Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Killer toxin HM-1

Gene

HMK

Organism
Cyberlindnera mrakii (Yeast) (Williopsis mrakii)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This toxin kills sensitive strains of yeast. It inhibits beta-1,3-glucan synthesis.

pH dependencei

Stable over a wide pH range.

Temperature dependencei

Thermostable.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Killer toxin HM-1
Gene namesi
Name:HMK
OrganismiCyberlindnera mrakii (Yeast) (Williopsis mrakii)
Taxonomic identifieri1004253 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesPhaffomycetaceaeCyberlindnera

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000002256820 – 371 PublicationAdd BLAST18
ChainiPRO_000002256938 – 125Killer toxin HM-1Add BLAST88

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi45 ↔ 55
Disulfide bondi48 ↔ 109
Disulfide bondi64 ↔ 95
Disulfide bondi86 ↔ 103
Disulfide bondi104 ↔ 110

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Interactioni

Subunit structurei

Monomer.

Structurei

Secondary structure

1125
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi42 – 48Combined sources7
Turni50 – 52Combined sources3
Beta strandi73 – 76Combined sources4
Turni79 – 82Combined sources4
Beta strandi85 – 92Combined sources8
Beta strandi99 – 104Combined sources6
Beta strandi106 – 111Combined sources6
Beta strandi120 – 123Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WKTNMR-A38-125[»]
ProteinModelPortaliP10410.
SMRiP10410.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10410.

Family & Domainsi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.60.20.20. 1 hit.
InterProiIPR011024. G_crystallin-rel.
IPR015290. Yeast-kill-tox.
[Graphical view]
PfamiPF09207. Yeast-kill-tox. 1 hit.
[Graphical view]
SUPFAMiSSF49695. SSF49695. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10410-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFSFVYGLT GFLAATSSAL PSEILSTGYE RSALEKRGDG YLIMCKNCDP
60 70 80 90 100
NTGSCDWKQN WNTCVGIGAN VHWMVTGGST DGKQGCATIW EGSGCVGRST
110 120
TMCCPANTCC NINTGFYIRS YRRVE
Length:125
Mass (Da):13,539
Last modified:May 27, 2002 - v2
Checksum:i8EE4BB0479E38925
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13445 Genomic DNA. Translation: BAA02704.1.
PIRiA23618. TZHQK.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13445 Genomic DNA. Translation: BAA02704.1.
PIRiA23618. TZHQK.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WKTNMR-A38-125[»]
ProteinModelPortaliP10410.
SMRiP10410.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP10410.

Family and domain databases

Gene3Di2.60.20.20. 1 hit.
InterProiIPR011024. G_crystallin-rel.
IPR015290. Yeast-kill-tox.
[Graphical view]
PfamiPF09207. Yeast-kill-tox. 1 hit.
[Graphical view]
SUPFAMiSSF49695. SSF49695. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTOXK_CYBMR
AccessioniPrimary (citable) accession number: P10410
Secondary accession number(s): Q00913
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: May 27, 2002
Last modified: November 2, 2016
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.