ID   OSTP$HUMAN     STANDARD;      PRT;   314 AA.
AC   P10451;
DT   01-MAR-1989 (REL. 10, CREATED)
DT   01-MAR-1989 (REL. 10, LAST SEQUENCE UPDATE)
DT   01-NOV-1990 (REL. 16, LAST ANNOTATION UPDATE)
DE   OSTEOPONTIN PRECURSOR (BONE SIALOPROTEIN) (GENE NAME: OPN).
OS   HOMO SAPIENS (HUMAN).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA;
OC   EUTHERIA; PRIMATES.
RN   [1]
RP   SEQUENCE FROM N.A.
RC   MEDLINE=89263749;
RA   KIEFER M.C., BAUER D.M., BARR P.J.;
RL   NUCLEIC ACIDS RES. 17:3306-3306(1989).
RN   [2]
RP   SEQUENCE FROM N.A.
RC   MEDLINE=90353945;
RA   YOUNG M.F., KERR J.M., TERMINE J.D., WEWER U.M., WANG M.G.,
RA   MCBRIDE O.W., FISHER L.W.;
RL   GENOMICS 7:491-502(1990).
CC   -!- FUNCTION: BINDS TIGHTLY TO HYDROXYAPATITE. APPEARS TO FORM AN
CC       AN INTEGRAL PART OF THE MINERALIZED MATRIX. PROBABLY IMPORTANT
CC       TO CELL-MATRIX INTERACTION.
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DR   EMBL; X13694; HSOP.
DR   EMBL; J04765; HSOSTRO.
DR   PIR; A35326; A35326.
DR   MIM; 166490; NINTH EDITION.
KW   GLYCOPROTEIN; SIALIC ACID; BONE; CELL ADHESION; SIGNAL.
FT   SIGNAL        1     16       PUTATIVE.
FT   CHAIN        17    314       OSTEOPONTIN.
FT   SITE        159    161       CELL ATTACHMENT SEQUENCE.
FT   CARBOHYD     79     79       POTENTIAL.
FT   CARBOHYD    106    106       POTENTIAL.
SQ   SEQUENCE   314 AA;  35422 MW;  505067 CN;
     MRIAVICFCL LGITCAIPVK QADSGSSEEK QLYNKYPDAV ATWLNPDPSQ KQNLLAPQNA
     VSSEETNDFK QETLPSKSNE SHDHMDDMDD EDDDDHVDSQ DSIDSNDSDD VDDTDDSHQS
     DESHHSDESD ELVTDFPTDL PATEVFTPVV PTVDTYDGRG DSVVYGLRSK SKKFRRPDIQ
     YPDATDEDIT SHMESEELNG AYKAIPVAQD LNAPSDWDSR GKDSYETSQL DDQSAETHSH
     KQSRLYKRKA NDESNEHSDV IDSQELSKVS REFHSHEFHS HEDMLVVDPK SKEEDKHLKF
     RISHELDSAS SEVN
//