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Protein

Protein S100-A2

Gene

S100A2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes. May also play a role in suppressing tumor cell growth (By similarity).By similarity

Miscellaneous

This protein binds two calcium ions.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi20 – 331; low affinityPROSITE-ProRule annotationAdd BLAST14
Calcium bindingi63 – 742; high affinityPROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A2
Alternative name(s):
Protein S-100L
S100 calcium-binding protein A2
Gene namesi
Name:S100A2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001439701 – 97Protein S100-A2Add BLAST97

Proteomic databases

PaxDbiP10462.
PeptideAtlasiP10462.
PRIDEiP10462.

Expressioni

Gene expression databases

BgeeiENSBTAG00000037651.

Interactioni

Subunit structurei

Homodimer. Interacts with FKBP4. Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity (By similarity).By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliP10462.
SMRiP10462.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 47EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini50 – 85EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the S-100 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IYI7. Eukaryota.
ENOG41115QW. LUCA.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP10462.
OMAiALVTIMC.
OrthoDBiEOG091G10JX.
TreeFamiTF332727.

Family and domain databases

CDDicd00213. S-100. 1 hit.
InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR034325. S-100_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
PfamiView protein in Pfam
PF01023. S_100. 1 hit.
SMARTiView protein in SMART
SM01394. S_100. 1 hit.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.

Sequencei

Sequence statusi: Complete.

P10462-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSPLEQALA VMVATFHKYS GQEGDKFKLS KGEMKELLHK ELPSFVGEKV
60 70 80 90
DEEGLKKLMG DLDENSDQQV DFQEYAVFLA LITIMCNDFF QGSPARS
Length:97
Mass (Da):10,893
Last modified:July 1, 1989 - v1
Checksum:i55ACC9F60CF9C9E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102570 mRNA. Translation: AAI02571.1.
PIRiA30129.
RefSeqiNP_001029539.1. NM_001034367.2.
UniGeneiBt.5970.

Genome annotation databases

EnsembliENSBTAT00000000589; ENSBTAP00000000589; ENSBTAG00000037651.
GeneIDi509860.
KEGGibta:509860.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiS10A2_BOVIN
AccessioniPrimary (citable) accession number: P10462
Secondary accession number(s): Q3T043
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: July 5, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families