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Protein

Delta-actitoxin-Afv1b

Gene
N/A
Organism
Anthopleura fuscoviridis (Sea anemone)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds specifically to voltage-gated sodium channels (Nav), thereby delaying their inactivation. This toxin has a great efficacy for Nav1.4/SCN4A (EC(50)=30.62 nM) and Nav1.5/SCN5A (EC(50)=62.5 nM). It is less potent on Nav1.6/SCN8A (EC(50)=about 300 nM), Nav1.1/SCN1A (EC(50)=390.55 nM), Nav1.3/SCN3A (EC(50)=459.36 nM) and Nav1.2/SCN2A (EC(50)=1998.00 nM) (when measured as the increase in the slow component).1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cardiotoxin, Ion channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-actitoxin-Afv1b1 Publication
Short name:
Delta-AITX-Afv1b1 Publication
Alternative name(s):
AFT-II2 Publications
Short name:
AFII
OrganismiAnthopleura fuscoviridis (Sea anemone)
Taxonomic identifieri6111 [NCBI]
Taxonomic lineageiEukaryotaMetazoaCnidariaAnthozoaHexacoralliaActiniariaNynantheaeActiniidaeAnthopleura

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nematocyst, Secreted

Pathology & Biotechi

Toxic dosei

LD50 is 450 µg/kg by intraperitoneal injection into mice.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4848Delta-actitoxin-Afv1b1 PublicationPRO_0000221519Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi5 ↔ 451 Publication
Disulfide bondi7 ↔ 351 Publication
Disulfide bondi28 ↔ 461 Publication

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliP10454.
SMRiP10454. Positions 2-48.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di2.20.20.10. 1 hit.
InterProiIPR000693. Anenome_toxin.
IPR023355. Myo_neuro_toxin.
[Graphical view]
PfamiPF00706. Toxin_4. 1 hit.
[Graphical view]
PIRSFiPIRSF001905. Anenome_toxin. 1 hit.

Sequencei

Sequence statusi: Complete.

P10454-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
GGVPCLCDSD GPSVRGNTLS GIIWLAGCPS GWHNCKAHGP TIGWCCKQ
Length:48
Mass (Da):4,941
Last modified:July 1, 1989 - v1
Checksum:i3CD4B66FADA1D999
GO

Mass spectrometryi

Molecular mass is 4941 Da from positions 1 - 48. Determined by MALDI. 1 Publication

Sequence databases

PIRiB25860.

Cross-referencesi

Sequence databases

PIRiB25860.

3D structure databases

ProteinModelPortaliP10454.
SMRiP10454. Positions 2-48.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.20.20.10. 1 hit.
InterProiIPR000693. Anenome_toxin.
IPR023355. Myo_neuro_toxin.
[Graphical view]
PfamiPF00706. Toxin_4. 1 hit.
[Graphical view]
PIRSFiPIRSF001905. Anenome_toxin. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNA12_ANTFU
AccessioniPrimary (citable) accession number: P10454
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 14, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.