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P10425

- BLA2_BAC17

UniProt

P10425 - BLA2_BAC17

Protein

Beta-lactamase 2

Gene
N/A
Organism
Bacillus sp. (strain 170)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
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    Functioni

    Can hydrolyze carbapenem compounds.

    Catalytic activityi

    A beta-lactam + H2O = a substituted beta-amino acid.

    Cofactori

    Binds 2 zinc ions per subunit.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi116 – 1161Zinc 1By similarity
    Metal bindingi118 – 1181Zinc 1By similarity
    Metal bindingi120 – 1201Zinc 2By similarity
    Metal bindingi179 – 1791Zinc 1By similarity
    Metal bindingi198 – 1981Zinc 2By similarity
    Metal bindingi240 – 2401Zinc 2By similarity

    GO - Molecular functioni

    1. beta-lactamase activity Source: UniProtKB-EC
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. antibiotic catabolic process Source: InterPro
    2. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-lactamase 2 (EC:3.5.2.6)
    Alternative name(s):
    Beta-lactamase II
    Penicillinase
    OrganismiBacillus sp. (strain 170)
    Taxonomic identifieri74566 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 30301 PublicationAdd
    BLAST
    Chaini31 – 257227Beta-lactamase 2PRO_0000016944Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP10425.
    SMRiP10425. Positions 38-247.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di3.60.15.10. 1 hit.
    InterProiIPR001279. Beta-lactamas-like.
    IPR001018. Beta-lactamase_class-B_CS.
    [Graphical view]
    PfamiPF00753. Lactamase_B. 1 hit.
    [Graphical view]
    SMARTiSM00849. Lactamase_B. 1 hit.
    [Graphical view]
    SUPFAMiSSF56281. SSF56281. 1 hit.
    PROSITEiPS00743. BETA_LACTAMASE_B_1. 1 hit.
    PS00744. BETA_LACTAMASE_B_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P10425-1 [UniParc]FASTAAdd to Basket

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    MKKNTLLKVG LCVSLLGTTQ FVSTISSVQA SQKVEQIVIK NETGTISISQ    50
    LNKNVWVHTE LGYFNGEAVP SNGLVLNTSK GLVLVDSSWD NKLTKELIEM 100
    VEKKFQKRVT DVIITHAHAD RIGGITALKE RGIKAHSTAL TAELAKKSGY 150
    EEPLGDLQTV TNLKFGNTKV ETFYPGKGHT EDNIVVWLPQ YQILAGGCLV 200
    KSAEAKNLGN VADAYVNEWS TSIENMLKRY RNINLVVPGH GKVGDKGLLL 250
    HTLDLLK 257
    Length:257
    Mass (Da):28,153
    Last modified:July 1, 1989 - v1
    Checksum:i23EEEBDC045AE571
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M15350 Genomic DNA. Translation: AAA22275.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M15350 Genomic DNA. Translation: AAA22275.1 .

    3D structure databases

    ProteinModelPortali P10425.
    SMRi P10425. Positions 38-247.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.60.15.10. 1 hit.
    InterProi IPR001279. Beta-lactamas-like.
    IPR001018. Beta-lactamase_class-B_CS.
    [Graphical view ]
    Pfami PF00753. Lactamase_B. 1 hit.
    [Graphical view ]
    SMARTi SM00849. Lactamase_B. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56281. SSF56281. 1 hit.
    PROSITEi PS00743. BETA_LACTAMASE_B_1. 1 hit.
    PS00744. BETA_LACTAMASE_B_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of the beta-lactamase gene of alkalophilic Bacillus sp. strain 170."
      Kato C., Kudo T., Watanabe K., Horikoshi K.
      J. Gen. Microbiol. 131:3317-3324(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 31-48.

    Entry informationi

    Entry nameiBLA2_BAC17
    AccessioniPrimary (citable) accession number: P10425
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3