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P10424

- BLA1_BACCE

UniProt

P10424 - BLA1_BACCE

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Protein
Beta-lactamase 1
Gene
penPC
Organism
Bacillus cereus
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Acts preferentially on penicillins.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei89 – 891Acyl-ester intermediate By similarity
Active sitei185 – 1851Proton acceptor By similarity

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC

GO - Biological processi

  1. beta-lactam antibiotic catabolic process Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase 1 (EC:3.5.2.6)
Alternative name(s):
Beta-lactamase I
Penicillinase
Gene namesi
Name:penPC
OrganismiBacillus cereus
Taxonomic identifieri1396 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 43431 Publication
Add
BLAST
Chaini44 – 306263Beta-lactamase 1
PRO_0000016971Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP10424.
SMRiP10424. Positions 52-305.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni251 – 2533Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10424-1 [UniParc]FASTAAdd to Basket

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MKNKKMLKIG MCVGILGLSI TSLVTFTGGA LQVEAKEKTG QVKHKNQATH    50
KEFSQLEKKF DARLGVYAID TGTNQTIAYR PNERFAFAST YKALAAGVLL 100
QQNSTKKLDE VITYTKEDLV DYSPVTEKHV DTGMTLGEIA EAAVRYSDNT 150
AGNILFHKIG GPKGYEKALR KMGDRVTMSD RFETELNEAI PGDIRDTSTA 200
KAIARNLKDF TVGNALPHQK RNILTEWMKG NATGDKLIRA GVPTDWVDAD 250
KSGAGSYGTR NDIAIVWPPN RSPIIIAILS SKDEKEATYD NQLIKEAAEV 300
VIDAIK 306
Length:306
Mass (Da):33,596
Last modified:July 1, 1989 - v1
Checksum:iAD0FE16E435A4D12
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M12607 Genomic DNA. Translation: AAA22668.1.
PIRiA23097. PNBS5B.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M12607 Genomic DNA. Translation: AAA22668.1 .
PIRi A23097. PNBS5B.

3D structure databases

ProteinModelPortali P10424.
SMRi P10424. Positions 52-305.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view ]
PRINTSi PR00118. BLACTAMASEA.
SUPFAMi SSF56601. SSF56601. 1 hit.
PROSITEi PS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and sequencing of the beta-lactamase I gene of Bacillus cereus 5/B and its expression in Bacillus subtilis."
    Wang W., Mezes P.S.F., Yang Y.Q., Blacher R.W., Lampen J.O.
    J. Bacteriol. 163:487-492(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 44-63.
    Strain: ATCC 13061 / DSM 6127 / NCIMB 8967 / NCTC 9946 / NRRL B-3537 / 5/B.

Entry informationi

Entry nameiBLA1_BACCE
AccessioniPrimary (citable) accession number: P10424
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 16, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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