Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Endo-1,4-beta-xylanase Z

Gene

xynZ

Organism
Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei645Proton donor1
Active sitei754Nucleophile1

GO - Molecular functioni

  • carbohydrate binding Source: InterPro
  • endo-1,4-beta-xylanase activity Source: MENGO
  • xylan endo-1,3-beta-xylosidase activity Source: MENGO

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Polysaccharide degradation, Xylan degradation

Enzyme and pathway databases

BioCyciCTHE203119:G1G86-2045-MONOMER
MetaCyc:MONOMER-16453
BRENDAi3.1.1.73 1530
3.2.1.8 1530

Protein family/group databases

CAZyiCBM6 Carbohydrate-Binding Module Family 6
GH10 Glycoside Hydrolase Family 10
ESTHERiclotm-xynz A85-Feruloyl-Esterase

Names & Taxonomyi

Protein namesi
Recommended name:
Endo-1,4-beta-xylanase Z (EC:3.2.1.8)
Short name:
Xylanase Z
Alternative name(s):
1,4-beta-D-xylan xylanohydrolase Z
Gene namesi
Name:xynZ
Ordered Locus Names:Cthe_1963
OrganismiClostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum)
Taxonomic identifieri203119 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesRuminococcaceaeRuminiclostridium
Proteomesi
  • UP000002145 Componenti: Chromosome

Pathology & Biotechi

Chemistry databases

DrugBankiDB07767 3-(4-HYDROXY-3-METHOXYPHENYL)-2-PROPENOIC ACID

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000000797329 – 837Endo-1,4-beta-xylanase ZAdd BLAST809

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi783 ↔ 789By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

IntActiP10478, 1 interactor
STRINGi203119.Cthe_1963

Structurei

Secondary structure

1837
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni37 – 40Combined sources4
Beta strandi50 – 58Combined sources9
Turni59 – 62Combined sources4
Beta strandi63 – 71Combined sources9
Beta strandi83 – 87Combined sources5
Turni94 – 102Combined sources9
Helixi104 – 113Combined sources10
Beta strandi121 – 125Combined sources5
Helixi137 – 147Combined sources11
Helixi149 – 156Combined sources8
Helixi163 – 165Combined sources3
Beta strandi166 – 171Combined sources6
Helixi173 – 183Combined sources11
Turni186 – 188Combined sources3
Beta strandi190 – 196Combined sources7
Helixi204 – 207Combined sources4
Turni209 – 212Combined sources4
Helixi213 – 218Combined sources6
Beta strandi220 – 227Combined sources8
Helixi233 – 245Combined sources13
Beta strandi251 – 255Combined sources5
Helixi262 – 279Combined sources18
Turni280 – 282Combined sources3
Helixi518 – 524Combined sources7
Beta strandi528 – 533Combined sources6
Helixi536 – 539Combined sources4
Helixi543 – 552Combined sources10
Beta strandi554 – 560Combined sources7
Helixi564 – 567Combined sources4
Helixi577 – 588Combined sources12
Beta strandi592 – 599Combined sources8
Beta strandi601 – 603Combined sources3
Helixi606 – 609Combined sources4
Helixi615 – 632Combined sources18
Turni633 – 636Combined sources4
Beta strandi638 – 645Combined sources8
Beta strandi651 – 654Combined sources4
Helixi658 – 663Combined sources6
Helixi667 – 678Combined sources12
Beta strandi682 – 690Combined sources9
Beta strandi692 – 695Combined sources4
Helixi696 – 710Combined sources15
Beta strandi717 – 720Combined sources4
Beta strandi723 – 727Combined sources5
Helixi730 – 745Combined sources16
Beta strandi749 – 760Combined sources12
Helixi765 – 785Combined sources21
Beta strandi789 – 795Combined sources7
Helixi804 – 807Combined sources4
Beta strandi815 – 817Combined sources3
Helixi825 – 834Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JJFX-ray1.75A20-287[»]
1JT2X-ray1.80A20-287[»]
1XYZX-ray1.40A/B491-837[»]
ProteinModelPortaliP10478
SMRiP10478
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10478

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini299 – 420CBM6PROSITE-ProRule annotationAdd BLAST122
Domaini424 – 492DockerinPROSITE-ProRule annotationAdd BLAST69
Domaini512 – 833GH10PROSITE-ProRule annotationAdd BLAST322

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2382 LUCA
COG3693 LUCA
KOiK01181
OMAiEMKFDAL
OrthoDBiPOG091H0560

Family and domain databases

Gene3Di2.60.120.260, 1 hit
3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR006584 Cellulose-bd_IV
IPR005084 CMB_fam6
IPR002105 Dockerin_1_rpt
IPR016134 Dockerin_dom
IPR036439 Dockerin_dom_sf
IPR018247 EF_Hand_1_Ca_BS
IPR000801 Esterase_put
IPR008979 Galactose-bd-like_sf
IPR001000 GH10
IPR031158 GH10_AS
IPR017853 Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF03422 CBM_6, 1 hit
PF00404 Dockerin_1, 2 hits
PF00756 Esterase, 1 hit
PF00331 Glyco_hydro_10, 1 hit
PRINTSiPR00134 GLHYDRLASE10
SMARTiView protein in SMART
SM00606 CBD_IV, 1 hit
SM00633 Glyco_10, 1 hit
SUPFAMiSSF49785 SSF49785, 1 hit
SSF51445 SSF51445, 1 hit
SSF53474 SSF53474, 1 hit
SSF63446 SSF63446, 1 hit
PROSITEiView protein in PROSITE
PS51175 CBM6, 1 hit
PS00448 CLOS_CELLULOSOME_RPT, 2 hits
PS51766 DOCKERIN, 1 hit
PS00018 EF_HAND_1, 2 hits
PS00591 GH10_1, 1 hit
PS51760 GH10_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10478-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRKLFSVLL VGLMLMTSLL VTISSTSAAS LPTMPPSGYD QVRNGVPRGQ
60 70 80 90 100
VVNISYFSTA TNSTRPARVY LPPGYSKDKK YSVLYLLHGI GGSENDWFEG
110 120 130 140 150
GGRANVIADN LIAEGKIKPL IIVTPNTNAA GPGIADGYEN FTKDLLNSLI
160 170 180 190 200
PYIESNYSVY TDREHRAIAG LSMGGGQSFN IGLTNLDKFA YIGPISAAPN
210 220 230 240 250
TYPNERLFPD GGKAAREKLK LLFIACGTND SLIGFGQRVH EYCVANNINH
260 270 280 290 300
VYWLIQGGGH DFNVWKPGLW NFLQMADEAG LTRDGNTPVP TPSPKPANTR
310 320 330 340 350
IEAEDYDGIN SSSIEIIGVP PEGGRGIGYI TSGDYLVYKS IDFGNGATSF
360 370 380 390 400
KAKVANANTS NIELRLNGPN GTLIGTLSVK STGDWNTYEE QTCSISKVTG
410 420 430 440 450
INDLYLVFKG PVNIDWFTFG VESSSTGLGD LNGDGNINSS DLQALKRHLL
460 470 480 490 500
GISPLTGEAL LRADVNRSGK VDSTDYSVLK RYILRIITEF PGQGDVQTPN
510 520 530 540 550
PSVTPTQTPI PTISGNALRD YAEARGIKIG TCVNYPFYNN SDPTYNSILQ
560 570 580 590 600
REFSMVVCEN EMKFDALQPR QNVFDFSKGD QLLAFAERNG MQMRGHTLIW
610 620 630 640 650
HNQNPSWLTN GNWNRDSLLA VMKNHITTVM THYKGKIVEW DVANECMDDS
660 670 680 690 700
GNGLRSSIWR NVIGQDYLDY AFRYAREADP DALLFYNDYN IEDLGPKSNA
710 720 730 740 750
VFNMIKSMKE RGVPIDGVGF QCHFINGMSP EYLASIDQNI KRYAEIGVIV
760 770 780 790 800
SFTEIDIRIP QSENPATAFQ VQANNYKELM KICLANPNCN TFVMWGFTDK
810 820 830
YTWIPGTFPG YGNPLIYDSN YNPKPAYNAI KEALMGY
Length:837
Mass (Da):92,263
Last modified:November 1, 1991 - v3
Checksum:iDD4C29F04D12B6CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22624 Genomic DNA Translation: AAA23286.1
CP000568 Genomic DNA Translation: ABN53181.1
PIRiA31842
RefSeqiWP_003513959.1, NC_009012.1

Genome annotation databases

EnsemblBacteriaiABN53181; ABN53181; Cthe_1963
GeneIDi35804788
KEGGicth:Cthe_1963

Similar proteinsi

Entry informationi

Entry nameiXYNZ_CLOTH
AccessioniPrimary (citable) accession number: P10478
Secondary accession number(s): A3DGV2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1991
Last modified: April 25, 2018
This is version 140 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health