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P10425

- BLA2_BAC17

UniProt

P10425 - BLA2_BAC17

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Protein

Beta-lactamase 2

Gene
N/A
Organism
Bacillus sp. (strain 170)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Can hydrolyze carbapenem compounds.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.

Cofactori

Zn2+Note: Binds 2 Zn(2+) ions per subunit.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi116 – 1161Zinc 1By similarity
Metal bindingi118 – 1181Zinc 1By similarity
Metal bindingi120 – 1201Zinc 2By similarity
Metal bindingi179 – 1791Zinc 1By similarity
Metal bindingi198 – 1981Zinc 2By similarity
Metal bindingi240 – 2401Zinc 2By similarity

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. antibiotic catabolic process Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase 2 (EC:3.5.2.6)
Alternative name(s):
Beta-lactamase II
Penicillinase
OrganismiBacillus sp. (strain 170)
Taxonomic identifieri74566 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 30301 PublicationAdd
BLAST
Chaini31 – 257227Beta-lactamase 2PRO_0000016944Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP10425.
SMRiP10425. Positions 38-247.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.60.15.10. 1 hit.
InterProiIPR001279. Beta-lactamas-like.
IPR001018. Beta-lactamase_class-B_CS.
[Graphical view]
PfamiPF00753. Lactamase_B. 1 hit.
[Graphical view]
SMARTiSM00849. Lactamase_B. 1 hit.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 1 hit.
PROSITEiPS00743. BETA_LACTAMASE_B_1. 1 hit.
PS00744. BETA_LACTAMASE_B_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10425-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKKNTLLKVG LCVSLLGTTQ FVSTISSVQA SQKVEQIVIK NETGTISISQ
60 70 80 90 100
LNKNVWVHTE LGYFNGEAVP SNGLVLNTSK GLVLVDSSWD NKLTKELIEM
110 120 130 140 150
VEKKFQKRVT DVIITHAHAD RIGGITALKE RGIKAHSTAL TAELAKKSGY
160 170 180 190 200
EEPLGDLQTV TNLKFGNTKV ETFYPGKGHT EDNIVVWLPQ YQILAGGCLV
210 220 230 240 250
KSAEAKNLGN VADAYVNEWS TSIENMLKRY RNINLVVPGH GKVGDKGLLL

HTLDLLK
Length:257
Mass (Da):28,153
Last modified:July 1, 1989 - v1
Checksum:i23EEEBDC045AE571
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15350 Genomic DNA. Translation: AAA22275.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15350 Genomic DNA. Translation: AAA22275.1 .

3D structure databases

ProteinModelPortali P10425.
SMRi P10425. Positions 38-247.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.60.15.10. 1 hit.
InterProi IPR001279. Beta-lactamas-like.
IPR001018. Beta-lactamase_class-B_CS.
[Graphical view ]
Pfami PF00753. Lactamase_B. 1 hit.
[Graphical view ]
SMARTi SM00849. Lactamase_B. 1 hit.
[Graphical view ]
SUPFAMi SSF56281. SSF56281. 1 hit.
PROSITEi PS00743. BETA_LACTAMASE_B_1. 1 hit.
PS00744. BETA_LACTAMASE_B_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of the beta-lactamase gene of alkalophilic Bacillus sp. strain 170."
    Kato C., Kudo T., Watanabe K., Horikoshi K.
    J. Gen. Microbiol. 131:3317-3324(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 31-48.

Entry informationi

Entry nameiBLA2_BAC17
AccessioniPrimary (citable) accession number: P10425
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 26, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3