ID   OSTP_HUMAN     STANDARD;      PRT;   314 AA.
AC   P10451;
DT   01-MAR-1989 (Rel. 10, Created)
DT   01-MAR-1989 (Rel. 10, Last sequence update)
DT   15-JUL-1999 (Rel. 38, Last annotation update)
DE   OSTEOPONTIN PRECURSOR (BONE SIALOPROTEIN 1) (URINARY STONE PROTEIN)
DE   (SECRETED PHOSPHOPROTEIN 1) (SPP-1) (NEPHROPONTIN) (UROPONTIN).
GN   SPP1 OR OPN.
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia;
OC   Eutheria; Primates; Catarrhini; Hominidae; Homo.
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE; 89263749.
RA   KIEFER M.C., BAUER D.M., BARR P.J.;
RT   "The cDNA and derived amino acid sequence for human osteopontin.";
RL   Nucleic Acids Res. 17:3306-3306(1989).
RN   [2]
RP   SEQUENCE FROM N.A.
RX   MEDLINE; 90353945.
RA   YOUNG M.F., KERR J.M., TERMINE J.D., WEWER U.M., WANG M.G.,
RA   MCBRIDE O.W., FISHER L.W.;
RT   "cDNA cloning, mRNA distribution and heterogeneity, chromosomal
RT   location, and RFLP analysis of human osteopontin (OPN).";
RL   Genomics 7:491-502(1990).
RN   [3]
RP   SEQUENCE FROM N.A.
RX   MEDLINE; 92108068.
RA   HOYER J.R.;
RT   "Inhibition of calcium oxalate crystal growth in vitro by uropontin:
RT   another member of the aspartic acid-rich protein superfamily.";
RL   Proc. Natl. Acad. Sci. U.S.A. 89:426-430(1992).
RN   [4]
RP   SEQUENCE FROM N.A.
RA   CROSBY A.H., EDWARDS S., MURRAY J.C., DIXON M.J.;
RL   Submitted (FEB-1995) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   SEQUENCE FROM N.A.
RC   TISSUE=LIVER;
RX   MEDLINE; 95031968.
RA   HIJIYA N., SETOGUCHI M., MATSUURA K., HIGUCHI Y., AKIZUKI S.,
RA   YAMAMOTO S.;
RT   "Cloning and characterization of the human osteopontin gene and its
RT   promoter.";
RL   Biochem. J. 303:255-262(1994).
RN   [6]
RP   SEQUENCE FROM N.A.
RC   TISSUE=BRAIN;
RA   YU W., SARGINSON J., GIBBS R.A.;
RL   Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   SEQUENCE OF 67-278 FROM N.A.
RC   TISSUE=KIDNEY;
RX   MEDLINE; 92246977.
RA   KOHRI K., SUZUKI Y., YOSHIDA K., YAMAMOTO K., AMASAKI N., YAMATE T.,
RA   UMEKAWA T., IGUCHI M., SINOHARA H., KURITA T.;
RT   "Molecular cloning and sequencing of cDNA encoding urinary stone
RT   protein, which is identical to osteopontin.";
RL   Biochem. Biophys. Res. Commun. 184:859-864(1992).
CC   -!- FUNCTION: BINDS TIGHTLY TO HYDROXYAPATITE. APPEARS TO FORM AN
CC       AN INTEGRAL PART OF THE MINERALIZED MATRIX. PROBABLY IMPORTANT
CC       TO CELL-MATRIX INTERACTION.
CC   -!- ALTERNATIVE PRODUCTS: TWO FORMS OF OPN ARE PRODUCES BY ALTERNATIVE
CC       SPLICING OF THE SAME GENE. THEY DIFFER BY THE PRESENCE (OP1B) OR
CC       ABSENCE (OP1A) OF 14 AMINO ACIDS AT RESIDUE 58 OF THE MOLECULE.
CC   -!- PTM: EXTENSIVELY PHOSPHORYLATED ON SERINE RESIDUES.
CC   -!- PTM: N- AND O-GLYCOSYLATED.
CC   -!- DISEASE: THIS PROTEIN PLAYS A PRINCIPAL ROLE IN URINARY STONE
CC       FORMATION AS THE STONE MATRIX.
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DR   EMBL; X13694; CAA31984.1; -.
DR   EMBL; J04765; AAA59974.1; -.
DR   EMBL; M83248; AAA17675.1; -.
DR   EMBL; U20758; AAA86886.1; -.
DR   EMBL; AF052124; AAC28619.1; -.
DR   EMBL; D14813; BAA03554.1; -.
DR   PIR; A35326; A35326.
DR   PIR; S09575; S09575.
DR   PIR; JQ1529; JQ1529.
DR   MIM; 166490; -.
DR   PFAM; PF00865; Osteopontin; 1.
DR   PROSITE; PS00884; OSTEOPONTIN; 1.
KW   Glycoprotein; Sialic acid; Bone; Cell adhesion; Phosphorylation;
KW   Signal; Alternative splicing.
FT   SIGNAL        1     16       POTENTIAL.
FT   CHAIN        17    314       OSTEOPONTIN.
FT   SITE        159    161       CELL ATTACHMENT SITE.
FT   VARSPLIC     59     72       MISSING (IN OP1A).
FT   CARBOHYD     79     79       POTENTIAL.
FT   CARBOHYD    106    106       POTENTIAL.
FT   CONFLICT    275    278       SHEF -> GNSL (IN REF. 2).
SQ   SEQUENCE   314 AA;  35422 MW;  B2A9B8C0 CRC32;
     MRIAVICFCL LGITCAIPVK QADSGSSEEK QLYNKYPDAV ATWLNPDPSQ KQNLLAPQNA
     VSSEETNDFK QETLPSKSNE SHDHMDDMDD EDDDDHVDSQ DSIDSNDSDD VDDTDDSHQS
     DESHHSDESD ELVTDFPTDL PATEVFTPVV PTVDTYDGRG DSVVYGLRSK SKKFRRPDIQ
     YPDATDEDIT SHMESEELNG AYKAIPVAQD LNAPSDWDSR GKDSYETSQL DDQSAETHSH
     KQSRLYKRKA NDESNEHSDV IDSQELSKVS REFHSHEFHS HEDMLVVDPK SKEEDKHLKF
     RISHELDSAS SEVN
//