVQE EPPRLPSSFP EDLRLFVDAC
310 320 330 340
LHKDPTLRAS PQQLCAMPYF QQALMINVDL ASWASNFRSS
Length:340
Mass (Da):38,189
Last modified:July 1, 1989 - v1
Checksum:i2AC885AEE971DB8A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07445 Genomic DNA Translation: CAA30326.1
CU329670 Genomic DNA Translation: CAA93222.1
PIRiS00473 OKBYR1
RefSeqiNP_593026.1, NM_001018425.2

Genome annotation databases

EnsemblFungiiSPAC1D4.13.1; SPAC1D4.13.1:pep; SPAC1D4.13
GeneIDi2542137
KEGGispo:SPAC1D4.13

Similar proteinsi

Entry informationi

Entry nameiBYR1_SCHPO
AccessioniPrimary (citable) accession number: P10506
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: March 28, 2018
This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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