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Protein

Retrovirus-related Pol polyprotein from transposon gypsy

Gene

pol

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, RNA-directed DNA polymerase, Transferase

Protein family/group databases

MEROPSiA02.021.

Names & Taxonomyi

Protein namesi
Recommended name:
Retrovirus-related Pol polyprotein from transposon gypsy
Including the following 2 domains:
Reverse transcriptase (EC:2.7.7.49)
Endonuclease
Gene namesi
Name:pol
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0014966. gypsy\pol.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10351035Retrovirus-related Pol polyprotein from transposon gypsyPRO_0000058512Add
BLAST

Proteomic databases

PRIDEiP10401.

Structurei

3D structure databases

ProteinModelPortaliP10401.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini205 – 390186Reverse transcriptasePROSITE-ProRule annotationAdd
BLAST
Domaini797 – 956160Integrase catalyticPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 integrase catalytic domain.PROSITE-ProRule annotation
Contains 1 reverse transcriptase domain.PROSITE-ProRule annotation

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiIPR001584. Integrase_cat-core.
IPR021109. Peptidase_aspartic_dom.
IPR012337. RNaseH-like_dom.
IPR000477. RT_dom.
[Graphical view]
PfamiPF00665. rve. 1 hit.
PF00078. RVT_1. 1 hit.
[Graphical view]
SUPFAMiSSF50630. SSF50630. 1 hit.
SSF53098. SSF53098. 1 hit.
PROSITEiPS50994. INTEGRASE. 1 hit.
PS50878. RT_POL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P10401-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
RLVEFFRGRS RLPFIERRLA GRTLKMLIDT DAAKNYIRPV KELKNVMPVA
60 70 80 90 100
SPFSVSSIHG STEIKHKCLM KVFKHISPFF LLDSLNAFDA IIGLDLLTQA
110 120 130 140 150
GVKLNLAEDS LEYQGIAEKL HYFSCPSVNF TDVNDIVVPD SVKKEFKDTI
160 170 180 190 200
IRRKKAFSTT NEALPFNTAV TATIRTVDNE PVYSRAYPTL MGVSDFVNNE
210 220 230 240 250
VKQLLKDGII RPSRSPYNSP TWVVDKKGTD AFGNPNKRLV IDFRKLNEKT
260 270 280 290 300
IPDRYPMPSI PMILANLGKA KFFTTLDLKS GYHQIYLAEH DREKTSFSVN
310 320 330 340 350
GGKYEFCRLP FGLRNASSIF QRALDDVLRE QIGKICYVYV DDVIIFSENE
360 370 380 390 400
SDHVRHIDTV LKCLIDANMR VSQEKTRFFK ESVEYLGFIV SKDGTKSDPE
410 420 430 440 450
KVKAIQEYPE PDCVYKVRSF LGLASYYRVF IKDFAAIARP ITDILKGENG
460 470 480 490 500
SVSKHMSKKI PVEFNETQRN AFQRLRNILA SEDVILKYPD FKKPFDLTTD
510 520 530 540 550
ASASGIGAVL SQEGRPITMI SRTLKQPEQN YATNERELLA IVWALGKLQN
560 570 580 590 600
FLYGSREINI FTDHQPLTFA VADRNTNAKI KRWKSYIDQH NAKVFYKPGK
610 620 630 640 650
ENFVADALSR QNLNALQNEP QSDAATIHSE LSLTYTVETT DKPLNCFRNQ
660 670 680 690 700
IILEAARFPL KRNLVLFRSK SRHLISFTDK SWLLKTLKEV VNPDVVNAIH
710 720 730 740 750
CDLPTLASFQ HDLIAHFPAT QFRHCKNVVL DITDKNEQIE IVTAEHNRAH
760 770 780 790 800
RAAQENIKQV LRDYYFPKMG SLAKEVVANC RVCTQAKYDR HPKKQELGET
810 820 830 840 850
PIPSYTGEMV HIDIFSTDRK LFLTCIDKFS KYAIVQPVVS RTIVDITAPL
860 870 880 890 900
LQIINLFPNI KTVYCDNEPA FNSETVTSML KNSFGIDIVN APPLHSSSNG
910 920 930 940 950
QVERFHSTLA EIARCLKLDK KTNDTVELIL RATIEYNKTV HSVTRERPIE
960 970 980 990 1000
VVHPGAHERC LEIKARLVKA QQDSIGRNNP SRQNRVFEVG ERVFVKNNKR
1010 1020 1030
LGNKLTPLCT EQKVQADLGT SVLIKGRVVH KDNLK
Length:1,035
Mass (Da):117,818
Last modified:July 1, 1989 - v1
Checksum:i7B985CA272B8A5A6
GO

Sequence cautioni

The sequence AAA70219 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti31 – 322DA → AR in CAA27371 (PubMed:2421255).Curated
Sequence conflicti60 – 601G → R in CAA27371 (PubMed:2421255).Curated
Sequence conflicti232 – 2321F → S in CAA27371 (PubMed:2421255).Curated
Sequence conflicti490 – 4901D → V in CAA27371 (PubMed:2421255).Curated
Sequence conflicti883 – 8831S → T in CAA27371 (PubMed:2421255).Curated
Sequence conflicti923 – 9231N → S in CAA27371 (PubMed:2421255).Curated
Sequence conflicti947 – 9504RPIE → NQLR (PubMed:2421255).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12927 Genomic DNA. Translation: AAA70219.1. Different initiation.
X03734 Genomic DNA. Translation: CAA27371.1.
PIRiB25666. GNFFG1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12927 Genomic DNA. Translation: AAA70219.1. Different initiation.
X03734 Genomic DNA. Translation: CAA27371.1.
PIRiB25666. GNFFG1.

3D structure databases

ProteinModelPortaliP10401.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiA02.021.

Proteomic databases

PRIDEiP10401.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

FlyBaseiFBgn0014966. gypsy\pol.

Miscellaneous databases

PROiP10401.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiIPR001584. Integrase_cat-core.
IPR021109. Peptidase_aspartic_dom.
IPR012337. RNaseH-like_dom.
IPR000477. RT_dom.
[Graphical view]
PfamiPF00665. rve. 1 hit.
PF00078. RVT_1. 1 hit.
[Graphical view]
SUPFAMiSSF50630. SSF50630. 1 hit.
SSF53098. SSF53098. 1 hit.
PROSITEiPS50994. INTEGRASE. 1 hit.
PS50878. RT_POL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPOLY_DROME
AccessioniPrimary (citable) accession number: P10401
Secondary accession number(s): P10402
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: September 16, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Transposable element

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.