P10454 (TXA2_ANTFU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Neurotoxin-2 Alternative name(s): Toxin AFT-II Short name=Toxin AFII
Organism	Anthopleura fuscoviridis (Sea anemone)
Taxonomic identifier	6111 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Cnidaria › Anthozoa › Hexacorallia › Actiniaria › Nynantheae › Actiniidae › Anthopleura

Protein attributes

Sequence length	48 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds specifically to the sodium channel (Nav), thereby delaying its inactivation during signal transduction. Thus it strongly stimulates mammalian cardiac muscle contraction.
Subcellular location	Secreted. Nematocyst.
Sequence similarities	Belongs to the sea anemone sodium channel inhibitory toxin family. Type I subfamily.

Ontologies

Keywords
Cellular component	Nematocyst Secreted
Molecular function	Cardiotoxin Ion channel impairing toxin Neurotoxin Sodium channel inhibitor Toxin
PTM	Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological_process	regulation of signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell nematocyst Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sodium channel inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 48	48	Neurotoxin-2		PRO_0000221519
Amino acid modifications
	Disulfide bond	5 ↔ 45		Ref.1
	Disulfide bond	7 ↔ 35		Ref.1
	Disulfide bond	28 ↔ 46		Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P10454 [UniParc]. Last modified July 1, 1989. Version 1. Checksum: 3CD4B66FADA1D999	FASTA	48	4,941
	10 20 30 40 GGVPCLCDSD GPSVRGNTLS GIIWLAGCPS GWHNCKAHGP TIGWCCKQ

References

[1]	"Amino acid sequence of two sea anemone toxins from Anthopleura fuscoviridis." Sunahara S., Muramoto K., Tenma K., Kamiya H. Toxicon 25:211-219(1987) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE, DISULFIDE BONDS. Tissue: Nematoblast.

Cross-references

Sequence databases
PIR	B25860.
3D structure databases
ProteinModelPortal	P10454.
SMR	P10454. Positions 2-48.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	2.20.20.10. 1 hit.
InterPro	IPR000693. Anenome_toxin. IPR023355. Myo_neuro_toxin. [Graphical view]
Pfam	PF00706. Toxin_4. 1 hit. [Graphical view]
PIRSF	PIRSF001905. Anenome_toxin. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TXA2_ANTFU

Accession

Primary (citable) accession number: P10454

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
Last sequence update:	July 1, 1989
Last modified:	May 1, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Animal Toxin Annotation Program