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Protein

Endoglucanase A

Gene

celA

Organism
Cellvibrio japonicus (strain Ueda107) (Pseudomonas fluorescens subsp. cellulosa)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei523By similarity1
Active sitei573By similarity1
Active sitei582By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Enzyme and pathway databases

BioCyciCJAP498211:G1GB3-2449-MONOMER

Protein family/group databases

CAZyiCBM10 Carbohydrate-Binding Module Family 10
CBM2 Carbohydrate-Binding Module Family 2
GH9 Glycoside Hydrolase Family 9

Names & Taxonomyi

Protein namesi
Recommended name:
Endoglucanase A (EC:3.2.1.4)
Short name:
EGA
Alternative name(s):
Cellulase
Endo-1,4-beta-glucanase
Gene namesi
Name:celA
Synonyms:cel9A
Ordered Locus Names:CJA_2472
OrganismiCellvibrio japonicus (strain Ueda107) (Pseudomonas fluorescens subsp. cellulosa)
Taxonomic identifieri498211 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaCellvibrionalesCellvibrionaceaeCellvibrio
Proteomesi
  • UP000001036 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_000000795733 – 962Endoglucanase AAdd BLAST930

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi671 ↔ 702By similarity
Disulfide bondi681 ↔ 696By similarity
Disulfide bondi866 ↔ 961By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP10476

Interactioni

Protein-protein interaction databases

STRINGi498211.CJA_2472

Structurei

3D structure databases

ProteinModelPortaliP10476
SMRiP10476
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini670 – 699CBM10PROSITE-ProRule annotationAdd BLAST30
Domaini859 – 962CBM2PROSITE-ProRule annotationAdd BLAST104

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi608 – 664Ser-richAdd BLAST57
Compositional biasi823 – 859Ser-rich (linker)Add BLAST37

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105E08 Bacteria
ENOG410XNTA LUCA
HOGENOMiHOG000245359
KOiK01179
OrthoDBiPOG091H04TS

Family and domain databases

CDDicd02850 E_set_Cellulase_N, 1 hit
Gene3Di1.50.10.10, 1 hit
2.30.32.30, 1 hit
2.60.40.10, 2 hits
2.60.40.290, 1 hit
InterProiView protein in InterPro
IPR008928 6-hairpin_glycosidase_sf
IPR012341 6hp_glycosidase-like_sf
IPR001919 CBD2
IPR002883 CBM10/Dockerin_dom
IPR036601 CBM10_sf
IPR008965 CBM2/CBM3_carb-bd_dom_sf
IPR012291 CBM2_carb-bd_dom_sf
IPR018366 CBM2_CS
IPR009031 CBM_fam10
IPR004197 Cellulase_Ig-like
IPR001701 Glyco_hydro_9
IPR033126 Glyco_hydro_9_Asp/Glu_AS
IPR018221 Glyco_hydro_9_His_AS
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR000601 PKD_dom
IPR035986 PKD_dom_sf
PfamiView protein in Pfam
PF02013 CBM_10, 1 hit
PF00553 CBM_2, 1 hit
PF02927 CelD_N, 1 hit
PF00759 Glyco_hydro_9, 1 hit
PF00801 PKD, 1 hit
SMARTiView protein in SMART
SM00637 CBD_II, 1 hit
SM01064 CBM_10, 1 hit
SUPFAMiSSF48208 SSF48208, 1 hit
SSF49299 SSF49299, 1 hit
SSF49384 SSF49384, 1 hit
SSF57615 SSF57615, 1 hit
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS51763 CBM10, 1 hit
PS51173 CBM2, 1 hit
PS00561 CBM2_A, 1 hit
PS00592 GLYCOSYL_HYDROL_F9_1, 1 hit
PS00698 GLYCOSYL_HYDROL_F9_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10476-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MINRSVLKIP ALVKPLVQAL VLVGCTLGVA QAEVGNPRVN QLGYIPNGDR
60 70 80 90 100
IAVYKASNNS AQTWQLTHNG SLIASGQTIP KGSDASSGDN IHHIDLSSVT
110 120 130 140 150
ATGSGFTLTV GGDSSYPFSI SSTTFNAAFY DALKYFYHNR SGIAIETPYT
160 170 180 190 200
GGGRGSYASH SRWSRPAGHL NQGANKGDMN VPCWSGTCNY SLNVTKGWYD
210 220 230 240 250
AGDHGKYVVN GGISVWTLLN LYERAQHITG NLAAVADGSM NIPESGNGVA
260 270 280 290 300
DILDEARWQM EFMLAMQVPQ GQAKAGMAHH KIHDVGWTGL PLAPHEDPQQ
310 320 330 340 350
RALVPPSTAA TLNLAATAAQ AARIWKDIDA GFAALCLTAA ERAWNAAQAN
360 370 380 390 400
PNDIYSGNYD NGGGGYGDRF VADEFYWAAA ELYITTGDSR YLPTINNYTL
410 420 430 440 450
ERTDFGWPDT ELLGVMSLAV VPATHTNSLR IAARNHIQTI ASTHLTTQSA
460 470 480 490 500
SGYPAPLSSL EYYWGSNSVI ANKLVLMGLA YDFSGNQNFA LGVSKGINYL
510 520 530 540 550
FGSNVLSTSF ITGLGTNTVA QPHHRFWAGA LNSNYPWAPP GALSGGPNAG
560 570 580 590 600
LEDSLSASRL SGCTSRPATC WLDSIDAWST NEITINWNAP LAWVLGFYND
610 620 630 640 650
FAATQGGSSS SSSSSSSSVP VSSSSSSSII PSSSSSSIQP SSSSSSMPSS
660 670 680 690 700
SSSSSSVVAS SSSSVSGGLR CNWYGTLYPL CVTTQSGWGW ENSQSCISAS
710 720 730 740 750
TCSAQPAPYG IVGAASSSSQ AANRSPTLQL SANATGFEGG SMVCCTLHIN
760 770 780 790 800
GAASDPDGDN LTYSWQVISG NTVVASGSSS SASIHVSNQR GYEVSMTVSD
810 820 830 840 850
GRGGVATETT FVSVYFSDYF PGSSSSASNI NSSSSSSSSS SSSAIVSSSS
860 870 880 890 900
SVVSSSSSSA ASGGNCQYVV TNQWNNGFTA VIRVRNNGSS AINGWSVNWS
910 920 930 940 950
YSDGSRITNS WNANVTGNNP YAASALGWNA NIQPGQTAEF GFQGTKGAGS
960
AQVPAVTGSV CQ
Length:962
Mass (Da):100,109
Last modified:April 20, 2010 - v2
Checksum:i95212655950CB52A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14K → T in CAA31082 (PubMed:2851699).Curated1
Sequence conflicti25C → G in CAA31082 (PubMed:2851699).Curated1
Sequence conflicti503S → I in CAA31082 (PubMed:2851699).Curated1
Sequence conflicti507S → P in CAA31082 (PubMed:2851699).Curated1
Sequence conflicti555L → F in CAA31082 (PubMed:2851699).Curated1
Sequence conflicti894G → R in CAA31082 (PubMed:2851699).Curated1
Sequence conflicti951A → R in CAA31082 (PubMed:2851699).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12570 Genomic DNA Translation: CAA31082.1
CP000934 Genomic DNA Translation: ACE85757.1
RefSeqiWP_012488069.1, NC_010995.1

Genome annotation databases

EnsemblBacteriaiACE85757; ACE85757; CJA_2472
KEGGicja:CJA_2472

Similar proteinsi

Entry informationi

Entry nameiGUNA_CELJU
AccessioniPrimary (citable) accession number: P10476
Secondary accession number(s): B3PKK4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: April 20, 2010
Last modified: May 23, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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