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P10481

- NANH_CLOPF

UniProt

P10481 - NANH_CLOPF

Protein

Sialidase

Gene

nanH

Organism
Clostridium perfringens
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
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    Functioni

    Sialidases have been suggested to be pathogenic factors in microbial infections.

    Catalytic activityi

    Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei37 – 371SubstrateBy similarity
    Active sitei62 – 621Proton acceptorBy similarity
    Binding sitei245 – 2451SubstrateSequence Analysis
    Active sitei347 – 3471NucleophileBy similarity

    GO - Molecular functioni

    1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
    2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
    3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. pathogenesis Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Enzyme and pathway databases

    SABIO-RKP10481.

    Protein family/group databases

    CAZyiGH33. Glycoside Hydrolase Family 33.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sialidase (EC:3.2.1.18)
    Alternative name(s):
    Neuraminidase
    Gene namesi
    Name:nanH
    OrganismiClostridium perfringens
    Taxonomic identifieri1502 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 382382SialidasePRO_0000208908Add
    BLAST

    Interactioni

    Structurei

    3D structure databases

    ProteinModelPortaliP10481.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati71 – 8212BNR 1Add
    BLAST
    Repeati140 – 15112BNR 2Add
    BLAST
    Repeati208 – 21912BNR 3Add
    BLAST
    Repeati255 – 26612BNR 4Add
    BLAST

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 33 family.Curated
    Contains 4 BNR repeats.Curated

    Keywords - Domaini

    Repeat

    Family and domain databases

    Gene3Di2.120.10.10. 1 hit.
    InterProiIPR002860. BNR_rpt.
    IPR026856. Sialidase_fam.
    IPR008377. Sialidase_trypan.
    IPR011040. Sialidases.
    [Graphical view]
    PANTHERiPTHR10628. PTHR10628. 1 hit.
    PTHR10628:SF5. PTHR10628:SF5. 1 hit.
    PfamiPF02012. BNR. 3 hits.
    [Graphical view]
    PRINTSiPR01803. TCSIALIDASE.
    SUPFAMiSSF50939. SSF50939. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P10481-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCNKNNTFEK NLDISHKPEP LILFNKDNNI WNSKYFRIPN IQLLNDGTIL    50
    TFSDIRYNGP DDHAYIDIAS ARSTDFGKTW SYNIAMKNNR IDSTYSRVMD 100
    STTVITNTGR IILIAGSWNT NGNWAMTTST RRSDWSVQMI YSDDNGLTWS 150
    NKIDLTKDSS KVKNQPSNTI GWLGGVGSGI VMDDGTIVMP AQISLRENNE 200
    NNYYSLIIYS KDNGETWTMG NKVPNSNTSE NMVIELDGAL IMSTRYDYSG 250
    YRAAYISHDL GTTWEIYEPL NGKILTGKGS GCQGSFIKAT TSNGHRIGLI 300
    SAPKNTKGEY IRDNIAVYMI DFDDLSKGVQ EICIPYPEDG NKLGGGYSCL 350
    SFKNNHLGIV YEANGNIEYQ DLTPYYSLIN KQ 382
    Length:382
    Mass (Da):42,813
    Last modified:July 1, 1989 - v1
    Checksum:iD50857BB50A4E886
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y00963 Genomic DNA. Translation: CAA68780.1.
    PIRiS01339.

    Cross-referencesi

    Web resourcesi

    Worthington enzyme manual

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y00963 Genomic DNA. Translation: CAA68780.1 .
    PIRi S01339.

    3D structure databases

    ProteinModelPortali P10481.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi P10481.
    ChEMBLi CHEMBL5189.

    Protein family/group databases

    CAZyi GH33. Glycoside Hydrolase Family 33.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    SABIO-RK P10481.

    Family and domain databases

    Gene3Di 2.120.10.10. 1 hit.
    InterProi IPR002860. BNR_rpt.
    IPR026856. Sialidase_fam.
    IPR008377. Sialidase_trypan.
    IPR011040. Sialidases.
    [Graphical view ]
    PANTHERi PTHR10628. PTHR10628. 1 hit.
    PTHR10628:SF5. PTHR10628:SF5. 1 hit.
    Pfami PF02012. BNR. 3 hits.
    [Graphical view ]
    PRINTSi PR01803. TCSIALIDASE.
    SUPFAMi SSF50939. SSF50939. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequencing of a Clostridium perfringens sialidase gene."
      Roggentin P., Rothe B., Lottspeich F., Schauer R.
      FEBS Lett. 238:31-34(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 8-27.
      Strain: A99.

    Entry informationi

    Entry nameiNANH_CLOPF
    AccessioniPrimary (citable) accession number: P10481
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3