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Protein

Calcyphosin

Gene

CAPS

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Calcium-binding protein. May play a role in cellular signaling events (Potential).Curated

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi34 – 45121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi70 – 81122PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi106 – 117123PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi149 – 161134PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcyphosin
Alternative name(s):
Calcyphosine
Protein 5
Thyroid protein p24
Short name:
TPP
Gene namesi
Name:CAPS
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 189189CalcyphosinPRO_0000073537Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei40 – 401Phosphoserine; by PKASequence analysis

Post-translational modificationi

Phosphorylated in response to thyrotropin and cAMP.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP10463.

Expressioni

Tissue specificityi

Detected in thyroid, salivary gland, lung, brain and cerebellum (at protein level).1 Publication

Interactioni

Subunit structurei

Monomer. Does not form oligomers in the presence of calcium (By similarity).By similarity

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000027658.

Structurei

3D structure databases

ProteinModelPortaliP10463.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 5636EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini57 – 9236EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini93 – 12836EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini136 – 17237EF-hand 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0032. Eukaryota.
ENOG410XRMJ. LUCA.
HOVERGENiHBG050808.
InParanoidiP10463.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10463-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAVDATVEK LRAQCLSRGA LGIQGLARFF RRLDRDRSRS LDSRELQRGL
60 70 80 90 100
AELGLVLDTA EAEGVCRRWD RDGSGTLDLE EFLRALRPPM SQAREAVIAA
110 120 130 140 150
AFAKLDRSGD GVVTVDDLRG VYSGRTHPKV QSGEWTEEEV LRRFLDNFDS
160 170 180
SEKDGQVTLA EFQDYYSGVS ASMDTDEEFV AMMTSAWQL
Length:189
Mass (Da):21,132
Last modified:July 1, 1989 - v1
Checksum:iD49CD36C8F1EB65A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14479 mRNA. Translation: CAA32641.1.
X14047 mRNA. Translation: CAA32205.1.
PIRiS03635.
RefSeqiNP_001003282.1. NM_001003282.1.
UniGeneiCfa.3833.

Genome annotation databases

GeneIDi403965.
KEGGicfa:403965.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14479 mRNA. Translation: CAA32641.1.
X14047 mRNA. Translation: CAA32205.1.
PIRiS03635.
RefSeqiNP_001003282.1. NM_001003282.1.
UniGeneiCfa.3833.

3D structure databases

ProteinModelPortaliP10463.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000027658.

Proteomic databases

PaxDbiP10463.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi403965.
KEGGicfa:403965.

Organism-specific databases

CTDi828.

Phylogenomic databases

eggNOGiKOG0032. Eukaryota.
ENOG410XRMJ. LUCA.
HOVERGENiHBG050808.
InParanoidiP10463.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAYP1_CANLF
AccessioniPrimary (citable) accession number: P10463
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: June 8, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.