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P10424 (BLA1_BACCE) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-lactamase 1

EC=3.5.2.6
Alternative name(s):
Beta-lactamase I
Penicillinase
Gene names
Name:penPC
OrganismBacillus cereus
Taxonomic identifier1396 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

Protein attributes

Sequence length306 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acts preferentially on penicillins.

Catalytic activity

A beta-lactam + H2O = a substituted beta-amino acid.

Subcellular location

Secreted.

Sequence similarities

Belongs to the class-A beta-lactamase family.

Ontologies

Keywords
   Biological processAntibiotic resistance
   Cellular componentSecreted
   DomainSignal
   Molecular functionHydrolase
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processbeta-lactam antibiotic catabolic process

Inferred from electronic annotation. Source: InterPro

response to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionbeta-lactamase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 4343 Ref.1
Chain44 – 306263Beta-lactamase 1
PRO_0000016971

Regions

Region251 – 2533Substrate binding By similarity

Sites

Active site891Acyl-ester intermediate By similarity
Active site1851Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
P10424 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: AD0FE16E435A4D12

FASTA30633,596
        10         20         30         40         50         60 
MKNKKMLKIG MCVGILGLSI TSLVTFTGGA LQVEAKEKTG QVKHKNQATH KEFSQLEKKF 

        70         80         90        100        110        120 
DARLGVYAID TGTNQTIAYR PNERFAFAST YKALAAGVLL QQNSTKKLDE VITYTKEDLV 

       130        140        150        160        170        180 
DYSPVTEKHV DTGMTLGEIA EAAVRYSDNT AGNILFHKIG GPKGYEKALR KMGDRVTMSD 

       190        200        210        220        230        240 
RFETELNEAI PGDIRDTSTA KAIARNLKDF TVGNALPHQK RNILTEWMKG NATGDKLIRA 

       250        260        270        280        290        300 
GVPTDWVDAD KSGAGSYGTR NDIAIVWPPN RSPIIIAILS SKDEKEATYD NQLIKEAAEV 


VIDAIK 

« Hide

References

[1]"Cloning and sequencing of the beta-lactamase I gene of Bacillus cereus 5/B and its expression in Bacillus subtilis."
Wang W., Mezes P.S.F., Yang Y.Q., Blacher R.W., Lampen J.O.
J. Bacteriol. 163:487-492(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 44-63.
Strain: ATCC 13061 / DSM 6127 / NCIMB 8967 / NCTC 9946 / NRRL B-3537 / 5/B.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M12607 Genomic DNA. Translation: AAA22668.1.
PIRPNBS5B. A23097.

3D structure databases

ProteinModelPortalP10424.
SMRP10424. Positions 52-305.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.710.10. 1 hit.
InterProIPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PRINTSPR00118. BLACTAMASEA.
SUPFAMSSF56601. SSF56601. 1 hit.
PROSITEPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBLA1_BACCE
AccessionPrimary (citable) accession number: P10424
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 16, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families