Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Killer toxin HM-1

Gene

HMK

Organism
Cyberlindnera mrakii (Yeast) (Williopsis mrakii)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This toxin kills sensitive strains of yeast. It inhibits beta-1,3-glucan synthesis.

pH dependencei

Stable over a wide pH range.

Temperature dependencei

Thermostable.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionToxin

Names & Taxonomyi

Protein namesi
Recommended name:
Killer toxin HM-1
Gene namesi
Name:HMK
OrganismiCyberlindnera mrakii (Yeast) (Williopsis mrakii)
Taxonomic identifieri1004253 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesPhaffomycetaceaeCyberlindnera

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000002256820 – 371 PublicationAdd BLAST18
ChainiPRO_000002256938 – 125Killer toxin HM-1Add BLAST88

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi45 ↔ 55
Disulfide bondi48 ↔ 109
Disulfide bondi64 ↔ 95
Disulfide bondi86 ↔ 103
Disulfide bondi104 ↔ 110

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Interactioni

Subunit structurei

Monomer.

Structurei

Secondary structure

1125
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi42 – 48Combined sources7
Turni50 – 52Combined sources3
Beta strandi73 – 76Combined sources4
Turni79 – 82Combined sources4
Beta strandi85 – 92Combined sources8
Beta strandi99 – 104Combined sources6
Beta strandi106 – 111Combined sources6
Beta strandi120 – 123Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WKTNMR-A38-125[»]
ProteinModelPortaliP10410
SMRiP10410
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10410

Family & Domainsi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.60.20.20, 1 hit
InterProiView protein in InterPro
IPR011024 G_crystallin-like
IPR015290 Yeast-kill-tox
IPR038651 Yeast_kill_tox_sf
PfamiView protein in Pfam
PF09207 Yeast-kill-tox, 1 hit
SUPFAMiSSF49695 SSF49695, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10410-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFSFVYGLT GFLAATSSAL PSEILSTGYE RSALEKRGDG YLIMCKNCDP
60 70 80 90 100
NTGSCDWKQN WNTCVGIGAN VHWMVTGGST DGKQGCATIW EGSGCVGRST
110 120
TMCCPANTCC NINTGFYIRS YRRVE
Length:125
Mass (Da):13,539
Last modified:May 27, 2002 - v2
Checksum:i8EE4BB0479E38925
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13445 Genomic DNA Translation: BAA02704.1
PIRiA23618 TZHQK

Similar proteinsi

Entry informationi

Entry nameiTOXK_CYBMR
AccessioniPrimary (citable) accession number: P10410
Secondary accession number(s): Q00913
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: May 27, 2002
Last modified: April 25, 2018
This is version 85 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health