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Protein

Tyrosine-protein kinase transforming protein Abl

Gene

ABL

Organism
Feline sarcoma virus (strain Hardy-Zuckerman 2)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Miscellaneous

This protein is synthesized as a Gag-Abl-Pol polyprotein.

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei220ATPPROSITE-ProRule annotation1
Active sitei312Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi197 – 205ATPPROSITE-ProRule annotation9
Nucleotide bindingi265 – 271ATPPROSITE-ProRule annotation7

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 2234.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase transforming protein Abl (EC:2.7.10.2)
Alternative name(s):
V-abl
Gene namesi
Name:ABL
OrganismiFeline sarcoma virus (strain Hardy-Zuckerman 2)
Taxonomic identifieri11776 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirus
Virus hostiFelidae (cat family) [TaxID: 9681]

Pathology & Biotechi

Keywords - Diseasei

Oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000880561 – 439Tyrosine-protein kinase transforming protein AblAdd BLAST439

Interactioni

Protein-protein interaction databases

MINTiMINT-364947.

Structurei

3D structure databases

ProteinModelPortaliP10447.
SMRiP10447.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 70SH3PROSITE-ProRule annotationAdd BLAST61
Domaini76 – 166SH2PROSITE-ProRule annotationAdd BLAST91
Domaini191 – 439Protein kinasePROSITE-ProRule annotationAdd BLAST249

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi330 – 354Kinase activation loopBy similarityAdd BLAST25

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain, SH3 domain

Family and domain databases

CDDicd09935. SH2_ABL. 1 hit.
Gene3Di3.30.505.10. 1 hit.
InterProiView protein in InterPro
IPR033221. ABL1.
IPR035837. ABL_SH2.
IPR011009. Kinase-like_dom_sf.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR036860. SH2_dom_sf.
IPR036028. SH3-like_dom_sf.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
PANTHERiPTHR24418:SF88. PTHR24418:SF88. 1 hit.
PfamiView protein in Pfam
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTiView protein in SMART
SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.

Sequencei

Sequence statusi: Complete.

P10447-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ENLLAGPSEN DPNLFVALYD FVASGDNTLS ITKGEKLRVL GYNHNGEWCE
60 70 80 90 100
AQTKNGQGWV PSNYITPVNS LEKHSWYHGP VSRNAAEYLL SSGINGSFLV
110 120 130 140 150
RESESSPGQR SISLRYEGRV YHYRINTASD GKLYVSPESR FNTLAELVHH
160 170 180 190 200
HSTVADGLIT TLHYPAPKRN KPTVYGVSPN YDKWEMERTD ITMKHKLGGG
210 220 230 240 250
QYGEVYEGVW KKYSLTVAVK TLKEDTMEVE EFLKEAAVMK EIKHPNLVQL
260 270 280 290 300
LGVCTREPPF YIITEFMTYG NLLDYLRECN RQEVNAVVLL YMATQISSAM
310 320 330 340 350
EYLEKKNFIH RDLAARNCLV GENHLVKVAD FGLSRLMTGD TYTAHAGTKF
360 370 380 390 400
PIKWTAPESL AYNKFSIKSD VWAFGVLLWE IATYGMSPYP GIDLSQVYEL
410 420 430
LEKDYRMERP EGCPEKVYEL MRACWQWNPS DRPAFAEIH
Length:439
Mass (Da):50,005
Last modified:July 1, 1989 - v1
Checksum:i13579EDFED1481AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15805 mRNA. Translation: AAA43042.1.
PIRiA26132.

Similar proteinsi

Entry informationi

Entry nameiABL_FSVHY
AccessioniPrimary (citable) accession number: P10447
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 22, 2017
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families