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Protein

Beta-lactamase 1

Gene

penPC

Organism
Bacillus cereus
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acts preferentially on penicillins.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei89 – 891Acyl-ester intermediatePROSITE-ProRule annotation
Active sitei185 – 1851Proton acceptorBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase 1 (EC:3.5.2.6)
Alternative name(s):
Beta-lactamase I
Penicillinase
Gene namesi
Name:penPC
OrganismiBacillus cereus
Taxonomic identifieri1396 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 43431 PublicationAdd
BLAST
Chaini44 – 306263Beta-lactamase 1PRO_0000016971Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP10424.
SMRiP10424. Positions 52-305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni251 – 2533Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the class-A beta-lactamase family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10424-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNKKMLKIG MCVGILGLSI TSLVTFTGGA LQVEAKEKTG QVKHKNQATH
60 70 80 90 100
KEFSQLEKKF DARLGVYAID TGTNQTIAYR PNERFAFAST YKALAAGVLL
110 120 130 140 150
QQNSTKKLDE VITYTKEDLV DYSPVTEKHV DTGMTLGEIA EAAVRYSDNT
160 170 180 190 200
AGNILFHKIG GPKGYEKALR KMGDRVTMSD RFETELNEAI PGDIRDTSTA
210 220 230 240 250
KAIARNLKDF TVGNALPHQK RNILTEWMKG NATGDKLIRA GVPTDWVDAD
260 270 280 290 300
KSGAGSYGTR NDIAIVWPPN RSPIIIAILS SKDEKEATYD NQLIKEAAEV

VIDAIK
Length:306
Mass (Da):33,596
Last modified:July 1, 1989 - v1
Checksum:iAD0FE16E435A4D12
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12607 Genomic DNA. Translation: AAA22668.1.
PIRiA23097. PNBS5B.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12607 Genomic DNA. Translation: AAA22668.1.
PIRiA23097. PNBS5B.

3D structure databases

ProteinModelPortaliP10424.
SMRiP10424. Positions 52-305.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and sequencing of the beta-lactamase I gene of Bacillus cereus 5/B and its expression in Bacillus subtilis."
    Wang W., Mezes P.S.F., Yang Y.Q., Blacher R.W., Lampen J.O.
    J. Bacteriol. 163:487-492(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 44-63.
    Strain: ATCC 13061 / DSM 6127 / NCIMB 8967 / NCTC 9946 / NRRL B-3537 / 5/B.

Entry informationi

Entry nameiBLA1_BACCE
AccessioniPrimary (citable) accession number: P10424
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: July 22, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.