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Protein

Protein S100-A2

Gene

S100A2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes. May also play a role in suppressing tumor cell growth (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi20 – 33141; low affinityPROSITE-ProRule annotationAdd
BLAST
Calcium bindingi63 – 74122; high affinityPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A2
Alternative name(s):
Protein S-100L
S100 calcium-binding protein A2
Gene namesi
Name:S100A2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 3

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9797Protein S100-A2PRO_0000143970Add
BLAST

Proteomic databases

PaxDbiP10462.
PeptideAtlasiP10462.

Expressioni

Gene expression databases

BgeeiENSBTAG00000037651.

Interactioni

Subunit structurei

Homodimer. Interacts with FKBP4. Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000000589.

Structurei

3D structure databases

ProteinModelPortaliP10462.
SMRiP10462. Positions 1-93.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 4736EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini50 – 8536EF-hand 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the S-100 family.Curated
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IYI7. Eukaryota.
ENOG41115QW. LUCA.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP10462.
OMAiALVTIMC.
OrthoDBiEOG091G10JX.
TreeFamiTF332727.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
[Graphical view]
PfamiPF01023. S_100. 1 hit.
[Graphical view]
SMARTiSM01394. S_100. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10462-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSPLEQALA VMVATFHKYS GQEGDKFKLS KGEMKELLHK ELPSFVGEKV
60 70 80 90
DEEGLKKLMG DLDENSDQQV DFQEYAVFLA LITIMCNDFF QGSPARS
Length:97
Mass (Da):10,893
Last modified:July 1, 1989 - v1
Checksum:i55ACC9F60CF9C9E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102570 mRNA. Translation: AAI02571.1.
PIRiA30129.
RefSeqiNP_001029539.1. NM_001034367.2.
UniGeneiBt.5970.

Genome annotation databases

EnsembliENSBTAT00000000589; ENSBTAP00000000589; ENSBTAG00000037651.
GeneIDi509860.
KEGGibta:509860.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102570 mRNA. Translation: AAI02571.1.
PIRiA30129.
RefSeqiNP_001029539.1. NM_001034367.2.
UniGeneiBt.5970.

3D structure databases

ProteinModelPortaliP10462.
SMRiP10462. Positions 1-93.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000000589.

Proteomic databases

PaxDbiP10462.
PeptideAtlasiP10462.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000000589; ENSBTAP00000000589; ENSBTAG00000037651.
GeneIDi509860.
KEGGibta:509860.

Organism-specific databases

CTDi6273.

Phylogenomic databases

eggNOGiENOG410IYI7. Eukaryota.
ENOG41115QW. LUCA.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP10462.
OMAiALVTIMC.
OrthoDBiEOG091G10JX.
TreeFamiTF332727.

Gene expression databases

BgeeiENSBTAG00000037651.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
[Graphical view]
PfamiPF01023. S_100. 1 hit.
[Graphical view]
SMARTiSM01394. S_100. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS10A2_BOVIN
AccessioniPrimary (citable) accession number: P10462
Secondary accession number(s): Q3T043
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: September 7, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein binds two calcium ions.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.