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P10482

- BGLS_CALSA

UniProt

P10482 - BGLS_CALSA

Protein

Beta-glucosidase A

Gene

bglA

Organism
Caldicellulosiruptor saccharolyticus (Caldocellum saccharolyticum)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei165 – 1651Proton donorSequence Analysis
    Active sitei363 – 3631NucleophilePROSITE-ProRule annotation

    GO - Molecular functioni

    1. beta-glucosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellulose catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

    Protein family/group databases

    CAZyiGH1. Glycoside Hydrolase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-glucosidase A (EC:3.2.1.21)
    Alternative name(s):
    Amygdalase
    Beta-D-glucoside glucohydrolase
    Cellobiase
    Gentiobiase
    Gene namesi
    Name:bglA
    OrganismiCaldicellulosiruptor saccharolyticus (Caldocellum saccharolyticum)
    Taxonomic identifieri44001 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacterales Family III. Incertae SedisCaldicellulosiruptor

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 455455Beta-glucosidase APRO_0000063875Add
    BLAST

    Interactioni

    Structurei

    3D structure databases

    ProteinModelPortaliP10482.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 1 family.Curated

    Family and domain databases

    Gene3Di3.20.20.80. 1 hit.
    InterProiIPR001360. Glyco_hydro_1.
    IPR018120. Glyco_hydro_1_AS.
    IPR017736. Glyco_hydro_1_beta-glucosidase.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR10353. PTHR10353. 1 hit.
    PfamiPF00232. Glyco_hydro_1. 1 hit.
    [Graphical view]
    PRINTSiPR00131. GLHYDRLASE1.
    SUPFAMiSSF51445. SSF51445. 1 hit.
    TIGRFAMsiTIGR03356. BGL. 1 hit.
    PROSITEiPS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
    PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P10482-1 [UniParc]FASTAAdd to Basket

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    MDMSFPKGFL WGAATASYQI EGAWNEDGKG ESIWDRFTHQ KRNILYGHNG    50
    DVACDHYHRF EEDVSLMKEL GLKAYRFSIA WTRIFPDGFG TVNQKGLEFY 100
    DRLINKLVEN GIEPVVTLYH WDLPQKLQDI GGWANPEIVN YYFDYAMLVI 150
    NRYKDKVKKW ITFNEPYCIA FLGYFHGIHA PGIKDFKVAM DVVHSLMLSH 200
    FKVVKAVKEN NIDVEVGITL NLTPVYLQTE RLGYKVSEIE REMVSLSSQL 250
    DNQLFLDPVL KGSYPQKLLD YLVQKDLLDS QKALSMQQEV KENFIFPDFL 300
    GINYYTRAVR LYDENSSWIF PIRWEHPAGE YTEMGWEVFP QGLFDLLIWI 350
    KESYPQIPIY ITENGAAYND IVTEDGKVHD SKRIEYLKQH FEAARKAIEN 400
    GVDLRGYFVW SLMDNFEWAM GYTKRFGIIY VDYETQKRIK KDSFYFYQQY 450
    IKENS 455
    Length:455
    Mass (Da):53,492
    Last modified:July 1, 1989 - v1
    Checksum:i9443ABB7EFC499E1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X12575 Genomic DNA. Translation: CAA31087.1.
    PIRiS03813.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X12575 Genomic DNA. Translation: CAA31087.1 .
    PIRi S03813.

    3D structure databases

    ProteinModelPortali P10482.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi P10482.
    ChEMBLi CHEMBL4622.

    Protein family/group databases

    CAZyi GH1. Glycoside Hydrolase Family 1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.20.20.80. 1 hit.
    InterProi IPR001360. Glyco_hydro_1.
    IPR018120. Glyco_hydro_1_AS.
    IPR017736. Glyco_hydro_1_beta-glucosidase.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR10353. PTHR10353. 1 hit.
    Pfami PF00232. Glyco_hydro_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00131. GLHYDRLASE1.
    SUPFAMi SSF51445. SSF51445. 1 hit.
    TIGRFAMsi TIGR03356. BGL. 1 hit.
    PROSITEi PS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
    PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence structure and expression of a cloned beta-glucosidase gene from an extreme thermophile."
      Love D.R., Bergquist P.L.
      Mol. Gen. Genet. 213:84-92(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiBGLS_CALSA
    AccessioniPrimary (citable) accession number: P10482
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    C.saccharolyticum is an extreme thermophile and appears to be a Gram-positive anaerobic bacterium.

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3