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Protein

Serine/threonine-protein kinase-transforming protein mos

Gene

V-MOS

Organism
Myeloproliferative sarcoma virus (isolate ts159)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei90ATPPROSITE-ProRule annotation1
Active sitei198Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi69 – 77ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2 3536

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase-transforming protein mos (EC:2.7.11.1)
Gene namesi
Name:V-MOS
OrganismiMyeloproliferative sarcoma virus (isolate ts159)
Taxonomic identifieri11814 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirus
Virus hostiMus musculus (Mouse) [TaxID: 10090]

Pathology & Biotechi

Keywords - Diseasei

Oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000863631 – 342Serine/threonine-protein kinase-transforming protein mosAdd BLAST342

Proteomic databases

PRIDEiP10421

Structurei

3D structure databases

ProteinModelPortaliP10421
SMRiP10421
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini63 – 338Protein kinasePROSITE-ProRule annotationAdd BLAST276

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

P10421-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSPLSLCRY LPRELSPSVD SRSCSIPLVA PRKAGKLFLG TTPPRAPGLP
60 70 80 90 100
RRLAWFSIDW EQVCLMHRLG SGGFGSVYKA TYHGVPVAIK QVNKCTKDLR
110 120 130 140 150
ASQRSFWAEL NIARLRHDNI VRVVAASTRT PEDSNSLGTI IMEFGGNVTL
160 170 180 190 200
HQVIYGATRS PEPLSCREQL SLGKCLKYSL DVVNGLLFLH SQSILHLDLK
210 220 230 240 250
PANILISEQD VCKISDFGCS QKLQDLRCRQ SPHHIGGTYT HQAPEILKGE
260 270 280 290 300
IATPKADIYS FGITLWQMTT REVPYSGEPQ YVQYAVVAYN LRPSLTGAVF
310 320 330 340
TASLTRKTLQ NIIQNCWEAR ALQRPGAELL QRDLKAFRGA LG
Length:342
Mass (Da):37,971
Last modified:July 1, 1989 - v1
Checksum:i83D16BA59DF8CE76
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15424 Genomic DNA Translation: AAA46581.1
PIRiA26592 TVMVM9

Similar proteinsi

Entry informationi

Entry nameiMOS_MSVTS
AccessioniPrimary (citable) accession number: P10421
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: May 23, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

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