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P10454

- TXA2_ANTFU

UniProt

P10454 - TXA2_ANTFU

Protein

Neurotoxin-2

Gene
N/A
Organism
Anthopleura fuscoviridis (Sea anemone)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Binds specifically to the sodium channel (Nav), thereby delaying its inactivation during signal transduction. Thus it strongly stimulates mammalian cardiac muscle contraction.

    GO - Biological processi

    1. regulation of signal transduction Source: InterPro

    Keywords - Molecular functioni

    Cardiotoxin, Ion channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neurotoxin-2
    Alternative name(s):
    Toxin AFT-II
    Short name:
    Toxin AFII
    OrganismiAnthopleura fuscoviridis (Sea anemone)
    Taxonomic identifieri6111 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaCnidariaAnthozoaHexacoralliaActiniariaNynantheaeActiniidaeAnthopleura

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    2. nematocyst Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nematocyst, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4848Neurotoxin-2PRO_0000221519Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi5 ↔ 451 Publication
    Disulfide bondi7 ↔ 351 Publication
    Disulfide bondi28 ↔ 461 Publication

    Keywords - PTMi

    Disulfide bond

    Structurei

    3D structure databases

    ProteinModelPortaliP10454.
    SMRiP10454. Positions 2-48.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di2.20.20.10. 1 hit.
    InterProiIPR000693. Anenome_toxin.
    IPR023355. Myo_neuro_toxin.
    [Graphical view]
    PfamiPF00706. Toxin_4. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001905. Anenome_toxin. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P10454-1 [UniParc]FASTAAdd to Basket

    « Hide

    GGVPCLCDSD GPSVRGNTLS GIIWLAGCPS GWHNCKAHGP TIGWCCKQ     48
    Length:48
    Mass (Da):4,941
    Last modified:July 1, 1989 - v1
    Checksum:i3CD4B66FADA1D999
    GO

    Sequence databases

    PIRiB25860.

    Cross-referencesi

    Sequence databases

    PIRi B25860.

    3D structure databases

    ProteinModelPortali P10454.
    SMRi P10454. Positions 2-48.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.20.20.10. 1 hit.
    InterProi IPR000693. Anenome_toxin.
    IPR023355. Myo_neuro_toxin.
    [Graphical view ]
    Pfami PF00706. Toxin_4. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001905. Anenome_toxin. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Amino acid sequence of two sea anemone toxins from Anthopleura fuscoviridis."
      Sunahara S., Muramoto K., Tenma K., Kamiya H.
      Toxicon 25:211-219(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE, DISULFIDE BONDS.
      Tissue: Nematoblast.

    Entry informationi

    Entry nameiTXA2_ANTFU
    AccessioniPrimary (citable) accession number: P10454
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3