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P10453 (TXA1_ANTFU) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Neurotoxin-1
Alternative name(s):
Neurotoxin I
Toxin AFT-I
Short name=Toxin AFI
OrganismAnthopleura fuscoviridis (Sea anemone)
Taxonomic identifier6111 [NCBI]
Taxonomic lineageEukaryotaMetazoaCnidariaAnthozoaHexacoralliaActiniariaNynantheaeActiniidaeAnthopleura

Protein attributes

Sequence length47 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds specifically to the sodium channel (Nav), thereby delaying its inactivation during signal transduction. Thus it strongly stimulates mammalian cardiac muscle contraction.

Subcellular location

Secreted. Nematocyst.

Sequence similarities

Belongs to the sea anemone sodium channel inhibitory toxin family. Type I subfamily.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4747Neurotoxin-1
PRO_0000221518

Amino acid modifications

Disulfide bond4 ↔ 44 Ref.1
Disulfide bond6 ↔ 34 Ref.1
Disulfide bond27 ↔ 45 Ref.1

Sequences

Sequence LengthMass (Da)Tools
P10453 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: BA0FB3FE9AEA3D8E

FASTA474,873
        10         20         30         40 
GVACLCDSDG PNVRGNTLSG TIWLAGCPSG WHNCKAHGPT IGWCCKQ 

« Hide

References

[1]"Amino acid sequence of two sea anemone toxins from Anthopleura fuscoviridis."
Sunahara S., Muramoto K., Tenma K., Kamiya H.
Toxicon 25:211-219(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE, DISULFIDE BONDS.
Tissue: Nematoblast.

Cross-references

Sequence databases

PIRA25860.

3D structure databases

ProteinModelPortalP10453.
SMRP10453. Positions 1-47.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.20.20.10. 1 hit.
InterProIPR000693. Anenome_toxin.
IPR023355. Myo_neuro_toxin.
[Graphical view]
PfamPF00706. Toxin_4. 1 hit.
[Graphical view]
PIRSFPIRSF001905. Anenome_toxin. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTXA1_ANTFU
AccessionPrimary (citable) accession number: P10453
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 16, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families