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P10421

- MOS_MSVTS

UniProt

P10421 - MOS_MSVTS

Protein

Serine/threonine-protein kinase-transforming protein mos

Gene

V-MOS

Organism
Myeloproliferative sarcoma virus (isolate ts159)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Jul 1989)
      Previous versions | rss
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    • Comment

    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei90 – 901ATPPROSITE-ProRule annotation
    Active sitei198 – 1981Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi69 – 779ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.2. 3536.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase-transforming protein mos (EC:2.7.11.1)
    Gene namesi
    Name:V-MOS
    OrganismiMyeloproliferative sarcoma virus (isolate ts159)
    Taxonomic identifieri11814 [NCBI]
    Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirus
    Virus hostiMus musculus (Mouse) [TaxID: 10090]

    Pathology & Biotechi

    Keywords - Diseasei

    Oncogene

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 342342Serine/threonine-protein kinase-transforming protein mosPRO_0000086363Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP10421.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini63 – 338276Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P10421-1 [UniParc]FASTAAdd to Basket

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    MPSPLSLCRY LPRELSPSVD SRSCSIPLVA PRKAGKLFLG TTPPRAPGLP    50
    RRLAWFSIDW EQVCLMHRLG SGGFGSVYKA TYHGVPVAIK QVNKCTKDLR 100
    ASQRSFWAEL NIARLRHDNI VRVVAASTRT PEDSNSLGTI IMEFGGNVTL 150
    HQVIYGATRS PEPLSCREQL SLGKCLKYSL DVVNGLLFLH SQSILHLDLK 200
    PANILISEQD VCKISDFGCS QKLQDLRCRQ SPHHIGGTYT HQAPEILKGE 250
    IATPKADIYS FGITLWQMTT REVPYSGEPQ YVQYAVVAYN LRPSLTGAVF 300
    TASLTRKTLQ NIIQNCWEAR ALQRPGAELL QRDLKAFRGA LG 342
    Length:342
    Mass (Da):37,971
    Last modified:July 1, 1989 - v1
    Checksum:i83D16BA59DF8CE76
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M15424 Genomic DNA. Translation: AAA46581.1.
    PIRiA26592. TVMVM9.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M15424 Genomic DNA. Translation: AAA46581.1 .
    PIRi A26592. TVMVM9.

    3D structure databases

    ProteinModelPortali P10421.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    BRENDAi 2.7.10.2. 3536.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A temperature-sensitive mutant of the myeloproliferative sarcoma virus, altered by a point mutation in the mos oncogene, has been modified as a selectable retroviral vector."
      Friel J., Stocking C., Stacey A., Ostertag W.
      J. Virol. 61:889-897(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiMOS_MSVTS
    AccessioniPrimary (citable) accession number: P10421
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3