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P10425 (BLA2_BAC17) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-lactamase 2

EC=3.5.2.6
Alternative name(s):
Beta-lactamase II
Penicillinase
OrganismBacillus sp. (strain 170)
Taxonomic identifier74566 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Protein attributes

Sequence length257 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Can hydrolyze carbapenem compounds.

Catalytic activity

A beta-lactam + H2O = a substituted beta-amino acid.

Cofactor

Binds 2 zinc ions per subunit.

Sequence similarities

Belongs to the metallo-beta-lactamase superfamily. Class-B beta-lactamase family.

Ontologies

Keywords
   Biological processAntibiotic resistance
   DomainSignal
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processantibiotic catabolic process

Inferred from electronic annotation. Source: InterPro

response to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionbeta-lactamase activity

Inferred from electronic annotation. Source: UniProtKB-EC

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3030 Ref.1
Chain31 – 257227Beta-lactamase 2
PRO_0000016944

Sites

Metal binding1161Zinc 1 By similarity
Metal binding1181Zinc 1 By similarity
Metal binding1201Zinc 2 By similarity
Metal binding1791Zinc 1 By similarity
Metal binding1981Zinc 2 By similarity
Metal binding2401Zinc 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
P10425 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: 23EEEBDC045AE571

FASTA25728,153
        10         20         30         40         50         60 
MKKNTLLKVG LCVSLLGTTQ FVSTISSVQA SQKVEQIVIK NETGTISISQ LNKNVWVHTE 

        70         80         90        100        110        120 
LGYFNGEAVP SNGLVLNTSK GLVLVDSSWD NKLTKELIEM VEKKFQKRVT DVIITHAHAD 

       130        140        150        160        170        180 
RIGGITALKE RGIKAHSTAL TAELAKKSGY EEPLGDLQTV TNLKFGNTKV ETFYPGKGHT 

       190        200        210        220        230        240 
EDNIVVWLPQ YQILAGGCLV KSAEAKNLGN VADAYVNEWS TSIENMLKRY RNINLVVPGH 

       250 
GKVGDKGLLL HTLDLLK 

« Hide

References

[1]"Nucleotide sequence of the beta-lactamase gene of alkalophilic Bacillus sp. strain 170."
Kato C., Kudo T., Watanabe K., Horikoshi K.
J. Gen. Microbiol. 131:3317-3324(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 31-48.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M15350 Genomic DNA. Translation: AAA22275.1.

3D structure databases

ProteinModelPortalP10425.
SMRP10425. Positions 38-247.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.60.15.10. 1 hit.
InterProIPR001279. Beta-lactamas-like.
IPR001018. Beta-lactamase_class-B_CS.
[Graphical view]
PfamPF00753. Lactamase_B. 1 hit.
[Graphical view]
SMARTSM00849. Lactamase_B. 1 hit.
[Graphical view]
SUPFAMSSF56281. SSF56281. 1 hit.
PROSITEPS00743. BETA_LACTAMASE_B_1. 1 hit.
PS00744. BETA_LACTAMASE_B_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBLA2_BAC17
AccessionPrimary (citable) accession number: P10425
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: April 16, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families