ID H14_HUMAN Reviewed; 219 AA. AC P10412; Q4VB25; DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot. DT 23-JAN-2007, sequence version 2. DT 07-JUL-2009, entry version 93. DE RecName: Full=Histone H1.4; DE AltName: Full=Histone H1b; GN Name=HIST1H1E; Synonyms=H1F4; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=92009931; PubMed=1916825; DOI=10.1016/0888-7543(91)90183-F; RA Albig W., Kardalinou E., Drabent B., Zimmer A., Doenecke D.; RT "Isolation and characterization of two human H1 histone genes within RT clusters of core histone genes."; RL Genomics 10:940-948(1991). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=22296985; PubMed=12408966; DOI=10.1016/S0888-7543(02)96850-3; RA Marzluff W.F., Gongidi P., Woods K.R., Jin J., Maltais L.J.; RT "The human and mouse replication-dependent histone genes."; RL Genomics 80:487-498(2002). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX MEDLINE=22935763; PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [5] RP PROTEIN SEQUENCE OF 2-219. RC TISSUE=Spleen; RX MEDLINE=87057092; PubMed=3782055; RA Ohe Y., Hayashi H., Iwai K.; RT "Human spleen histone H1. Isolation and amino acid sequence of a main RT variant, H1b."; RL J. Biochem. 100:359-368(1986). RN [6] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-18 AND SER-187, AND MASS RP SPECTROMETRY. RC TISSUE=Epithelium; RX PubMed=17081983; DOI=10.1016/j.cell.2006.09.026; RA Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., RA Mann M.; RT "Global, in vivo, and site-specific phosphorylation dynamics in RT signaling networks."; RL Cell 127:635-648(2006). RN [7] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-18, AND MASS RP SPECTROMETRY. RC TISSUE=Epithelium; RX PubMed=17924679; DOI=10.1021/pr070152u; RA Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; RT "Improved titanium dioxide enrichment of phosphopeptides from HeLa RT cells and high confident phosphopeptide identification by cross- RT validation of MS/MS and MS/MS/MS spectra."; RL J. Proteome Res. 6:4150-4162(2007). RN [8] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-18; SER-27 AND SER-36, RP AND MASS SPECTROMETRY. RX PubMed=17287340; DOI=10.1073/pnas.0611217104; RA Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; RT "Global proteomic profiling of phosphopeptides using electron transfer RT dissociation tandem mass spectrometry."; RL Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). RN [9] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-18, AND MASS RP SPECTROMETRY. RX PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007; RA Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., RA Greff Z., Keri G., Stemmann O., Mann M.; RT "Kinase-selective enrichment enables quantitative phosphoproteomics of RT the kinome across the cell cycle."; RL Mol. Cell 31:438-448(2008). RN [10] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-18, AND MASS RP SPECTROMETRY. RX PubMed=18669648; DOI=10.1073/pnas.0805139105; RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., RA Elledge S.J., Gygi S.P.; RT "A quantitative atlas of mitotic phosphorylation."; RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). RN [11] RP IDENTIFICATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY. RA Colinge J., Superti-Furga G., Bennett K.L.; RL Submitted (OCT-2008) to UniProtKB. RN [12] RP VARIANT [LARGE SCALE ANALYSIS] VAL-128. RX PubMed=16959974; DOI=10.1126/science.1133427; RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., RA Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., RA Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C., RA Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., RA Vogelstein B., Kinzler K.W., Velculescu V.E.; RT "The consensus coding sequences of human breast and colorectal RT cancers."; RL Science 314:268-274(2006). CC -!- FUNCTION: Histones H1 are necessary for the condensation of CC nucleosome chains into higher order structures. CC -!- INTERACTION: CC Q9Y468:L3MBTL; NbExp=3; IntAct=EBI-358163, EBI-1265089; CC P16333:NCK1; NbExp=1; IntAct=EBI-358163, EBI-389883; CC -!- SUBCELLULAR LOCATION: Nucleus. CC -!- MISCELLANEOUS: This variant accounts for 60% of histone H1. CC -!- SIMILARITY: Belongs to the histone H1/H5 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; M60748; AAA63187.1; -; Genomic_DNA. DR EMBL; AF531302; AAN06702.1; -; Genomic_DNA. DR EMBL; AL353759; CAC04132.1; -; Genomic_DNA. DR EMBL; BC096168; AAH96168.1; -; mRNA. DR EMBL; BC096169; AAH96169.1; -; mRNA. DR EMBL; BC099632; AAH99632.1; -; mRNA. DR IPI; IPI00217467; -. DR PIR; C40335; HSHU1B. DR RefSeq; NP_005312.1; -. DR UniGene; Hs.248133; -. DR HSSP; P08287; 1GHC. DR SMR; P10412; 36-109. DR IntAct; P10412; 7. DR PhosphoSite; P10412; -. DR PeptideAtlas; P10412; -. DR PRIDE; P10412; -. DR Ensembl; ENSG00000168298; Homo sapiens. DR GeneID; 3008; -. DR KEGG; hsa:3008; -. DR UCSC; uc003ngq.1; human. DR GeneCards; GC06P026264; -. DR H-InvDB; HIX0032905; -. DR HGNC; HGNC:4718; HIST1H1E. DR HPA; CAB011506; -. DR MIM; 142220; gene. DR PharmGKB; PA29096; -. DR HOGENOM; P10412; -. DR HOVERGEN; P10412; -. DR OMA; P10412; EAKPRAK. DR Pathway_Interaction_DB; hdac_classiii_pathway; Signaling events mediated by HDAC Class III. DR Reactome; REACT_578; Apoptosis. DR NextBio; 11928; -. DR ArrayExpress; P10412; -. DR Bgee; P10412; -. DR CleanEx; HS_HIST1H1E; -. DR GermOnline; ENSG00000168298; Homo sapiens. DR GO; GO:0000786; C:nucleosome; NAS:UniProtKB. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0003677; F:DNA binding; NAS:UniProtKB. DR GO; GO:0005515; F:protein binding; IPI:IntAct. DR GO; GO:0006334; P:nucleosome assembly; NAS:UniProtKB. DR InterPro; IPR005818; Histone_H1/H5. DR InterPro; IPR005819; Histone_H5. DR InterPro; IPR011991; Wing_hlx_DNA_bd. DR Gene3D; G3DSA:1.10.10.10; Wing_hlx_DNA_bd; 1. DR Pfam; PF00538; Linker_histone; 1. DR PRINTS; PR00624; HISTONEH5. DR SMART; SM00526; H15; 1. PE 1: Evidence at protein level; KW Acetylation; Chromosomal protein; Complete proteome; KW Direct protein sequencing; DNA-binding; Methylation; Nucleus; KW Phosphoprotein; Polymorphism. FT INIT_MET 1 1 Removed. FT CHAIN 2 219 Histone H1.4. FT /FTId=PRO_0000195908. FT REGION 36 114 Globular. FT MOD_RES 2 2 N-acetylserine. FT MOD_RES 4 4 Phosphothreonine (By similarity). FT MOD_RES 18 18 Phosphothreonine. FT MOD_RES 26 26 N6-methyllysine; partial. FT MOD_RES 27 27 Phosphoserine. FT MOD_RES 36 36 Phosphoserine. FT MOD_RES 187 187 Phosphoserine. FT VARIANT 128 128 A -> V (in a colorectal cancer sample; FT somatic mutation). FT /FTId=VAR_036203. FT VARIANT 152 152 K -> R (in dbSNP:rs2298090). FT /FTId=VAR_049307. SQ SEQUENCE 219 AA; 21865 MW; 1720FECCCBEBCC7F CRC64; MSETAPAAPA APAPAEKTPV KKKARKSAGA AKRKASGPPV SELITKAVAA SKERSGVSLA ALKKALAAAG YDVEKNNSRI KLGLKSLVSK GTLVQTKGTG ASGSFKLNKK AASGEAKPKA KKAGAAKAKK PAGAAKKPKK ATGAATPKKS AKKTPKKAKK PAAAAGAKKA KSPKKAKAAK PKKAPKSPAK AKAVKPKAAK PKTAKPKAAK PKKAAAKKK //