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P10482

- BGLS_CALSA

UniProt

P10482 - BGLS_CALSA

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Protein

Beta-glucosidase A

Gene

bglA

Organism
Caldicellulosiruptor saccharolyticus (Caldocellum saccharolyticum)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei165 – 1651Proton donorSequence Analysis
Active sitei363 – 3631NucleophilePROSITE-ProRule annotation

GO - Molecular functioni

  1. beta-glucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellulose catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Protein family/group databases

CAZyiGH1. Glycoside Hydrolase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-glucosidase A (EC:3.2.1.21)
Alternative name(s):
Amygdalase
Beta-D-glucoside glucohydrolase
Cellobiase
Gentiobiase
Gene namesi
Name:bglA
OrganismiCaldicellulosiruptor saccharolyticus (Caldocellum saccharolyticum)
Taxonomic identifieri44001 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacterales Family III. Incertae SedisCaldicellulosiruptor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 455455Beta-glucosidase APRO_0000063875Add
BLAST

Interactioni

Structurei

3D structure databases

ProteinModelPortaliP10482.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 1 family.Curated

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR017736. Glyco_hydro_1_beta-glucosidase.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10353. PTHR10353. 1 hit.
PfamiPF00232. Glyco_hydro_1. 1 hit.
[Graphical view]
PRINTSiPR00131. GLHYDRLASE1.
SUPFAMiSSF51445. SSF51445. 1 hit.
TIGRFAMsiTIGR03356. BGL. 1 hit.
PROSITEiPS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10482 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDMSFPKGFL WGAATASYQI EGAWNEDGKG ESIWDRFTHQ KRNILYGHNG
60 70 80 90 100
DVACDHYHRF EEDVSLMKEL GLKAYRFSIA WTRIFPDGFG TVNQKGLEFY
110 120 130 140 150
DRLINKLVEN GIEPVVTLYH WDLPQKLQDI GGWANPEIVN YYFDYAMLVI
160 170 180 190 200
NRYKDKVKKW ITFNEPYCIA FLGYFHGIHA PGIKDFKVAM DVVHSLMLSH
210 220 230 240 250
FKVVKAVKEN NIDVEVGITL NLTPVYLQTE RLGYKVSEIE REMVSLSSQL
260 270 280 290 300
DNQLFLDPVL KGSYPQKLLD YLVQKDLLDS QKALSMQQEV KENFIFPDFL
310 320 330 340 350
GINYYTRAVR LYDENSSWIF PIRWEHPAGE YTEMGWEVFP QGLFDLLIWI
360 370 380 390 400
KESYPQIPIY ITENGAAYND IVTEDGKVHD SKRIEYLKQH FEAARKAIEN
410 420 430 440 450
GVDLRGYFVW SLMDNFEWAM GYTKRFGIIY VDYETQKRIK KDSFYFYQQY

IKENS
Length:455
Mass (Da):53,492
Last modified:July 1, 1989 - v1
Checksum:i9443ABB7EFC499E1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X12575 Genomic DNA. Translation: CAA31087.1.
PIRiS03813.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X12575 Genomic DNA. Translation: CAA31087.1 .
PIRi S03813.

3D structure databases

ProteinModelPortali P10482.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi P10482.
ChEMBLi CHEMBL4622.

Protein family/group databases

CAZyi GH1. Glycoside Hydrolase Family 1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
InterProi IPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR017736. Glyco_hydro_1_beta-glucosidase.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR10353. PTHR10353. 1 hit.
Pfami PF00232. Glyco_hydro_1. 1 hit.
[Graphical view ]
PRINTSi PR00131. GLHYDRLASE1.
SUPFAMi SSF51445. SSF51445. 1 hit.
TIGRFAMsi TIGR03356. BGL. 1 hit.
PROSITEi PS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence structure and expression of a cloned beta-glucosidase gene from an extreme thermophile."
    Love D.R., Bergquist P.L.
    Mol. Gen. Genet. 213:84-92(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiBGLS_CALSA
AccessioniPrimary (citable) accession number: P10482
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 1, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

C.saccharolyticum is an extreme thermophile and appears to be a Gram-positive anaerobic bacterium.

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3