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P10421

- MOS_MSVTS

UniProt

P10421 - MOS_MSVTS

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Protein

Serine/threonine-protein kinase-transforming protein mos

Gene

V-MOS

Organism
Myeloproliferative sarcoma virus (isolate ts159)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei90 – 901ATPPROSITE-ProRule annotation
Active sitei198 – 1981Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi69 – 779ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 3536.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase-transforming protein mos (EC:2.7.11.1)
Gene namesi
Name:V-MOS
OrganismiMyeloproliferative sarcoma virus (isolate ts159)
Taxonomic identifieri11814 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirus
Virus hostiMus musculus (Mouse) [TaxID: 10090]

Pathology & Biotechi

Keywords - Diseasei

Oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 342342Serine/threonine-protein kinase-transforming protein mosPRO_0000086363Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP10421.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini63 – 338276Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10421-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPSPLSLCRY LPRELSPSVD SRSCSIPLVA PRKAGKLFLG TTPPRAPGLP
60 70 80 90 100
RRLAWFSIDW EQVCLMHRLG SGGFGSVYKA TYHGVPVAIK QVNKCTKDLR
110 120 130 140 150
ASQRSFWAEL NIARLRHDNI VRVVAASTRT PEDSNSLGTI IMEFGGNVTL
160 170 180 190 200
HQVIYGATRS PEPLSCREQL SLGKCLKYSL DVVNGLLFLH SQSILHLDLK
210 220 230 240 250
PANILISEQD VCKISDFGCS QKLQDLRCRQ SPHHIGGTYT HQAPEILKGE
260 270 280 290 300
IATPKADIYS FGITLWQMTT REVPYSGEPQ YVQYAVVAYN LRPSLTGAVF
310 320 330 340
TASLTRKTLQ NIIQNCWEAR ALQRPGAELL QRDLKAFRGA LG
Length:342
Mass (Da):37,971
Last modified:July 1, 1989 - v1
Checksum:i83D16BA59DF8CE76
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15424 Genomic DNA. Translation: AAA46581.1.
PIRiA26592. TVMVM9.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15424 Genomic DNA. Translation: AAA46581.1 .
PIRi A26592. TVMVM9.

3D structure databases

ProteinModelPortali P10421.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

BRENDAi 2.7.10.2. 3536.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A temperature-sensitive mutant of the myeloproliferative sarcoma virus, altered by a point mutation in the mos oncogene, has been modified as a selectable retroviral vector."
    Friel J., Stocking C., Stacey A., Ostertag W.
    J. Virol. 61:889-897(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiMOS_MSVTS
AccessioniPrimary (citable) accession number: P10421
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 1, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3