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P10410 (TOXK_CYBMR) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Killer toxin HM-1
Gene names
Name:HMK
OrganismCyberlindnera mrakii (Yeast) (Williopsis mrakii)
Taxonomic identifier1004253 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesPhaffomycetaceaeCyberlindnera

Protein attributes

Sequence length125 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This toxin kills sensitive strains of yeast. It inhibits beta-1,3-glucan synthesis.

Subunit structure

Monomer.

Subcellular location

Secreted.

Biophysicochemical properties

pH dependence:

Stable over a wide pH range.

Temperature dependence:

Thermostable.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionToxin
   PTMCleavage on pair of basic residues
Disulfide bond
   Technical term3D-structure
Direct protein sequencing
Gene Ontology (GO)
   Biological_processcell death

Inferred from electronic annotation. Source: InterPro

pathogenesis

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Propeptide20 – 3718
PRO_0000022568
Chain38 – 12588Killer toxin HM-1
PRO_0000022569

Amino acid modifications

Disulfide bond45 ↔ 55
Disulfide bond48 ↔ 109
Disulfide bond64 ↔ 95
Disulfide bond86 ↔ 103
Disulfide bond104 ↔ 110

Secondary structure

................. 125
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P10410 [UniParc].

Last modified May 27, 2002. Version 2.
Checksum: 8EE4BB0479E38925

FASTA12513,539
        10         20         30         40         50         60 
MKFSFVYGLT GFLAATSSAL PSEILSTGYE RSALEKRGDG YLIMCKNCDP NTGSCDWKQN 

        70         80         90        100        110        120 
WNTCVGIGAN VHWMVTGGST DGKQGCATIW EGSGCVGRST TMCCPANTCC NINTGFYIRS 


YRRVE 

« Hide

References

[1]"Isolation and nucleotide sequences of the genes encoding killer toxins from Hansenula mrakii and H. saturnus."
Kimura T., Kitamoto N., Matsuoka K., Nakamura K., Iimura Y., Kito Y.
Gene 137:265-270(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: NBRC 0895 / NCYC 2251 / VTT C-01434.
[2]"Application of monoclonal antibodies to the isolation and characterization of a killer toxin secreted by Hansenula mrakii."
Yamamoto T., Imai M., Tachibana K., Mayumi M.
FEBS Lett. 195:253-257(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 38-125.
[3]"Ancestral beta gamma-crystallin precursor structure in a yeast killer toxin."
Antuch W., Guntert P., Wuethrich K.
Nat. Struct. Biol. 3:662-665(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF 38-125.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D13445 Genomic DNA. Translation: BAA02704.1.
PIRTZHQK. A23618.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1WKTNMR-A38-125[»]
ProteinModelPortalP10410.
SMRP10410. Positions 38-124.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.60.20.20. 1 hit.
InterProIPR011024. G_crystallin-rel.
IPR015290. Yeast-kill-tox.
[Graphical view]
PfamPF09207. Yeast-kill-tox. 1 hit.
[Graphical view]
SUPFAMSSF49695. SSF49695. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceP10410.

Entry information

Entry nameTOXK_CYBMR
AccessionPrimary (citable) accession number: P10410
Secondary accession number(s): Q00913
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: May 27, 2002
Last modified: October 16, 2013
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references