ID   OSTP_HUMAN     STANDARD;      PRT;   314 AA.
AC   P10451;
DT   01-MAR-1989 (REL. 10, CREATED)
DT   01-MAR-1989 (REL. 10, LAST SEQUENCE UPDATE)
DT   01-JUN-1994 (REL. 29, LAST ANNOTATION UPDATE)
DE   OSTEOPONTIN PRECURSOR (BONE SIALOPROTEIN 1) (URINARY STONE PROTEIN)
DE   (SECRETED PHOSPHOPROTEIN 1) (SPP-1) (NEPHROPONTIN) (UROPONTIN).
GN   SPP1 OR OPN.
OS   HOMO SAPIENS (HUMAN).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA;
OC   EUTHERIA; PRIMATES.
RN   [1]
RP   SEQUENCE FROM N.A.
RM   89263749
RA   KIEFER M.C., BAUER D.M., BARR P.J.;
RL   NUCLEIC ACIDS RES. 17:3306-3306(1989).
RN   [2]
RP   SEQUENCE FROM N.A.
RM   90353945
RA   YOUNG M.F., KERR J.M., TERMINE J.D., WEWER U.M., WANG M.G.,
RA   MCBRIDE O.W., FISHER L.W.;
RL   GENOMICS 7:491-502(1990).
RN   [3]
RP   SEQUENCE FROM N.A.
RM   92108068
RA   HOYER J.R.;
RL   PROC. NATL. ACAD. SCI. U.S.A. 89:426-430(1992).
RN   [4]
RP   SEQUENCE OF 67-274 FROM N.A.
RC   TISSUE=KIDNEY;
RM   92246977
RA   KOHRI K., SUZUKI Y., YOSHIDA K., YAMAMOTO K., AMASAKI N., YAMATE T.,
RA   UMEKAWA T., IGUCHI M., SINOHARA H., KURITA T.;
RL   BIOCHEM. BIOPHYS. RES. COMMUN. 184:859-864(1992).
CC   -!- FUNCTION: BINDS TIGHTLY TO HYDROXYAPATITE. APPEARS TO FORM AN
CC       AN INTEGRAL PART OF THE MINERALIZED MATRIX. PROBABLY IMPORTANT
CC       TO CELL-MATRIX INTERACTION.
CC   -!- PTM: EXTENSIVELY PHOSPHORYLATED ON SERINE RESIDUES.
CC   -!- PTM: N- AND O-GLYCOSYLATED.
CC   -!- DISEASE: THIS PROTEIN PLAYS A PRINCIPAL ROLE IN URINARY STONE
CC       FORMATION AS THE STONE MATRIX.
CC   -!- ALTERNATIVE SPLICING: TWO FORMS OF OPN ARE PRODUCES BY ALTERNATIVE
CC       SPLICING OF THE SAME GENE. THEY DIFFER BY THE PRESENCE (OP1B) OR
CC       ABSENCE (OP1A) OF 14 AMINO ACIDS AT RESIDUE 58 OF THE MOLECULE.
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DR   EMBL; X13694; HSOP.
DR   EMBL; J04765; HSOSTRO.
DR   EMBL; M83248; HSNEPPON.
DR   PIR; A35326; A35326.
DR   PIR; S09575; S09575.
DR   PIR; JQ1529; JQ1529.
DR   MIM; 166490; 11TH EDITION.
DR   PROSITE; PS00884; OSTEOPONTIN.
KW   GLYCOPROTEIN; SIALIC ACID; BONE; CELL ADHESION; PHOSPHORYLATION;
KW   SIGNAL; ALTERNATIVE SPLICING.
FT   SIGNAL        1     16       POTENTIAL.
FT   CHAIN        17    314       OSTEOPONTIN.
FT   SITE        159    161       CELL ATTACHMENT SITE.
FT   VARSPLIC     58     71       MISSING (IN OP1A).
FT   CARBOHYD     79     79       POTENTIAL.
FT   CARBOHYD    106    106       POTENTIAL.
FT   CONFLICT    275    278       SHEF -> GNSL (IN REF. 2).
SQ   SEQUENCE   314 AA;  35422 MW;  505067 CN;
     MRIAVICFCL LGITCAIPVK QADSGSSEEK QLYNKYPDAV ATWLNPDPSQ KQNLLAPQNA
     VSSEETNDFK QETLPSKSNE SHDHMDDMDD EDDDDHVDSQ DSIDSNDSDD VDDTDDSHQS
     DESHHSDESD ELVTDFPTDL PATEVFTPVV PTVDTYDGRG DSVVYGLRSK SKKFRRPDIQ
     YPDATDEDIT SHMESEELNG AYKAIPVAQD LNAPSDWDSR GKDSYETSQL DDQSAETHSH
     KQSRLYKRKA NDESNEHSDV IDSQELSKVS REFHSHEFHS HEDMLVVDPK SKEEDKHLKF
     RISHELDSAS SEVN
//