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P10482 (BGLS_CALSA) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-glucosidase A

EC=3.2.1.21
Alternative name(s):
Amygdalase
Beta-D-glucoside glucohydrolase
Cellobiase
Gentiobiase
Gene names
Name:bglA
OrganismCaldicellulosiruptor saccharolyticus (Caldocellum saccharolyticum)
Taxonomic identifier44001 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacterales Family III. Incertae SedisCaldicellulosiruptor

Protein attributes

Sequence length455 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

Miscellaneous

C.saccharolyticum is an extreme thermophile and appears to be a Gram-positive anaerobic bacterium.

Sequence similarities

Belongs to the glycosyl hydrolase 1 family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Cellulose degradation
Polysaccharide degradation
   Molecular functionGlycosidase
Hydrolase
Gene Ontology (GO)
   Biological_processcellulose catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionbeta-glucosidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 455455Beta-glucosidase A
PRO_0000063875

Sites

Active site1651Proton donor Potential
Active site3631Nucleophile By similarity

Sequences

Sequence LengthMass (Da)Tools
P10482 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: 9443ABB7EFC499E1

FASTA45553,492
        10         20         30         40         50         60 
MDMSFPKGFL WGAATASYQI EGAWNEDGKG ESIWDRFTHQ KRNILYGHNG DVACDHYHRF 

        70         80         90        100        110        120 
EEDVSLMKEL GLKAYRFSIA WTRIFPDGFG TVNQKGLEFY DRLINKLVEN GIEPVVTLYH 

       130        140        150        160        170        180 
WDLPQKLQDI GGWANPEIVN YYFDYAMLVI NRYKDKVKKW ITFNEPYCIA FLGYFHGIHA 

       190        200        210        220        230        240 
PGIKDFKVAM DVVHSLMLSH FKVVKAVKEN NIDVEVGITL NLTPVYLQTE RLGYKVSEIE 

       250        260        270        280        290        300 
REMVSLSSQL DNQLFLDPVL KGSYPQKLLD YLVQKDLLDS QKALSMQQEV KENFIFPDFL 

       310        320        330        340        350        360 
GINYYTRAVR LYDENSSWIF PIRWEHPAGE YTEMGWEVFP QGLFDLLIWI KESYPQIPIY 

       370        380        390        400        410        420 
ITENGAAYND IVTEDGKVHD SKRIEYLKQH FEAARKAIEN GVDLRGYFVW SLMDNFEWAM 

       430        440        450 
GYTKRFGIIY VDYETQKRIK KDSFYFYQQY IKENS 

« Hide

References

[1]"Sequence structure and expression of a cloned beta-glucosidase gene from an extreme thermophile."
Love D.R., Bergquist P.L.
Mol. Gen. Genet. 213:84-92(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X12575 Genomic DNA. Translation: CAA31087.1.
PIRS03813.

3D structure databases

ProteinModelPortalP10482.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBP10482.
ChEMBLCHEMBL4622.

Protein family/group databases

CAZyGH1. Glycoside Hydrolase Family 1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.20.20.80. 1 hit.
InterProIPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR017736. Glyco_hydro_1_beta-glucosidase.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERPTHR10353. PTHR10353. 1 hit.
PfamPF00232. Glyco_hydro_1. 1 hit.
[Graphical view]
PRINTSPR00131. GLHYDRLASE1.
SUPFAMSSF51445. SSF51445. 1 hit.
TIGRFAMsTIGR03356. BGL. 1 hit.
PROSITEPS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBGLS_CALSA
AccessionPrimary (citable) accession number: P10482
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: December 11, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries