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P10447 (ABL_FSVHY) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein kinase transforming protein Abl

EC=2.7.10.2
Alternative name(s):
V-abl
Gene names
Name:ABL
OrganismFeline sarcoma virus (strain Hardy-Zuckerman 2)
Taxonomic identifier11776 [NCBI]
Taxonomic lineageVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirus
Virus hostFelidae (cat family) [TaxID: 9681]

Protein attributes

Sequence length439 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Miscellaneous

This protein is synthesized as a Gag-Abl-Pol polyprotein.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily.

Contains 1 protein kinase domain.

Contains 1 SH2 domain.

Contains 1 SH3 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 439439Tyrosine-protein kinase transforming protein Abl
PRO_0000088056

Regions

Domain10 – 7061SH3
Domain76 – 16691SH2
Domain191 – 439249Protein kinase
Nucleotide binding197 – 2059ATP By similarity
Nucleotide binding265 – 2717ATP By similarity
Motif330 – 35425Kinase activation loop By similarity

Sites

Active site3121Proton acceptor By similarity
Binding site2201ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P10447 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: 13579EDFED1481AB

FASTA43950,005
        10         20         30         40         50         60 
ENLLAGPSEN DPNLFVALYD FVASGDNTLS ITKGEKLRVL GYNHNGEWCE AQTKNGQGWV 

        70         80         90        100        110        120 
PSNYITPVNS LEKHSWYHGP VSRNAAEYLL SSGINGSFLV RESESSPGQR SISLRYEGRV 

       130        140        150        160        170        180 
YHYRINTASD GKLYVSPESR FNTLAELVHH HSTVADGLIT TLHYPAPKRN KPTVYGVSPN 

       190        200        210        220        230        240 
YDKWEMERTD ITMKHKLGGG QYGEVYEGVW KKYSLTVAVK TLKEDTMEVE EFLKEAAVMK 

       250        260        270        280        290        300 
EIKHPNLVQL LGVCTREPPF YIITEFMTYG NLLDYLRECN RQEVNAVVLL YMATQISSAM 

       310        320        330        340        350        360 
EYLEKKNFIH RDLAARNCLV GENHLVKVAD FGLSRLMTGD TYTAHAGTKF PIKWTAPESL 

       370        380        390        400        410        420 
AYNKFSIKSD VWAFGVLLWE IATYGMSPYP GIDLSQVYEL LEKDYRMERP EGCPEKVYEL 

       430 
MRACWQWNPS DRPAFAEIH 

« Hide

References

[1]"Nucleic acid sequence and oncogenic properties of the HZ2 feline sarcoma virus v-abl insert."
Bergold P.J., Blumenthal J.A., D'Andrea E., Snyder H.W. Jr., Lederman L., Silverstone A., Nguyen H., Besmer P.
J. Virol. 61:1193-1202(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M15805 mRNA. Translation: AAA43042.1.
PIRA26132.

3D structure databases

ProteinModelPortalP10447.
SMRP10447. Positions 1-439.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-364947.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BRENDA2.7.10.2. 2234.

Family and domain databases

Gene3D3.30.505.10. 1 hit.
InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameABL_FSVHY
AccessionPrimary (citable) accession number: P10447
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: April 16, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families