Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P10424

- BLA1_BACCE

UniProt

P10424 - BLA1_BACCE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Beta-lactamase 1

Gene

penPC

Organism
Bacillus cereus
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Acts preferentially on penicillins.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei89 – 891Acyl-ester intermediatePROSITE-ProRule annotation
Active sitei185 – 1851Proton acceptorBy similarity

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC

GO - Biological processi

  1. beta-lactam antibiotic catabolic process Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase 1 (EC:3.5.2.6)
Alternative name(s):
Beta-lactamase I
Penicillinase
Gene namesi
Name:penPC
OrganismiBacillus cereus
Taxonomic identifieri1396 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 43431 PublicationAdd
BLAST
Chaini44 – 306263Beta-lactamase 1PRO_0000016971Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP10424.
SMRiP10424. Positions 52-305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni251 – 2533Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the class-A beta-lactamase family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10424-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKNKKMLKIG MCVGILGLSI TSLVTFTGGA LQVEAKEKTG QVKHKNQATH
60 70 80 90 100
KEFSQLEKKF DARLGVYAID TGTNQTIAYR PNERFAFAST YKALAAGVLL
110 120 130 140 150
QQNSTKKLDE VITYTKEDLV DYSPVTEKHV DTGMTLGEIA EAAVRYSDNT
160 170 180 190 200
AGNILFHKIG GPKGYEKALR KMGDRVTMSD RFETELNEAI PGDIRDTSTA
210 220 230 240 250
KAIARNLKDF TVGNALPHQK RNILTEWMKG NATGDKLIRA GVPTDWVDAD
260 270 280 290 300
KSGAGSYGTR NDIAIVWPPN RSPIIIAILS SKDEKEATYD NQLIKEAAEV

VIDAIK
Length:306
Mass (Da):33,596
Last modified:July 1, 1989 - v1
Checksum:iAD0FE16E435A4D12
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12607 Genomic DNA. Translation: AAA22668.1.
PIRiA23097. PNBS5B.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12607 Genomic DNA. Translation: AAA22668.1 .
PIRi A23097. PNBS5B.

3D structure databases

ProteinModelPortali P10424.
SMRi P10424. Positions 52-305.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view ]
PRINTSi PR00118. BLACTAMASEA.
SUPFAMi SSF56601. SSF56601. 1 hit.
PROSITEi PS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and sequencing of the beta-lactamase I gene of Bacillus cereus 5/B and its expression in Bacillus subtilis."
    Wang W., Mezes P.S.F., Yang Y.Q., Blacher R.W., Lampen J.O.
    J. Bacteriol. 163:487-492(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 44-63.
    Strain: ATCC 13061 / DSM 6127 / NCIMB 8967 / NCTC 9946 / NRRL B-3537 / 5/B.

Entry informationi

Entry nameiBLA1_BACCE
AccessioniPrimary (citable) accession number: P10424
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 29, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3