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Protein

Sialidase

Gene

nanH

Organism
Clostridium perfringens
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sialidases have been suggested to be pathogenic factors in microbial infections.

Catalytic activityi

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei37SubstrateBy similarity1
Active sitei62Proton acceptorBy similarity1
Binding sitei245SubstrateSequence analysis1
Active sitei347NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-18998
BRENDAi3.2.1.18 1503
SABIO-RKP10481

Protein family/group databases

CAZyiGH33 Glycoside Hydrolase Family 33

Names & Taxonomyi

Protein namesi
Recommended name:
Sialidase (EC:3.2.1.18)
Alternative name(s):
Neuraminidase
Gene namesi
Name:nanH
OrganismiClostridium perfringens
Taxonomic identifieri1502 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5189

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002089081 – 382SialidaseAdd BLAST382

Proteomic databases

PRIDEiP10481

Interactioni

Chemistry databases

BindingDBiP10481

Structurei

3D structure databases

ProteinModelPortaliP10481
SMRiP10481
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati71 – 82BNR 1Add BLAST12
Repeati140 – 151BNR 2Add BLAST12
Repeati208 – 219BNR 3Add BLAST12
Repeati255 – 266BNR 4Add BLAST12

Sequence similaritiesi

Belongs to the glycosyl hydrolase 33 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105W5A Bacteria
COG4409 LUCA

Family and domain databases

InterProiView protein in InterPro
IPR011040 Sialidase
IPR026856 Sialidase_fam
IPR036278 Sialidase_sf
IPR008377 Sialidase_trypan
PANTHERiPTHR10628 PTHR10628, 1 hit
PfamiView protein in Pfam
PF13859 BNR_3, 1 hit
PRINTSiPR01803 TCSIALIDASE
SUPFAMiSSF50939 SSF50939, 1 hit

Sequencei

Sequence statusi: Complete.

P10481-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCNKNNTFEK NLDISHKPEP LILFNKDNNI WNSKYFRIPN IQLLNDGTIL
60 70 80 90 100
TFSDIRYNGP DDHAYIDIAS ARSTDFGKTW SYNIAMKNNR IDSTYSRVMD
110 120 130 140 150
STTVITNTGR IILIAGSWNT NGNWAMTTST RRSDWSVQMI YSDDNGLTWS
160 170 180 190 200
NKIDLTKDSS KVKNQPSNTI GWLGGVGSGI VMDDGTIVMP AQISLRENNE
210 220 230 240 250
NNYYSLIIYS KDNGETWTMG NKVPNSNTSE NMVIELDGAL IMSTRYDYSG
260 270 280 290 300
YRAAYISHDL GTTWEIYEPL NGKILTGKGS GCQGSFIKAT TSNGHRIGLI
310 320 330 340 350
SAPKNTKGEY IRDNIAVYMI DFDDLSKGVQ EICIPYPEDG NKLGGGYSCL
360 370 380
SFKNNHLGIV YEANGNIEYQ DLTPYYSLIN KQ
Length:382
Mass (Da):42,813
Last modified:July 1, 1989 - v1
Checksum:iD50857BB50A4E886
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00963 Genomic DNA Translation: CAA68780.1
PIRiS01339

Similar proteinsi

Entry informationi

Entry nameiNANH_CLOPF
AccessioniPrimary (citable) accession number: P10481
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: May 23, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

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