Reviewed, UniProtKB/Swiss-Prot P10482 (BGLS_CALSA)

Names and origin

Protein names

Recommended name:
    Beta-glucosidase A
    EC=3.2.1.21
Alternative name(s):
    Gentiobiase
    Cellobiase
    Beta-D-glucoside glucohydrolase
    Amygdalase

Gene names

Name:

bglA

Organism

Caldocellum saccharolyticum (Caldicellulosiruptor saccharolyticus)

Taxonomic identifier

44001 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacterales Family III. Incertae Sedis › Caldicellulosiruptor

Protein attributes

Sequence length	455 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose.
Miscellaneous	C.saccharolyticum is an extreme thermophile and appears to be a Gram-positive anaerobic bacterium.
Sequence similarities	Belongs to the glycosyl hydrolase 1 family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Cellulose degradation Polysaccharide degradation
Molecular function	Glycosidase Hydrolase
Gene Ontology (GO)
Biological process	cellulose catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	beta-glucosidase activity Inferred from electronic annotation. Source: EC cation binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 455	455	Beta-glucosidase A		PRO_0000063875
Sites
	Active site	165	1	Proton donor Potential
	Active site	363	1	Nucleophile By similarity

Sequences

	Sequence		Length	Mass (Da)
	P10482-1 [UniParc]. Last modified July 1, 1989. Version 1. Checksum: 9443ABB7EFC499E1	FASTA	455	53,492
	10 20 30 40 50 60 MDMSFPKGFL WGAATASYQI EGAWNEDGKG ESIWDRFTHQ KRNILYGHNG DVACDHYHRF 70 80 90 100 110 120 EEDVSLMKEL GLKAYRFSIA WTRIFPDGFG TVNQKGLEFY DRLINKLVEN GIEPVVTLYH 130 140 150 160 170 180 WDLPQKLQDI GGWANPEIVN YYFDYAMLVI NRYKDKVKKW ITFNEPYCIA FLGYFHGIHA 190 200 210 220 230 240 PGIKDFKVAM DVVHSLMLSH FKVVKAVKEN NIDVEVGITL NLTPVYLQTE RLGYKVSEIE 250 260 270 280 290 300 REMVSLSSQL DNQLFLDPVL KGSYPQKLLD YLVQKDLLDS QKALSMQQEV KENFIFPDFL 310 320 330 340 350 360 GINYYTRAVR LYDENSSWIF PIRWEHPAGE YTEMGWEVFP QGLFDLLIWI KESYPQIPIY 370 380 390 400 410 420 ITENGAAYND IVTEDGKVHD SKRIEYLKQH FEAARKAIEN GVDLRGYFVW SLMDNFEWAM 430 440 450 GYTKRFGIIY VDYETQKRIK KDSFYFYQQY IKENS

References

[1]	"Sequence structure and expression of a cloned beta-glucosidase gene from an extreme thermophile." Love D.R., Bergquist P.L. Mol. Gen. Genet. 213:84-92(1988) [PubMed: 2851713] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	X12575 Genomic DNA. Translation: CAA31087.1.
PIR	S03813.
3D structure databases
HSSP	HSSP built from PDB template 1OD0 based on UniProtKB Q08638.
ModBase	Search...
Family and domain databases
InterPro	IPR001360. Glyco_hydro_1. IPR017736. Glyco_hydro_1_beta-glucosidase. IPR013781. Glyco_hydro_sub_cat. [Graphical view]
Gene3D	G3DSA:3.20.20.80. Glyco_hydro_cat. 1 hit.
PANTHER	PTHR10353. Glyco_hydro_1. 1 hit.
Pfam	PF00232. Glyco_hydro_1. 1 hit. [Graphical view]
PRINTS	PR00131. GLHYDRLASE1.
PROSITE	PS00572. GLYCOSYL_HYDROL_F1_1. 1 hit. PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
LinkHub	P10482.

Entry information

Entry name

BGLS_CALSA

Accession

Primary (citable) accession number: P10482

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	July 1, 1989
Last modified:	November 25, 2008
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)