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P10421 (MOS_MSVTS) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase-transforming protein mos

EC=2.7.11.1
Gene names
Name:V-MOS
OrganismMyeloproliferative sarcoma virus (isolate ts159)
Taxonomic identifier11814 [NCBI]
Taxonomic lineageVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirus
Virus hostMus musculus (Mouse) [TaxID: 10090]

Protein attributes

Sequence length342 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 342342Serine/threonine-protein kinase-transforming protein mos
PRO_0000086363

Regions

Domain63 – 338276Protein kinase
Nucleotide binding69 – 779ATP By similarity

Sites

Active site1981Proton acceptor By similarity
Binding site901ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P10421 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: 83D16BA59DF8CE76

FASTA34237,971
        10         20         30         40         50         60 
MPSPLSLCRY LPRELSPSVD SRSCSIPLVA PRKAGKLFLG TTPPRAPGLP RRLAWFSIDW 

        70         80         90        100        110        120 
EQVCLMHRLG SGGFGSVYKA TYHGVPVAIK QVNKCTKDLR ASQRSFWAEL NIARLRHDNI 

       130        140        150        160        170        180 
VRVVAASTRT PEDSNSLGTI IMEFGGNVTL HQVIYGATRS PEPLSCREQL SLGKCLKYSL 

       190        200        210        220        230        240 
DVVNGLLFLH SQSILHLDLK PANILISEQD VCKISDFGCS QKLQDLRCRQ SPHHIGGTYT 

       250        260        270        280        290        300 
HQAPEILKGE IATPKADIYS FGITLWQMTT REVPYSGEPQ YVQYAVVAYN LRPSLTGAVF 

       310        320        330        340 
TASLTRKTLQ NIIQNCWEAR ALQRPGAELL QRDLKAFRGA LG 

« Hide

References

[1]"A temperature-sensitive mutant of the myeloproliferative sarcoma virus, altered by a point mutation in the mos oncogene, has been modified as a selectable retroviral vector."
Friel J., Stocking C., Stacey A., Ostertag W.
J. Virol. 61:889-897(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M15424 Genomic DNA. Translation: AAA46581.1.
PIRTVMVM9. A26592.

3D structure databases

ProteinModelPortalP10421.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BRENDA2.7.10.2. 3536.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMOS_MSVTS
AccessionPrimary (citable) accession number: P10421
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 16, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families